Ronen Zaidel-Bar, Mechanobiology Institute Singapore and Tel-Aviv University Medical School<\/address>\nThe actomyosin cortex is responsible for cell shape and for dynamic processes such as cell polarization and cytokinesis. We are studying the regulation of cortical contractility in the C. elegans<\/em> zygote, using genetic loss of function and live-imaging. In my talk, I will discuss recent findings regarding two proteins: the actin cross-linking protein plastin (PLST-1) and the transmembrane receptor E-cadherin (HMR-1). Consistent with previous in-vitro reconstitution studies, we show that an optimal level of cross-linking by plastin is required for the generation of coordinated long-range contractions in the cortex; without the connectivity afforded by plastin, zygote polarization and cytokinesis are severely perturbed. E-cadherin is well known for its role as a cell-cell adhesion receptor.<\/p>\nSurprisingly, we discovered a role for non-junctional E-cadherin clusters in regulating cortical contractility. E-cadherin clusters inhibit RhoA and non-muscle myosin II activity at the cortex and form a physical barrier that slows actin flows. In the absence of non-junctional E-cadherin cytokinesis proceeds faster, but the cortex is also at a risk of detaching from the plasma membrane. Thus, our studies in the C. elegans<\/em> zygote are shedding light on structural and regulatory mechanisms underlying cortex function.<\/p>\n","protected":false},"excerpt":{"rendered":"Regulation of actomyosin contractility in C. elegans<\/p>\n","protected":false},"author":4,"featured_media":0,"template":"","meta":{"_tribe_events_status":"","_tribe_events_status_reason":"","footnotes":""},"tags":[],"tribe_events_cat":[354],"class_list":["post-30584","tribe_events","type-tribe_events","status-publish","hentry","tribe_events_cat-ibec-seminar-ca","cat_ibec-seminar-ca"],"yoast_head":"\n
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