{"id":29353,"date":"2017-04-25T15:03:38","date_gmt":"2017-04-25T13:03:38","guid":{"rendered":"http:\/\/ibecbarcelona.eu\/ca\/event\/phd-discussions-session-carlos-perez-and-victor-gonzalez\/"},"modified":"2017-04-25T15:03:38","modified_gmt":"2017-04-25T13:03:38","slug":"phd-discussions-session-carlos-perez-and-victor-gonzalez","status":"publish","type":"tribe_events","link":"https:\/\/ibecbarcelona.eu\/ca\/event\/phd-discussions-session-carlos-perez-and-victor-gonzalez\/","title":{"rendered":"PhD Discussions Session: Carlos P\u00e9rez and V\u00edctor Gonz\u00e1lez"},"content":{"rendered":"<hr \/>\n<h2>Active wetting of epithelial tissues<\/h2>\n<address>Carlos P\u00e9rez, Integrative cell and tissue dynamics group<\/address>\n<p>Key biological processes such as cancer and development are characterized by drastic transitions in tissue morphology. These rearrangements have been classically studied as a wetting problem. According to this theory, wettability of a substrate by an epithelium is determined by the competition between cell-cell and cell-substrate adhesion energies. In contrast, we found that, far from a passive process, tissue dewetting is an active process driven by tissue internal forces. Experimentally, we reproduced epithelial dewetting by promoting a progressive formation of intercellular junctions in a monolayer of epithelial cells. Interestingly, the formation of intercellular junctions produces an increase in cell contractility, with the subsequent increase in traction and intercellular stress. At a certain time, tissue tension overcomes cell-substrate maximum adhesion and the monolayer spontaneously dewets the substrate. We developed an active polar fluid model, finding both theoretically and experimentally that critical contractility to promote wetting-dewetting transition depends on cell-substrate adhesion and, unexpectedly, on tissue size. As a whole, this work generalizes wetting theory to living tissues, unveiling unprecedented properties due to their unique active nature.<\/p>\n<p>&nbsp;<\/p>\n<h2>Binding of ZO-1 to \u03b15\u03b21 integrins regulates the mechanical properties of \u03b15\u03b21-fibronectin links<\/h2>\n<address>V\u00edctor Gonz\u00e1lez, Cellular and molecular mechanobiology group<\/address>\n<p>Fundamental processes in cell adhesion, motility, and rigidity adaptation are regulated by integrin-mediated adhesion to the extracellular matrix (ECM). The link between the ECM component fibronectin (fn) and integrin \u03b15\u03b21 forms a complex with ZO-1 in cells at the edge of migrating monolayers, regulating cell migration. However, how this complex affects the \u03b15\u03b21-fn link is unknown. Here we show that the \u03b15\u03b21\/ZO-1 complex decreases the resistance to force of \u03b15\u03b21\u2013fn adhesions located at the edge of migrating cell monolayers while also increasing \u03b15\u03b21 recruitment. Consistently with a molecular clutch model of adhesion, this effect of ZO-1 leads to a decrease in the density and intensity of adhesions in cells at the edge of migrating monolayers. Taken together, our results unveil a new mode of integrin regulation through modification of the mechanical properties of integrin\u2013ECM links, which may be harnessed by cells to control adhesion and migration.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>PhD Discussion sessions are open to all staff and researchers at all career stages, and are intended to help PhD students gain feedback from colleagues by presenting their research results and discussing them with each other, as well as with more experienced researchers. <\/p>\n","protected":false},"author":4,"featured_media":0,"template":"","meta":{"_tribe_events_status":"","_tribe_events_status_reason":"","footnotes":""},"tags":[],"tribe_events_cat":[369],"class_list":["post-29353","tribe_events","type-tribe_events","status-publish","hentry","tribe_events_cat-phd-discussions-session-ca","cat_phd-discussions-session-ca"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>PhD Discussions Session: Carlos P\u00e9rez and V\u00edctor Gonz\u00e1lez - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/ca\/event\/phd-discussions-session-carlos-perez-and-victor-gonzalez\/\" \/>\n<meta property=\"og:locale\" content=\"ca_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"PhD Discussions Session: Carlos P\u00e9rez and V\u00edctor Gonz\u00e1lez - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"PhD Discussion sessions are open to all staff and researchers at all career stages, and are intended to help PhD students gain feedback from colleagues by presenting their research results and discussing them with each other, as well as with more experienced researchers.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/ibecbarcelona.eu\/ca\/event\/phd-discussions-session-carlos-perez-and-victor-gonzalez\/\" \/>\n<meta property=\"og:site_name\" content=\"Institute for Bioengineering of Catalonia\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Temps estimat de lectura\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 minuts\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/event\\\/phd-discussions-session-carlos-perez-and-victor-gonzalez\\\/\",\"url\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/event\\\/phd-discussions-session-carlos-perez-and-victor-gonzalez\\\/\",\"name\":\"PhD Discussions Session: Carlos P\u00e9rez and V\u00edctor Gonz\u00e1lez - 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