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DTSTART;TZID=Europe/Madrid:20180404T120000
DTEND;TZID=Europe/Madrid:20180404T130000
DTSTAMP:20260424T200315
CREATED:20180222T110811Z
LAST-MODIFIED:20180222T110811Z
UID:96178-1522843200-1522846800@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Fernando López-Gallego
DESCRIPTION:Immobilization of multi-enzyme systems; an avenue to fabricate self-sufficient heterogeneous biocatalysts\nFernando López-Gallego\, Heterogeneous Biocatalysis Lab\, University of Zaragoza (iQSCH-CSIC) / ARAID\, Science Foundation of Aragón\nIn the last decade\, the chemists have been delighted by the catalytic orchestration found in vivo\, and have isolated multi-enzyme system to work ex-vivo in both natural and non-natural tandem reactions creating a new concept: systems biocatalysis. These systems are the pioneers of the cell-free synthetic biology; an emerging discipline that seeks the simplest biology to make the most complex chemistry. We have paid our attention to the heterogenization of multi-enzyme system to catalyze tandem reactions. Co-immobilization of multi-enzyme systems improve: 1) the kinetics of the chemical cascades due to the spatial localization of the different biocatalytic modules that avoids intermediate accumulation and increases cofactor recycling efficiency\, 2) the stability of the biocatalysts due to both structural rigidification and in situ elimination of toxic by-products\, 3) the biocatalyst recycle and 4) the biocatalyst adaptation to continuous processes. Nevertheless\, the co-immobilization of several enzymes to carry out synthetic cascades is challenging because there is no a universal immobilization chemistry that optimally attaches all the enzymes to the same surface. We have recently developed different immobilized multi-enzyme systems formed by a 3-enzyme cascade for oxidizing phenol derivatives with in situ H2O2 supply\, a 3-enzyme cascade for synthesizing 1\,3-dihydroxyacetone with both in situ cofactor recycling and H2O2 elimination\, a 4-enzyme cascade for quantitatively synthesizing pro-chiral ketones starting from racemic esters and a 2-enzyme cascades to synthesize optically pure secondary alcohols integrating the cofactor recycling in the solid-phase. The optimal design of the immobilization protocols enables co-immobilizing several enzymes and cofactors on the porous carrier to optimize their spatial localization across the carrier microstructure and preserve both global activity and stability of the multi-enzyme systems.
URL:https://ibecbarcelona.eu/event/ibec-seminar-fernando-lopez-gallego-2/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20180404T120000
DTEND;TZID=Europe/Madrid:20180404T130000
DTSTAMP:20260424T200315
CREATED:20180222T110811Z
LAST-MODIFIED:20180222T110811Z
UID:57824-1522843200-1522846800@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Fernando López-Gallego
DESCRIPTION:Immobilization of multi-enzyme systems; an avenue to fabricate self-sufficient heterogeneous biocatalysts\nFernando López-Gallego\, Heterogeneous Biocatalysis Lab\, University of Zaragoza (iQSCH-CSIC) / ARAID\, Science Foundation of Aragón\nIn the last decade\, the chemists have been delighted by the catalytic orchestration found in vivo\, and have isolated multi-enzyme system to work ex-vivo in both natural and non-natural tandem reactions creating a new concept: systems biocatalysis. These systems are the pioneers of the cell-free synthetic biology; an emerging discipline that seeks the simplest biology to make the most complex chemistry. We have paid our attention to the heterogenization of multi-enzyme system to catalyze tandem reactions. Co-immobilization of multi-enzyme systems improve: 1) the kinetics of the chemical cascades due to the spatial localization of the different biocatalytic modules that avoids intermediate accumulation and increases cofactor recycling efficiency\, 2) the stability of the biocatalysts due to both structural rigidification and in situ elimination of toxic by-products\, 3) the biocatalyst recycle and 4) the biocatalyst adaptation to continuous processes. Nevertheless\, the co-immobilization of several enzymes to carry out synthetic cascades is challenging because there is no a universal immobilization chemistry that optimally attaches all the enzymes to the same surface. We have recently developed different immobilized multi-enzyme systems formed by a 3-enzyme cascade for oxidizing phenol derivatives with in situ H2O2 supply\, a 3-enzyme cascade for synthesizing 1\,3-dihydroxyacetone with both in situ cofactor recycling and H2O2 elimination\, a 4-enzyme cascade for quantitatively synthesizing pro-chiral ketones starting from racemic esters and a 2-enzyme cascades to synthesize optically pure secondary alcohols integrating the cofactor recycling in the solid-phase. The optimal design of the immobilization protocols enables co-immobilizing several enzymes and cofactors on the porous carrier to optimize their spatial localization across the carrier microstructure and preserve both global activity and stability of the multi-enzyme systems.
URL:https://ibecbarcelona.eu/event/ibec-seminar-fernando-lopez-gallego/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20180413T100000
DTEND;TZID=Europe/Madrid:20180413T110000
DTSTAMP:20260424T200315
CREATED:20180226T153414Z
LAST-MODIFIED:20180226T153414Z
UID:96181-1523613600-1523617200@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Joan Seoane
DESCRIPTION:Intratumor heterogeneity in brain cancer\nJoan Seoane\, Group Leader / Director of Translational Research at Vall d’Hebron Institute of Oncology (VHIO)\nJoan Seoane is a Group Leader and Director of the Translational Research program at the Vall d’Hebron Institute of Oncology (VHIO) within the Vall d’Hebron University Hospital since 2011. \nIn 1998\, Joan obtained his PhD in Biochemistry and Molecular Biology from the University of Barcelona. Previously\, in 1993\, he obtained his BSc degree in Chemistry. Joan joined the Memorial Sloan-Kettering Cancer Center (MSKCC) in New York as a post-doctoral fellow in 1998. \nFrom 1998 to 2001\, he worked as a Research Fellow and subsequently\, from 2001 to 2003\, as a Research Associate. He was appointed ICREA Research Professor in 2004 and joined VHIO. \nIn 2007\, he became a member of the EMBO Young Investigator program and the recipient of a European Research Council (ERC) grant in 2008. Later\, he obtained two ERC Proof of Concept grants (2011\, 2013). In 2008\, he became Board member of the European Association of Cancer Research (EACR) and Professor of the Autonomous University of Barcelona. \nIn 2012\, founded Mosaic Biomedicals as a spin-off company from his lab and\, in 2013\, he was the recipient of the Dr. Josef Steiner Award. In 2016\, he became Secretary General of the EACR.
URL:https://ibecbarcelona.eu/event/ibec-seminar-joan-seoane-2/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20180413T100000
DTEND;TZID=Europe/Madrid:20180413T110000
DTSTAMP:20260424T200315
CREATED:20180226T153414Z
LAST-MODIFIED:20180409T075629Z
UID:57830-1523613600-1523617200@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Joan Seoane
DESCRIPTION:Intratumor heterogeneity in brain cancer\nJoan Seoane\, Group Leader / Director of Translational Research at Vall d’Hebron Institute of Oncology (VHIO)\nJoan Seoane is a Group Leader and Director of the Translational Research program at the Vall d’Hebron Institute of Oncology (VHIO) within the Vall d’Hebron University Hospital since 2011. \nIn 1998\, Joan obtained his PhD in Biochemistry and Molecular Biology from the University of Barcelona. Previously\, in 1993\, he obtained his BSc degree in Chemistry. Joan joined the Memorial Sloan-Kettering Cancer Center (MSKCC) in New York as a post-doctoral fellow in 1998. \nFrom 1998 to 2001\, he worked as a Research Fellow and subsequently\, from 2001 to 2003\, as a Research Associate. He was appointed ICREA Research Professor in 2004 and joined VHIO. \nIn 2007\, he became a member of the EMBO Young Investigator program and the recipient of a European Research Council (ERC) grant in 2008. Later\, he obtained two ERC Proof of Concept grants (2011\, 2013). In 2008\, he became Board member of the European Association of Cancer Research (EACR) and Professor of the Autonomous University of Barcelona. \nIn 2012\, founded Mosaic Biomedicals as a spin-off company from his lab and\, in 2013\, he was the recipient of the Dr. Josef Steiner Award. In 2016\, he became Secretary General of the EACR.
URL:https://ibecbarcelona.eu/event/ibec-seminar-joan-seoane/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20180420T100000
DTEND;TZID=Europe/Madrid:20180420T110000
DTSTAMP:20260424T200315
CREATED:20180403T074519Z
LAST-MODIFIED:20180403T074519Z
UID:96200-1524218400-1524222000@ibecbarcelona.eu
SUMMARY:IBEC Seminar: (David) Dagan Feng
DESCRIPTION:Biomedical Engineering and Technology Research at USYD and beyond\n(David) Dagan Feng\, PhD\, FACS\, FATSE\, FHKIE\, FIEEE\, & FIET\nRecent advances in engineering\, information technology and imaging have revolutionized biotechnology\, biomedical research and healthcare. This talk will initially focus on some of his core theories and enabling techniques research in molecular imaging for E-Healthcare and its impact to clinical practice\, in particular in cancer and metabolic diseases. This talk will then give an overview of the Biomedical Engineering and Technology research at the University of Sydney and beyond\, in particular several University new initiatives and the USYD-SJTU Joint Research Alliance.
URL:https://ibecbarcelona.eu/event/ibec-seminar-david-dagan-feng-2/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20180420T100000
DTEND;TZID=Europe/Madrid:20180420T110000
DTSTAMP:20260424T200315
CREATED:20180403T074519Z
LAST-MODIFIED:20180403T074519Z
UID:58189-1524218400-1524222000@ibecbarcelona.eu
SUMMARY:IBEC Seminar: (David) Dagan Feng
DESCRIPTION:Biomedical Engineering and Technology Research at USYD and beyond\n(David) Dagan Feng\, PhD\, FACS\, FATSE\, FHKIE\, FIEEE\, & FIET\nRecent advances in engineering\, information technology and imaging have revolutionized biotechnology\, biomedical research and healthcare. This talk will initially focus on some of his core theories and enabling techniques research in molecular imaging for E-Healthcare and its impact to clinical practice\, in particular in cancer and metabolic diseases. This talk will then give an overview of the Biomedical Engineering and Technology research at the University of Sydney and beyond\, in particular several University new initiatives and the USYD-SJTU Joint Research Alliance.
URL:https://ibecbarcelona.eu/event/ibec-seminar-david-dagan-feng/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
END:VCALENDAR