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DTSTART;TZID=Europe/Madrid:20180608T100000
DTEND;TZID=Europe/Madrid:20180608T110000
DTSTAMP:20260425T000017
CREATED:20180604T083617Z
LAST-MODIFIED:20180604T083617Z
UID:96259-1528452000-1528455600@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Mar Alvarez
DESCRIPTION:Organ-on-chip monitoring\nMar Alvarez\, Ramon y Cajal researcher\, Biomedical Applications Group\, IMB-CNM\nOrgan-on-chip (OOC) is the term used to define a microfluidic 3D culture model that contains continuously perfused chambers inhabited by living cells. The development of the OOC technology has been possible thanks to the advancement in micro- and nanotechnologies. The engineered cellular microenvironments reproduce more accurately the in vivo structure and physiological conditions\, and allow simulating the activities\, mechanics and physiological response of tissues and organs. OOC are considered as very promising tools for investigating many aspects of human physiology and pathophysiology as well as drug testing platforms with future progressions to be used for precision medicine. As the complexity of OOC systems increases\, the necessity to integrate relevant assessment methods to provide information about cell physiology\, secreted metabolites as well as pharmacodynamics drug responses also increases. \nIn this talk\, I will focus on the different engineering approaches that we have used to develop physical and chemical sensors that can be integrated into OOC. I will describe our recent works on biological barrier models\, including blood-retinal barrier\, renal tubule and liver sinusoid. In particular\, I will talk about compartmentalization strategies and integration of transepithelial electrical resistance electrodes into these models\, fabricated by standard photolithographic processes\, for the on-line quantification of ion permeability and continuous evaluation of the barrier functioning. I will as well describe the integration of inkjet-printed electrodes into the culture porous membrane for the monitorization in real-time of the dissolved oxygen levels.
URL:https://ibecbarcelona.eu/event/ibec-seminar-mar-alvarez-2/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20180608T100000
DTEND;TZID=Europe/Madrid:20180608T110000
DTSTAMP:20260425T000017
CREATED:20180604T083617Z
LAST-MODIFIED:20180604T083617Z
UID:59409-1528452000-1528455600@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Mar Alvarez
DESCRIPTION:Organ-on-chip monitoring\nMar Alvarez\, Ramon y Cajal researcher\, Biomedical Applications Group\, IMB-CNM\nOrgan-on-chip (OOC) is the term used to define a microfluidic 3D culture model that contains continuously perfused chambers inhabited by living cells. The development of the OOC technology has been possible thanks to the advancement in micro- and nanotechnologies. The engineered cellular microenvironments reproduce more accurately the in vivo structure and physiological conditions\, and allow simulating the activities\, mechanics and physiological response of tissues and organs. OOC are considered as very promising tools for investigating many aspects of human physiology and pathophysiology as well as drug testing platforms with future progressions to be used for precision medicine. As the complexity of OOC systems increases\, the necessity to integrate relevant assessment methods to provide information about cell physiology\, secreted metabolites as well as pharmacodynamics drug responses also increases. \nIn this talk\, I will focus on the different engineering approaches that we have used to develop physical and chemical sensors that can be integrated into OOC. I will describe our recent works on biological barrier models\, including blood-retinal barrier\, renal tubule and liver sinusoid. In particular\, I will talk about compartmentalization strategies and integration of transepithelial electrical resistance electrodes into these models\, fabricated by standard photolithographic processes\, for the on-line quantification of ion permeability and continuous evaluation of the barrier functioning. I will as well describe the integration of inkjet-printed electrodes into the culture porous membrane for the monitorization in real-time of the dissolved oxygen levels.
URL:https://ibecbarcelona.eu/event/ibec-seminar-mar-alvarez/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20180615T100000
DTEND;TZID=Europe/Madrid:20180615T110000
DTSTAMP:20260425T000017
CREATED:20180517T085601Z
LAST-MODIFIED:20180517T085601Z
UID:96251-1529056800-1529060400@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Vivek Shenoy
DESCRIPTION:Cell-Matrix Interactions in Fibrosis and Cancer: Multiscale mechano-chemical models\nVivek Shenoy\, University of Pennsylvania\nMuch of our understanding of the biological mechanisms that underlie cellular functions\, such as migration\, differentiation and force sensing has been garnered from studying cells cultured on two-dimensional (2D) substrates. In the recent years there has been intense interest and effort to understand cell mechanics in three-dimensional (3D) cultures\, which more closely resemble the in vivo microenvironment. However\, a major challenge unique to 3D settings is the dynamic feedback between cells and their surroundings. In many 3D matrices\, cells remodel and reorient local extracellular microenvironment\, which in turn alters the active mechanics and in many cases\, the cell phenotype. Most models for matrices to date do not account for such positive feedback. Such models\, validated by experiments\, can provide a quantitative framework to study how injury related factors (in pathological conditions such as fibrosis and cancer metastasis) alter extracellular matrix (ECM) mechanics. They can also be used to analyze tissue morphology in complex 3D environments such as during morphogenesis and organogenesis\, and guide such processes in engineered 3D tissues. In this talk\, I will present discrete network simulations to study how cells remodel matrices and how this remodeling can lead to force transmission over large distances in cells. I will also discuss an active tissue model to quantitatively study the influence of mechanical constraints and matrix stiffness on contractility and stability of micropatterned tissues.
URL:https://ibecbarcelona.eu/event/ibec-seminar-vivek-shenoy-2/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20180615T100000
DTEND;TZID=Europe/Madrid:20180615T110000
DTSTAMP:20260425T000017
CREATED:20180517T085601Z
LAST-MODIFIED:20180517T085601Z
UID:59170-1529056800-1529060400@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Vivek Shenoy
DESCRIPTION:Cell-Matrix Interactions in Fibrosis and Cancer: Multiscale mechano-chemical models\nVivek Shenoy\, University of Pennsylvania\nMuch of our understanding of the biological mechanisms that underlie cellular functions\, such as migration\, differentiation and force sensing has been garnered from studying cells cultured on two-dimensional (2D) substrates. In the recent years there has been intense interest and effort to understand cell mechanics in three-dimensional (3D) cultures\, which more closely resemble the in vivo microenvironment. However\, a major challenge unique to 3D settings is the dynamic feedback between cells and their surroundings. In many 3D matrices\, cells remodel and reorient local extracellular microenvironment\, which in turn alters the active mechanics and in many cases\, the cell phenotype. Most models for matrices to date do not account for such positive feedback. Such models\, validated by experiments\, can provide a quantitative framework to study how injury related factors (in pathological conditions such as fibrosis and cancer metastasis) alter extracellular matrix (ECM) mechanics. They can also be used to analyze tissue morphology in complex 3D environments such as during morphogenesis and organogenesis\, and guide such processes in engineered 3D tissues. In this talk\, I will present discrete network simulations to study how cells remodel matrices and how this remodeling can lead to force transmission over large distances in cells. I will also discuss an active tissue model to quantitatively study the influence of mechanical constraints and matrix stiffness on contractility and stability of micropatterned tissues.
URL:https://ibecbarcelona.eu/event/ibec-seminar-vivek-shenoy/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
END:VCALENDAR