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X-WR-CALDESC:Events for Institute for Bioengineering of Catalonia
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DTSTART;TZID=Europe/Madrid:20161116T123000
DTEND;TZID=Europe/Madrid:20161116T133000
DTSTAMP:20260421T172707
CREATED:20161111T084218Z
LAST-MODIFIED:20161115T115233Z
UID:25828-1479299400-1479303000@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Dr. Silvia Muro\, Nanobiotechnology for drug delivery
DESCRIPTION:Nanobio-technology for drug delivery: fundamental aspects and translational applications\nDr. Silvia Muro\, University of Maryland\, College Park\, MD\, USA\nThe design of targeting and carrier strategies to enable delivery of therapeutic or diagnostic agents to areas of the body requiring intervention is an active research field. Therapeutic and diagnostic targets are often confined to specific regions or tissues in the body\, where access may require active transport from the circulation into the subjacent tissue. In addition\, once within the tissue or body compartment of interest\, most targets of intervention relate to sub-cellular environments\, e.g.\, the cell surface versus different intracellular compartments\, further requiring strategies to achieve this goal. \nUsing polymer nanocarriers functionalized with affinity moieties against single or combined cell-surface receptors\, along with additional biological signaling moieties\, my laboratory focuses on understanding the parameters that regulate transport of drug delivery vehicles across cellular barriers and into cells of subjacent tissues. We examine these aspects using cell culture models with subsequent validation in laboratory animals to correlate molecular/cellular mechanisms with in vivo outcomes. We investigate the influence exerted on targeting and uptake by drug carrier design parameters (size\, shape\, avidity\, combination targeting\, etc.) and parameters that are intrinsic to the physiological system (disease states\, flow\, receptor epitopes being targeted\, modulation of regulatory molecules\, etc.). The characterization of these complex physiological and design parameters\, along with the understanding of the mechanisms governing the interaction of drugs carriers with the surrounding biological environment\, are necessary steps toward achieving efficient drug delivery systems.
URL:https://ibecbarcelona.eu/event/ibec-seminar-nanobio-technology-for-drug-delivery-fundamental-aspects-and-translational-applications/
CATEGORIES:IBEC Seminar
ORGANIZER;CN="IBEC":MAILTO:www.ibecbarcelona.eu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20161116T123000
DTEND;TZID=Europe/Madrid:20161116T133000
DTSTAMP:20260421T172707
CREATED:20161111T084218Z
LAST-MODIFIED:20161111T084218Z
UID:95938-1479299400-1479303000@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Dr. Silvia Muro\, Nanobiotechnology for drug delivery
DESCRIPTION:Nanobio-technology for drug delivery: fundamental aspects and translational applications\nDr. Silvia Muro\, University of Maryland\, College Park\, MD\, USA\nThe design of targeting and carrier strategies to enable delivery of therapeutic or diagnostic agents to areas of the body requiring intervention is an active research field. Therapeutic and diagnostic targets are often confined to specific regions or tissues in the body\, where access may require active transport from the circulation into the subjacent tissue. In addition\, once within the tissue or body compartment of interest\, most targets of intervention relate to sub-cellular environments\, e.g.\, the cell surface versus different intracellular compartments\, further requiring strategies to achieve this goal. \nUsing polymer nanocarriers functionalized with affinity moieties against single or combined cell-surface receptors\, along with additional biological signaling moieties\, my laboratory focuses on understanding the parameters that regulate transport of drug delivery vehicles across cellular barriers and into cells of subjacent tissues. We examine these aspects using cell culture models with subsequent validation in laboratory animals to correlate molecular/cellular mechanisms with in vivo outcomes. We investigate the influence exerted on targeting and uptake by drug carrier design parameters (size\, shape\, avidity\, combination targeting\, etc.) and parameters that are intrinsic to the physiological system (disease states\, flow\, receptor epitopes being targeted\, modulation of regulatory molecules\, etc.). The characterization of these complex physiological and design parameters\, along with the understanding of the mechanisms governing the interaction of drugs carriers with the surrounding biological environment\, are necessary steps toward achieving efficient drug delivery systems.
URL:https://ibecbarcelona.eu/event/ibec-seminar-nanobio-technology-for-drug-delivery-fundamental-aspects-and-translational-applications-2/
CATEGORIES:IBEC Seminar
ORGANIZER;CN="IBEC":MAILTO:www.ibecbarcelona.eu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20161118T120000
DTEND;TZID=Europe/Madrid:20161118T130000
DTSTAMP:20260421T172707
CREATED:20161111T084848Z
LAST-MODIFIED:20161111T084848Z
UID:95939-1479470400-1479474000@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Enabling technologies for biofabrication of functional materials and biomimetic environments
DESCRIPTION:Enabling technologies for biofabrication of functional materials and biomimetic environments\nDr. Alvaro Mata\, Director of the Institute of Bioengineering at Queen Mary University of London\nThe talk will present novel self-assembling and printing technologies enabling the fabrication of 2D and 3D bioactive and/or biomimetic materials for potential application in tissue engineering\, regenerative medicine\, and in vitro models. \nExamples of projects that will be presented include a) a bioactive membrane capable of growing hierarchically-ordered hydroxyapatite structures that resemble those found in human dental enamel; b) a dynamic self-assembling peptide-protein system capable of controllably accessing non-equilibrium to grow tubes and capillaries with potential application in tissue engineering; and c) a simple 3D molecular printing method to create distinct chemical environments ranging from tens of microns to centimeters in size and depth within different types of hydrogels.
URL:https://ibecbarcelona.eu/event/ibec-seminar-enabling-technologies-for-biofabrication-of-functional-materials-and-biomimetic-environments-2/
CATEGORIES:IBEC Seminar
ORGANIZER;CN="IBEC":MAILTO:www.ibecbarcelona.eu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20161118T120000
DTEND;TZID=Europe/Madrid:20161118T130000
DTSTAMP:20260421T172707
CREATED:20161111T084848Z
LAST-MODIFIED:20161114T164758Z
UID:25831-1479470400-1479474000@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Enabling technologies for biofabrication of functional materials and biomimetic environments
DESCRIPTION:Enabling technologies for biofabrication of functional materials and biomimetic environments\nDr. Alvaro Mata\, Director of the Institute of Bioengineering at Queen Mary University of London\nThe talk will present novel self-assembling and printing technologies enabling the fabrication of 2D and 3D bioactive and/or biomimetic materials for potential application in tissue engineering\, regenerative medicine\, and in vitro models. \nExamples of projects that will be presented include a) a bioactive membrane capable of growing hierarchically-ordered hydroxyapatite structures that resemble those found in human dental enamel; b) a dynamic self-assembling peptide-protein system capable of controllably accessing non-equilibrium to grow tubes and capillaries with potential application in tissue engineering; and c) a simple 3D molecular printing method to create distinct chemical environments ranging from tens of microns to centimeters in size and depth within different types of hydrogels.
URL:https://ibecbarcelona.eu/event/ibec-seminar-enabling-technologies-for-biofabrication-of-functional-materials-and-biomimetic-environments/
CATEGORIES:IBEC Seminar
ORGANIZER;CN="IBEC":MAILTO:www.ibecbarcelona.eu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20161122T150000
DTEND;TZID=Europe/Madrid:20161122T160000
DTSTAMP:20260421T172707
CREATED:20161116T160120Z
LAST-MODIFIED:20161116T160120Z
UID:95955-1479826800-1479830400@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Herbert Levine
DESCRIPTION:Models of individual and collective cell motility\nHerbert Levine\, Director\, Center for Theoretical Biological Physics (CTBP)\, Rice University\, Houston\nEukaryotic cells can move either individually or collectively and this property is crucial for many biological functions. Often cells use directional information to decide on their direction; for single cells this can take the form of chemical or mechanical gradients. For collective motion\, additional information can be obtained from neighboring cells through such processes as the contact inhibition of locomotion. Our group develops a variety of computational models for studying actin-based crawling motions. These models range from rather complex and detailed at the single cell levels to simple reduced representations that can handle tissue-level processes. This talk will focus on out recent progress in this direction\, specifically on collective chemotaxis of cellular clusters and the role of contact inhibition in the mechanical state of expanding tissues.
URL:https://ibecbarcelona.eu/event/ibec-seminar-herbert-levine-2/
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20161122T150000
DTEND;TZID=Europe/Madrid:20161122T160000
DTSTAMP:20260421T172707
CREATED:20161116T160120Z
LAST-MODIFIED:20161116T160456Z
UID:25914-1479826800-1479830400@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Herbert Levine
DESCRIPTION:Models of individual and collective cell motility\nHerbert Levine\, Director\, Center for Theoretical Biological Physics (CTBP)\, Rice University\, Houston\nEukaryotic cells can move either individually or collectively and this property is crucial for many biological functions. Often cells use directional information to decide on their direction; for single cells this can take the form of chemical or mechanical gradients. For collective motion\, additional information can be obtained from neighboring cells through such processes as the contact inhibition of locomotion. Our group develops a variety of computational models for studying actin-based crawling motions. These models range from rather complex and detailed at the single cell levels to simple reduced representations that can handle tissue-level processes. This talk will focus on out recent progress in this direction\, specifically on collective chemotaxis of cellular clusters and the role of contact inhibition in the mechanical state of expanding tissues.
URL:https://ibecbarcelona.eu/event/ibec-seminar-herbert-levine/
CATEGORIES:IBEC Seminar
END:VEVENT
END:VCALENDAR