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DTSTART;TZID=Europe/Madrid:20180320T160000
DTEND;TZID=Europe/Madrid:20180320T170000
DTSTAMP:20260424T184110
CREATED:20180312T101441Z
LAST-MODIFIED:20180312T101441Z
UID:96186-1521561600-1521565200@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Carlo A. Bortolotti
DESCRIPTION:Monitoring biorecognition with organic bioelectronic transistors\nCarlo A. Bortolotti\, Dipartimento di Scienze della Vita\, Universita di Modena ed Regio Emilia\, Italy\nElectrolyte-gated OFETs (EGOFETs) and Organic Electrochemical transistors (OECTs) are emerging as an important class of chemo- and biosensors to meet the main requirements of healthcare diagnostics: portability\, manufacturing with low cost\, miniaturization\, low-temperature processing. These devices can be operated either in accumulation (EGOFETs) or in depletion mode (OECTs). Devices that allow transduction of protein/protein interactions can be used not only for analytical purposes\, but also for real time monitoring of surface adsorption and recognition events\, and may therefore provide insights into both the kinetics and thermodynamics of biomolecular interactions. These devices provide a real-time\, label-free response and the ultra-low sensitivity arising from the capacitive coupling between the electrolyte solution and the channel. We are currently investigating a wide range of biorecognition events\, differing in terms of size of the surface bound biomolecule and of the chemical nature and lateral dimensions of the biological partner in solution\, ranging from receptor/ligand interactions to antibody/antigene (protein) and antibody/virus couples. I will present a few examples of the EGOFET-based and OECT-based detection of detection of biorecognition events. Different surface functionalization strategies\, aiming at reducing non-specific binding\, increasing sensitivity and ensuring re-usability of the electrodes with immobilized sensing units will be described. I will also present our latest achievements in the development of a multigate lab-on-a-chip device\, aiming at the multiplexed detection of different analytes in a biological fluid\, also including an internal reference electrode.
URL:https://ibecbarcelona.eu/event/ibec-seminar-carlo-a-bortolotti-2/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20180320T160000
DTEND;TZID=Europe/Madrid:20180320T170000
DTSTAMP:20260424T184110
CREATED:20180312T101441Z
LAST-MODIFIED:20180312T101441Z
UID:57987-1521561600-1521565200@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Carlo A. Bortolotti
DESCRIPTION:Monitoring biorecognition with organic bioelectronic transistors\nCarlo A. Bortolotti\, Dipartimento di Scienze della Vita\, Universita di Modena ed Regio Emilia\, Italy\nElectrolyte-gated OFETs (EGOFETs) and Organic Electrochemical transistors (OECTs) are emerging as an important class of chemo- and biosensors to meet the main requirements of healthcare diagnostics: portability\, manufacturing with low cost\, miniaturization\, low-temperature processing. These devices can be operated either in accumulation (EGOFETs) or in depletion mode (OECTs). Devices that allow transduction of protein/protein interactions can be used not only for analytical purposes\, but also for real time monitoring of surface adsorption and recognition events\, and may therefore provide insights into both the kinetics and thermodynamics of biomolecular interactions. These devices provide a real-time\, label-free response and the ultra-low sensitivity arising from the capacitive coupling between the electrolyte solution and the channel. We are currently investigating a wide range of biorecognition events\, differing in terms of size of the surface bound biomolecule and of the chemical nature and lateral dimensions of the biological partner in solution\, ranging from receptor/ligand interactions to antibody/antigene (protein) and antibody/virus couples. I will present a few examples of the EGOFET-based and OECT-based detection of detection of biorecognition events. Different surface functionalization strategies\, aiming at reducing non-specific binding\, increasing sensitivity and ensuring re-usability of the electrodes with immobilized sensing units will be described. I will also present our latest achievements in the development of a multigate lab-on-a-chip device\, aiming at the multiplexed detection of different analytes in a biological fluid\, also including an internal reference electrode.
URL:https://ibecbarcelona.eu/event/ibec-seminar-carlo-a-bortolotti/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20180328T100000
DTEND;TZID=Europe/Madrid:20180328T110000
DTSTAMP:20260424T184110
CREATED:20180322T115517Z
LAST-MODIFIED:20180322T115517Z
UID:96199-1522231200-1522234800@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Aurélien Bancaud
DESCRIPTION:µLAS technology for DNA processing: setting up elementary functions (concentration\, separation\, purification\, identification) and application in oncology and targeted sequencing\nAurélien Bancaud\, LAAS-CNRS\, Toulouse\, France\nWe recently developed the µLAS technology for nucleic acids processing. Its operating principle relies on the monitoring of DNA transport in a viscoelastic liquid under the combined action of hydrodynamic and electrophoretic forces (1). DNA molecules are dragged toward the walls of microchannels by a transverse force proportional to their contour length. Because the hydrodynamic decreases near the wall\, DNA molecules are sorted according to their molecular weight. Furthermore\, by tailoring the geometry of a channel with a constriction\, we can tune the amplitude of transverse forces and stop molecules to design a concentrator that achieves enrichment rates of 100 to 1000 fold per minute. \nWe will derive a quantitative model of DNA transport in µLAS that relies on 1 fitting parameter and perform rational optimizations of the technology. We will then exploit µLAS for sizing cell-free circulating DNA (cfDNA) in the blood (2)\, and demonstrate that cfDNA profiling is a promissing biomarker for the follow-up of cancer patients. Finally\, we will present the principle of a DNA size-selective valve for the purification and sequencing of target genomic regions by combining µLAS with Cas9 endonuclease. \n(1) Ranchon et al.\, Lab Chip (2016)\n (2) Andriamanampisoa et al.\, Anal Chem (2018)
URL:https://ibecbarcelona.eu/event/ibec-seminar-aurelien-bancaud-2/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20180328T100000
DTEND;TZID=Europe/Madrid:20180328T110000
DTSTAMP:20260424T184110
CREATED:20180322T115517Z
LAST-MODIFIED:20180322T115517Z
UID:58142-1522231200-1522234800@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Aurélien Bancaud
DESCRIPTION:µLAS technology for DNA processing: setting up elementary functions (concentration\, separation\, purification\, identification) and application in oncology and targeted sequencing\nAurélien Bancaud\, LAAS-CNRS\, Toulouse\, France\nWe recently developed the µLAS technology for nucleic acids processing. Its operating principle relies on the monitoring of DNA transport in a viscoelastic liquid under the combined action of hydrodynamic and electrophoretic forces (1). DNA molecules are dragged toward the walls of microchannels by a transverse force proportional to their contour length. Because the hydrodynamic decreases near the wall\, DNA molecules are sorted according to their molecular weight. Furthermore\, by tailoring the geometry of a channel with a constriction\, we can tune the amplitude of transverse forces and stop molecules to design a concentrator that achieves enrichment rates of 100 to 1000 fold per minute. \nWe will derive a quantitative model of DNA transport in µLAS that relies on 1 fitting parameter and perform rational optimizations of the technology. We will then exploit µLAS for sizing cell-free circulating DNA (cfDNA) in the blood (2)\, and demonstrate that cfDNA profiling is a promissing biomarker for the follow-up of cancer patients. Finally\, we will present the principle of a DNA size-selective valve for the purification and sequencing of target genomic regions by combining µLAS with Cas9 endonuclease. \n(1) Ranchon et al.\, Lab Chip (2016)\n (2) Andriamanampisoa et al.\, Anal Chem (2018)
URL:https://ibecbarcelona.eu/event/ibec-seminar-aurelien-bancaud/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
END:VCALENDAR