{"id":86916,"date":"2021-09-01T16:57:22","date_gmt":"2021-09-01T14:57:22","guid":{"rendered":"https:\/\/ibecbarcelona.eu\/event\/online-ibec-seminar-daniel-gonzalez-carter\/"},"modified":"2021-09-06T13:00:20","modified_gmt":"2021-09-06T11:00:20","slug":"online-ibec-seminar-daniel-gonzalez-carter","status":"publish","type":"tribe_events","link":"https:\/\/ibecbarcelona.eu\/ca\/event\/online-ibec-seminar-daniel-gonzalez-carter\/","title":{"rendered":"Online IBEC Seminar: Daniel Gonzalez-Carter"},"content":{"rendered":"

Delivering Nanoparticles Specifically to the Brain by Generating Artificial Brain Targets<\/h2>\n

Daniel Gonzalez-Carter, Molecular Bionics group at IBEC<\/em><\/p>\n

Achieving efficient therapy delivery to the brain is one of the most pressing medical issues today. Therapy brain delivery is severely hampered by the protective blood-brain barrier (BBB), composed of the highly impermeable endothelial cells lining the brain vasculature.\u00a0 To overcome the BBB, therapies may be loaded onto nanoparticles functionalized with ligands which bind to target proteins expressed at the surface of brain endothelial cells (BEC), thereby increasing brain uptake. However, such strategies have inherent brain-specificity limitations, as the target proteins are also expressed on the vasculature of other organs, resulting in increased \u2018off-target\u2019 nanoparticle accumulation.<\/p>\n

To achieve truly selective brain targeting, our group is developing a strategy to generate artificial targets exclusively at the BBB. This is done by exploiting the low endocytic rate of BEC, a key requirement for their high impermeability, to selectively retain exogenous targets on their surface. By generating nanoparticles capable of efficiently recognizing the artificial targets, we hope to increase nanoparticle delivery exclusively to the brain with minimal \u2018off-target\u2019 nanoparticle accumulation. Furthermore, we are developing an mRNA delivery platform to continuously re<\/em>-generate the artificial targets from within the BEC to allow for repeated dosing in chronic diseases like Alzheimer\u2019s disease.<\/p>\n","protected":false},"excerpt":{"rendered":"

Delivering Nanoparticles Specifically to the Brain by Generating Artificial Brain Targets Daniel Gonzalez-Carter, Molecular Bionics group at IBEC Achieving efficient therapy delivery to the brain is one of the most … Read more<\/a><\/p>\n","protected":false},"author":4,"featured_media":0,"template":"","meta":{"_tribe_events_status":"","_tribe_events_status_reason":"","footnotes":""},"tags":[],"tribe_events_cat":[354],"class_list":["post-86916","tribe_events","type-tribe_events","status-publish","hentry","tribe_events_cat-ibec-seminar-ca","cat_ibec-seminar-ca"],"yoast_head":"\nOnline IBEC Seminar: Daniel Gonzalez-Carter - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/ca\/event\/online-ibec-seminar-daniel-gonzalez-carter\/?lang=ca\" \/>\n<meta property=\"og:locale\" content=\"ca_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Online IBEC Seminar: Daniel Gonzalez-Carter - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"Delivering Nanoparticles Specifically to the Brain by Generating Artificial Brain Targets Daniel Gonzalez-Carter, Molecular Bionics group at IBEC Achieving efficient therapy delivery to the brain is one of the most ... Read more\" \/>\n<meta property=\"og:url\" content=\"https:\/\/ibecbarcelona.eu\/ca\/event\/online-ibec-seminar-daniel-gonzalez-carter\/?lang=ca\" \/>\n<meta property=\"og:site_name\" content=\"Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"article:modified_time\" content=\"2021-09-06T11:00:20+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Temps estimat de lectura\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minut\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/event\\\/online-ibec-seminar-daniel-gonzalez-carter\\\/?lang=ca\",\"url\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/event\\\/online-ibec-seminar-daniel-gonzalez-carter\\\/?lang=ca\",\"name\":\"Online IBEC Seminar: Daniel Gonzalez-Carter - Institute for Bioengineering of Catalonia\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#website\"},\"datePublished\":\"2021-09-01T14:57:22+00:00\",\"dateModified\":\"2021-09-06T11:00:20+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/event\\\/online-ibec-seminar-daniel-gonzalez-carter\\\/?lang=ca#breadcrumb\"},\"inLanguage\":\"ca\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/event\\\/online-ibec-seminar-daniel-gonzalez-carter\\\/?lang=ca\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/event\\\/online-ibec-seminar-daniel-gonzalez-carter\\\/?lang=ca#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/ibecbarcelona.eu\\\/ca\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Eventos\",\"item\":\"https:\\\/\\\/ibecbarcelona.eu\\\/es\\\/calendar\\\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Online IBEC Seminar: Daniel Gonzalez-Carter\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#website\",\"url\":\"https:\\\/\\\/ibecbarcelona.eu\\\/\",\"name\":\"Institute for Bioengineering of Catalonia\",\"description\":\"Bioengineering Solutions for Health\",\"publisher\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/ibecbarcelona.eu\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"ca\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#organization\",\"name\":\"Institute for Bioengineering of Catalonia\",\"url\":\"https:\\\/\\\/ibecbarcelona.eu\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"ca\",\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/ibecbarcelona.eu\\\/wp-content\\\/uploads\\\/2026\\\/01\\\/cropped-IBEC_20ANYS_GRIS.png\",\"contentUrl\":\"https:\\\/\\\/ibecbarcelona.eu\\\/wp-content\\\/uploads\\\/2026\\\/01\\\/cropped-IBEC_20ANYS_GRIS.png\",\"width\":696,\"height\":257,\"caption\":\"Institute for Bioengineering of Catalonia\"},\"image\":{\"@id\":\"https:\\\/\\\/ibecbarcelona.eu\\\/#\\\/schema\\\/logo\\\/image\\\/\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Online IBEC Seminar: Daniel Gonzalez-Carter - Institute for Bioengineering of Catalonia","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/ibecbarcelona.eu\/ca\/event\/online-ibec-seminar-daniel-gonzalez-carter\/?lang=ca","og_locale":"ca_ES","og_type":"article","og_title":"Online IBEC Seminar: Daniel Gonzalez-Carter - Institute for Bioengineering of Catalonia","og_description":"Delivering Nanoparticles Specifically to the Brain by Generating Artificial Brain Targets Daniel Gonzalez-Carter, Molecular Bionics group at IBEC Achieving efficient therapy delivery to the brain is one of the most ... Read more","og_url":"https:\/\/ibecbarcelona.eu\/ca\/event\/online-ibec-seminar-daniel-gonzalez-carter\/?lang=ca","og_site_name":"Institute for Bioengineering of Catalonia","article_modified_time":"2021-09-06T11:00:20+00:00","twitter_card":"summary_large_image","twitter_misc":{"Temps estimat de lectura":"1 minut"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/ibecbarcelona.eu\/ca\/event\/online-ibec-seminar-daniel-gonzalez-carter\/?lang=ca","url":"https:\/\/ibecbarcelona.eu\/ca\/event\/online-ibec-seminar-daniel-gonzalez-carter\/?lang=ca","name":"Online IBEC Seminar: Daniel Gonzalez-Carter - Institute for Bioengineering of Catalonia","isPartOf":{"@id":"https:\/\/ibecbarcelona.eu\/#website"},"datePublished":"2021-09-01T14:57:22+00:00","dateModified":"2021-09-06T11:00:20+00:00","breadcrumb":{"@id":"https:\/\/ibecbarcelona.eu\/ca\/event\/online-ibec-seminar-daniel-gonzalez-carter\/?lang=ca#breadcrumb"},"inLanguage":"ca","potentialAction":[{"@type":"ReadAction","target":["https:\/\/ibecbarcelona.eu\/ca\/event\/online-ibec-seminar-daniel-gonzalez-carter\/?lang=ca"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/ibecbarcelona.eu\/ca\/event\/online-ibec-seminar-daniel-gonzalez-carter\/?lang=ca#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/ibecbarcelona.eu\/ca\/"},{"@type":"ListItem","position":2,"name":"Eventos","item":"https:\/\/ibecbarcelona.eu\/es\/calendar\/"},{"@type":"ListItem","position":3,"name":"Online IBEC Seminar: Daniel Gonzalez-Carter"}]},{"@type":"WebSite","@id":"https:\/\/ibecbarcelona.eu\/#website","url":"https:\/\/ibecbarcelona.eu\/","name":"Institute for Bioengineering of Catalonia","description":"Bioengineering Solutions for Health","publisher":{"@id":"https:\/\/ibecbarcelona.eu\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/ibecbarcelona.eu\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"ca"},{"@type":"Organization","@id":"https:\/\/ibecbarcelona.eu\/#organization","name":"Institute for Bioengineering of Catalonia","url":"https:\/\/ibecbarcelona.eu\/","logo":{"@type":"ImageObject","inLanguage":"ca","@id":"https:\/\/ibecbarcelona.eu\/#\/schema\/logo\/image\/","url":"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2026\/01\/cropped-IBEC_20ANYS_GRIS.png","contentUrl":"https:\/\/ibecbarcelona.eu\/wp-content\/uploads\/2026\/01\/cropped-IBEC_20ANYS_GRIS.png","width":696,"height":257,"caption":"Institute for Bioengineering of Catalonia"},"image":{"@id":"https:\/\/ibecbarcelona.eu\/#\/schema\/logo\/image\/"}}]}},"AFP_featured_media_urls":{"full":false,"thumbnail":false,"medium":false,"medium_large":false,"large":false},"AFP_attachments":[],"AFP_videos":[],"AFP_video_blocks":"","AFP_category_names":[],"_links":{"self":[{"href":"https:\/\/ibecbarcelona.eu\/ca\/wp-json\/wp\/v2\/tribe_events\/86916","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ibecbarcelona.eu\/ca\/wp-json\/wp\/v2\/tribe_events"}],"about":[{"href":"https:\/\/ibecbarcelona.eu\/ca\/wp-json\/wp\/v2\/types\/tribe_events"}],"author":[{"embeddable":true,"href":"https:\/\/ibecbarcelona.eu\/ca\/wp-json\/wp\/v2\/users\/4"}],"version-history":[{"count":2,"href":"https:\/\/ibecbarcelona.eu\/ca\/wp-json\/wp\/v2\/tribe_events\/86916\/revisions"}],"predecessor-version":[{"id":86995,"href":"https:\/\/ibecbarcelona.eu\/ca\/wp-json\/wp\/v2\/tribe_events\/86916\/revisions\/86995"}],"wp:attachment":[{"href":"https:\/\/ibecbarcelona.eu\/ca\/wp-json\/wp\/v2\/media?parent=86916"}],"wp:term":[{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ibecbarcelona.eu\/ca\/wp-json\/wp\/v2\/tags?post=86916"},{"taxonomy":"tribe_events_cat","embeddable":true,"href":"https:\/\/ibecbarcelona.eu\/ca\/wp-json\/wp\/v2\/tribe_events_cat?post=86916"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}