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DTSTART;TZID=Europe/Madrid:20150612T100000
DTEND;TZID=Europe/Madrid:20150612T110000
DTSTAMP:20260418T205339
CREATED:20150311T075156Z
LAST-MODIFIED:20150311T075156Z
UID:95840-1434103200-1434106800@ibecbarcelona.eu
SUMMARY:IBEC Seminar:  Alexandra P. Marques
DESCRIPTION:Driving skin wound healing: stem cells and extracellular matrix role\n \nAlexandra P. Marques\, 3B’s Research Group\, University of Minho\, Portugal\nWound care products have evolved into skin tissue engineered substitutes\, which despite the longest history of application and the highest record of marketing\, proved to represent replacement strategies instead of promoting tissue regeneration. \nCurrent research indicates that the interactions between resident progenitor cells and their niche dictate the triggering of skin regeneration pathway. In alignment\, mesenchymal stem cells (MSCs)-based therapies\, have been proposed to enhance cutaneous wound healing.  The rationale lies on transplanted cells ability to interact/respond to the wound microenvironment\, which is advantageous when compared to the exogenous administration of healing factors. However\, the involved mechanisms are still elusive and poor outcomes were achieved in terms of attainment of functional skin tissue due to low cell survival rates\, and poor engraftment or cell fusion upon transplantation.  Extracellular matrix (ECM)-mimicking is currently seen as the “Holy Grail” of Tissue Engineering in the sense that by recreating natural tissues microenvironments researchers will be able to increase the residence time and consequently the action of the transplanted cells and thus uncover “therapeutic niches”. \nUnder this context we have been exploring two perspectives; one takes advantage of the tunable ECM-like properties along with the 3D support that hydrogels can provide\, and the second benefits from an intact native ECM offered by cell sheet engineering technology. Hydrogels features such as high hygroscopic nature\, tunable elasticity and facilitated mass transportation\, render such materials attractive for the development of skin ECM-analogues. Although succeeding in improved cell engraftment\, hydrogels fail to provide biological instructive cues as well as cell adhesion sites\, only overcome by cell adhesive peptides bonding to polymers backbone. We developed a new method of processing gellan gum-based materials\, having as start material gellan gum-based hydrogels\, to obtain structures that exhibit features of both sponges and hydrogels depicting intrinsic cell-adhesive properties. By creating constructs comprising adipose tissue cells and artificial and natural ECM we were able to demonstrated that skin healing is dependent on tissue engineered constructs self cell-cell and cell-ECM interactions\, as well as on constructs cell-cell interactions and paracrine signaling with resident cells. In particular\, our results suggest that cell-ECM and cell-cell interactions have a dramatic effect over re-epithelialisation. In opposition\, neo-vascularisation did not seem to be dependent on the nature of the cell-ECM interactions\, but was significantly improved with the incorporation of microvascular endothelial cells. \nUltimately the generation of knowledge on how to direct skin regeneration lead the creation of “off-the-shelf” 3D stem cell-based engineered products inspired by the role of wound healing microenvironments.
URL:https://ibecbarcelona.eu/event/ibec-seminar-alexandra-p-marques-2/
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20150612T100000
DTEND;TZID=Europe/Madrid:20150612T110000
DTSTAMP:20260418T205339
CREATED:20150311T075156Z
LAST-MODIFIED:20150608T143446Z
UID:15401-1434103200-1434106800@ibecbarcelona.eu
SUMMARY:IBEC Seminar:  Alexandra P. Marques
DESCRIPTION:Driving skin wound healing: stem cells and extracellular matrix role\n \nAlexandra P. Marques\, 3B’s Research Group\, University of Minho\, Portugal\nWound care products have evolved into skin tissue engineered substitutes\, which despite the longest history of application and the highest record of marketing\, proved to represent replacement strategies instead of promoting tissue regeneration. \nCurrent research indicates that the interactions between resident progenitor cells and their niche dictate the triggering of skin regeneration pathway. In alignment\, mesenchymal stem cells (MSCs)-based therapies\, have been proposed to enhance cutaneous wound healing.  The rationale lies on transplanted cells ability to interact/respond to the wound microenvironment\, which is advantageous when compared to the exogenous administration of healing factors. However\, the involved mechanisms are still elusive and poor outcomes were achieved in terms of attainment of functional skin tissue due to low cell survival rates\, and poor engraftment or cell fusion upon transplantation.  Extracellular matrix (ECM)-mimicking is currently seen as the “Holy Grail” of Tissue Engineering in the sense that by recreating natural tissues microenvironments researchers will be able to increase the residence time and consequently the action of the transplanted cells and thus uncover “therapeutic niches”. \nUnder this context we have been exploring two perspectives; one takes advantage of the tunable ECM-like properties along with the 3D support that hydrogels can provide\, and the second benefits from an intact native ECM offered by cell sheet engineering technology. Hydrogels features such as high hygroscopic nature\, tunable elasticity and facilitated mass transportation\, render such materials attractive for the development of skin ECM-analogues. Although succeeding in improved cell engraftment\, hydrogels fail to provide biological instructive cues as well as cell adhesion sites\, only overcome by cell adhesive peptides bonding to polymers backbone. We developed a new method of processing gellan gum-based materials\, having as start material gellan gum-based hydrogels\, to obtain structures that exhibit features of both sponges and hydrogels depicting intrinsic cell-adhesive properties. By creating constructs comprising adipose tissue cells and artificial and natural ECM we were able to demonstrated that skin healing is dependent on tissue engineered constructs self cell-cell and cell-ECM interactions\, as well as on constructs cell-cell interactions and paracrine signaling with resident cells. In particular\, our results suggest that cell-ECM and cell-cell interactions have a dramatic effect over re-epithelialisation. In opposition\, neo-vascularisation did not seem to be dependent on the nature of the cell-ECM interactions\, but was significantly improved with the incorporation of microvascular endothelial cells. \nUltimately the generation of knowledge on how to direct skin regeneration lead the creation of “off-the-shelf” 3D stem cell-based engineered products inspired by the role of wound healing microenvironments.
URL:https://ibecbarcelona.eu/event/ibec-seminar-alexandra-p-marques/
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20150616T160000
DTEND;TZID=Europe/Madrid:20150616T170000
DTSTAMP:20260418T205339
CREATED:20150604T150254Z
LAST-MODIFIED:20150604T150254Z
UID:16893-1434470400-1434474000@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Javier G. Fernández
DESCRIPTION:Bioinspired materials\n \nJavier G. Fernández\, Assistant Professor and Founder Academic Member · Singapore University of Technology and Design\nNature is abundant with materials that possess extraordinary mechanical characteristics. New techniques in biochemistry and advances in microelectronic engineering are boosting our knowledge of biological materials\, and providing tools to fabricate at the scale at which these materials are made in nature. This investigation of the structural organization of these materials leads to understanding of the principles of natural materials design that are beginning to be harnessed to fabricate biologically-inspired composites for materials engineering with tunable properties that mimic living materials\, which might provide useful for environmental challenges\, as well as medical applications.
URL:https://ibecbarcelona.eu/event/ibec-seminar-javier-g-fernandez/
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20150616T160000
DTEND;TZID=Europe/Madrid:20150616T170000
DTSTAMP:20260418T205339
CREATED:20150604T150254Z
LAST-MODIFIED:20150604T150254Z
UID:95856-1434470400-1434474000@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Javier G. Fernández
DESCRIPTION:Bioinspired materials\n \nJavier G. Fernández\, Assistant Professor and Founder Academic Member · Singapore University of Technology and Design\nNature is abundant with materials that possess extraordinary mechanical characteristics. New techniques in biochemistry and advances in microelectronic engineering are boosting our knowledge of biological materials\, and providing tools to fabricate at the scale at which these materials are made in nature. This investigation of the structural organization of these materials leads to understanding of the principles of natural materials design that are beginning to be harnessed to fabricate biologically-inspired composites for materials engineering with tunable properties that mimic living materials\, which might provide useful for environmental challenges\, as well as medical applications.
URL:https://ibecbarcelona.eu/event/ibec-seminar-javier-g-fernandez-2/
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20150619T100000
DTEND;TZID=Europe/Madrid:20150619T110000
DTSTAMP:20260418T205339
CREATED:20150410T120745Z
LAST-MODIFIED:20150616T113709Z
UID:15930-1434708000-1434711600@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Matteo Palma
DESCRIPTION:Bio-inspired self-assembly for single-molecule investigations \n \nMatteo Palma\, Queen Mary University of London\nOne of the ultimate goals in nanotechnology is the ability to produce efficient devices based on individual molecules and nanostructures. Despite the many potential benefits envisioned for single-molecule technology (in electronics and biotechnology) the strategies employed to date suffer from various limitations. Principal among these limitations is the poor control over the molecular assembly of nanostructures and individual molecules with respect to one another\, as well as their position on devices with respect to other material components. \nI will first discuss techniques based on the combined use of lithographic nanopatterning and bio-molecular self-assembly to control the immobilization of biomolecules in arrayed nanodomains. I will show how this allows us to produce highly ordered\, self-assembled arrangements of nano-objects\, ranging from proteins to DNA nanostructures\, and bio-inorganic assemblies\, for a variety of (nanoscale) investigations. \nI will show how by specific design of the biomolecular nanoarrays\, it is possible to simultaneously monitor hundreds of protein/DNA binding events at the single-molecule level. Moreover I will discuss the use of our nanopatterned biomimetic surfaces to probe the importance of transmembrane proteins (integrins) clustering and geometric arrangement of binding sites\, in the formation of cell focal adhesions \nI will then highlight the broader utility of such nanopatterned surfaces for the self-organization (on surfaces) of bio-inorganic assemblies as well as DNA nanostructures and carbon nanotubes. In particular\, I will discuss how the combination of high resolution patterning with end-functional chemistry enables the assembly of 1D functional nanostructures in an orderly fashion. \nFinally\, building on our novel bottom-up assembly strategy for the formation of (chemically and geometrically) versatile carbon nanotube (CNTs) junctions\, I will present a universal approach for the generation of multifunctional nanomaterials that employ molecular building blocks assembled between DNA wrapped CNT electrodes. We will demonstrate single-molecule control in the formation of nanohybrids via the in-solution assembly of classes of molecular materials (organic\, and inorganic which display promising attributes) to DNA wrapped CNTs. We believe this may be a viable avenue towards the integration of these materials in complex and functional nano-architectures. \nOur findings are of general interest for the controlled assembly of a broad range of functional molecules and nanostructures\, towards the fabrication of solution-processable nanoscale devices. Moreover\, we believe that the knowledge developed makes a significant contribution towards the facile fabrication of nanohybrid materials for single-molecule investigations. Future technologies will require devices of this type in a variety of key areas\, including biodiagnostics\, ultra-high speed computation\, bioelectronics\, and for renewable energy applications.
URL:https://ibecbarcelona.eu/event/ibec-seminar-matteo-palma/
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20150619T100000
DTEND;TZID=Europe/Madrid:20150619T110000
DTSTAMP:20260418T205339
CREATED:20150410T120745Z
LAST-MODIFIED:20150410T120745Z
UID:95844-1434708000-1434711600@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Matteo Palma
DESCRIPTION:Bio-inspired self-assembly for single-molecule investigations \n \nMatteo Palma\, Queen Mary University of London\nOne of the ultimate goals in nanotechnology is the ability to produce efficient devices based on individual molecules and nanostructures. Despite the many potential benefits envisioned for single-molecule technology (in electronics and biotechnology) the strategies employed to date suffer from various limitations. Principal among these limitations is the poor control over the molecular assembly of nanostructures and individual molecules with respect to one another\, as well as their position on devices with respect to other material components. \nI will first discuss techniques based on the combined use of lithographic nanopatterning and bio-molecular self-assembly to control the immobilization of biomolecules in arrayed nanodomains. I will show how this allows us to produce highly ordered\, self-assembled arrangements of nano-objects\, ranging from proteins to DNA nanostructures\, and bio-inorganic assemblies\, for a variety of (nanoscale) investigations. \nI will show how by specific design of the biomolecular nanoarrays\, it is possible to simultaneously monitor hundreds of protein/DNA binding events at the single-molecule level. Moreover I will discuss the use of our nanopatterned biomimetic surfaces to probe the importance of transmembrane proteins (integrins) clustering and geometric arrangement of binding sites\, in the formation of cell focal adhesions \nI will then highlight the broader utility of such nanopatterned surfaces for the self-organization (on surfaces) of bio-inorganic assemblies as well as DNA nanostructures and carbon nanotubes. In particular\, I will discuss how the combination of high resolution patterning with end-functional chemistry enables the assembly of 1D functional nanostructures in an orderly fashion. \nFinally\, building on our novel bottom-up assembly strategy for the formation of (chemically and geometrically) versatile carbon nanotube (CNTs) junctions\, I will present a universal approach for the generation of multifunctional nanomaterials that employ molecular building blocks assembled between DNA wrapped CNT electrodes. We will demonstrate single-molecule control in the formation of nanohybrids via the in-solution assembly of classes of molecular materials (organic\, and inorganic which display promising attributes) to DNA wrapped CNTs. We believe this may be a viable avenue towards the integration of these materials in complex and functional nano-architectures. \nOur findings are of general interest for the controlled assembly of a broad range of functional molecules and nanostructures\, towards the fabrication of solution-processable nanoscale devices. Moreover\, we believe that the knowledge developed makes a significant contribution towards the facile fabrication of nanohybrid materials for single-molecule investigations. Future technologies will require devices of this type in a variety of key areas\, including biodiagnostics\, ultra-high speed computation\, bioelectronics\, and for renewable energy applications.
URL:https://ibecbarcelona.eu/event/ibec-seminar-matteo-palma-2/
CATEGORIES:IBEC Seminar
END:VEVENT
END:VCALENDAR