{"id":94120,"date":"2022-05-13T09:00:00","date_gmt":"2022-05-13T07:00:00","guid":{"rendered":"https:\/\/testweb.ibecbarcelona.eu\/?p=94120"},"modified":"2022-05-13T14:31:26","modified_gmt":"2022-05-13T12:31:26","slug":"mini-ronyons-generats-en-el-laboratori-ajuden-a-entendre-la-relacio-entre-la-malaltia-de-la-diabetis-i-la-covid-19","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/ca\/mini-ronyons-generats-en-el-laboratori-ajuden-a-entendre-la-relacio-entre-la-malaltia-de-la-diabetis-i-la-covid-19\/","title":{"rendered":"Mini ronyons generats en el laboratori ajuden a entendre la relaci\u00f3 entre la malaltia de la diabetis i la COVID-19"},"content":{"rendered":"\n

En una col\u00b7laboraci\u00f3 internacional, investigadors liderats per Nuria Montserrat, Professora de Recerca ICREA a l’IBEC, han generat mini ronyons humans que simulen el rony\u00f3 d’una persona amb diabetis en les etapes inicials de la malaltia. Aquests mini ronyons diab\u00e8tics obren les portes a estudiar, entre altres, la relaci\u00f3 entre la diabetis i la COVID-19.<\/h4>\n\n\n\n

Fa dos anys que milers de cient\u00edfics i metges de tot el m\u00f3n treballen per a entendre com es desenvolupa la COVID-19 i quina relaci\u00f3 t\u00e9 amb una altra mena de malalties. Diversos estudis han assenyalat, que les persones diab\u00e8tiques eren m\u00e9s propenses a desenvolupar una COVID-19 severa, aix\u00ed com que m\u00e9s del 20% dels pacients hospitalitzats per COVID-19 patien problemes renals aguts. No obstant aix\u00f2, fins avui, es desconeixia com era el factor causal que originava que aix\u00f2 succe\u00eds.\u00a0<\/p>\n\n\n\n

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Ara, un equip internacional liderat per Nuria Montserrat, professora de recerca ICREA en l’Institut de Bioenginyeria de Catalunya (IBEC) i investigadora principal del grup \u201cPluripotencia per a la regeneraci\u00f3 d’\u00f2rgans<\/a>\u201d, en col\u00b7laboraci\u00f3, entre altres, amb investigadors de la Universitat de Florida, el Life Sciences Institute de la Universitat de British Columbia al Canad\u00e0, Karolinska Institute i Karolinska University Hospital a Su\u00e8cia, ha utilitzat la bioenginyeria per a desenvolupar mini ronyons que simulen el rony\u00f3 de pacients en les fases inicials de la diabetis.<\/strong>\u00a0<\/p>\n\n\n\n

El nostre model de organoide renal diab\u00e8tic ens ha perm\u00e8s observar que els mini ronyons diab\u00e8tics, amb major nombre de receptors ACE2, presenten una major susceptibilitat a la infecci\u00f3 viral.<\/p>Elena Garreta, investigadora en l’IBEC i primera coautora de l’estudi\u00a0<\/cite><\/blockquote>\n\n\n\n

En el treball, Montserrat tamb\u00e9 ha comptat amb la col\u00b7laboraci\u00f3 d’investigadors espanyols del Cl\u00ednic CIMA i la Universitat de Navarra, l’Hospital Cl\u00ednic de Barcelona, l’Hospital de la Santa Creu i Sant Pau a Barcelona i de la Universitat de Barcelona. Aquest estudi ha rebut finan\u00e7ament de l’Institut de Salut Carles III (ISCIII), a trav\u00e9s de les ajudes FONS COVID19: Convocat\u00f2ria Finan\u00e7ament Extraordinari de Projectes de Recerca sobre el SARS-CoV-2 i la malaltia COVID-19 i PLATAFORMA ISCIII BIOBANCOS I BIOMODELOS: Plataformes ISCIII de suport a la I+D+I en Biomedicina i Ci\u00e8ncies de la Salut. <\/p>\n\n\n\n

Aquesta \u00e9s la primera vegada que els investigadors utilitzen organoides de rony\u00f3 per a entendre les primeres fases de la diabetis en aquest \u00f2rgan. <\/p>\n\n\n\n

Amb la finalitat de demostrar que el receptor ACE2 t\u00e9 un paper essencial per a la infecci\u00f3 de SARS-CoV-2 en el rony\u00f3<\/strong>, els investigadors tamb\u00e9 van generar, mitjan\u00e7ant enginyeria gen\u00e8tica, organoides defectius per a altres receptors descrits fins avui com a \u201cportes d’entrada\u201d per al virus. Aquesta fase de l’estudi es va realitzar amb finan\u00e7ament de les Ajudes Fundaci\u00f3 BBVA a equips de recerca cient\u00edfica SARS-CoV-2 i COVID-19. <\/p>\n\n\n\n

El treball ha utilitzat, a m\u00e9s, mostres de pacients, posant en relleu el paper del metabolisme energ\u00e8tic en la infecci\u00f3 per SARS-CoV-2. Aquestes troballes obren la porta a la identificaci\u00f3 de noves intervencions terap\u00e8utiques per a tractar la COVID-19. Aquest estudi trencador s’acaba de publicar en la prestigiosa revista Cell Metabolism<\/em>. <\/p>\n\n\n\n

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Els mini ronyons diab\u00e8tics tenen m\u00e9s portes d’entrada per al SARS-CoV-2\u00a0<\/strong><\/strong><\/h3>\n\n\n\n

\u00c9s absolutament imperatiu entendre els mecanismes moleculars que subjauen a un COVID-19 m\u00e9s sever en pacients amb diabetis i altres comorbiditats metab\u00f2liques. El desenvolupament d’un organoide de rony\u00f3 diab\u00e8tic \u00e9s un gran pas cap a la dissecci\u00f3 experimental de com els canvis metab\u00f2lics poden afectar les infeccions SARS-CoV-2. Les dades tornen a demostrar que l’ACE2 \u00e9s el receptor essencial del SARS-CoV-2, fins i tot en condicions de comorbiditat.<\/p>Josef Penninger, Institut de Biotecnologia Molecular<\/cite><\/blockquote>\n\n\n\n

Per a crear mini ronyons amb les mateixes caracter\u00edstiques cel\u00b7lulars, i les mateixes alteracions metab\u00f2liques que les que es troben en els ronyons d’una persona diab\u00e8tica en la fase inicial de la malaltia, els investigadors van desenvolupar mini ronyons en el laboratori a partir de c\u00e8l\u00b7lules mare humanes pluripotents que van ser sotmesos a condicions de cultiu en el laboratori amb la finalitat de reproduir l’entorn diab\u00e8tic. <\/p>\n\n\n\n

Posteriorment, utilitzant diferents t\u00e8cniques de biologia molecular, com l’edici\u00f3 gen\u00e8tica, els investigadors van observar que, en els mini ronyons diab\u00e8tics, l’abund\u00e0ncia de receptor ACE2 era la que determinava la susceptibilitat a la infecci\u00f3 viral, establint una relaci\u00f3 causal entre la diabetis i la pres\u00e8ncia d’un dels receptors decisius en la infecci\u00f3 per SARS-CoV-2.\u00a0<\/p>\n\n\n\n

A m\u00e9s, utilitzant t\u00e8cniques capdavanteres com la seq\u00fcenciaci\u00f3 de RNA, els investigadors van identificar que els mini ronyons diab\u00e8tics posseeixen una signatura metab\u00f2lica que podria explicar perqu\u00e8 els mini ronyons diab\u00e8tics s’infecten m\u00e9s.\u00a0<\/p>\n\n\n\n

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Imatge de microsc\u00f2pia \u00f2ptica d’un organoide de rony\u00f3 generat a partir de c\u00e8l\u00b7lules mare pluripotents humanes [imatge de l’esquerra]. Detall d’una estructura tubular proximal (magenta) d’un organoide renal infectat amb SARS-CoV-2, que mostra c\u00e8l\u00b7lules positives per a ACE2 (verd) i c\u00e8l\u00b7lules infectades amb SARS-CoV-2 (vermell) [imatge central]. Imatge de microsc\u00f2pia electr\u00f2nica de transmissi\u00f3 que mostra un detall de c\u00e8l\u00b7lules de l’organoide infectades amb SARS-CoV-2 [imatge de la dreta].\u200b<\/h6>\n\n\n\n

<\/p>\n\n\n\n

La diabetis augmenta la susceptibilitat a la infecci\u00f3 per SARS-CoV-2 en c\u00e8l\u00b7lules de pacients\u00a0<\/strong><\/strong><\/h3>\n\n\n\n

Aquest descobriment llan\u00e7a una llum sobre un mecanisme potencial darrere de casos m\u00e9s greus de pacients diab\u00e8tics. Aquesta tecnologia millorar\u00e0 la nostra capacitat per investigar com el virus interacciona amb diferents \u00f2rgans en el cos hum\u00e0.<\/em><\/p>Ali Mirazimi, professor adjunt a l’Institut Karolinska<\/cite><\/blockquote>\n\n\n\n

Per a verificar si els resultats obtinguts amb els mini ronyons s’observaven tamb\u00e9 en l’\u00f2rgan natiu, els investigadors van analitzar c\u00e8l\u00b7lules renals de pacients amb diabetis i d’individus sense diabetis. Les dades van demostrar que les c\u00e8l\u00b7lules renals de pacients diab\u00e8tics, de la mateixa manera que el que ocorre en els mini ronyons, presentaven m\u00e9s receptors ACE2 i patien susceptibilitat a la infecci\u00f3 per SARS-CoV-2. Amb la finalitat d’aprofundir en els mecanismes que poden explicar tals observacions, els investigadors van utilitzar un compost que modula l’estat metab\u00f2lic de les c\u00e8l\u00b7lules i van comprovar que el tractament disminu\u00efa la infecci\u00f3 viral.\u00a0<\/p>\n\n\n\n

<\/div>\n\n\n\n

Hem demostrat que el virus SARS-CoV-2 \u00e9s capa\u00e7 d’infectar directament les c\u00e8l\u00b7lules de t\u00fabul proximal a\u00efllades del rony\u00f3 hum\u00e0, i que la diabetis fa que aquestes c\u00e8l\u00b7lules siguin m\u00e9s propenses a la infecci\u00f3.<\/p>Megan Stanifer, investigadora de la Universitat de Florida i primera coautora de l’estudi<\/cite><\/blockquote>\n\n\n\n

Aquest nou model de mini rony\u00f3 diab\u00e8tic obrir\u00e0 les portes a estudiar el paper d’altres malalties anomenades \u201ccom\u00f2rbides\u201d, com la hipertensi\u00f3, en el desenvolupament de la COVID-19 i altres patologies complexes. <\/p>\n\n\n\n

Aquesta recerca va ser recolzada en part per l’Institut de Salut Carles III i la Fundaci\u00f3 Banc Bilbao Biscaia a trav\u00e9s de fons d’emerg\u00e8ncia enfocats a accelerar el desenvolupament, prova i implementaci\u00f3 de mesures per a fer front al brot de COVID-19.<\/em> <\/p>\n\n\n\n

Nuria Montserrat \u00e9s membre del Centro de Investigaci\u00f3n Biom\u00e9dica en Red \u2013 Bioingenier\u00eda, Biomateriales y Nanomedicina (CIBER- BBN).\u00a0<\/em>\u00a0<\/p>\n\n\n\n

<\/div>\n\n\n\n

Article de refer\u00e8ncia: <\/strong>Elena Garreta, Patricia Prado, Megan Stanifer, Vanessa Monteil, Andr\u00e9s Marco, Asier Ullate-Agote, Daniel Moya-Rull, Amaia Vilas-Zornoza, Carolina Tarantino, Juan Pablo Romero, Gustav Jonsson, Roger Oria, Alexandra Leopoldi, Astrid Hagelkruys, Maria Gallo, Federico Gonz\u00e1lez, Pere Domingo-Pedrol, Aleix Gavald\u00e0, Carmen Hurtado del Pozo, Omar Hasan Ali, Pedro Ventura-Aguiar, Josep Mar\u00eda Campistol, Felipe Prosper, Ali Mirazimi, Steeve Boulant, Josef M. Penninger, Nuria Montserrat. A diabetic milieu increases ACE2 expression and cellular susceptibility to SARS-CoV-2 infections in human kidney organoids and patient cells<\/a>. Cell Metabolism. 2022.<\/p>\n\n\n\n

DOI: https:\/\/doi.org\/10.1016\/j.cmet.2022.04.009<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

En una col\u00b7laboraci\u00f3 internacional, investigadors liderats per Nuria Montserrat, Professora de Recerca ICREA a l’IBEC, han generat mini ronyons humans que simulen el rony\u00f3 d’una persona amb diabetis en les etapes inicials de la malaltia. Aquests mini ronyons diab\u00e8tics obren les portes a estudiar, entre altres, la relaci\u00f3 entre la diabetis i la COVID-19.<\/h3>\n","protected":false},"author":4,"featured_media":94118,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[96],"tags":[1123],"post_formats":[],"class_list":["post-94120","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticies-de-recerca","tag-nuria-montserrat-ca-2"],"yoast_head":"\nMini ronyons generats en el laboratori ajuden a entendre la relaci\u00f3 entre la malaltia de la diabetis i la COVID-19 - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/ca\/mini-ronyons-generats-en-el-laboratori-ajuden-a-entendre-la-relacio-entre-la-malaltia-de-la-diabetis-i-la-covid-19\/\" \/>\n<meta property=\"og:locale\" content=\"ca_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Mini ronyons generats en el laboratori ajuden a entendre la relaci\u00f3 entre la malaltia de la diabetis i la COVID-19 - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"En una col\u00b7laboraci\u00f3 internacional, investigadors liderats per Nuria Montserrat, Professora de Recerca ICREA a l'IBEC, han generat mini ronyons humans que simulen el rony\u00f3 d'una persona amb diabetis en les etapes inicials de la malaltia. 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