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DTSTART;TZID=Europe/Madrid:20181025T160000
DTEND;TZID=Europe/Madrid:20181025T170000
DTSTAMP:20260510T022154
CREATED:20181022T110725Z
LAST-MODIFIED:20181022T111002Z
UID:62160-1540483200-1540486800@ibecbarcelona.eu
SUMMARY:IN2UB International Research Seminars: Pere Roca-Cusachs
DESCRIPTION:IBEC group leader Pere Roca-Cusachs is the speaker at the inaugural seminar of the new IN2UB International Research Seminar series. \nSensing the matrix: transducing mechanical signals from integrins to the nucleus\nPere Roca-Cusachs\, IBEC\nCell proliferation and differentiation\, as well as key processes in development\, tumorigenesis\, and wound healing\,are strongly determined by the properties of the extra cellular matrix (ECM)\, including its mechanical rigidity and the density and distribution of its ligands. In this talk\, I will explain how we combine molecular biology\, biophysical measurements\, and theoretical modelling to understand the mechanisms by which cells sense and respond to matrix properties. I will discuss how the properties under force of integrin-ECM bonds\, and of the adaptor protein talin\, drive and regulate matrix sensing. I will further discuss how this sensing can be understood through a computational molecular clutch model\, which can quantitatively predict the role of integrins\, talin\, myosin\, and ECM receptors\, and their effect on cell response. Finally\, I will analyze how signals triggered by rigidity at cell-ECM adhesions are transmitted to the nucleus\, leading to the activation of the transcriptional regulator YAP. \n 
URL:https://ibecbarcelona.eu/event/in2ub-international-research-seminars-pere-roca-cusachs/
LOCATION:Sala de Graus Eduard Fontseré\, Martí i Franquès\, 1-11\, Barcelona\, 08028
CATEGORIES:External seminar
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BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20181025T160000
DTEND;TZID=Europe/Madrid:20181025T170000
DTSTAMP:20260510T022154
CREATED:20181022T110725Z
LAST-MODIFIED:20181022T110725Z
UID:96324-1540483200-1540486800@ibecbarcelona.eu
SUMMARY:IN2UB International Research Seminars: Pere Roca-Cusachs
DESCRIPTION:IBEC group leader Pere Roca-Cusachs is the speaker at the inaugural seminar of the new IN2UB International Research Seminar series. \nSensing the matrix: transducing mechanical signals from integrins to the nucleus\nPere Roca-Cusachs\, IBEC\nCell proliferation and differentiation\, as well as key processes in development\, tumorigenesis\, and wound healing\,are strongly determined by the properties of the extra cellular matrix (ECM)\, including its mechanical rigidity and the density and distribution of its ligands. In this talk\, I will explain how we combine molecular biology\, biophysical measurements\, and theoretical modelling to understand the mechanisms by which cells sense and respond to matrix properties. I will discuss how the properties under force of integrin-ECM bonds\, and of the adaptor protein talin\, drive and regulate matrix sensing. I will further discuss how this sensing can be understood through a computational molecular clutch model\, which can quantitatively predict the role of integrins\, talin\, myosin\, and ECM receptors\, and their effect on cell response. Finally\, I will analyze how signals triggered by rigidity at cell-ECM adhesions are transmitted to the nucleus\, leading to the activation of the transcriptional regulator YAP. \n 
URL:https://ibecbarcelona.eu/event/in2ub-international-research-seminars-pere-roca-cusachs-2/
LOCATION:Sala de Graus Eduard Fontseré\, Martí i Franquès\, 1-11\, Barcelona\, 08028
CATEGORIES:External seminar
END:VEVENT
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