{"id":88642,"date":"2021-11-02T11:50:43","date_gmt":"2021-11-02T10:50:43","guid":{"rendered":"https:\/\/ibecbarcelona.eu\/?p=88642"},"modified":"2021-11-16T11:03:16","modified_gmt":"2021-11-16T10:03:16","slug":"nou-biosensor-amb-alta-sensibilitat-detecta-marcador-inflamatori-al-muscul","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/ca\/nou-biosensor-amb-alta-sensibilitat-detecta-marcador-inflamatori-al-muscul\/","title":{"rendered":"Nou biosensor amb alta sensibilitat detecta marcador inflamatori al m\u00fascul"},"content":{"rendered":"

\"\"
Esquerra: Fotografia d’un substrat de disc Blu-ray evaporat d’Au de 70\u00a0<\/span>nm<\/span>\u00a0i la difracci\u00f3 caracter\u00edstica de la llum. Dreta: Imatges representatives de microsc\u00f2pia confocal de\u00a0<\/span>microteixits<\/span>\u00a0de m\u00fascul esquel\u00e8tic en 3D.<\/span><\/span>\u00a0<\/span><\/figcaption><\/figure>Qu\u00e8 tenen en com\u00fa malalties com el c\u00e0ncer, l’artritis\u00a0reumatoide, la diabetis, la COVID-19, la depressi\u00f3 o la distr\u00f2fia muscular? Tot i les seves profundes difer\u00e8ncies, cadascuna est\u00e0 relacionada amb processos inflamatoris desencadenats per un culpable com\u00fa: la interleucina-6 (IL-6). Aquesta biomol\u00e8cula pertany a una \u00e0mplia fam\u00edlia de prote\u00efnes conegudes com a citocines, que participen en la resposta immunit\u00e0ria de l’organisme. At\u00e8s que els seus nivells solen estar elevats en infeccions, inflamacions i malalties autoimmunes, \u00e9s un indicador fiable de la gravetat en nombrosos casos. Per contra, nivells redu\u00efts poden mostrar fins a quin punt funciona un tractament. Per tant, ser capa\u00e7 de mesurar citocines com a IL-6 de forma r\u00e0pida i precisa \u00e9s crucial per descobrir i testejar f\u00e0rmacs. No obstant aix\u00f2, malauradament sovint \u00e9s dif\u00edcil fer-ho, ja que\u202f\u00e9s present en concentracions extremadament baixes.<\/span>\u00a0<\/span><\/p>\n

Ara, investigadors del grup\u00a0<\/span>Biosensors per a Bioenginyeria<\/span><\/a>\u00a0de l’IBEC presenten, en un nou estudi publicat a la revista\u00a0<\/span>Nanophotonics<\/span><\/i>, la utilitzaci\u00f3 de la\u00a0nanoenginyeria\u00a0per a la detecci\u00f3 r\u00e0pida, precisa, f\u00e0cilment reprodu\u00efble i rendible d’IL-6. L’estudi va ser liderat pel cap del grup\u00a0<\/span>Javier Ram\u00f3n\u00a0Azc\u00f3n<\/span><\/a>, signat per l’investigador\u00a0postdoctoral\u00a0<\/span>Gerardo L\u00f3pez Mu\u00f1oz<\/span><\/a>\u00a0com a primer autor, i amb les contribucions de Trias i Eduard Martin-Lasierra, i dels membres del grup\u00a0<\/span>Juanma Fern\u00e1ndez Costa<\/span><\/a>,\u00a0<\/span>Maria Alejandra Ortega\u00a0Machuc<\/span><\/a>a\u00a0i Jordina Balaguer.<\/span>\u00a0<\/span><\/p>\n

Millorant la sensibilitat i la reproductibilitat<\/span><\/span>\u00a0<\/span><\/strong><\/h3>\n

En aquest treball, es va desenvolupar un nou biosensor basat en Blu-ray produ\u00eft industrialment per detectar la prote\u00efna IL-6 en m\u00fasculs esquel\u00e8tics obtinguts per bioenginyeria 3D. En primer lloc, els investigadors van fer bioenginyeria de teixits musculars esquel\u00e8tics en 3D mitjan\u00e7ant l’\u00fas d’una t\u00e8cnica d’encapsulaci\u00f3 de\u00a0fotomotlles\u00a0que havien desenvolupat pr\u00e8viament. Despr\u00e9s, van induir l’alliberament de diferents concentracions d’IL-6 a les mostres i van analitzar cadascuna amb el seu biosensor. El biosensor, que es basa en una\u00a0nanoestructura\u00a0plasm\u00f2nica\u00a0– una part\u00edcula la densitat d’electrons de la qual pot acoblar-se amb radiaci\u00f3 electromagn\u00e8tica de longituds d’ona molt m\u00e9s grans que la mateixa part\u00edcula – va mostrar m\u00e9s sensibilitat en mesurar variacions en les concentracions d’IL-6, fins i tot quan eren extremadament baixes.<\/span>\u00a0<\/span><\/p>\n

De fet, aquesta t\u00e8cnica va superar altres plataformes de biosensors\u00a0plasm\u00f2niques\u00a0i\u00a0nanopl\u00e0smiques\u00a0en almenys un ordre de magnitud en la detecci\u00f3 d’IL-6 al teixit muscular. La seva sensibilitat va ser similar a la de les plataformes de\u00a0biodetecci\u00f3\u00a0electroqu\u00edmiques, per\u00f2 ofereix l’avantatge addicional de ser directe i sense necessitat de fer servir marcadors. A m\u00e9s, gr\u00e0cies a l’\u00fas de\u00a0nanocristalls\u00a01D fabricats a escala industrial presents a Blu-ray, podria convertir-se en un sensor multicanal altament reprodu\u00efble.<\/span>\u00a0<\/span><\/p>\n

Una eina prometedora per a l’avaluaci\u00f3 de medicaments<\/span><\/span>\u00a0<\/span><\/strong><\/h3>\n

Els autors identifiquen noves oportunitats per afinar la seva t\u00e8cnica, incl\u00f2s l’\u00fas d’altres materials\u00a0<\/span>plasm\u00f2nics<\/span>\u00a0com el\u00a0<\/span>graf\u00e8<\/span>\u00a0o l’or\u202f<\/span>nanopor\u00f2s<\/span>, per estendre’n l’aplicaci\u00f3 a una gamma m\u00e9s \u00e0mplia de\u00a0<\/span>biomarcadors<\/span>.<\/span><\/span>\u00a0<\/span>
<\/span>\u00a0<\/span>
<\/span>El nou enfocament ofereix una quantificaci\u00f3 directa, sense marcadors i en temps\u00a0<\/span>real de\u00a0<\/span>biomarcadors<\/span>\u00a0que minimitza la complexitat d’utilitzaci\u00f3. Podria utilitzar-se per mesurar\u00a0<\/span>biomarcadors<\/span>\u00a0en teixits o\u00a0<\/span>organoides<\/span>\u00a0produ\u00efts per bioenginyeria 3D a les fases inicials del\u202f<\/span>testatge<\/span>\u202fde nous f\u00e0rmacs candidats per a\u202finnombrables\u202fmalalties. Els estudis futurs se centraran en la\u202f<\/span>biodetecci\u00f3<\/span>\u202fmultiplexada i en temps real per desenvolupar plataformes de seguiment de cultius cel\u00b7lulars.<\/span><\/span>\u00a0<\/span><\/p>\n

La nostra t\u00e8cnica va superar altres plataformes de biosensors d’aquest tipus en almenys un ordre de magnitud a la detecci\u00f3 d’IL-6 en teixit muscular.<\/span><\/span>\u00a0<\/span><\/strong><\/p>\n

Javier Ramon, professor de recerca ICREA a l’IBEC<\/span><\/span><\/strong>\u00a0<\/span><\/p>\n<\/blockquote>\n

\u00a0<\/span><\/p>\n

Article de refer\u00e8ncia:\u00a0<\/strong><\/p>\n

Gerardo A Lopez-Mu\u00f1oz,\u202fJuan M Fern\u00e1ndez-Costa\u202f<\/span>,\u202fMaria Alejandra Ortega,\u202fJordina Balaguer-Trias,\u202fEduard Martin-Lasierra\u202fand\u202fJavier Ram\u00f3n-Azc\u00f3n.\u00a0<\/span>Plasmonic nanocrystals on polycarbonate substrates for direct and label-free\u00a0biodetection\u00a0of Interleukin-6 in bioengineered 3D skeletal muscles<\/span><\/a>.\u00a0<\/span>Nanophotonics<\/span><\/a>, 2021.<\/span>\u00a0<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

En una publicaci\u00f3 recent a la revista\u202fNanophotonics, investigadors de l’IBEC\u202fpresenten un nou biosensor per a la detecci\u00f3 directa i sensible de la prote\u00efna interleucina-6 al m\u00fascul, un indicador d’inflamaci\u00f3 i de potencial malaltia, demostrant l’alt rendiment del dispositiu en m\u00fasculs esquel\u00e8tics obtinguts per bioenginyeria 3D. Aquest nou enfocament pot resultar en una eina prometedora per mesurar l’efic\u00e0cia de f\u00e0rmacs davant de malalties en qu\u00e8 hi ha inflamaci\u00f3, com la distr\u00f2fia muscular. <\/h3>\n","protected":false},"author":4,"featured_media":88153,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[96],"tags":[1131],"post_formats":[],"class_list":["post-88642","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticies-de-recerca","tag-javier-ramon-ca"],"yoast_head":"\nNou biosensor amb alta sensibilitat detecta marcador inflamatori al m\u00fascul - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/ca\/nou-biosensor-amb-alta-sensibilitat-detecta-marcador-inflamatori-al-muscul\/\" \/>\n<meta property=\"og:locale\" content=\"ca_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Nou biosensor amb alta sensibilitat detecta marcador inflamatori al m\u00fascul - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"En una publicaci\u00f3 recent a la revista\u202fNanophotonics, investigadors de l'IBEC\u202fpresenten un nou biosensor per a la detecci\u00f3 directa i sensible de la prote\u00efna interleucina-6 al m\u00fascul, un indicador d'inflamaci\u00f3 i de potencial malaltia, demostrant l'alt rendiment del dispositiu en m\u00fasculs esquel\u00e8tics obtinguts per bioenginyeria 3D. 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