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DTSTART;TZID=Europe/Madrid:20180502T120000
DTEND;TZID=Europe/Madrid:20180502T130000
DTSTAMP:20260424T212723
CREATED:20180406T090351Z
LAST-MODIFIED:20180427T111212Z
UID:58285-1525262400-1525266000@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Francesco Ricci
DESCRIPTION:DNA-based nanodevices for diagnostic and drug-delivery applications\nFrancesco Ricci\, Chemistry Department\, University of Rome\, Tor Vergata\, Rome\, Italy\nDNA nanotechnology uses DNA (or nucleic acids) as a versatile material to rationally engineer tools and molecular devices that can find a multitude of different applications (e.g.\, in-vivo and in-vitro diagnostics\, drug delivery\, genetic circuits etc.). \nDuring this presentation I will introduce the field of DNA nanotechnology and I will talk about some of the most exciting examples of the last decade. \nI will show how to exploit the “designability” of DNA to fabricate nature-inspired DNA-based nanoswitches and nanodevices that are specifically designed to undergo a conformational change (switch) upon binding to a specific input (i.e. target). This input-triggered conformational change can be used for diagnostic\, drug-delivery or synthetic-biology applications. \nI will demonstrate how to characterize and recreate in-vitro several mechanisms to control the response of DNA-based nanodevices (1-2) and how to regulate their activity with different chemical and environmental stimuli including pH (3-8)\, antibodies (2-3)\, enzymes (9)\, small molecules (10) and electronic inputs (11). \nReferences\n[1] Porchetta. A.\, et al.\, J. Am. Chem. Soc.\, 2013\, 135\, 13238.\n[2] Ranallo\, S. et al.\, Angew. Chem.\, 2015\, 54\, 13214.\n[3] Ranallo\, S. et al.\, Nat. Commun.\, 2017\, 8\, 15150.\n[4] Idili\, A. et al.\, Nano Lett.\, 2015\, 15\, 5539.\n[5] Porchetta\, A\, et al. Nano Lett.\, 2015\, 15\, 4467.\n[6] Amodio\, A. et al.\, J. Am. Chem. Soc.\, 2014\, 136\, 16469.\n[7] Idili\, A. et al.\, J. Am. Chem. Soc.\, 2014\, 136\, 5836.\n[8] Mariottini\, D. et al.\, Nano Lett.\, 2017\, 17\, 3225.\n[9] Amodio\, A. et al.\, J. Am. Chem. Soc.\, 2016\, \, 138\, 12735.\n[10] Del Grosso\, E. et al.\, Nano Lett.\, 2015\, 15\, 8407.\n[11] Ranallo\, S. et al.\, Chem. Sc.\, 2016\, 7\, 66-71.
URL:https://ibecbarcelona.eu/event/ibec-seminar-francesco-ricci/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20180502T120000
DTEND;TZID=Europe/Madrid:20180502T130000
DTSTAMP:20260424T212723
CREATED:20180406T090351Z
LAST-MODIFIED:20180406T090351Z
UID:96216-1525262400-1525266000@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Francesco Ricci
DESCRIPTION:DNA-based nanodevices for diagnostic and drug-delivery applications\nFrancesco Ricci\, Chemistry Department\, University of Rome\, Tor Vergata\, Rome\, Italy\nDNA nanotechnology uses DNA (or nucleic acids) as a versatile material to rationally engineer tools and molecular devices that can find a multitude of different applications (e.g.\, in-vivo and in-vitro diagnostics\, drug delivery\, genetic circuits etc.). \nDuring this presentation I will introduce the field of DNA nanotechnology and I will talk about some of the most exciting examples of the last decade. \nI will show how to exploit the “designability” of DNA to fabricate nature-inspired DNA-based nanoswitches and nanodevices that are specifically designed to undergo a conformational change (switch) upon binding to a specific input (i.e. target). This input-triggered conformational change can be used for diagnostic\, drug-delivery or synthetic-biology applications. \nI will demonstrate how to characterize and recreate in-vitro several mechanisms to control the response of DNA-based nanodevices (1-2) and how to regulate their activity with different chemical and environmental stimuli including pH (3-8)\, antibodies (2-3)\, enzymes (9)\, small molecules (10) and electronic inputs (11). \nReferences\n[1] Porchetta. A.\, et al.\, J. Am. Chem. Soc.\, 2013\, 135\, 13238.\n[2] Ranallo\, S. et al.\, Angew. Chem.\, 2015\, 54\, 13214.\n[3] Ranallo\, S. et al.\, Nat. Commun.\, 2017\, 8\, 15150.\n[4] Idili\, A. et al.\, Nano Lett.\, 2015\, 15\, 5539.\n[5] Porchetta\, A\, et al. Nano Lett.\, 2015\, 15\, 4467.\n[6] Amodio\, A. et al.\, J. Am. Chem. Soc.\, 2014\, 136\, 16469.\n[7] Idili\, A. et al.\, J. Am. Chem. Soc.\, 2014\, 136\, 5836.\n[8] Mariottini\, D. et al.\, Nano Lett.\, 2017\, 17\, 3225.\n[9] Amodio\, A. et al.\, J. Am. Chem. Soc.\, 2016\, \, 138\, 12735.\n[10] Del Grosso\, E. et al.\, Nano Lett.\, 2015\, 15\, 8407.\n[11] Ranallo\, S. et al.\, Chem. Sc.\, 2016\, 7\, 66-71.
URL:https://ibecbarcelona.eu/event/ibec-seminar-francesco-ricci-2/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
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