{"id":86932,"date":"2021-09-01T17:15:22","date_gmt":"2021-09-01T15:15:22","guid":{"rendered":"https:\/\/ibecbarcelona.eu\/event\/online-ibec-seminar-cristina-mayor-ruiz\/"},"modified":"2021-11-10T13:08:08","modified_gmt":"2021-11-10T12:08:08","slug":"online-ibec-seminar-cristina-mayor-ruiz","status":"publish","type":"tribe_events","link":"https:\/\/ibecbarcelona.eu\/ca\/event\/ibec-seminar-cristina-mayor-ruiz\/%3Flang%3Dca","title":{"rendered":"IBEC Seminar: Cristina Mayor-Ruiz"},"content":{"rendered":"

Targeted protein degradation: genetic determinants and drug discovery opportunities<\/h2>\n

Cristina Mayor-Ruiz, IRBarcelona<\/em><\/p>\n

Targeted protein degradation is a new therapeutic modality based on drugs that destabilize proteins by inducing their proximity\u00a0to E3 ubiquitin ligases. Of particular interest are “molecular glue degrader<\/strong>s”: compounds that can degrade otherwise unligandable proteins by orchestrating\u00a0direct interactions between target and E3. However, their discovery has been serendipitous, thus hampering\u00a0broad translational efforts. I will present a scalable target-agnostic strategy toward glue degrader discovery. This approach is based on differential chemical\u00a0screening coupled to a multi-omics target deconvolution campaign. Collectively, our data outline a versatile and broadly applicable strategy to identify\u00a0degraders and thus empower future drug discovery efforts.<\/p>\n

\n

This seminar will be held at Tower I, 11th floor Baobab room, there will be 30 avialable seats, the free spots will be assigned on a first come first served basis. If you wish to attend this seminar online, please write to ibeccommunications@ibecbarcelona.eu<\/a>.<\/p>\n

More information about Cristina Mayor-Ruiz\u2019s research here<\/a><\/p>\n

Cristina Mayor-Ruiz obtained her PhD in 2017 at the CNIO (Madrid) under the supervision of \u00d3scar Fern\u00e1ndez-Capetillo. There, she explored mechanisms of resistance to anticancer therapies. In 2018, she joined the group of Georg Winter at CeMM (Vienna) supported by EMBO and Marie Curie postdoctoral fellowships, where her interests focused on different aspects of chemical biology and drug screening. Since January 2021, she leads the \u201cTargeted Protein Degradation & Drug discovery\u201d lab at IRB Barcelona. Her research focuses on:<\/p>\n

(1) Developing screening strategies for early drug discovery. In particular,\u00a0\u00a0to identify monovalent degraders and other proximity-inducing drugs with therapeutic interest.<\/p>\n

(2) Tackling exciting biological questions that either benefit from the high kinetic resolution provided by targeted protein degradation, or that involve E3 (dys)regulation dynamics.<\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

Targeted protein degradation: genetic determinants and drug discovery opportunities Cristina Mayor-Ruiz, IRBarcelona Targeted protein degradation is a new therapeutic modality based on drugs that destabilize proteins by inducing their proximity\u00a0to … Read more<\/a><\/p>\n","protected":false},"author":4,"featured_media":0,"template":"","meta":{"_tribe_events_status":"","_tribe_events_status_reason":"","footnotes":""},"tags":[],"tribe_events_cat":[354],"class_list":["post-86932","tribe_events","type-tribe_events","status-publish","hentry","tribe_events_cat-ibec-seminar-ca","cat_ibec-seminar-ca"],"yoast_head":"\nIBEC Seminar: Cristina Mayor-Ruiz - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/ca\/event\/ibec-seminar-cristina-mayor-ruiz\/?lang=ca\/\" \/>\n<meta property=\"og:locale\" content=\"ca_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"IBEC Seminar: Cristina Mayor-Ruiz - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"Targeted protein degradation: genetic determinants and drug discovery opportunities Cristina Mayor-Ruiz, IRBarcelona Targeted protein degradation is a new therapeutic modality based on drugs that destabilize proteins by inducing their proximity\u00a0to ... 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