{"id":74892,"date":"2020-06-05T10:12:03","date_gmt":"2020-06-05T08:12:03","guid":{"rendered":"http:\/\/ibecbarcelona.eu\/event\/online-ibec-seminar-pere-roca-cusachs\/"},"modified":"2020-06-18T12:07:15","modified_gmt":"2020-06-18T10:07:15","slug":"online-ibec-seminar-pere-roca-cusachs","status":"publish","type":"tribe_events","link":"https:\/\/ibecbarcelona.eu\/ca\/event\/online-ibec-seminar-pere-roca-cusachs\/","title":{"rendered":"Online IBEC Seminar: Pere Roca-Cusachs"},"content":{"rendered":"

Sensing the matrix: transducing mechanical signals from integrins to the nucleus<\/h2>\n

\"\"<\/a><\/p>\n

Pere Roca-Cusachs<\/em>\u00a0,<\/em> IBEC<\/em><\/p>\n

Cell proliferation and differentiation, as well as key processes in development, tumorigenesis, and wound healing, are strongly determined by the properties of the extracellular matrix (ECM), including its mechanical rigidity and the density and distribution of its ligands. In this talk, I will explain how we combine molecular biology, biophysical measurements, and theoretical modelling to understand the mechanisms by which cells sense and respond to matrix properties.<\/p>\n

I will discuss how the properties under force of integrin-ECM bonds, and of the adaptor protein talin, drive and regulate matrix sensing. I will further discuss how this sensing can be understood through a computational molecular clutch model, which can quantitatively predict the role of integrins, talin, myosin, and ECM receptors, and their effect on cell response. Finally, I will analyze how signals triggered by rigidity at cell-ECM adhesions are transmitted to the nucleus, leading to transcriptional regulation.<\/p>\n

The seminar will take place online at the GoToMeeting Platform<\/a><\/p>\n

Know more about Pere Roca-Cusachs’ research here<\/a><\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

Sensing the matrix: transducing mechanical signals from integrins to the nucleus Pere Roca-Cusachs\u00a0, IBEC Cell proliferation and differentiation, as well as key processes in development, tumorigenesis, and wound healing, are … Read more<\/a><\/p>\n","protected":false},"author":4,"featured_media":0,"template":"","meta":{"_tribe_events_status":"","_tribe_events_status_reason":"","footnotes":""},"tags":[],"tribe_events_cat":[354],"class_list":["post-74892","tribe_events","type-tribe_events","status-publish","hentry","tribe_events_cat-ibec-seminar-ca","cat_ibec-seminar-ca"],"yoast_head":"\nOnline IBEC Seminar: Pere Roca-Cusachs - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/ca\/event\/online-ibec-seminar-pere-roca-cusachs\/?lang=esfeedcalendarcalendarcalendar\/calendar\/\" \/>\n<meta property=\"og:locale\" content=\"ca_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Online IBEC Seminar: Pere Roca-Cusachs - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"Sensing the matrix: transducing mechanical signals from integrins to the nucleus Pere Roca-Cusachs\u00a0, IBEC Cell proliferation and differentiation, as well as key processes in development, tumorigenesis, and wound healing, are ... Read more\" \/>\n<meta property=\"og:url\" content=\"https:\/\/ibecbarcelona.eu\/ca\/event\/online-ibec-seminar-pere-roca-cusachs\/?lang=esfeedcalendarcalendarcalendar\/calendar\/\/\" \/>\n<meta property=\"og:site_name\" content=\"Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"article:modified_time\" content=\"2020-06-18T10:07:15+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2019\/02\/PereRoca_ESBA_ibec.png\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Temps estimat de lectura\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minut\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/event\\\/online-ibec-seminar-pere-roca-cusachs\\\/?lang=esfeedcalendarcalendarcalendar\\\/calendar\\\/\\\/\",\"url\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/event\\\/online-ibec-seminar-pere-roca-cusachs\\\/?lang=esfeedcalendarcalendarcalendar\\\/calendar\\\/\\\/\",\"name\":\"Online IBEC Seminar: Pere Roca-Cusachs - 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