Abstract<\/strong><\/p>\nCell migration acquires special relevance during embryonic development and tissue regeneration. During the development of the adult individual, cells multiply, differentiate and mature, having to move to their destination regions through migration. Once the adult individual has formed, these tissues can suffer damage, leading to an altered state. In this process of tissue regeneration, they try to set tissue homeostasis, cell migration is essential. This thesis analyses the mechanical factors involved in cell migration in brain development and neural regeneration, as a fundamental tool to understand these processes. OECs migrate greater distances over CXCL12 functionalized PLA 80\/20 nanofibers, thus responding to the chemotactic gradient. Measurements made with by means of BIO-AFM of the mouse embryonic brain reveals differences between the pallium and the subpallium. These differences determine the differential migration rates when transplanting explants of various origins outside their usual site and analysing the migration of Cajal-Retzius cells. In addition, Cajal-Retzius cells respond by calcium entry to the inhibition of mechanosensitive cation channels, changing their migration rate. So, we conclude that physical factors are a key factor involved in the migration and disposition of Cajal-Retzius cells.<\/p>\n
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The public event will take place in the Sala de Graus of the Faculty of Biology of the UB on January 12 at 11:30.\u00a0If you prefer to attend to this defence virtually, contact with Ana L\u00f3pez (alopezm@ibecbarcelona.eu) and she will send you the link of the defence and the instructions.<\/p>\n
<\/p>\n","protected":false},"excerpt":{"rendered":"
Factores f\u00edsicos y moleculares implicados en la migraci\u00f3n celular y en el desarrollo de la corteza cerebral. Ana L\u00f3pez Mengual, Molecular and cellular neurobiotechnology group Abstract Cell migration acquires special … Read more<\/a><\/p>\n","protected":false},"author":4,"featured_media":0,"template":"","meta":{"_tribe_events_status":"","_tribe_events_status_reason":"","footnotes":""},"tags":[1132,1581,1582],"tribe_events_cat":[367],"class_list":["post-89872","tribe_events","type-tribe_events","status-publish","hentry","tag-jose-antonio-del-rio-ca","tag-molecular-and-cellular-neurobiotechnology-group-ca","tag-thesis-ca","tribe_events_cat-phd-thesis-defence-ca","cat_phd-thesis-defence-ca"],"yoast_head":"\nPhD Thesis Defence: Ana L\u00f3pez Mengual - Institute for Bioengineering of Catalonia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibecbarcelona.eu\/ca\/event\/phd-thesis-defence-ana-lopez-mengual\/\" \/>\n<meta property=\"og:locale\" content=\"ca_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"PhD Thesis Defence: Ana L\u00f3pez Mengual - Institute for Bioengineering of Catalonia\" \/>\n<meta property=\"og:description\" content=\"Factores f\u00edsicos y moleculares implicados en la migraci\u00f3n celular y en el desarrollo de la corteza cerebral. 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