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DTSTART;TZID=Europe/Madrid:20191001T100000
DTEND;TZID=Europe/Madrid:20191001T110000
DTSTAMP:20260425T173250
CREATED:20190927T102638Z
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SUMMARY:IBEC Seminar: Carlos Rodríguez Cabello
DESCRIPTION:Dynamic Systems Based on Elastin-Like Recombinamers\nCarlos Rodríguez Cabello\, Bioforge Lab\, University of Valladolid CIBER-BBN \nThe use of recombinant technology in the production of macromolecule-based advanced biomaterials has caused a breakthrough increase in achievable degree of complexity and control on the molecular designs and compositions. Those recombinant macromolecules of polpeptide nature are called recombinamers. They are produced from a purely synthetic gene\, in which the amino-acid sequence is not restricted to those found in naturally occurring proteins and it is dictated only by engineering design parameters. The high degree of complexity and control of the recombinamer compositions permit to reach unmatched levels of functionality in the materials produced by this way and on the systems based on them. \nThe development of functionality in such systems comes by to different ways. In one hand\, these materials can display direct functionality. Such functionality is based on the presence in their composition of functional epitopes\, typically inspired by functional epitopes found in natural proteins. The other source of functionality is the holistic functionality that emerges by the precise combination and interactions of direct functions in a precise and well designed macromolecular composition. This holistic function is particularly evident in system with a dynamic nature; systems that rearrange and respond to changes in their environment. \nExamples of such dynamic systems will be presented. The examples will expand from complex 3D structures for regenerative medicine and tissue engineering that are able to incorporate a designed program of degradation and time evolution\, to more fundamental matters such as the hierarchical spontaneous development of morphology and macroscopical shapes in natural and artificial systems. \nDr. Rodríguez-Cabello is a full professor at the Dept. of Condensed Matter Physics of the University of Valladolid (UVa) Spain. During his career he has been teaching courses related to physics of polymers and biomaterials science in both undergraduate and graduate levels. In 1997\, he founded BIOFORGE in the UVa\, which nowadays is an internationally recognized and word leading group in the field of recombinamers. His current research interests include the development of biofunctional\, smart and customized protein polymers towards obtaining advanced biomedical devices.
URL:https://ibecbarcelona.eu/event/ibec-seminar-carlos-rodriguez-cabello/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20191001T100000
DTEND;TZID=Europe/Madrid:20191001T110000
DTSTAMP:20260425T173250
CREATED:20190927T102638Z
LAST-MODIFIED:20190927T102638Z
UID:96500-1569924000-1569927600@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Carlos Rodríguez Cabello
DESCRIPTION:Dynamic Systems Based on Elastin-Like Recombinamers\nCarlos Rodríguez Cabello\, Bioforge Lab\, University of Valladolid CIBER-BBN \nThe use of recombinant technology in the production of macromolecule-based advanced biomaterials has caused a breakthrough increase in achievable degree of complexity and control on the molecular designs and compositions. Those recombinant macromolecules of polpeptide nature are called recombinamers. They are produced from a purely synthetic gene\, in which the amino-acid sequence is not restricted to those found in naturally occurring proteins and it is dictated only by engineering design parameters. The high degree of complexity and control of the recombinamer compositions permit to reach unmatched levels of functionality in the materials produced by this way and on the systems based on them. \nThe development of functionality in such systems comes by to different ways. In one hand\, these materials can display direct functionality. Such functionality is based on the presence in their composition of functional epitopes\, typically inspired by functional epitopes found in natural proteins. The other source of functionality is the holistic functionality that emerges by the precise combination and interactions of direct functions in a precise and well designed macromolecular composition. This holistic function is particularly evident in system with a dynamic nature; systems that rearrange and respond to changes in their environment. \nExamples of such dynamic systems will be presented. The examples will expand from complex 3D structures for regenerative medicine and tissue engineering that are able to incorporate a designed program of degradation and time evolution\, to more fundamental matters such as the hierarchical spontaneous development of morphology and macroscopical shapes in natural and artificial systems. \nDr. Rodríguez-Cabello is a full professor at the Dept. of Condensed Matter Physics of the University of Valladolid (UVa) Spain. During his career he has been teaching courses related to physics of polymers and biomaterials science in both undergraduate and graduate levels. In 1997\, he founded BIOFORGE in the UVa\, which nowadays is an internationally recognized and word leading group in the field of recombinamers. His current research interests include the development of biofunctional\, smart and customized protein polymers towards obtaining advanced biomedical devices.
URL:https://ibecbarcelona.eu/event/ibec-seminar-carlos-rodriguez-cabello-2/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20191004T100000
DTEND;TZID=Europe/Madrid:20191004T110000
DTSTAMP:20260425T173250
CREATED:20190925T080454Z
LAST-MODIFIED:20190925T080506Z
UID:68382-1570183200-1570186800@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Martijn Gloerich
DESCRIPTION:Mechanical control of cell division\nMartijn Gloerich\, UMC Utrecth\, Center for Molecular Medicine\, Molecular Cancer Research \nDuring development and adult tissue homeostasis\, cellular behavior is controlled by signals that cells receive from their local environment. This is not limited to biochemical signals\, as cell behavior can be instructed by mechanical forces exerted by neighbouring cells and the surrounding tissue. Cells sense this mechanical information through numerous molecules\, including cell adhesion receptors\, which translate mechanical cues into an appropriate cellular response. I will discuss our recent findings on force transduction through the cell-cell adhesion protein E-cadherin\, and its central role in the mechanical control of cell division to regulate epithelial integrity and architecture. \nMartijn Gloerich is Assistant Professor at the department of Molecular Cancer Research at the University Medical Center Utrecht\, The Netherlands. Martijn obtained his PhD cum laude in 2011 from Utrecht University for his work on the regulation of small GTPases. Following his PhD\, he received fellowships from the Netherlands Organization for Scientific Research (NWO) and Dutch Cancer Foundation (KWF) to perform postdoctoral research in the lab of James Nelson at Stanford University. Here\, he gained experience with numerous microfabrication and bio-engineering techniques to study how communication between cells regulates cell behavior. In 2016 Martijn returned to the Netherlands to start his own research group at the University Medical Center Utrecht. His group uses an interdisciplinary approach to understand how cells sense and respond to mechanical forces to control tissue development and homeostasis\, and how its disruption contributes to tumor progression.
URL:https://ibecbarcelona.eu/event/ibec-seminar-martijn-gloerich/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
ORGANIZER;CN="IBEC":MAILTO:www.ibecbarcelona.eu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20191004T100000
DTEND;TZID=Europe/Madrid:20191004T110000
DTSTAMP:20260425T173250
CREATED:20190925T080454Z
LAST-MODIFIED:20190925T080454Z
UID:96496-1570183200-1570186800@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Martijn Gloerich
DESCRIPTION:Mechanical control of cell division\nMartijn Gloerich\, UMC Utrecth\, Center for Molecular Medicine\, Molecular Cancer Research \nDuring development and adult tissue homeostasis\, cellular behavior is controlled by signals that cells receive from their local environment. This is not limited to biochemical signals\, as cell behavior can be instructed by mechanical forces exerted by neighbouring cells and the surrounding tissue. Cells sense this mechanical information through numerous molecules\, including cell adhesion receptors\, which translate mechanical cues into an appropriate cellular response. I will discuss our recent findings on force transduction through the cell-cell adhesion protein E-cadherin\, and its central role in the mechanical control of cell division to regulate epithelial integrity and architecture. \nMartijn Gloerich is Assistant Professor at the department of Molecular Cancer Research at the University Medical Center Utrecht\, The Netherlands. Martijn obtained his PhD cum laude in 2011 from Utrecht University for his work on the regulation of small GTPases. Following his PhD\, he received fellowships from the Netherlands Organization for Scientific Research (NWO) and Dutch Cancer Foundation (KWF) to perform postdoctoral research in the lab of James Nelson at Stanford University. Here\, he gained experience with numerous microfabrication and bio-engineering techniques to study how communication between cells regulates cell behavior. In 2016 Martijn returned to the Netherlands to start his own research group at the University Medical Center Utrecht. His group uses an interdisciplinary approach to understand how cells sense and respond to mechanical forces to control tissue development and homeostasis\, and how its disruption contributes to tumor progression.
URL:https://ibecbarcelona.eu/event/ibec-seminar-martijn-gloerich-2/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
ORGANIZER;CN="IBEC":MAILTO:www.ibecbarcelona.eu
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