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DTSTART;TZID=Europe/Madrid:20150116T100000
DTEND;TZID=Europe/Madrid:20150116T110000
DTSTAMP:20260419T034154
CREATED:20141113T150633Z
LAST-MODIFIED:20150112T161125Z
UID:2488-1421402400-1421406000@ibecbarcelona.eu
SUMMARY:IBEC Seminar: David Caballero
DESCRIPTION:The cell ratchet: interplay between protrusion activity and adhesion determines cell motion\n \nDavid Caballero\, Nanobioengineering group\, IBEC\nMany physiological and pathological processes involve directed cell motion\, either collective or as single cells. Typically\, migrating cells are characterized by a polarized morphology with extending and retracting protrusions at the leading edge. However\, cell motion is a much more complex phenomenon. Cells show heterogeneous morphologies and high protrusive dynamics. This prevents the quantitative prediction of cell motion and the identification of the cellular mechanism responsible of directionality. In this seminar\, I discuss about the importance of protrusion fluctuations in the physicochemical mechanism of directed cell motion. I show how their spatiotemporal distribution and dynamics determines univocally the direction of cell motion on NIH3T3 fibroblasts deposited on micropatterned adhesive ratchets. Novel physical concepts describing short-term cell motility are introduced which allows the prediction of parameters characteristic of long-term motion of cells. The obtained results may have important implications for the study of biological phenomena where directed cell migration is involved\, such as morphogenesis or cancer.
URL:https://ibecbarcelona.eu/event/ibec-seminar-david-caballero-ibec/
CATEGORIES:IBEC Seminar
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BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20150116T100000
DTEND;TZID=Europe/Madrid:20150116T110000
DTSTAMP:20260419T034154
CREATED:20141113T150633Z
LAST-MODIFIED:20141113T150633Z
UID:95816-1421402400-1421406000@ibecbarcelona.eu
SUMMARY:IBEC Seminar: David Caballero
DESCRIPTION:The cell ratchet: interplay between protrusion activity and adhesion determines cell motion\n \nDavid Caballero\, Nanobioengineering group\, IBEC\nMany physiological and pathological processes involve directed cell motion\, either collective or as single cells. Typically\, migrating cells are characterized by a polarized morphology with extending and retracting protrusions at the leading edge. However\, cell motion is a much more complex phenomenon. Cells show heterogeneous morphologies and high protrusive dynamics. This prevents the quantitative prediction of cell motion and the identification of the cellular mechanism responsible of directionality. In this seminar\, I discuss about the importance of protrusion fluctuations in the physicochemical mechanism of directed cell motion. I show how their spatiotemporal distribution and dynamics determines univocally the direction of cell motion on NIH3T3 fibroblasts deposited on micropatterned adhesive ratchets. Novel physical concepts describing short-term cell motility are introduced which allows the prediction of parameters characteristic of long-term motion of cells. The obtained results may have important implications for the study of biological phenomena where directed cell migration is involved\, such as morphogenesis or cancer.
URL:https://ibecbarcelona.eu/event/ibec-seminar-david-caballero-ibec-2/
CATEGORIES:IBEC Seminar
END:VEVENT
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