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DTSTART;TZID=Europe/Madrid:20150917T100000
DTEND;TZID=Europe/Madrid:20150917T110000
DTSTAMP:20260418T143101
CREATED:20150803T122810Z
LAST-MODIFIED:20150803T122810Z
UID:95865-1442484000-1442487600@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Richard Reilly
DESCRIPTION:All a question of Timing:  Sensory processing in Dystonia and Parkinson’s Disease\nProfessor Richard Reilly\, Trinity Centre for Bioengineering · Trinity College Dublin\nThere are many challenges in the diagnosis and management of neurological disorders. Neural Engineering can help address some of these by the development of novel engineering\, computational and experimental methods to help understand the pathogenesis of neurological disorders. This talk will detail results from recent neural engineering studies into understanding cervical dystonia and Parkinson’s disease. \nWhile the pathogenesis of cervical dystonia remains unknown\, recent animal and clinical experimental studies have indicated its probable mechanisms. Human movement involves a complex series of coordinated musculoskeletal but also neural processes. A breakdown in any of these processes can result in irregular movement. The temporal discrimination threshold is the shortest time interval at which two sensory stimuli presented sequentially are detected as asynchronous by the observer. Studies in our group and that of others have shown that abnormal temporal discrimination is a mediational endophenotype of cervical dystonia and informs new concepts of disease pathogenesis. Our hypothesis is that both abnormal temporal discrimination and cervical dystonia are due to a disorder of the midbrain network for covert attentional orienting caused by reduced gamma-aminobutyric acid inhibition\, resulting from\, in turn\, from as yet undetermined\, genetic mutations. Such disinhibition is a) subclinically manifested by abnormal temporal discrimination due to prolonged duration firing of the visual sensory neurons in the superficial laminae of the superior colliculus\, b) clinically manifested by cervical dystonia due to disinhibited burst activity of the cephalomotor neurons of the intermediate and deep laminae of the superior colliculus. Abnormal temporal discrimination in unaffected first-degree relatives of patients with cervical dystonia represents a subclinical manifestation of defective gamma-aminobutyric acid activity both within the superior colliculus and from the substantia nigra pars reticulata. This talk will review some our recent experiments addressing this hypothesis. \nSensory and perceptual disturbances are common in Parkinson’s disease. Subtle deficits of the sensory system\, often not detected by routine examination\, occur in people with Parkinson’s disease. From simple anosmia and impaired kinesthetic perception\, to more complex visual hallucinations and spatiotemporal perceptual abnormalities\, altered sensory processing is found across multiple modalities. Of note\, integration of multiple environmental sensory inputs is crucial for a refined but complex goal-directed motor output (e.g. locomotion through a crowded environment). There is increasing evidence that these sensory deficits contribute to the pathophysiology of some of the abnormal motor features of Parkinson’s disease. This talk will review some of our recent experiments to probe multisensory deficits in Parkinson’s disease and introduce one intervention developed around sensory and cognitive processing.
URL:https://ibecbarcelona.eu/event/ibec-seminar-richard-reilly-2/
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20150917T100000
DTEND;TZID=Europe/Madrid:20150917T110000
DTSTAMP:20260418T143101
CREATED:20150803T122810Z
LAST-MODIFIED:20150803T122810Z
UID:18430-1442484000-1442487600@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Richard Reilly
DESCRIPTION:All a question of Timing:  Sensory processing in Dystonia and Parkinson’s Disease\nProfessor Richard Reilly\, Trinity Centre for Bioengineering · Trinity College Dublin\nThere are many challenges in the diagnosis and management of neurological disorders. Neural Engineering can help address some of these by the development of novel engineering\, computational and experimental methods to help understand the pathogenesis of neurological disorders. This talk will detail results from recent neural engineering studies into understanding cervical dystonia and Parkinson’s disease. \nWhile the pathogenesis of cervical dystonia remains unknown\, recent animal and clinical experimental studies have indicated its probable mechanisms. Human movement involves a complex series of coordinated musculoskeletal but also neural processes. A breakdown in any of these processes can result in irregular movement. The temporal discrimination threshold is the shortest time interval at which two sensory stimuli presented sequentially are detected as asynchronous by the observer. Studies in our group and that of others have shown that abnormal temporal discrimination is a mediational endophenotype of cervical dystonia and informs new concepts of disease pathogenesis. Our hypothesis is that both abnormal temporal discrimination and cervical dystonia are due to a disorder of the midbrain network for covert attentional orienting caused by reduced gamma-aminobutyric acid inhibition\, resulting from\, in turn\, from as yet undetermined\, genetic mutations. Such disinhibition is a) subclinically manifested by abnormal temporal discrimination due to prolonged duration firing of the visual sensory neurons in the superficial laminae of the superior colliculus\, b) clinically manifested by cervical dystonia due to disinhibited burst activity of the cephalomotor neurons of the intermediate and deep laminae of the superior colliculus. Abnormal temporal discrimination in unaffected first-degree relatives of patients with cervical dystonia represents a subclinical manifestation of defective gamma-aminobutyric acid activity both within the superior colliculus and from the substantia nigra pars reticulata. This talk will review some our recent experiments addressing this hypothesis. \nSensory and perceptual disturbances are common in Parkinson’s disease. Subtle deficits of the sensory system\, often not detected by routine examination\, occur in people with Parkinson’s disease. From simple anosmia and impaired kinesthetic perception\, to more complex visual hallucinations and spatiotemporal perceptual abnormalities\, altered sensory processing is found across multiple modalities. Of note\, integration of multiple environmental sensory inputs is crucial for a refined but complex goal-directed motor output (e.g. locomotion through a crowded environment). There is increasing evidence that these sensory deficits contribute to the pathophysiology of some of the abnormal motor features of Parkinson’s disease. This talk will review some of our recent experiments to probe multisensory deficits in Parkinson’s disease and introduce one intervention developed around sensory and cognitive processing.
URL:https://ibecbarcelona.eu/event/ibec-seminar-richard-reilly/
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20150918T100000
DTEND;TZID=Europe/Madrid:20150918T110000
DTSTAMP:20260418T143101
CREATED:20150629T072320Z
LAST-MODIFIED:20150629T072320Z
UID:17667-1442570400-1442574000@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Marc Martí-Renom
DESCRIPTION:Structure determination of genomes and genomic domains by satisfaction of spatial restraints\nMarc Martí-Renom\, ICREA Research Professor / CNAG / CRG\nThe genome three-dimensional (3D) organization plays important\, yet poorly understood roles in gene regulation. Chromosomes assume multiple distinct conformations in relation to the expression status of resident genes and undergo dramatic alterations in higher order structure through the cell cycle. Despite advances in microscopy\, a general technique to determine the 3D conformation of chromatin has been lacking. We developed a new method for the determination of the 3D conformation of chromatin domains in the interphase nucleus\, which combines 3C-based experiments with the computational Integrative Modeling Platform (IMP). The general approach of our method\, which has been applied to study the 3D conformation of the alpha-globin domain in the human genome [1]\, the Caulobacter crescentus whole genome [2]\, and the dynamic response of Topologically Associating Domains (TADs) to hormone treatment in breast cancer cell lines [3]\, opens the field for comprehensive studies of the 3D conformation of chromosomal domains and contributes to a more complete characterization of genome regulation.\n[1] D. Baù et al. Nat Struct Mol Biol (2011) 18:107.\n[2] M.A. Umbarger\, et al. Molecular Cell (2011) 44:252\n[3] Le Dily\, et al. Genes & Dev (2014) 28:2151
URL:https://ibecbarcelona.eu/event/ibec-seminar-marc-marti-renom/
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20150918T100000
DTEND;TZID=Europe/Madrid:20150918T110000
DTSTAMP:20260418T143101
CREATED:20150629T072320Z
LAST-MODIFIED:20150629T072320Z
UID:95859-1442570400-1442574000@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Marc Martí-Renom
DESCRIPTION:Structure determination of genomes and genomic domains by satisfaction of spatial restraints\nMarc Martí-Renom\, ICREA Research Professor / CNAG / CRG\nThe genome three-dimensional (3D) organization plays important\, yet poorly understood roles in gene regulation. Chromosomes assume multiple distinct conformations in relation to the expression status of resident genes and undergo dramatic alterations in higher order structure through the cell cycle. Despite advances in microscopy\, a general technique to determine the 3D conformation of chromatin has been lacking. We developed a new method for the determination of the 3D conformation of chromatin domains in the interphase nucleus\, which combines 3C-based experiments with the computational Integrative Modeling Platform (IMP). The general approach of our method\, which has been applied to study the 3D conformation of the alpha-globin domain in the human genome [1]\, the Caulobacter crescentus whole genome [2]\, and the dynamic response of Topologically Associating Domains (TADs) to hormone treatment in breast cancer cell lines [3]\, opens the field for comprehensive studies of the 3D conformation of chromosomal domains and contributes to a more complete characterization of genome regulation.\n[1] D. Baù et al. Nat Struct Mol Biol (2011) 18:107.\n[2] M.A. Umbarger\, et al. Molecular Cell (2011) 44:252\n[3] Le Dily\, et al. Genes & Dev (2014) 28:2151
URL:https://ibecbarcelona.eu/event/ibec-seminar-marc-marti-renom-2/
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20150922T000000
DTEND;TZID=Europe/Madrid:20150922T130000
DTSTAMP:20260418T143101
CREATED:20150918T102346Z
LAST-MODIFIED:20150918T102346Z
UID:95868-1442880000-1442926800@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Albert Folch
DESCRIPTION:Print-and-Play Microfluidics\nAlbert Folch\, Associate Professor\, University of Washington\nBiologists and clinicians typically do not have access to microfluidic technology because they do not have the engineering expertise or equipment required to fabricate and/or operate microfluidic devices. Furthermore\, the present commercialization path for microfluidic devices is usually restricted to high-volume applications in order to recover the large investment needed to develop the plastic molding processes. We are developing microfluidic devices through stereolithography\, a form of 3D printing\, in order to make microfluidic technology readily available via the web to biomedical scientists. Our lab presently focuses on developing 3D-printable microdevices that facilitate the advancement of basic neuroscience and translational cancer applications. The lab’s long-term mission is to make microfluidic devices as easy to use as smartphones and make them easily available to clinicians in order to enable novel cancer diagnostics and therapies.
URL:https://ibecbarcelona.eu/event/ibec-seminar-albert-folch-2/
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20150922T000000
DTEND;TZID=Europe/Madrid:20150922T130000
DTSTAMP:20260418T143101
CREATED:20150918T102346Z
LAST-MODIFIED:20150918T102346Z
UID:18953-1442880000-1442926800@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Albert Folch
DESCRIPTION:Print-and-Play Microfluidics\nAlbert Folch\, Associate Professor\, University of Washington\nBiologists and clinicians typically do not have access to microfluidic technology because they do not have the engineering expertise or equipment required to fabricate and/or operate microfluidic devices. Furthermore\, the present commercialization path for microfluidic devices is usually restricted to high-volume applications in order to recover the large investment needed to develop the plastic molding processes. We are developing microfluidic devices through stereolithography\, a form of 3D printing\, in order to make microfluidic technology readily available via the web to biomedical scientists. Our lab presently focuses on developing 3D-printable microdevices that facilitate the advancement of basic neuroscience and translational cancer applications. The lab’s long-term mission is to make microfluidic devices as easy to use as smartphones and make them easily available to clinicians in order to enable novel cancer diagnostics and therapies.
URL:https://ibecbarcelona.eu/event/ibec-seminar-albert-folch/
CATEGORIES:IBEC Seminar
END:VEVENT
END:VCALENDAR