{"id":99416,"date":"2022-09-23T09:32:07","date_gmt":"2022-09-23T07:32:07","guid":{"rendered":"https:\/\/ibecbarcelona.eu\/?p=99416"},"modified":"2022-09-29T12:54:07","modified_gmt":"2022-09-29T10:54:07","slug":"identifiquen-les-millors-vies-per-portar-farmacs-al-cervell-durant-la-malaltia-de-niemann-pick-tipus-a-una-patologia-neurologica","status":"publish","type":"post","link":"https:\/\/ibecbarcelona.eu\/ca\/identifiquen-les-millors-vies-per-portar-farmacs-al-cervell-durant-la-malaltia-de-niemann-pick-tipus-a-una-patologia-neurologica\/","title":{"rendered":"Identifiquen les millors vies per portar f\u00e0rmacs al cervell durant la malaltia de Niemann-Pick tipus A, una patologia neurol\u00f2gica\u00a0"},"content":{"rendered":"\n

Investigadors identifiquen com la malaltia neurol\u00f2gica\u202fNiemann-Pick tipus A altera les vies naturals d’entrada de mol\u00e8cules al cervell i van identificar les m\u00e9s actives i propenses a ser utilitzades amb nanopart\u00edcules, capaces de subministrar f\u00e0rmacs.<\/h4>\n\n\n\n

Aquestes troballes obren la porta a millorar tractaments actuals per a les malalties neurol\u00f2giques,\u202fi a\u202fdesenvolupar-ne de noves, basades en l’\u00fas de nanopart\u00edcules com a “cavalls de Troia” per introduir f\u00e0rmacs al cervell a trav\u00e9s de les noves vies identificades.\u00a0<\/h4>\n\n\n\n
\"\"<\/figure>
\n

La barrera hematoencef\u00e0lica protegeix el cervell de l’entrada de mol\u00e8cules t\u00f2xiques, per\u00f2 tamb\u00e9 dificulta l’entrada i els efectes terap\u00e8utics de la majoria dels f\u00e0rmacs. Aix\u00ed, l’administraci\u00f3 de ter\u00e0pies al cervell continua sent un gran repte, i encara que s’han intentat moltes estrat\u00e8gies per creuar-la, no s’ha tingut gaire \u00e8xit en el transport de grans mol\u00e8cules, com ara enzims i altres prote\u00efnes. En aquest context, la nanomedicina est\u00e0 buscant maneres d’explotar les rutes naturals de transport a trav\u00e9s d’aquesta barrera, per\u00f2 es desconeix com es veuen afectades durant una malaltia neurol\u00f2gica, cosa que dificulta el disseny de tractaments efica\u00e7os.\u00a0<\/p>\n<\/div><\/div>\n\n\n\n

Ara, investigadors de l’Institut de Bioenginyeria de Catalunya (IBEC), en col\u00b7laboraci\u00f3 amb l’Institut de Recerca en\u202fBioci\u00e8ncia\u202fi Biotecnologia de la Universitat de Maryland, als Estats Units, han observat com una malaltia neurol\u00f2gica altera les rutes naturals de transport entre el sistema circulatori,\u202f\u00e9s a dir la sang, i el cervell<\/strong>. Examinant tres d’aquestes rutes, van identificar quines s\u00f3n m\u00e9s actives per al disseny de nanopart\u00edcules capaces de fer arribar f\u00e0rmacs al cervell. <\/strong>Els resultats s’han publicat recentment al\u202fJournal\u202fof\u202fControlled\u202fRelease<\/em><\/a>.\u00a0<\/p>\n\n\n\n

Creuant la barrera hematoencef\u00e0lica durant la malaltia<\/strong>\u00a0<\/strong><\/p>\n\n\n\n

Els investigadors de l’IBEC i els seus col\u00b7laboradors es van centrar en un mecanisme de transport conegut com a transcitosi, en qu\u00e8 una mol\u00e8cula travessa la barrera hematoencef\u00e0lica passant per l’interior de les seves c\u00e8l\u00b7lules endotelials, la capa cel\u00b7lular protectora que envolta el cervell. L’objectiu \u00e9s explotar aquest transport transcel\u00b7lular per provocar l’entrada efectiva de f\u00e0rmacs al cervell. <\/p>\n\n\n\n

A l’estudi van analitzar com una malaltia neurol\u00f2gica influeix en tres vies diferents de les rutes de transcitosi, per aix\u00ed identificar la(es) m\u00e9s adequades per a una eventual ter\u00e0pia. Es tracta de la malaltia de Niemann Pick tipus A, actualment intractable. Apareix en nadons i joves i es caracteritza per un metabolisme anormal dels greixos (l\u00edpids), que acaben acumulant-se en \u00f2rgans vitals com el fetge, els pulmons i, principalment, el cervell.\u00a0\u00a0<\/p>\n\n\n\n

Aquesta malaltia s’inclou en un grup de m\u00e9s de 60 trastorns metab\u00f2lics hereditaris, anomenats trastorns d’emmagatzematge lisos\u00f2mic (TLS), la majoria sense tractament fins ara. El sistema nervi\u00f3s dels pacients es deteriora progressivament, provocant una mortalitat elevada\u202fal cap de pocs mesos\u202fo anys de vida. A m\u00e9s, se sap que alguns d’aquests defectes metab\u00f2lics estan associats a malalties neurol\u00f2giques comunes i cr\u00f2niques com el Parkinson, que afecta m\u00e9s de 10 milions de persones a tot el m\u00f3n, amb un cost de 10.000-20.000 euros anuals per pacient a Europa.\u00a0<\/p>\n\n\n\n

Les rutes adequades identificades i les plataformes nanotecnol\u00f2giques dissenyades per explotar-les ofereixen una nova oportunitat per reformular ter\u00e0pies que abans no podien entrar al cervell per al tractament d’aquestes afeccions<\/em>.<\/em>\u00a0<\/p>

\u00a0<\/p>Silvia Muro (IBEC), investigadora principal de l’estudi<\/em><\/cite><\/blockquote>\n\n\n\n

Els lisosomes s\u00f3n coneguts com els “contenidors de reciclatge” de les c\u00e8l\u00b7lules del nostre cos, incloses les neurones, ja que la seva funci\u00f3 principal \u00e9s processar el material no desitjat per convertir-lo en subst\u00e0ncies que la c\u00e8l\u00b7lula pugui utilitzar o rebutjar, trencant-lo i modificant-lo amb enzims.\u202fSi un o diversos enzims s\u00f3n defectuosos (a causa de mutacions gen\u00e8tiques), un exc\u00e9s de productes “no desitjats” s’acumula a la c\u00e8l\u00b7lula de forma delet\u00e8ria.\u00a0<\/p>\n\n\n\n

Aplicant t\u00e8cniques capdavanteres com la microsc\u00f2pia confocal, la\u202fradiotracci\u00f3\u202fi la nanotecnologia per analitzar teixit cerebral\u202fpost mortem<\/em>\u202fde pacients i models animals, aix\u00ed com models cel\u00b7lulars de la barrera hematoencef\u00e0lica, els investigadors van poder identificar quina de les tres rutes examinades estava alterada per la malaltia i seleccionar la millor per al transport de mol\u00e8cules, i potencialment f\u00e0rmacs, a trav\u00e9s de la barrera hematoencef\u00e0lica.\u00a0<\/p>\n\n\n\n

Nanotransportadors per transportar f\u00e0rmacs<\/strong>\u00a0<\/p>\n\n\n\n

La identificaci\u00f3 de les millors rutes per creuar la barrera hematoencef\u00e0lica durant una malaltia neurol\u00f2gica facilitar\u00e0 el desenvolupament de nous enfocaments de tractament en qu\u00e8 els f\u00e0rmacs podran travessar aquesta barrera de manera m\u00e9s efectiva a trav\u00e9s de la transitosi. Aqu\u00ed entren en joc els nanotransportadors, eines de nanomedicina que es poden utilitzar en una estrat\u00e8gia de \u201ccavall de Troia molecular\u201d, ja que es poden carregar amb una varietat de f\u00e0rmacs, protegir-los de l’entorn, i portar-los de manera segura fins a l’interior del cervell. <\/p>\n\n\n\n

El disseny efica\u00e7 dels nanotransportadors enfocats a ter\u00e0pies per al cervell pot guiar futures intervencions terap\u00e8utiques per al tractament de la malaltia de Niemann-Pick tipus A, altres LSD, i es podria estendre f\u00e0cilment al tractament de les malalties d’Alzheimer i Parkinson. <\/p>\n\n\n\n

Article de refer\u00e8ncia<\/strong>: Melani Solomon, Maximilian Loeck, Marcelle Silva-Abreau, Ronaldo Moscoso, Ronelle Bautista, Marco Vigo, Silvia Muro. Altered blood-brain barrier transport of nanotherapeutics in lysosomal storage diseases. Journal of Controlled Release<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Investigadors identifiquen com la malaltia neurol\u00f2gica\u202fNiemann-Pick tipus A altera les vies naturals d’entrada de mol\u00e8cules al cervell i van identificar les m\u00e9s actives i propenses a ser utilitzades amb nanopart\u00edcules, … Read more<\/a><\/p>\n","protected":false},"author":4,"featured_media":99412,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[96],"tags":[1125],"post_formats":[],"class_list":["post-99416","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticies-de-recerca","tag-silvia-muro-ca"],"yoast_head":"\nIdentifiquen les millors vies per portar f\u00e0rmacs al cervell durant la malaltia de Niemann-Pick tipus A, una patologia neurol\u00f2gica\u00a0 - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/ca\/identifiquen-les-millors-vies-per-portar-farmacs-al-cervell-durant-la-malaltia-de-niemann-pick-tipus-a-una-patologia-neurologica\/\" \/>\n<meta property=\"og:locale\" content=\"ca_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Identifiquen les millors vies per portar f\u00e0rmacs al cervell durant la malaltia de Niemann-Pick tipus A, una patologia neurol\u00f2gica\u00a0 - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"Investigadors identifiquen com la malaltia neurol\u00f2gica\u202fNiemann-Pick tipus A altera les vies naturals d’entrada de mol\u00e8cules al cervell i van identificar les m\u00e9s actives i propenses a ser utilitzades amb nanopart\u00edcules, ... Read more\" \/>\n<meta property=\"og:url\" content=\"https:\/\/ibecbarcelona.eu\/ca\/identifiquen-les-millors-vies-per-portar-farmacs-al-cervell-durant-la-malaltia-de-niemann-pick-tipus-a-una-patologia-neurologica\/\" \/>\n<meta property=\"og:site_name\" content=\"Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"article:published_time\" content=\"2022-09-23T07:32:07+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2022-09-29T10:54:07+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2022\/09\/Brain-capillaries.png\" \/>\n\t<meta property=\"og:image:width\" content=\"886\" \/>\n\t<meta property=\"og:image:height\" content=\"886\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"\u00c0ngels L\u00f3pez\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrit per\" \/>\n\t<meta name=\"twitter:data1\" content=\"\u00c0ngels L\u00f3pez\" \/>\n\t<meta name=\"twitter:label2\" content=\"Temps estimat de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"4 minuts\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/identifiquen-les-millors-vies-per-portar-farmacs-al-cervell-durant-la-malaltia-de-niemann-pick-tipus-a-una-patologia-neurologica\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/identifiquen-les-millors-vies-per-portar-farmacs-al-cervell-durant-la-malaltia-de-niemann-pick-tipus-a-una-patologia-neurologica\\\/\"},\"author\":{\"name\":\"\u00c0ngels L\u00f3pez\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#\\\/schema\\\/person\\\/c212c6b589546130be67986b9290e2b8\"},\"headline\":\"Identifiquen les millors vies per portar f\u00e0rmacs al cervell durant la malaltia de Niemann-Pick tipus A, una patologia neurol\u00f2gica\u00a0\",\"datePublished\":\"2022-09-23T07:32:07+00:00\",\"dateModified\":\"2022-09-29T10:54:07+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/identifiquen-les-millors-vies-per-portar-farmacs-al-cervell-durant-la-malaltia-de-niemann-pick-tipus-a-una-patologia-neurologica\\\/\"},\"wordCount\":923,\"publisher\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/identifiquen-les-millors-vies-per-portar-farmacs-al-cervell-durant-la-malaltia-de-niemann-pick-tipus-a-una-patologia-neurologica\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/ibecbarcelona.eu\\\/wp-content\\\/uploads\\\/2022\\\/09\\\/Brain-capillaries.png\",\"keywords\":[\"Silvia Muro\"],\"articleSection\":[\"Not\u00edcies de recerca\"],\"inLanguage\":\"ca\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/identifiquen-les-millors-vies-per-portar-farmacs-al-cervell-durant-la-malaltia-de-niemann-pick-tipus-a-una-patologia-neurologica\\\/\",\"url\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/identifiquen-les-millors-vies-per-portar-farmacs-al-cervell-durant-la-malaltia-de-niemann-pick-tipus-a-una-patologia-neurologica\\\/\",\"name\":\"Identifiquen les millors vies per portar f\u00e0rmacs al cervell durant la malaltia de Niemann-Pick tipus A, una patologia neurol\u00f2gica\u00a0 - Institute for Bioengineering of Catalonia\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/identifiquen-les-millors-vies-per-portar-farmacs-al-cervell-durant-la-malaltia-de-niemann-pick-tipus-a-una-patologia-neurologica\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/identifiquen-les-millors-vies-per-portar-farmacs-al-cervell-durant-la-malaltia-de-niemann-pick-tipus-a-una-patologia-neurologica\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/ibecbarcelona.eu\\\/wp-content\\\/uploads\\\/2022\\\/09\\\/Brain-capillaries.png\",\"datePublished\":\"2022-09-23T07:32:07+00:00\",\"dateModified\":\"2022-09-29T10:54:07+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/identifiquen-les-millors-vies-per-portar-farmacs-al-cervell-durant-la-malaltia-de-niemann-pick-tipus-a-una-patologia-neurologica\\\/#breadcrumb\"},\"inLanguage\":\"ca\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/identifiquen-les-millors-vies-per-portar-farmacs-al-cervell-durant-la-malaltia-de-niemann-pick-tipus-a-una-patologia-neurologica\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"ca\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/identifiquen-les-millors-vies-per-portar-farmacs-al-cervell-durant-la-malaltia-de-niemann-pick-tipus-a-una-patologia-neurologica\\\/#primaryimage\",\"url\":\"https:\\\/\\\/ibecbarcelona.eu\\\/wp-content\\\/uploads\\\/2022\\\/09\\\/Brain-capillaries.png\",\"contentUrl\":\"https:\\\/\\\/ibecbarcelona.eu\\\/wp-content\\\/uploads\\\/2022\\\/09\\\/Brain-capillaries.png\",\"width\":886,\"height\":886},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/identifiquen-les-millors-vies-per-portar-farmacs-al-cervell-durant-la-malaltia-de-niemann-pick-tipus-a-una-patologia-neurologica\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Identifiquen les millors vies per portar f\u00e0rmacs al cervell durant la malaltia de Niemann-Pick tipus A, una patologia neurol\u00f2gica\u00a0\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#website\",\"url\":\"https:\\\/\\\/ibecbarcelona.eu\\\/\",\"name\":\"Institute for Bioengineering of Catalonia\",\"description\":\"Bioengineering Solutions for Health\",\"publisher\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/ibecbarcelona.eu\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"ca\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#organization\",\"name\":\"Institute for Bioengineering of Catalonia\",\"url\":\"https:\\\/\\\/ibecbarcelona.eu\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"ca\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/ibecbarcelona.eu\\\/wp-content\\\/uploads\\\/2026\\\/01\\\/cropped-IBEC_20ANYS_GRIS.png\",\"contentUrl\":\"https:\\\/\\\/ibecbarcelona.eu\\\/wp-content\\\/uploads\\\/2026\\\/01\\\/cropped-IBEC_20ANYS_GRIS.png\",\"width\":696,\"height\":257,\"caption\":\"Institute for Bioengineering of Catalonia\"},\"image\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#\\\/schema\\\/logo\\\/image\\\/\"}},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#\\\/schema\\\/person\\\/c212c6b589546130be67986b9290e2b8\",\"name\":\"\u00c0ngels L\u00f3pez\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"ca\",\"@id\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/09ad6ba116bea0b15c5511860f83b302579fd7404c1180e9dae55c3f11d988c6?s=96&d=mm&r=g\",\"url\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/09ad6ba116bea0b15c5511860f83b302579fd7404c1180e9dae55c3f11d988c6?s=96&d=mm&r=g\",\"contentUrl\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/09ad6ba116bea0b15c5511860f83b302579fd7404c1180e9dae55c3f11d988c6?s=96&d=mm&r=g\",\"caption\":\"\u00c0ngels L\u00f3pez\"},\"url\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/author\\\/alopez\\\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Identifiquen les millors vies per portar f\u00e0rmacs al cervell durant la malaltia de Niemann-Pick tipus A, una patologia neurol\u00f2gica\u00a0 - Institute for Bioengineering of Catalonia","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/ibecbarcelona.eu\/ca\/identifiquen-les-millors-vies-per-portar-farmacs-al-cervell-durant-la-malaltia-de-niemann-pick-tipus-a-una-patologia-neurologica\/","og_locale":"ca_ES","og_type":"article","og_title":"Identifiquen les millors vies per portar f\u00e0rmacs al cervell durant la malaltia de Niemann-Pick tipus A, una patologia neurol\u00f2gica\u00a0 - Institute for Bioengineering of Catalonia","og_description":"Investigadors identifiquen com la malaltia neurol\u00f2gica\u202fNiemann-Pick tipus A altera les vies naturals d’entrada de mol\u00e8cules al cervell i van identificar les m\u00e9s actives i propenses a ser utilitzades amb nanopart\u00edcules, ... Read more","og_url":"https:\/\/ibecbarcelona.eu\/ca\/identifiquen-les-millors-vies-per-portar-farmacs-al-cervell-durant-la-malaltia-de-niemann-pick-tipus-a-una-patologia-neurologica\/","og_site_name":"Institute for Bioengineering of Catalonia","article_published_time":"2022-09-23T07:32:07+00:00","article_modified_time":"2022-09-29T10:54:07+00:00","og_image":[{"width":886,"height":886,"url":"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2022\/09\/Brain-capillaries.png","type":"image\/png"}],"author":"\u00c0ngels L\u00f3pez","twitter_card":"summary_large_image","twitter_misc":{"Escrit per":"\u00c0ngels L\u00f3pez","Temps estimat de lectura":"4 minuts"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/ibecbarcelona.eu\/ca\/identifiquen-les-millors-vies-per-portar-farmacs-al-cervell-durant-la-malaltia-de-niemann-pick-tipus-a-una-patologia-neurologica\/#article","isPartOf":{"@id":"https:\/\/ibecbarcelona.eu\/ca\/identifiquen-les-millors-vies-per-portar-farmacs-al-cervell-durant-la-malaltia-de-niemann-pick-tipus-a-una-patologia-neurologica\/"},"author":{"name":"\u00c0ngels L\u00f3pez","@id":"https:\/\/ibecbarcelona.eu\/#\/schema\/person\/c212c6b589546130be67986b9290e2b8"},"headline":"Identifiquen les millors vies per portar f\u00e0rmacs al cervell durant la malaltia de Niemann-Pick tipus A, una patologia neurol\u00f2gica\u00a0","datePublished":"2022-09-23T07:32:07+00:00","dateModified":"2022-09-29T10:54:07+00:00","mainEntityOfPage":{"@id":"https:\/\/ibecbarcelona.eu\/ca\/identifiquen-les-millors-vies-per-portar-farmacs-al-cervell-durant-la-malaltia-de-niemann-pick-tipus-a-una-patologia-neurologica\/"},"wordCount":923,"publisher":{"@id":"https:\/\/ibecbarcelona.eu\/#organization"},"image":{"@id":"https:\/\/ibecbarcelona.eu\/ca\/identifiquen-les-millors-vies-per-portar-farmacs-al-cervell-durant-la-malaltia-de-niemann-pick-tipus-a-una-patologia-neurologica\/#primaryimage"},"thumbnailUrl":"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2022\/09\/Brain-capillaries.png","keywords":["Silvia Muro"],"articleSection":["Not\u00edcies de recerca"],"inLanguage":"ca"},{"@type":"WebPage","@id":"https:\/\/ibecbarcelona.eu\/ca\/identifiquen-les-millors-vies-per-portar-farmacs-al-cervell-durant-la-malaltia-de-niemann-pick-tipus-a-una-patologia-neurologica\/","url":"https:\/\/ibecbarcelona.eu\/ca\/identifiquen-les-millors-vies-per-portar-farmacs-al-cervell-durant-la-malaltia-de-niemann-pick-tipus-a-una-patologia-neurologica\/","name":"Identifiquen les millors vies per portar f\u00e0rmacs al cervell durant la malaltia de Niemann-Pick tipus A, una patologia neurol\u00f2gica\u00a0 - Institute for Bioengineering of Catalonia","isPartOf":{"@id":"https:\/\/ibecbarcelona.eu\/#website"},"primaryImageOfPage":{"@id":"https:\/\/ibecbarcelona.eu\/ca\/identifiquen-les-millors-vies-per-portar-farmacs-al-cervell-durant-la-malaltia-de-niemann-pick-tipus-a-una-patologia-neurologica\/#primaryimage"},"image":{"@id":"https:\/\/ibecbarcelona.eu\/ca\/identifiquen-les-millors-vies-per-portar-farmacs-al-cervell-durant-la-malaltia-de-niemann-pick-tipus-a-una-patologia-neurologica\/#primaryimage"},"thumbnailUrl":"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2022\/09\/Brain-capillaries.png","datePublished":"2022-09-23T07:32:07+00:00","dateModified":"2022-09-29T10:54:07+00:00","breadcrumb":{"@id":"https:\/\/ibecbarcelona.eu\/ca\/identifiquen-les-millors-vies-per-portar-farmacs-al-cervell-durant-la-malaltia-de-niemann-pick-tipus-a-una-patologia-neurologica\/#breadcrumb"},"inLanguage":"ca","potentialAction":[{"@type":"ReadAction","target":["https:\/\/ibecbarcelona.eu\/ca\/identifiquen-les-millors-vies-per-portar-farmacs-al-cervell-durant-la-malaltia-de-niemann-pick-tipus-a-una-patologia-neurologica\/"]}]},{"@type":"ImageObject","inLanguage":"ca","@id":"https:\/\/ibecbarcelona.eu\/ca\/identifiquen-les-millors-vies-per-portar-farmacs-al-cervell-durant-la-malaltia-de-niemann-pick-tipus-a-una-patologia-neurologica\/#primaryimage","url":"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2022\/09\/Brain-capillaries.png","contentUrl":"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2022\/09\/Brain-capillaries.png","width":886,"height":886},{"@type":"BreadcrumbList","@id":"https:\/\/ibecbarcelona.eu\/ca\/identifiquen-les-millors-vies-per-portar-farmacs-al-cervell-durant-la-malaltia-de-niemann-pick-tipus-a-una-patologia-neurologica\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/ibecbarcelona.eu\/ca\/"},{"@type":"ListItem","position":2,"name":"Identifiquen les millors vies per portar f\u00e0rmacs al cervell durant la malaltia de Niemann-Pick tipus A, una patologia neurol\u00f2gica\u00a0"}]},{"@type":"WebSite","@id":"https:\/\/ibecbarcelona.eu\/#website","url":"https:\/\/ibecbarcelona.eu\/","name":"Institute for Bioengineering of Catalonia","description":"Bioengineering Solutions for Health","publisher":{"@id":"https:\/\/ibecbarcelona.eu\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/ibecbarcelona.eu\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"ca"},{"@type":"Organization","@id":"https:\/\/ibecbarcelona.eu\/#organization","name":"Institute for Bioengineering of Catalonia","url":"https:\/\/ibecbarcelona.eu\/","logo":{"@type":"ImageObject","inLanguage":"ca","@id":"https:\/\/ibecbarcelona.eu\/#\/schema\/logo\/image\/","url":"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2026\/01\/cropped-IBEC_20ANYS_GRIS.png","contentUrl":"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2026\/01\/cropped-IBEC_20ANYS_GRIS.png","width":696,"height":257,"caption":"Institute for Bioengineering of Catalonia"},"image":{"@id":"https:\/\/ibecbarcelona.eu\/#\/schema\/logo\/image\/"}},{"@type":"Person","@id":"https:\/\/ibecbarcelona.eu\/#\/schema\/person\/c212c6b589546130be67986b9290e2b8","name":"\u00c0ngels L\u00f3pez","image":{"@type":"ImageObject","inLanguage":"ca","@id":"https:\/\/secure.gravatar.com\/avatar\/09ad6ba116bea0b15c5511860f83b302579fd7404c1180e9dae55c3f11d988c6?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/09ad6ba116bea0b15c5511860f83b302579fd7404c1180e9dae55c3f11d988c6?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/09ad6ba116bea0b15c5511860f83b302579fd7404c1180e9dae55c3f11d988c6?s=96&d=mm&r=g","caption":"\u00c0ngels L\u00f3pez"},"url":"https:\/\/ibecbarcelona.eu\/ca\/author\/alopez\/"}]}},"AFP_featured_media_urls":{"full":["https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2022\/09\/Brain-capillaries.png",886,886,false],"thumbnail":["https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2022\/09\/Brain-capillaries-150x150.png",150,150,true],"medium":["https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2022\/09\/Brain-capillaries-300x300.png",300,300,true],"medium_large":["https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2022\/09\/Brain-capillaries-768x768.png",768,768,true],"large":["https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2022\/09\/Brain-capillaries.png",886,886,false]},"AFP_attachments":{"full":["https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2022\/09\/Brain-capillaries.png",886,886,false],"thumbnail":["https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2022\/09\/Brain-capillaries-150x150.png",150,150,true],"medium":["https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2022\/09\/Brain-capillaries-300x300.png",300,300,true],"medium_large":["https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2022\/09\/Brain-capillaries-768x768.png",768,768,true],"large":["https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2022\/09\/Brain-capillaries.png",886,886,false]},"AFP_videos":[],"AFP_video_blocks":"","AFP_category_names":["Not\u00edcies de recerca"],"_links":{"self":[{"href":"https:\/\/ibecbarcelona.eu\/ca\/wp-json\/wp\/v2\/posts\/99416","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ibecbarcelona.eu\/ca\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ibecbarcelona.eu\/ca\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ibecbarcelona.eu\/ca\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/ibecbarcelona.eu\/ca\/wp-json\/wp\/v2\/comments?post=99416"}],"version-history":[{"count":1,"href":"https:\/\/ibecbarcelona.eu\/ca\/wp-json\/wp\/v2\/posts\/99416\/revisions"}],"predecessor-version":[{"id":99417,"href":"https:\/\/ibecbarcelona.eu\/ca\/wp-json\/wp\/v2\/posts\/99416\/revisions\/99417"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/ibecbarcelona.eu\/ca\/wp-json\/wp\/v2\/media\/99412"}],"wp:attachment":[{"href":"https:\/\/ibecbarcelona.eu\/ca\/wp-json\/wp\/v2\/media?parent=99416"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ibecbarcelona.eu\/ca\/wp-json\/wp\/v2\/categories?post=99416"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ibecbarcelona.eu\/ca\/wp-json\/wp\/v2\/tags?post=99416"},{"taxonomy":"post_format","embeddable":true,"href":"https:\/\/ibecbarcelona.eu\/ca\/wp-json\/wp\/v2\/post_formats?post=99416"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}