{"id":87196,"date":"2021-09-15T12:30:29","date_gmt":"2021-09-15T10:30:29","guid":{"rendered":"https:\/\/ibecbarcelona.eu\/?p=87196"},"modified":"2021-09-30T09:45:09","modified_gmt":"2021-09-30T07:45:09","slug":"un-xip-contra-les-infeccions-bacterianes-croniques","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/ca\/un-xip-contra-les-infeccions-bacterianes-croniques\/","title":{"rendered":"Un xip contra les infeccions bacterianes cr\u00f2niques"},"content":{"rendered":"

\"\"El 80% de les infeccions cr\u00f2niques s’associen al creixement de biofilms o <\/span>biopel\u00b7l\u00edcul<\/span>es<\/span>. Es tracta de comunitats bacterianes de diferents esp\u00e8cies que es formen i viuen en superf\u00edcies de teixits vius o inerts. Aquest tipus d’infeccions s\u00f3n complexes, dif\u00edcils de tractar i solen perdurar per un llarg per\u00edode de temps, ja que els biofilms estan\u00a0<\/span>encastats<\/span> en una matriu que protegeix els bacteris dels tractaments antimicrobians i del sistema immune, convertint-se aix\u00ed molt m\u00e9s resistents als antibi\u00f2tics.<\/span><\/span> Malgrat la import\u00e0ncia cl\u00ednica de les infeccions produ\u00efdes per biofilms, encara no s’ha descrit un m\u00e8tode simple i efectiu per a diagnosticar la seva susceptibilitat a antibi\u00f2tics i avaluar noves estrat\u00e8gies per al seu control i erradicaci\u00f3<\/span><\/span><\/span>.\u00a0<\/span>\u00a0<\/span><\/p>\n

Ara, investigadors de l’Institut de\u00a0<\/span>Bioenginyeria<\/span>\u00a0de Catalunya (IBEC), liderats per Eduard Torrents,\u00a0<\/span>investigador principal del grup \u201cInfeccions bacterianes i ter\u00e0pies antimicrobianes<\/a>\u201d i professor de la Universitat de Barcelona (UB),\u00a0<\/span>en col\u00b7laboraci\u00f3 amb Josep Samitier, investigador principal del grup \u201c<\/span>Nanobioingenier\u00eda<\/span><\/a>\u201d de l’IBEC, i Maite Martin, de l’Hospital Universitari Vall d\u2019Hebron a Barcelona, han desenvolupat un nou dispositiu, denominat\u00a0<\/strong><\/span>BiofilmChip<\/span><\/strong>, que permet un diagn\u00f2stic personalitzat i prec\u00eds de les infeccions cr\u00f2niques<\/strong>. Aquest treball ha estat publicat recentment en la revista del grup\u00a0<\/span>Nature<\/span>,<\/span>\u00a0<\/span><\/span>Biofilms\u00a0<\/span>and<\/span>\u00a0<\/span>Microbiomes<\/span><\/span><\/a>,<\/span><\/span>\u00a0i compta amb el suport de la Fundaci\u00f3 \u201cla Caixa\u201d per al seu desenvolupament.<\/span><\/span>\u00a0<\/span><\/p>\n

Aquest nou dispositiu permetr\u00e0 fer cr\u00e9ixer biofilms en el laboratori reproduint les condicions que ocorren durant el proc\u00e9s d’infecci\u00f3. Aix\u00ed, es podr\u00e0 determinar el seu patr\u00f3 de resist\u00e8ncia i sensibilitat a diferents antibi\u00f2tics i identificar el tractament m\u00e9s adequat, fins i tot de forma personalitzada a cada pacient.<\/span>\u00a0<\/span><\/p>\n

El\u00a0BiofilmChip\u00a0obre les portes a l’estudi i tractament de biofilms, tant en infeccions cr\u00f2niques com la fibrosi qu\u00edstica i infeccions pulmonars o urin\u00e0ries, com en \u00e0mbits relacionats amb les contaminacions de material hospitalari (cat\u00e8ters, v\u00e0lvules card\u00edaques i pr\u00f2tesis) o en la ind\u00fastria aliment\u00e0ria (superf\u00edcies i plans de treball).<\/span>\u00a0<\/span><\/p>\n

BiofilmChip<\/span>: una nova manera de lluitar contra les infeccions produ\u00efdes per biofilms<\/span><\/span>\u00a0<\/span><\/strong><\/h2>\n

\"\"El mal \u00fas dels antibi\u00f2tics sumat a les infeccions cr\u00f2niques produ\u00efdes per biofilms, est\u00e0 portant a un augment de les resist\u00e8ncies bacterianes. Fins avui no s’ha descrit cap antibi\u00f2tic capa\u00e7 d’erradicar els biofilms, entre altres coses per la falta d’un sistema\u00a0<\/span>in vitro<\/span><\/i>\u00a0realment efectiu que permeti la recerca i el desenvolupament de noves mol\u00e8cules\u00a0antibiofilm.<\/span>\u00a0<\/span><\/p>\n

El\u00a0BiofilmChip\u00a0permet el cultiu del biofilm com a tal, amb tota la comunitat bacteriana que el\u00a0forma, a difer\u00e8ncia dels m\u00e8todes cl\u00e0ssics de microbiologia on es\u00a0cultiven\u00a0els bacteris per separat en plaques individuals. Aquest punt \u00e9s crucial, ja que els bacteris presenten susceptibilitats molt diferents al mateix antibi\u00f2tic si es troben a\u00efllades o formant part d’un biofilm.<\/span>\u00a0<\/span><\/p>\n

El nostre\u00a0<\/span>BiofilmChip<\/span>\u00a0permet avaluar l’acci\u00f3 de diferents antibi\u00f2tics directament sobre un biofilm, aproximant-se molt m\u00e9s al que\u00a0<\/span>passa<\/span>\u00a0en infeccions reals.<\/span> \u00a0<\/strong><\/p>\n

N\u00faria Blanco-Cabra, coautora principal de l’estudi<\/i>\u00a0<\/strong><\/p>\n<\/blockquote>\n

En col\u00b7laboraci\u00f3 amb l’Hospital Vall d\u2019Hebron, els investigadors han fet cr\u00e9ixer en el\u00a0BiofilmChip\u00a0els bacteris continguts en mostres d’esput de pacients amb fibrosi qu\u00edstica. El\u00a0BiofilmChip\u00a0\u00e9s una plataforma de\u00a0microflu\u00eddica\u00a0que permet portar al biofilm no sols els nutrients i compostos necessaris per al seu creixement, sin\u00f3 tamb\u00e9 els diferents antibi\u00f2tics que es vulguin analitzar.<\/span>\u00a0<\/span><\/p>\n

En aquest dispositiu s’ha integrat un el\u00e8ctrode que permet determinar el creixement bacteri\u00e0 i la resposta del biofilm a un antibi\u00f2tic o tractament, mitjan\u00e7ant la detecci\u00f3 de par\u00e0metres el\u00e8ctrics (imped\u00e0ncia). Al mateix temps, el dispositiu permet l’observaci\u00f3 del biofilm al microscopi sense pr\u00e8via manipulaci\u00f3. La utilitzaci\u00f3 del\u00a0BiofilmChip\u00a0\u00e9s simple i no requereix una infraestructura complexa per al seu funcionament, de manera que es podria emprar de manera rutin\u00e0ria en els laboratoris de microbiologia cl\u00ednica o en la ind\u00fastria.<\/span>\u00a0<\/span><\/p>\n

Els resultats que vam obtenir amb el\u00a0<\/span>BiofilmChip<\/span>\u00a0demostren que \u00e9s una eina molt \u00fatil per a determinar la susceptibilitat de biofilms a antibi\u00f2tics i que es podria implementar f\u00e0cilment als hospitals.<\/span> <\/strong><\/p>\n

Maria Jos\u00e9 L\u00f3pez-Mart\u00ednez, coautora principal de l’estudi<\/i>\u00a0<\/strong><\/p>\n<\/blockquote>\n

\u00a0<\/span>Article de refer\u00e8ncia:<\/span><\/b>\u00a0<\/span>\u00a0<\/span> N\u00faria Blanco-Cabra, Maria Jos\u00e9 L\u00f3pez-Mart\u00ednez, Betsy Ver\u00f3nica Ar\u00e9valo-Jaimes, Mar\u00eda Teresa Martin-G\u00f3mez, Josep Samitier, Eduard Torrents.\u00a0<\/span>A new\u00a0BiofilmChip\u00a0device for testing biofilm formation and antibiotic susceptibility<\/span><\/a>.\u00a0npj\u00a0Biofilms and Microbiomes (2021) 7:62.<\/span>\u00a0<\/span> \u00a0<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

Investigadors de l’IBEC desenvolupen un dispositiu que permet cr\u00e9ixer biofilms i analitzar la seva susceptibilitat enfront de diferents antibi\u00f2tics de manera senzilla i a partir de mostres de pacients. L’innovador BiofilmChip, un dispositiu de diagn\u00f2stic de f\u00e0cil utilitzaci\u00f3 i baix cost, obre les portes a trobar tractaments efectius i personalitzats contra infeccions cr\u00f2niques produ\u00efdes per biofilms.\u00a0<\/h3>\n

.<\/p>\n","protected":false},"author":4,"featured_media":87208,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[96],"tags":[1141,1136],"post_formats":[],"class_list":["post-87196","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticies-de-recerca","tag-eduard-torrents-ca","tag-josep-samitier-ca"],"yoast_head":"\nUn xip contra les infeccions bacterianes cr\u00f2niques - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/ca\/un-xip-contra-les-infeccions-bacterianes-croniques\/\" \/>\n<meta property=\"og:locale\" content=\"ca_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Un xip contra les infeccions bacterianes cr\u00f2niques - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"Investigadors de l'IBEC desenvolupen un dispositiu que permet cr\u00e9ixer biofilms i analitzar la seva susceptibilitat enfront de diferents antibi\u00f2tics de manera senzilla i a partir de mostres de pacients. L'innovador BiofilmChip, un dispositiu de diagn\u00f2stic de f\u00e0cil utilitzaci\u00f3 i baix cost, obre les portes a trobar tractaments efectius i personalitzats contra infeccions cr\u00f2niques produ\u00efdes per biofilms.\u00a0.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/ibecbarcelona.eu\/ca\/un-xip-contra-les-infeccions-bacterianes-croniques\/\" \/>\n<meta property=\"og:site_name\" content=\"Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"article:published_time\" content=\"2021-09-15T10:30:29+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2021-09-30T07:45:09+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2021\/09\/0c526950-595c-4948-ae7c-17761f505782.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"500\" \/>\n\t<meta property=\"og:image:height\" content=\"281\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"\u00c0ngels L\u00f3pez\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrit per\" \/>\n\t<meta name=\"twitter:data1\" content=\"\u00c0ngels L\u00f3pez\" \/>\n\t<meta name=\"twitter:label2\" content=\"Temps estimat de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"4 minuts\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/un-xip-contra-les-infeccions-bacterianes-croniques\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/un-xip-contra-les-infeccions-bacterianes-croniques\\\/\"},\"author\":{\"name\":\"\u00c0ngels L\u00f3pez\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#\\\/schema\\\/person\\\/c212c6b589546130be67986b9290e2b8\"},\"headline\":\"Un xip contra les infeccions bacterianes cr\u00f2niques\",\"datePublished\":\"2021-09-15T10:30:29+00:00\",\"dateModified\":\"2021-09-30T07:45:09+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/un-xip-contra-les-infeccions-bacterianes-croniques\\\/\"},\"wordCount\":762,\"publisher\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/un-xip-contra-les-infeccions-bacterianes-croniques\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/ibecbarcelona.eu\\\/wp-content\\\/uploads\\\/2021\\\/09\\\/0c526950-595c-4948-ae7c-17761f505782.jpg\",\"keywords\":[\"Eduard Torrents\",\"Josep Samitier\"],\"articleSection\":[\"Not\u00edcies de recerca\"],\"inLanguage\":\"ca\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/un-xip-contra-les-infeccions-bacterianes-croniques\\\/\",\"url\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/un-xip-contra-les-infeccions-bacterianes-croniques\\\/\",\"name\":\"Un xip contra les infeccions bacterianes cr\u00f2niques - 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