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X-WR-CALDESC:Events for Institute for Bioengineering of Catalonia
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DTSTART:20150101T000000
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DTSTART;TZID=UTC:20160712T100000
DTEND;TZID=UTC:20160712T230000
DTSTAMP:20260417T063724
CREATED:20160510T055158Z
LAST-MODIFIED:20160510T055158Z
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SUMMARY:IBEC Seminar: Prof. Shulamit Levenberg
DESCRIPTION:Engineering Vascularized Tissue Constructs\nProf. Shulamit Levenberg\, Faculty of Biomedical Engineering\, Technion\, Haifa\, Israel\nVascularization continues to represent a major challenge in the successful implementation of regenerative strategies. Cell organization into 3D tissue vascularized structures involves cell-matrix and cell-cell interactions\, some of which occur between the different tissue cell types. During this process\, cells further differentiate and assemble into structures resembling the final tissue architecture. We have established that vessel network assembly yielding vascularized 3D tissue structures can be induced in-vitro by means of coculturing endothelial cells\, fibroblasts and tissue-specific cells. We have also shown that in vitro pre-vascularization of engineered tissues can promote tissue survival and further vascularization upon implantation\, via anastomosis of the engineered vessels with host vasculature\, forming functional blood vessels in vivo. Vascularization of engineered tissues can be enhanced through coordinated application of improved biomaterial systems with relevant cell types. Moreover\, we have shown that vessel network maturity and morphology can be highly regulated by both matrix composition and by external mechanical stimulations. Our recent studies have focused on investigation of the degree of the in vitro prevascularization required to achieve best postimplantation vascularization of tissue constructs\, as well as on understanding the mechanisms underlying host-implant vessel integration and anastomosis. New co-culture approaches for inducing pre-defined vessel structures in vitro will also be discussed\, as will novel studies on vascularized muscle flaps engineered to reconstruct large soft tissue defects.
URL:https://ibecbarcelona.eu/event/ibec-seminar-prof-shulamit-levenberg/
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20160712T100000
DTEND;TZID=UTC:20160712T230000
DTSTAMP:20260417T063724
CREATED:20160510T055158Z
LAST-MODIFIED:20160510T055158Z
UID:95913-1468317600-1468364400@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Prof. Shulamit Levenberg
DESCRIPTION:Engineering Vascularized Tissue Constructs\nProf. Shulamit Levenberg\, Faculty of Biomedical Engineering\, Technion\, Haifa\, Israel\nVascularization continues to represent a major challenge in the successful implementation of regenerative strategies. Cell organization into 3D tissue vascularized structures involves cell-matrix and cell-cell interactions\, some of which occur between the different tissue cell types. During this process\, cells further differentiate and assemble into structures resembling the final tissue architecture. We have established that vessel network assembly yielding vascularized 3D tissue structures can be induced in-vitro by means of coculturing endothelial cells\, fibroblasts and tissue-specific cells. We have also shown that in vitro pre-vascularization of engineered tissues can promote tissue survival and further vascularization upon implantation\, via anastomosis of the engineered vessels with host vasculature\, forming functional blood vessels in vivo. Vascularization of engineered tissues can be enhanced through coordinated application of improved biomaterial systems with relevant cell types. Moreover\, we have shown that vessel network maturity and morphology can be highly regulated by both matrix composition and by external mechanical stimulations. Our recent studies have focused on investigation of the degree of the in vitro prevascularization required to achieve best postimplantation vascularization of tissue constructs\, as well as on understanding the mechanisms underlying host-implant vessel integration and anastomosis. New co-culture approaches for inducing pre-defined vessel structures in vitro will also be discussed\, as will novel studies on vascularized muscle flaps engineered to reconstruct large soft tissue defects.
URL:https://ibecbarcelona.eu/event/ibec-seminar-prof-shulamit-levenberg-2/
CATEGORIES:IBEC Seminar
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