{"id":99063,"date":"2022-09-13T16:05:54","date_gmt":"2022-09-13T14:05:54","guid":{"rendered":"https:\/\/ibecbarcelona.eu\/?p=99063"},"modified":"2022-09-29T12:53:13","modified_gmt":"2022-09-29T10:53:13","slug":"identificada-una-nova-diana-terapeutica-contra-el-cancer-de-pulmo-mes-frequent%ef%bf%bc","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/ca\/identificada-una-nova-diana-terapeutica-contra-el-cancer-de-pulmo-mes-frequent\/","title":{"rendered":"Identificada una nova diana terap\u00e8utica contra el c\u00e0ncer de pulm\u00f3 m\u00e9s freq\u00fcent"},"content":{"rendered":"\n<h4 class=\"wp-block-heading\">Un estudi liderat per Jordi Alcaraz, investigador associat de l&#8217;IBEC i professor de la Universitat de Barcelona, en col\u00b7laboraci\u00f3 amb l&#8217;Hospital Cl\u00ednic, ha determinat que la prote\u00efna TIMP-1 est\u00e0 implicada en la progressi\u00f3 de l&#8217;adenocarcinoma de pulm\u00f3. Es tracta d&#8217;un biomarcador que ja estava associat a un mal pron\u00f2stic en diversos tipus de c\u00e0ncer, per\u00f2 del qual es desconeixia la funci\u00f3.<\/h4>\n\n\n\n<figure class=\"wp-block-image size-full\"><img decoding=\"async\" width=\"900\" height=\"521\" data-src=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2022\/09\/radiografiapulmones_web.jpg\" alt=\"\" class=\"wp-image-99075 lazyload\" data-srcset=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2022\/09\/radiografiapulmones_web.jpg 900w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2022\/09\/radiografiapulmones_web-300x174.jpg 300w, https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2022\/09\/radiografiapulmones_web-768x445.jpg 768w\" data-sizes=\"(max-width: 900px) 100vw, 900px\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 900px; --smush-placeholder-aspect-ratio: 900\/521;\" \/><\/figure>\n\n\n\n<p>Els nivells de la prote\u00efna TIMP-1 tant en teixits com a la sang s\u2019han associat repetidament a un mal pron\u00f2stic en diversos c\u00e0ncers humans, per\u00f2 la seva funci\u00f3 en el proc\u00e9s tumoral era, fins ara, un misteri. Un estudi liderat pel professor de la Facultat de Medicina i Ci\u00e8ncies de la Salut de la UB i investigador de l\u2019Institut de Bioenginyeria de Catalunya (IBEC) Jordi Alcaraz ha determinat que aquesta prote\u00efna no \u00e9s nom\u00e9s un bon biomarcador, sin\u00f3 que tamb\u00e9 est\u00e0 implicada en la progressi\u00f3 de l\u2019adenocarcinoma de pulm\u00f3. Aquests resultats, publicats a la revista <a href=\"https:\/\/doi.org\/10.1016\/j.matbio.2022.06.009\"><em>Matrix Biology<\/em><\/a>, obren la porta al disseny de nous tractaments contra aquesta malaltia.&nbsp;<\/p>\n\n\n\n<p>En les \u00faltimes d\u00e8cades, la recerca en c\u00e0ncer s\u2019ha dirigit a tenir tractaments cada cop m\u00e9s espec\u00edfics per a cada tipus de tumor i pacient, cosa que ha millorat la prognosi dels pacients. En aquesta l\u00ednia, aquest treball identifica una diana terap\u00e8utica per a aquells pacients amb c\u00e0ncer de pulm\u00f3 de c\u00e8l\u00b7lula no petita del subtipus adenocarcinoma, que \u00e9s el tipus de c\u00e0ncer de pulm\u00f3 m\u00e9s freq\u00fcent.<\/p>\n\n\n\n<p>En el treball tamb\u00e9 hi han participat investigadors de l\u2019Hospital Cl\u00ednic, l\u2019Institut d\u2019Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS), el Centre de Recerca Biom\u00e8dica en Xarxa de Malalties Respirat\u00f2ries (CIBERES), l\u2019Institut de Recerca Sanit\u00e0ria San Carlos (IdISSC) i la Cl\u00ednica Mayo, dels Estats Units. El treball ha rebut finan\u00e7ament de l\u2019Ag\u00e8ncia Espanyola de Recerca i de la Fundaci\u00f3 Privada Cellex.<\/p>\n\n\n\n<p><strong>Una col\u00b7lecci\u00f3 \u00fanica a Espanya de fibroblasts derivats de pacients<\/strong><\/p>\n\n\n\n<p>El TIMP-1 \u00e9s una prote\u00efna secretada de manera an\u00f2mala pels fibroblasts, un tipus de c\u00e8l\u00b7lules no malignes que acompanyen les c\u00e8l\u00b7lules canceroses i que s\u00f3n el principal component del que s\u2019anomena microambient tumoral. Per entendre la funci\u00f3 del TIMP-1 en aquest proc\u00e9s, els investigadors han fet servir una col\u00b7lecci\u00f3 \u00fanica a Espanya de fibroblasts derivats de pacients amb c\u00e0ncer de pulm\u00f3 de l\u2019Hospital Cl\u00ednic. En concret, van fer assajos amb cultius cel\u00b7lulars <em>in vitro<\/em> i amb ratolins (<em>in vivo<\/em>) centrats en el c\u00e0ncer de pulm\u00f3 de c\u00e8l\u00b7lules no petites, que representa fins al 85&nbsp;% dels c\u00e0ncers de pulm\u00f3 i que se subdivideix en dos subtipus: l\u2019adenocarcinoma i el carcinoma de c\u00e8l\u00b7lules escamoses.<\/p>\n\n\n\n<p><strong>Interacci\u00f3 protumoral amb el receptor CD63<\/strong><\/p>\n\n\n\n<p>Els resultats van demostrar, en primer lloc, que els nivells elevats de TIMP-1 en c\u00e0ncer de pulm\u00f3 es deuen al fet que els fibroblasts secreten \u00abnivells patol\u00f2gics\u00bb d\u2019aquesta prote\u00efna. Despr\u00e9s, tamb\u00e9 van detectar que el TIMP-1 provinent dels fibroblasts causa un augment de la proliferaci\u00f3 i invasi\u00f3 tumoral quan interactua amb el receptor CD63 de les c\u00e8l\u00b7lules canceroses. I, finalment, van comprovar que \u00abaquest eix protumoral format per la interacci\u00f3 entre el TIMP-1 i el CD63 es dona nom\u00e9s en el subtipus d\u2019adenocarcinoma i no en el carcinoma de c\u00e8l\u00b7lules escamoses\u00bb, subratlla Jordi Alcaraz, que tamb\u00e9 \u00e9s investigador del CIBERES.<\/p>\n\n\n\n<p><strong>Nova estrat\u00e8gia terap\u00e8utica<\/strong><\/p>\n\n\n\n<p>Aquests resultats poden facilitar el desenvolupament de noves ter\u00e0pies dirigides contra aquesta interacci\u00f3 patol\u00f2gica. \u00abEl fet de saber que els pacients amb adenocarcinoma tenen uns fibroblasts hiperactius que secreten el TIMP-1 de manera excessiva ens permet plantejar l\u2019\u00fas de ter\u00e0pies que n\u2019impedeixin la secreci\u00f3\u00bb, explica Paula Duch, investigadora de la UB i primera autora de l\u2019article.&nbsp;<\/p>\n\n\n\n<p>En aquest sentit, l\u2019estudi, a m\u00e9s de posar de manifest que els fibroblasts tenen un paper molt important en la progressi\u00f3 dels tumors, tamb\u00e9 obre una via per \u00abatacar aquest eix protumoral\u00bb mitjan\u00e7ant f\u00e0rmacs antifibr\u00f2tics, desenvolupats per inhibir les funcions patol\u00f2giques d\u2019aquestes c\u00e8l\u00b7lules. \u00abLa idea seria investigar, d\u2019una banda, si els f\u00e0rmacs antifibr\u00f2tics s\u00f3n capa\u00e7os d\u2019inhibir la secreci\u00f3 an\u00f2mala del TIMP-1 i, de l\u2019altra, si aquesta inhibici\u00f3 redueix la progressi\u00f3 dels tumors d\u2019adenocarcinoma\u00bb, destaca la investigadora.<\/p>\n\n\n\n<p>\u00abA llarg termini \u2014afegeix\u2014, si aquesta aproximaci\u00f3 funcion\u00e9s, es podria plantejar l\u2019\u00fas d\u2019aquests f\u00e0rmacs antifibr\u00f2tics combinat amb ter\u00e0pies anticancer\u00edgenes, com ara la immunoter\u00e0pia, que ataquessin altres aspectes del tumor\u00bb.<\/p>\n\n\n\n<p><strong>Implicacions en altres tipus de c\u00e0ncer<\/strong><\/p>\n\n\n\n<p>Aquests resultats podrien traslladar-se a altres c\u00e0ncers, ja que la prote\u00efna TIMP-1 tamb\u00e9 est\u00e0 extensament descrita com a biomarcador de mala prognosi en molts tipus de tumors s\u00f2lids. \u00abPer tant, en altres tumors altament fibr\u00f2tics amb nivells elevats de TIMP-1 i del seu receptor, el CD63, \u00e9s probable que aquest eix tamb\u00e9 tingui un paper protumoral important\u00bb, conclou Paula Duch.<\/p>\n\n\n\n<p><strong>Article de refer\u00e8ncia<\/strong><\/p>\n\n\n\n<p>Duch, P.; D\u00edaz-Valdivia, N.; Ikemori, R.; Gabasa, M.; S. Radisky, E. S.; Arshakyan, M.; Gea-Sorl\u00ed, S.; Mateu-Bosch, A.; Bragado, P.; Josep Carrasco, J. Ll.; Mori, H.; Ram\u00edrez, J.; Teixid\u00f3, C.; Reguart, N.; Fillat, C.; Radisky, D. C.; Alcaraz, J. <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0945053X22000890?via%3Dihub\">\u00abAberrant TIMP-1 overexpression in tumor-associated fibroblasts drives tumor progression through CD63 in lung adenocarcinoma\u00bb<\/a>. <em>Matrix Biology<\/em>, juliol de 2022. DOI:<strong> <\/strong>https:\/\/doi.org\/10.1016\/j.matbio.2022.06.009<\/p>\n\n\n\n<p>Via: <a href=\"https:\/\/www.ub.edu\/web\/ub\/ca\/menu_eines\/noticies\/2022\/09\/009.html\">UB<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Un estudi liderat per Jordi Alcaraz, investigador associat de l&#8217;IBEC i professor de la Universitat de Barcelona, en col\u00b7laboraci\u00f3 amb l&#8217;Hospital Cl\u00ednic, ha determinat que la prote\u00efna TIMP-1 est\u00e0 implicada &#8230; <a title=\"Identificada una nova diana terap\u00e8utica contra el c\u00e0ncer de pulm\u00f3 m\u00e9s freq\u00fcent\" class=\"read-more\" href=\"https:\/\/ibecbarcelona.eu\/ca\/identificada-una-nova-diana-terapeutica-contra-el-cancer-de-pulmo-mes-frequent\/\" aria-label=\"More on Identificada una nova diana terap\u00e8utica contra el c\u00e0ncer de pulm\u00f3 m\u00e9s freq\u00fcent\">Read more<\/a><\/p>\n","protected":false},"author":4,"featured_media":99075,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[96],"tags":[1774,1795],"post_formats":[],"class_list":["post-99063","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticies-de-recerca","tag-cancer-ca","tag-investigador-associat"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Identificada una nova diana terap\u00e8utica contra el c\u00e0ncer de pulm\u00f3 m\u00e9s freq\u00fcent - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/ca\/identificada-una-nova-diana-terapeutica-contra-el-cancer-de-pulmo-mes-frequent\/\" \/>\n<meta property=\"og:locale\" content=\"ca_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Identificada una nova diana terap\u00e8utica contra el c\u00e0ncer de pulm\u00f3 m\u00e9s freq\u00fcent - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"Un estudi liderat per Jordi Alcaraz, investigador associat de l&#8217;IBEC i professor de la Universitat de Barcelona, en col\u00b7laboraci\u00f3 amb l&#8217;Hospital Cl\u00ednic, ha determinat que la prote\u00efna TIMP-1 est\u00e0 implicada ... 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