{"id":87427,"date":"2021-09-23T17:40:17","date_gmt":"2021-09-23T15:40:17","guid":{"rendered":"https:\/\/ibecbarcelona.eu\/?p=87427"},"modified":"2021-09-30T09:42:11","modified_gmt":"2021-09-30T07:42:11","slug":"medicina-personalitzada-per-a-lluitar-contra-la-leucemia-infantil","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/ca\/medicina-personalitzada-per-a-lluitar-contra-la-leucemia-infantil\/","title":{"rendered":"Medicina personalitzada per a lluitar contra la leuc\u00e8mia infantil"},"content":{"rendered":"

\"\"La leuc\u00e8mia\u00a0<\/span>linfobl<\/span>\u00e0<\/span>stica<\/span>\u00a0aguda (LLA) representa una quarta part de tots els casos de c\u00e0ncer diagnosticats en nens i adults joves, i \u00e9s el que causa major\u00a0<\/span>mortalitat\u00a0<\/span>en aquesta franja d’edat. Encara que la gran majoria dels pacients respon<\/span>guin<\/span>\u00a0b\u00e9 al tractament, en el 15-20% dels casos el c\u00e0ncer reapareix. El tractament est\u00e0ndard per a aquests pacients es basa\u00a0<\/span>en l\u2019<\/span>administra<\/span>ci\u00f3<\/span>\u00a0<\/span>de\u00a0<\/span>ter\u00e0pies agressives que, encara que salv<\/span>i<\/span>n vides, tamb\u00e9 poden induir efectes secundaris a llarg termini, incloses la discapacitat mental i f\u00edsica.<\/span><\/span>\u00a0<\/span>
\n<\/span><\/p>\n

Ara, un estudi dirigit per\u00a0<\/span><\/span>l’Institut de Bioenginyeria de Catalunya, IBEC<\/span><\/span><\/a>, i publicat en la revista cient\u00edfica\u00a0<\/span><\/span>Frontiers<\/span>\u00a0in Cell\u00a0<\/span>and<\/span>\u00a0<\/span>Developmental<\/span>\u00a0<\/span>Biology<\/span><\/span><\/a>, aborda la necessitat urgent de desenvolupar ter\u00e0pies personalitzades que s’adaptin a cada pacient, al mateix temps que redueixin els efectes secundaris que deriven de l’actual enfocament \u201cunificat\u201d. El treball ha estat liderat per l’investigador s\u00e8nior Joan Montero i l’estudiant de doctorat Albert Manzano, del\u00a0<\/span><\/span>laboratori de\u00a0<\/span>Nanobio<\/span>e<\/span>ngi<\/span>nye<\/span>r<\/span>i<\/span>a<\/span>\u00a0de l’IBEC<\/span><\/span><\/a>. En l’estudi tamb\u00e9 han contribu\u00eft Josep Samitier, l\u00edder de grup, i Clara Alcon, t\u00e8cnica s\u00e8nior, tamb\u00e9 del laboratori de\u00a0<\/span>Nanobioenginyeria<\/span>\u00a0<\/span>de l’IBEC; i investigadors d’altres instituts, com la Universitat de Barcelona.<\/span><\/span> <\/span>\u00a0<\/span><\/p>\n

Predir la resposta al tractament<\/span><\/span><\/strong>\u00a0<\/span><\/h2>\n

En aquest estudi, els investigadors van utilitzar una metodologia nova, coneguda com a \u201cperfil din\u00e0mic de BH3\u201d, que mesura la capacitat dels f\u00e0rmacs a induir les c\u00e8l\u00b7lules canceroses a morir (apoptosis), per a avaluar nous tractaments que podrien millorar concretament els resultats dels pacients amb Leuc\u00e8mia\u00a0<\/span>linfobl<\/span>\u00e0<\/span>stica<\/span>\u00a0aguda precursora de c\u00e8l\u00b7lules B (BCP-ALL), i especialment d’aquells que hagin recaigut. En aquesta t\u00e8cnica, els medicaments contra el c\u00e0ncer s’administren a les c\u00e8l\u00b7lules en el laboratori. D’aquesta manera, els investigadors poden analitzar els esdeveniments\u00a0<\/span>apopt<\/span>\u00f2<\/span>tics<\/span>\u00a0primerencs de forma m\u00e9s r\u00e0pida, \u00e9s a dir, poden determinar si els medicaments mataran les c\u00e8l\u00b7lules (en aquest cas leuc\u00e8miques)\u00a0<\/span>de una manera m\u00e9s r\u00e0pida<\/span>.<\/span><\/span>\u00a0<\/span><\/p>\n

Aquesta nova t\u00e8cnica permet reduir significativament el temps d’an\u00e0lisi i predir amb precisi\u00f3 l’efectivitat dels tractaments seq\u00fcencials per a la leuc\u00e8mia\u00a0<\/span>linfobl<\/span>\u00e0<\/span>stica<\/span> aguda pedi\u00e0trica.<\/span><\/strong><\/p>\n

Joan Montero, autor principal del treball.<\/span><\/span><\/strong><\/p>\n<\/blockquote>\n

L’estudi tamb\u00e9 va investigar com les diferents variacions gen\u00e8tiques de BCP-ALL van respondre als f\u00e0rmacs\u00a0<\/span>antitumorals<\/span>\u00a0en combinaci\u00f3 amb mim\u00e8tics de BH3, petites mol\u00e8cules que bloquegen espec\u00edficament les prote\u00efnes que eviten la mort de les c\u00e8l\u00b7lules canceroses. Aquests inhibidors de la mort cel\u00b7lular s\u00f3n un segell distintiu dels c\u00e0ncers que es tornen resistents als tractaments.<\/span><\/span>\u00a0<\/span> <\/span><\/p>\n

Descobrim que molts dels f\u00e0rmacs, que nom\u00e9s tenien una efic\u00e0cia modesta quan s’administraven per si sols, mataven a una proporci\u00f3 significativament major de c\u00e8l\u00b7lules canceroses quan s’administraven en combinaci\u00f3 amb mim\u00e8tics de BH3<\/span><\/span>.<\/strong><\/p>\n

Albert Manzano, primer autor de l’estudi. \u00a0<\/strong><\/p>\n<\/blockquote>\n

De fet, l’efecte va ser sovint sin\u00e8rgic, com per exemple en la inhibici\u00f3 dual de les prote\u00efnes MEK i MCL-1<\/span>,<\/span>\u00a0que va aconseguir l’eliminaci\u00f3 gaireb\u00e9 completa de les c\u00e8l\u00b7lules leuc\u00e8miques. Aquests resultats poden ser particularment rellevants en el disseny de noves combinacions terap\u00e8utiques per a pacients que han sofert recaigudes.<\/span><\/span>\u00a0<\/span><\/p>\n

\u00a0<\/span><\/p>\n

Cap a una medicina personalitzada contra la leuc\u00e8mia pedi\u00e0trica<\/span><\/span>\u00a0<\/span><\/strong><\/h2>\n
\"\"
Clara Alcon, Joan Montero i Albert Manzano, investigadors de l’IBEC.<\/figcaption><\/figure>\n

Els resultats del treball mostren la utilitat d’usar\u00a0el\u00a0\u201cperfil din\u00e0mic de BH3\u201d per a predir la millor combinaci\u00f3 de tractaments per a cada pacient i augmentar aix\u00ed la pot\u00e8ncia i efic\u00e0cia de la ter\u00e0pia. A m\u00e9s, demostra que els BH3 mim\u00e8tics poden millorar les ter\u00e0pies actuals per a tractar la leuc\u00e8mia\u00a0linfobl\u00e0stica\u00a0aguda i superar la resist\u00e8ncia en bloquejar les prote\u00efnes que prevenen la mort de les c\u00e8l\u00b7lules canceroses. A m\u00e9s, at\u00e8s que l’efecte dels BH3\u00a0mim\u00e0tics\u00a0\u00e9s sovint sin\u00e8rgic, es requeriran concentracions m\u00e9s baixes de cada f\u00e0rmac i, per tant, ser\u00e0 menys probable que els pacients\u00a0pateixin\u00a0efectes secundaris greus.<\/span>\u00a0<\/span><\/p>\n

\u00c9s important destacar que totes aquestes observacions es van realitzar despr\u00e9s d’un temps d’incubaci\u00f3 molt curt, la qual cosa emfatitza la utilitat d’aquests assajos predictius funcionals en la cl\u00ednica. En resum, aquestes troballes podrien representar noves estrat\u00e8gies terap\u00e8utiques prometedores enfront d’aquest\u00a0tipus\u00a0de leuc\u00e8mia.<\/span>\u00a0<\/span><\/p>\n

Esperem<\/span>\u00a0que\u00a0<\/span>aquest<\/span>\u00a0i futurs estudis en el nostre laboratori puguin ajudar els pacients pedi\u00e0trics amb leuc\u00e8mia a curar-se amb els m\u00ednims efectes secundaris adversos possibles<\/span>.\u00a0<\/strong><\/p>\n

Joan Montero, IBEC.\u00a0<\/strong><\/p>\n<\/blockquote>\n

Article de refer\u00e8ncia: <\/span><\/b>Albert Manzano-Mu\u00f1oz, Clara\u00a0Alcon, Pablo Men\u00e9ndez, Manuel Ram\u00edrez,\u00a0Felix\u00a0Seyfried, Klaus-Michael\u00a0Debatin,\u00a0L\u00fcder\u00a0H. Meyer, Josep\u00a0Samitier\u00a0and Joan Montero.\u00a0<\/span>MCL-1\u00a0Inhibition\u00a0Overcomes\u00a0Anti-apoptotic\u00a0Adaptation\u00a0to\u00a0Targeted\u00a0Therapies\u00a0in B-Cell\u00a0Precursor\u00a0Acute\u00a0Lymphoblastic\u00a0Leukemia<\/span><\/a>. 2021, Front.\u00a0Cell\u00a0Dev. Biol. 9:695225.<\/span>\u00a0<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

Investigadors de l’IBEC han utilitzat una t\u00e8cnica anal\u00edtica d’avantguarda per a avaluar noves combinacions de f\u00e0rmacs per a tractar amb \u00e8xit la leuc\u00e8mia linfobl\u00e0stica aguda. L’estudi acosta la medicina personalitzada a la cl\u00ednica per a aquest tipus de c\u00e0ncer i coincideix amb el mes de la conscienciaci\u00f3 sobre el c\u00e0ncer infantil.<\/h3>\n

\u00a0<\/p>\n","protected":false},"author":4,"featured_media":87342,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[96],"tags":[1136],"post_formats":[],"class_list":["post-87427","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticies-de-recerca","tag-josep-samitier-ca"],"yoast_head":"\nMedicina personalitzada per a lluitar contra la leuc\u00e8mia infantil - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/ca\/medicina-personalitzada-per-a-lluitar-contra-la-leucemia-infantil\/\" \/>\n<meta property=\"og:locale\" content=\"ca_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Medicina personalitzada per a lluitar contra la leuc\u00e8mia infantil - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"Investigadors de l'IBEC han utilitzat una t\u00e8cnica anal\u00edtica d'avantguarda per a avaluar noves combinacions de f\u00e0rmacs per a tractar amb \u00e8xit la leuc\u00e8mia linfobl\u00e0stica aguda. 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