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X-WR-CALNAME:Institute for Bioengineering of Catalonia
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DTSTART;TZID=Europe/Madrid:20191105T160000
DTEND;TZID=Europe/Madrid:20191105T170000
DTSTAMP:20260425T184539
CREATED:20191029T084555Z
LAST-MODIFIED:20191029T084555Z
UID:96525-1572969600-1572973200@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Christine Horejs
DESCRIPTION:Inside Nature Nanotechnology\, an editor’s view\nChristine Horejs\, Nature Nanotechnology \nNature Nanotechnology was launched in October 2006 with the aim of publishing the most significant results in fundamental aspects\, applications and implications on nanomaterials. In my presentation I will provide an overview of what the journal looks for in the field of nanomedicine and bioimaging\, and I will give insight into the editorial process and some tips and tricks for submitting to our journal. \nChristine Horejs received her MSci and PhD in nanobiotechnology from the University of Natural Resources and Life Sciences\, Vienna\, Austria\, studying protein conformations and self-assembly using biophysical and theoretical approaches. She then joined the lab of Molly Stevens at Imperial College London\, UK\, investigating the extracellular matrix and cell–material interactions. In 2015\, she moved to the Karolinska Institute\, Sweden\, conducting in vivo studies of anti-fibrotic biomaterials. In September 2017\, she joined the Nature Reviews Materials team as an Associate Editor\, and since July 2019 she is a Senior Editor at Nature Nanotechnology\, where she is primarily responsible for nanomedicine and nanobiotechnology. \nShe has been invited to IBEC by Xavier Trepat
URL:https://ibecbarcelona.eu/event/ibec-seminar-christine-horejs-2/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
ORGANIZER;CN="IBEC":MAILTO:www.ibecbarcelona.eu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20191105T160000
DTEND;TZID=Europe/Madrid:20191105T170000
DTSTAMP:20260425T184539
CREATED:20191029T084555Z
LAST-MODIFIED:20191029T084604Z
UID:68942-1572969600-1572973200@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Christine Horejs
DESCRIPTION:Inside Nature Nanotechnology\, an editor’s view\nChristine Horejs\, Nature Nanotechnology \nNature Nanotechnology was launched in October 2006 with the aim of publishing the most significant results in fundamental aspects\, applications and implications on nanomaterials. In my presentation I will provide an overview of what the journal looks for in the field of nanomedicine and bioimaging\, and I will give insight into the editorial process and some tips and tricks for submitting to our journal. \nChristine Horejs received her MSci and PhD in nanobiotechnology from the University of Natural Resources and Life Sciences\, Vienna\, Austria\, studying protein conformations and self-assembly using biophysical and theoretical approaches. She then joined the lab of Molly Stevens at Imperial College London\, UK\, investigating the extracellular matrix and cell–material interactions. In 2015\, she moved to the Karolinska Institute\, Sweden\, conducting in vivo studies of anti-fibrotic biomaterials. In September 2017\, she joined the Nature Reviews Materials team as an Associate Editor\, and since July 2019 she is a Senior Editor at Nature Nanotechnology\, where she is primarily responsible for nanomedicine and nanobiotechnology. \nShe has been invited to IBEC by Xavier Trepat
URL:https://ibecbarcelona.eu/event/ibec-seminar-christine-horejs/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
ORGANIZER;CN="IBEC":MAILTO:www.ibecbarcelona.eu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20191115T100000
DTEND;TZID=Europe/Madrid:20191115T120000
DTSTAMP:20260425T184539
CREATED:20191111T153956Z
LAST-MODIFIED:20191111T153956Z
UID:96538-1573812000-1573819200@ibecbarcelona.eu
SUMMARY:Clinical Colloquia
DESCRIPTION:Theoretical and practical aspects of biophysiotherapy\nJosep Pous\, Medical Director at Cematec-Teknon de Barcelona \nIn this clinical colloquia\, the different treatment methods used in Biophysiotherapy such as Multifrequency Laser Therapy\, Shock Waves\, Modular Electromagnetic Waves\, Mechanotherapy\, Growth Factors\, Stem Cells\, will be exposed. The different mechanisms of action will be discussed at the cellular level such as mechanotransduction\, mechanotranscription\, depolarization of membarane or at the mitochondrial level through REDOX mechanisms\, to achieve biological effects at the cellular and tissue levels. Biophysiotherapy aims to apply the possibilities of diagnosis and treatment of the laboratory (biosensors\, nanobiosensors\, quantum dots) to the medical practice with fewer drugs and fewer surgeries. \nDr. Josep Pous\, specialist in Orthopedic Surgery\, Traumatology and Rehabilitation\, works at Cematec-Teknon of Barcelona (Center of Advanced and Technological Medicine) using the latest technologies in arthroscopy and prosthesis of the shoulder\, hip\, knee and ankle joints. Dr. Pous is a pioneer in the use of new non-invasive treatments for all musculoskeletal pathology and has incorporated new methods for its integral treatment. \nHe has been invited to IBEC by Pau Gorostiza
URL:https://ibecbarcelona.eu/event/clinical-colloquia-2/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20191115T100000
DTEND;TZID=Europe/Madrid:20191115T120000
DTSTAMP:20260425T184539
CREATED:20191111T153956Z
LAST-MODIFIED:20191111T154047Z
UID:69125-1573812000-1573819200@ibecbarcelona.eu
SUMMARY:Clinical Colloquia
DESCRIPTION:Theoretical and practical aspects of biophysiotherapy\nJosep Pous\, Medical Director at Cematec-Teknon de Barcelona \nIn this clinical colloquia\, the different treatment methods used in Biophysiotherapy such as Multifrequency Laser Therapy\, Shock Waves\, Modular Electromagnetic Waves\, Mechanotherapy\, Growth Factors\, Stem Cells\, will be exposed. The different mechanisms of action will be discussed at the cellular level such as mechanotransduction\, mechanotranscription\, depolarization of membarane or at the mitochondrial level through REDOX mechanisms\, to achieve biological effects at the cellular and tissue levels. Biophysiotherapy aims to apply the possibilities of diagnosis and treatment of the laboratory (biosensors\, nanobiosensors\, quantum dots) to the medical practice with fewer drugs and fewer surgeries. \nDr. Josep Pous\, specialist in Orthopedic Surgery\, Traumatology and Rehabilitation\, works at Cematec-Teknon of Barcelona (Center of Advanced and Technological Medicine) using the latest technologies in arthroscopy and prosthesis of the shoulder\, hip\, knee and ankle joints. Dr. Pous is a pioneer in the use of new non-invasive treatments for all musculoskeletal pathology and has incorporated new methods for its integral treatment. \nHe has been invited to IBEC by Pau Gorostiza
URL:https://ibecbarcelona.eu/event/clinical-colloquia/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20191122T100000
DTEND;TZID=Europe/Madrid:20191122T120000
DTSTAMP:20260425T184539
CREATED:20191114T092711Z
LAST-MODIFIED:20191114T092711Z
UID:96550-1574416800-1574424000@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Taher Saif
DESCRIPTION:Emergent living machines\nTaher Saif \, Professor\, Mechanical Science and Engineering University of Illinois at Urbana-Champaign \nIndustrial revolution of the 19th century marked the onset of the era of machines that transformed societies. However\, these machines cannot self assemble or heal themselves. On the other hand\, since the discovery of genes\, there is a considerable body of knowledge on engineering living cells. It is now possible to envision biohybrid machines with engineered living cells and scaffolds. These machines may self assemble and emerge from complex interactions between the cells and the scaffolds at various hierarchical levels. In this talk we will present two elementary biohybrid machines. They are both small scale swimmers. One of the swimmers is powered by primary rat cardiomyocytes. These cells are plated without any patterning on a scaffold which consists of a head and a tail. The cells self-orient to maximize scaffold deformation\, and synchronize their beating. As a result\, the tail deforms periodically and propels the swimmer forward. As a first step towards intelligent machines\, the second swimmer consists of optogenetic neurons and muscle cells. It’s scaffold consists of a head and two tails. The muscle cells self assemble into myotubes around the tails\, while the neurons are hosted by the head. The neurons spontaneously send out long cables of axons preferentially towards the muscle forming functional neuro functional junctions. They also form a neural network within themselves. Upon shining light\, the neurons fire synchronously in a periodic fashion. The muscle contracts and bends the tails to propel the swimmer. This new generation of swimmer powered by neurons paves the way towards intelligent biohybrid machines. The central role of mechanics in the emergence of the biohybrid machines will be highlighted. \nDr Taher Saif received his BS and MS degrees in Civil Engineering from Bangladesh University of Engineering and Technology and Washington State University respectively in 1984 and 1986. He obtained his Ph.D degree in Theoretical and Applied Mechanics from Cornell University in 1993. He worked as a Post Doctoral Associate in Electrical Engineering and the National Nanofabrication Facility at Cornell University during 1993-97. He joined the Department of Mechanical Science and Engineering at the University of Illinois at Urbana-Champaign during 1997. He is curently the Gutgsell Professor in the department. His current research includes tumor micro environment\, mechanics of neurons and cardiac cells\, development of biological machines\, and electro-thermo-mechanical behavior of nano scale metals and semiconductors. \nHe has been invited to IBEC by Samuel Sánchez
URL:https://ibecbarcelona.eu/event/ibec-seminar-taher-saif-3/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20191122T100000
DTEND;TZID=Europe/Madrid:20191122T120000
DTSTAMP:20260425T184539
CREATED:20191114T092711Z
LAST-MODIFIED:20191114T094956Z
UID:69228-1574416800-1574424000@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Taher Saif
DESCRIPTION:Emergent living machines\nTaher Saif \, Professor\, Mechanical Science and Engineering University of Illinois at Urbana-Champaign \nIndustrial revolution of the 19th century marked the onset of the era of machines that transformed societies. However\, these machines cannot self assemble or heal themselves. On the other hand\, since the discovery of genes\, there is a considerable body of knowledge on engineering living cells. It is now possible to envision biohybrid machines with engineered living cells and scaffolds. These machines may self assemble and emerge from complex interactions between the cells and the scaffolds at various hierarchical levels. In this talk we will present two elementary biohybrid machines. They are both small scale swimmers. One of the swimmers is powered by primary rat cardiomyocytes. These cells are plated without any patterning on a scaffold which consists of a head and a tail. The cells self-orient to maximize scaffold deformation\, and synchronize their beating. As a result\, the tail deforms periodically and propels the swimmer forward. As a first step towards intelligent machines\, the second swimmer consists of optogenetic neurons and muscle cells. It’s scaffold consists of a head and two tails. The muscle cells self assemble into myotubes around the tails\, while the neurons are hosted by the head. The neurons spontaneously send out long cables of axons preferentially towards the muscle forming functional neuro functional junctions. They also form a neural network within themselves. Upon shining light\, the neurons fire synchronously in a periodic fashion. The muscle contracts and bends the tails to propel the swimmer. This new generation of swimmer powered by neurons paves the way towards intelligent biohybrid machines. The central role of mechanics in the emergence of the biohybrid machines will be highlighted. \nDr Taher Saif received his BS and MS degrees in Civil Engineering from Bangladesh University of Engineering and Technology and Washington State University respectively in 1984 and 1986. He obtained his Ph.D degree in Theoretical and Applied Mechanics from Cornell University in 1993. He worked as a Post Doctoral Associate in Electrical Engineering and the National Nanofabrication Facility at Cornell University during 1993-97. He joined the Department of Mechanical Science and Engineering at the University of Illinois at Urbana-Champaign during 1997. He is curently the Gutgsell Professor in the department. His current research includes tumor micro environment\, mechanics of neurons and cardiac cells\, development of biological machines\, and electro-thermo-mechanical behavior of nano scale metals and semiconductors. \nHe has been invited to IBEC by Samuel Sánchez
URL:https://ibecbarcelona.eu/event/ibec-seminar-taher-saif/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20191126T100000
DTEND;TZID=Europe/Madrid:20191126T120000
DTSTAMP:20260425T184539
CREATED:20191118T093609Z
LAST-MODIFIED:20191118T093609Z
UID:96552-1574762400-1574769600@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Emilio Parisini
DESCRIPTION:Drugging the undruggable: towards the development of selective modulators of cadherin-mediated cell-cell adhesion\nEmilio Parisi\, Italian Institute of Technology (Milano) and Latvian Institute of Organic Synthesis (Riga) \nCadherins are transmembrane calcium-dependent cell adhesion proteins that mediate cellular adherens junction formation and tissue morphogenesis. Loss of cadherin-mediated adhesion has been implicated in many different steps of tumor progression such as invasion and migration\, and is strongly related to cell–cell detachment and metastasis. Altered expression profiles of epithelial E-cadherin (CDH1) and neuronal N-cadherin (CDH2) have often been observed in cancer cells\, most notably in the context of the epithelial-to-mesenchymal transition (EMT) process that occurs during cancer progression. Interestingly\, while in the majority of carcinomas E-cadherin is down-regulated\, in some epithelial ovarian cancer (EOC) cells are characterized by high expression levels of E-cadherin\, which facilitates EOC cell proliferation. So far\, structural and mutational studies have provided a rather detailed picture of the highly dynamic cadherin homo-dimerization mechanism. However\, because of this intrinsic dynamic behavior\, the rational design of small ligands targeting cadherin homophilic interactions has proved difficult. We determined the crystal structure of an E-cadherin extracellular fragment in complex with a peptidomimetic compound that partially inhibits cadherin homophilic adhesion. The structure\, which is the first and to date the only crystal structure of a cadherin extracellular portion in complex with a small molecule inhibitor\, reveals an unexpected binding mode and allows the identification of a druggable cadherin interface. Effective cell−cell adhesion modulators may represent potential anti-angiogenic drugs or pharmaceutical excipients to improve drug delivery across biological barriers. \nEmilio Parisini is a Group Leader at the Center for Nano Science and Technology of the Istituto Italiano di Tecnologia (IIT) in Milano. After completing a PhD in Chemistry at the University of Bologna (Italy)\, he worked at the Universities of Göttingen (Germany)\, Cambridge (UK) and Harvard (USA). In his laboratory\, he studies structure-function relationship in several chemical and biological systems\, focusing primarily on the study of the interactions between proteins and their ligands\, substrates or inhibitors. His current research interests include the functional and structural characterization of different members of the Cadherin family of cell adhesion proteins and of several different classes of enzymes for diagnostic (biosensors)\, therapeutic (structure-based drug design) and technological (protein and enzyme engineering) applications. \nHe has been invited to IBEC by Pau Gorostiza.
URL:https://ibecbarcelona.eu/event/ibec-seminar-emilio-parisi-2/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
ORGANIZER;CN="IBEC":MAILTO:www.ibecbarcelona.eu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20191126T100000
DTEND;TZID=Europe/Madrid:20191126T120000
DTSTAMP:20260425T184539
CREATED:20191118T093609Z
LAST-MODIFIED:20191119T141506Z
UID:69274-1574762400-1574769600@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Emilio Parisini
DESCRIPTION:Drugging the undruggable: towards the development of selective modulators of cadherin-mediated cell-cell adhesion\nEmilio Parisi\, Italian Institute of Technology (Milano) and Latvian Institute of Organic Synthesis (Riga) \nCadherins are transmembrane calcium-dependent cell adhesion proteins that mediate cellular adherens junction formation and tissue morphogenesis. Loss of cadherin-mediated adhesion has been implicated in many different steps of tumor progression such as invasion and migration\, and is strongly related to cell–cell detachment and metastasis. Altered expression profiles of epithelial E-cadherin (CDH1) and neuronal N-cadherin (CDH2) have often been observed in cancer cells\, most notably in the context of the epithelial-to-mesenchymal transition (EMT) process that occurs during cancer progression. Interestingly\, while in the majority of carcinomas E-cadherin is down-regulated\, in some epithelial ovarian cancer (EOC) cells are characterized by high expression levels of E-cadherin\, which facilitates EOC cell proliferation. So far\, structural and mutational studies have provided a rather detailed picture of the highly dynamic cadherin homo-dimerization mechanism. However\, because of this intrinsic dynamic behavior\, the rational design of small ligands targeting cadherin homophilic interactions has proved difficult. We determined the crystal structure of an E-cadherin extracellular fragment in complex with a peptidomimetic compound that partially inhibits cadherin homophilic adhesion. The structure\, which is the first and to date the only crystal structure of a cadherin extracellular portion in complex with a small molecule inhibitor\, reveals an unexpected binding mode and allows the identification of a druggable cadherin interface. Effective cell−cell adhesion modulators may represent potential anti-angiogenic drugs or pharmaceutical excipients to improve drug delivery across biological barriers. \nEmilio Parisini is a Group Leader at the Center for Nano Science and Technology of the Istituto Italiano di Tecnologia (IIT) in Milano. After completing a PhD in Chemistry at the University of Bologna (Italy)\, he worked at the Universities of Göttingen (Germany)\, Cambridge (UK) and Harvard (USA). In his laboratory\, he studies structure-function relationship in several chemical and biological systems\, focusing primarily on the study of the interactions between proteins and their ligands\, substrates or inhibitors. His current research interests include the functional and structural characterization of different members of the Cadherin family of cell adhesion proteins and of several different classes of enzymes for diagnostic (biosensors)\, therapeutic (structure-based drug design) and technological (protein and enzyme engineering) applications. \nHe has been invited to IBEC by Pau Gorostiza.
URL:https://ibecbarcelona.eu/event/ibec-seminar-emilio-parisi/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
ORGANIZER;CN="IBEC":MAILTO:www.ibecbarcelona.eu
END:VEVENT
END:VCALENDAR