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DTSTART;TZID=Europe/Madrid:20170203T100000
DTEND;TZID=Europe/Madrid:20170203T110000
DTSTAMP:20260422T020452
CREATED:20170202T075031Z
LAST-MODIFIED:20170202T075031Z
UID:27390-1486116000-1486119600@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Giuseppe Battaglia
DESCRIPTION:Bionic nanoscopic carriers for precision drug delivery\nGiuseppe Battaglia\, Department of Chemistry and Department of Chemical Engineering\, University College London\nGetting across biological barriers and deliver therapeutic cargo to the right site is indeed a very challenging task that requires the judicious combination of physiological information with carrier engineering. In the last decade\, we have approached this problem\, applying a constructionist approach where we mimic biological complexity in the form of design principles to produce functional bionic units from simple building blocks and their interactions. We combine synthetic and supramolecular chemistry to tune inter/intramolecular interactions and self-assembly processes to form dynamic soft materials. Among the different bionic efforts\, we have focussed our attention to possibly one of the few that encompasses polymerisation\, compartmentalisation and positional self-assembly in the same unit; Polymersomes. These are vesicles formed by the self-assembly of amphiphilic block copolymers in water. We have equipped polymersomes with the critical elements to address the challenges for getting across biological barriers. They have surface engineered to control both attractive (binding) and repulsive (anti-fouling) interaction with proteins and receptors to create systems that can avoid opsonisation and yet target specific cell populations. We have engineered their mechanical properties so as to be flexible and able to penetrate dense tissues exploiting size-exclusion percolation patterns. We have equipped them with both asymmetric topology and enzymes to control their fluid-dynamics and diffusion so as to create chemotactic and active propulsion toward endogenous signalling molecules. Finally\, we have engineered their shape and size to guide cellular endocytosis as well as to escape the endocytic sorting accessing and delivering cargo within the cell interior. \nI will present our design efforts discussing each structural and functional elements as a function of the respective biological challenge\, I will conclude presenting applications where these precision systems are being applied to address challenges in oncology\, immunology and neurology.
URL:https://ibecbarcelona.eu/event/ibec-seminar-giuseppe-battaglia/
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20170203T100000
DTEND;TZID=Europe/Madrid:20170203T110000
DTSTAMP:20260422T020452
CREATED:20170202T075031Z
LAST-MODIFIED:20170202T075031Z
UID:95975-1486116000-1486119600@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Giuseppe Battaglia
DESCRIPTION:Bionic nanoscopic carriers for precision drug delivery\nGiuseppe Battaglia\, Department of Chemistry and Department of Chemical Engineering\, University College London\nGetting across biological barriers and deliver therapeutic cargo to the right site is indeed a very challenging task that requires the judicious combination of physiological information with carrier engineering. In the last decade\, we have approached this problem\, applying a constructionist approach where we mimic biological complexity in the form of design principles to produce functional bionic units from simple building blocks and their interactions. We combine synthetic and supramolecular chemistry to tune inter/intramolecular interactions and self-assembly processes to form dynamic soft materials. Among the different bionic efforts\, we have focussed our attention to possibly one of the few that encompasses polymerisation\, compartmentalisation and positional self-assembly in the same unit; Polymersomes. These are vesicles formed by the self-assembly of amphiphilic block copolymers in water. We have equipped polymersomes with the critical elements to address the challenges for getting across biological barriers. They have surface engineered to control both attractive (binding) and repulsive (anti-fouling) interaction with proteins and receptors to create systems that can avoid opsonisation and yet target specific cell populations. We have engineered their mechanical properties so as to be flexible and able to penetrate dense tissues exploiting size-exclusion percolation patterns. We have equipped them with both asymmetric topology and enzymes to control their fluid-dynamics and diffusion so as to create chemotactic and active propulsion toward endogenous signalling molecules. Finally\, we have engineered their shape and size to guide cellular endocytosis as well as to escape the endocytic sorting accessing and delivering cargo within the cell interior. \nI will present our design efforts discussing each structural and functional elements as a function of the respective biological challenge\, I will conclude presenting applications where these precision systems are being applied to address challenges in oncology\, immunology and neurology.
URL:https://ibecbarcelona.eu/event/ibec-seminar-giuseppe-battaglia-2/
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20170208T120000
DTEND;TZID=Europe/Madrid:20170208T130000
DTSTAMP:20260422T020452
CREATED:20170203T102730Z
LAST-MODIFIED:20170203T102730Z
UID:95984-1486555200-1486558800@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Stijn Mertens
DESCRIPTION:Electrochemical surface science of TiO2 rutile (110)\, graphene and boron nitride\nStijn Mertens\, TU Wien\, Institute of Applied Physics / KU Leuven\, Chemistry Department\nThe rational design of catalysts and other functional materials requires an atomic-level understanding of their structure and of the interface to supporting surfaces. I will present an in situ electrochemical STM study of TiO2 rutile (110) with atomic resolution. This is achieved using a new wet-chemical cleaning procedure for the substrate and with Pt-Ir tips. If tungsten tips are used\, WO3 is spontaneously formed at the tungsten–liquid interface and strongly adsorbs on oxide surfaces below their point of zero charge through an electrostatic mechanism. Under clean conditions\, the TiO2 rutile (110) surface shows a bulk-like\, unreconstructed structure\, which resembles its appearance in vacuum\, even though the surface is probably fully hydroxylated. \nIn the second part of my talk\, I will focus on 2D materials graphene and hexagonal boron nitride. By combining electrochemical grafting of diazonium salts with tip-induced nanolithography\, nanopatterned sp3 defects can be introduced\, opening perspectives towards graphene band gap engineering [1\,2]. Hexagonal boron nitride\, isoelectronic with graphene\, can be grown on Rh(111) and forms a so-called nanomesh superstructure [3]\, characterized by a 3.2-nm lattice constant and strong electronic corrugation\, useful for trapping atoms and molecules. Electrochemical intercalation of hydrogen between the boron nitride layer and the rhodium substrate leads to microscopic flattening within the 2-dimensional material and a macroscopic 10% change in adsorption energy [4]. \n[1] Greenwood et al.\, ACS Nano 9\, 2015\, 5520.\n[2] Huynh et al.\, Nanoscale 9\, 2017\, 362.\n[3] Corso et al.\, Science 303\, 2004\, 217.\n[4] Mertens et al.\, Nature 534\, 2016\, 676.
URL:https://ibecbarcelona.eu/event/ibec-seminar-stijn-mertens-2/
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20170208T120000
DTEND;TZID=Europe/Madrid:20170208T130000
DTSTAMP:20260422T020452
CREATED:20170203T102730Z
LAST-MODIFIED:20170213T120656Z
UID:27427-1486555200-1486558800@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Stijn Mertens
DESCRIPTION:Electrochemical surface science of TiO2 rutile (110)\, graphene and boron nitride\nStijn Mertens\, TU Wien\, Institute of Applied Physics / KU Leuven\, Chemistry Department\nThe rational design of catalysts and other functional materials requires an atomic-level understanding of their structure and of the interface to supporting surfaces. I will present an in situ electrochemical STM study of TiO2 rutile (110) with atomic resolution. This is achieved using a new wet-chemical cleaning procedure for the substrate and with Pt-Ir tips. If tungsten tips are used\, WO3 is spontaneously formed at the tungsten–liquid interface and strongly adsorbs on oxide surfaces below their point of zero charge through an electrostatic mechanism. Under clean conditions\, the TiO2 rutile (110) surface shows a bulk-like\, unreconstructed structure\, which resembles its appearance in vacuum\, even though the surface is probably fully hydroxylated. \nIn the second part of my talk\, I will focus on 2D materials graphene and hexagonal boron nitride. By combining electrochemical grafting of diazonium salts with tip-induced nanolithography\, nanopatterned sp3 defects can be introduced\, opening perspectives towards graphene band gap engineering [1\,2]. Hexagonal boron nitride\, isoelectronic with graphene\, can be grown on Rh(111) and forms a so-called nanomesh superstructure [3]\, characterized by a 3.2-nm lattice constant and strong electronic corrugation\, useful for trapping atoms and molecules. Electrochemical intercalation of hydrogen between the boron nitride layer and the rhodium substrate leads to microscopic flattening within the 2-dimensional material and a macroscopic 10% change in adsorption energy [4]. \n[1] Greenwood et al.\, ACS Nano 9\, 2015\, 5520.\n[2] Huynh et al.\, Nanoscale 9\, 2017\, 362.\n[3] Corso et al.\, Science 303\, 2004\, 217.\n[4] Mertens et al.\, Nature 534\, 2016\, 676.
URL:https://ibecbarcelona.eu/event/ibec-seminar-stijn-mertens/
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20170216T100000
DTEND;TZID=Europe/Madrid:20170216T110000
DTSTAMP:20260422T020452
CREATED:20170213T100423Z
LAST-MODIFIED:20170213T100423Z
UID:95987-1487239200-1487242800@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Jesús Martínez de la Fuente
DESCRIPTION:Designing Hybrid Nanoparticles for Therapy and Diagnosis\nJesús Martínez de la Fuente\, Instituto de Ciencia de Materiales de Aragón\, CSIC/University of Zaragoza\nIn the last decades\, inorganic nanoparticles have been steadily gaining more attention from scientists from a wide variety of fields such as material science\, engineering\, physics or chemistry. The very different properties compared to that of the respective bulk\, and thus intriguing characteristics of materials in the nanometre scale\, have driven nanoscience to be the centre of many basic and applied research topics. Moreover\, a wide variety of recently developed methodologies for their surface functionalization provide these materials with very specific properties such as drug delivery and circulating cancer biomarkers detection. In this talk we describe the synthesis and functionalization of gold nanoparticles as therapeutic and diagnosis tools against cancer: \n-Pseudo-spherical gold nanoparticles derivatized with with fluorescent dyes\, cell penetrating peptides and small interfering RNA (siRNA) complementary to the proto-oncogene myc have been tested using a hierarchical approach including three biological systems of increasing complexity: in vitro cultured human cells\, in vivo invertebrate (freshwater polyp\, Hydra) and in vivo vertebrate (mouse) model. Selection of the most active functionalities was assisted step by step through functional testing adopting this hierarchical strategy.(1) Merging these chemical and biological approaches lead to a siRNA/RGD gold nanoparticle capable of targeting tumor cells in lung cancer xenograft mouse model\, resulting in successful and significant c-myc oncogene downregulation followed by tumor growth inhibition and prolonged survival of the animals.(2) \n-Gold nanoprisms (NPRs) have been functionalized with PEG\, glucose\, cell penetrating and RGD peptides\, antibodies and/or fluorescent dyes\, aiming to enhance NPRs stability\, cellular uptake and imaging capabilities\, respectively.(3) Cellular uptake and impact was assayed by a multiparametric investigation on the impact of surface modified NPRs on mice and human primary and transform cell lines. Under NIR illumination\, these nanoprobes can cause apoptosis. Moreover\, these nanoparticles have also been used for optoacoustic imaging and cancer treatment\,(4) as well as for tumoral marker detection using a novel type of thermal ELISA nanobiosensor using a thermosensitive support.(5) \nReferences\n[1] J. Conde\, A. Ambrosone\, V. Sanz\, Y. Hernandez\, F. Tian\, P. V. Baptista\, M. R. Ibarra\, C. Tortiglione\, J. M. de la Fuente. ACS Nano\, 2012\, 6\, 8316.\n[2] J. Conde\, F. Tian\, Y. Hernández\, C. Bao\, D. Cui\, M. R. Ibarra\, P. V. Baptista\, J. M. de la Fuente. Biomaterials. 2013\, 34\, 7744.\n[3] a) B. Pelaz\, V. Grazú\, A. Ibarra\, C. Magén\, P. del Pino\, J. M. de la Fuente. Langmuir\, 2012\, 28\, 8965 ; b) M. Perez-Hernandez\, P. del Pino\, S.G. Mitchell\, M. Moros\, G. Stepien\, B. Pelaz\, W.J. Parak\, E.M. Galvez\, J. Pardo\, J.M. de la Fuente. ACS Nano\, 2015\, 9\, 52\n[4] a) C. Bao\, N. Beziere\, P. del Pino\, B. Pelaz\, G. Estrada\, F. Tian\, V. Ntziachristos\, J. M. de la Fuente\, D. Cui. Small\, 2013\, 9\, 68 ; b) J. Han\, J. Zhang\, M. Yang\, D. Cui\, J.M. de la Fuente. Nanoscale\, 2016 (in press)\n[5] E. Polo\, P. del Pino\,  B. Pelaz\,  V. Grazu\, J.M. de la Fuente. Chemical Communications\, 2013\, 49\, 3676.
URL:https://ibecbarcelona.eu/event/ibec-seminar-jesus-martinez-de-la-fuente-2/
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20170216T100000
DTEND;TZID=Europe/Madrid:20170216T110000
DTSTAMP:20260422T020452
CREATED:20170213T100423Z
LAST-MODIFIED:20170214T123640Z
UID:27592-1487239200-1487242800@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Jesús Martínez de la Fuente
DESCRIPTION:Designing Hybrid Nanoparticles for Therapy and Diagnosis\nJesús Martínez de la Fuente\, Instituto de Ciencia de Materiales de Aragón\, CSIC/University of Zaragoza\nIn the last decades\, inorganic nanoparticles have been steadily gaining more attention from scientists from a wide variety of fields such as material science\, engineering\, physics or chemistry. The very different properties compared to that of the respective bulk\, and thus intriguing characteristics of materials in the nanometre scale\, have driven nanoscience to be the centre of many basic and applied research topics. Moreover\, a wide variety of recently developed methodologies for their surface functionalization provide these materials with very specific properties such as drug delivery and circulating cancer biomarkers detection. In this talk we describe the synthesis and functionalization of gold nanoparticles as therapeutic and diagnosis tools against cancer: \n-Pseudo-spherical gold nanoparticles derivatized with with fluorescent dyes\, cell penetrating peptides and small interfering RNA (siRNA) complementary to the proto-oncogene myc have been tested using a hierarchical approach including three biological systems of increasing complexity: in vitro cultured human cells\, in vivo invertebrate (freshwater polyp\, Hydra) and in vivo vertebrate (mouse) model. Selection of the most active functionalities was assisted step by step through functional testing adopting this hierarchical strategy.(1) Merging these chemical and biological approaches lead to a siRNA/RGD gold nanoparticle capable of targeting tumor cells in lung cancer xenograft mouse model\, resulting in successful and significant c-myc oncogene downregulation followed by tumor growth inhibition and prolonged survival of the animals.(2) \n-Gold nanoprisms (NPRs) have been functionalized with PEG\, glucose\, cell penetrating and RGD peptides\, antibodies and/or fluorescent dyes\, aiming to enhance NPRs stability\, cellular uptake and imaging capabilities\, respectively.(3) Cellular uptake and impact was assayed by a multiparametric investigation on the impact of surface modified NPRs on mice and human primary and transform cell lines. Under NIR illumination\, these nanoprobes can cause apoptosis. Moreover\, these nanoparticles have also been used for optoacoustic imaging and cancer treatment\,(4) as well as for tumoral marker detection using a novel type of thermal ELISA nanobiosensor using a thermosensitive support.(5) \nReferences\n[1] J. Conde\, A. Ambrosone\, V. Sanz\, Y. Hernandez\, F. Tian\, P. V. Baptista\, M. R. Ibarra\, C. Tortiglione\, J. M. de la Fuente. ACS Nano\, 2012\, 6\, 8316.\n[2] J. Conde\, F. Tian\, Y. Hernández\, C. Bao\, D. Cui\, M. R. Ibarra\, P. V. Baptista\, J. M. de la Fuente. Biomaterials. 2013\, 34\, 7744.\n[3] a) B. Pelaz\, V. Grazú\, A. Ibarra\, C. Magén\, P. del Pino\, J. M. de la Fuente. Langmuir\, 2012\, 28\, 8965 ; b) M. Perez-Hernandez\, P. del Pino\, S.G. Mitchell\, M. Moros\, G. Stepien\, B. Pelaz\, W.J. Parak\, E.M. Galvez\, J. Pardo\, J.M. de la Fuente. ACS Nano\, 2015\, 9\, 52\n[4] a) C. Bao\, N. Beziere\, P. del Pino\, B. Pelaz\, G. Estrada\, F. Tian\, V. Ntziachristos\, J. M. de la Fuente\, D. Cui. Small\, 2013\, 9\, 68 ; b) J. Han\, J. Zhang\, M. Yang\, D. Cui\, J.M. de la Fuente. Nanoscale\, 2016 (in press)\n[5] E. Polo\, P. del Pino\,  B. Pelaz\,  V. Grazu\, J.M. de la Fuente. Chemical Communications\, 2013\, 49\, 3676.
URL:https://ibecbarcelona.eu/event/ibec-seminar-jesus-martinez-de-la-fuente/
CATEGORIES:IBEC Seminar
END:VEVENT
END:VCALENDAR