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DTSTART;TZID=Europe/Madrid:20200417T100000
DTEND;TZID=Europe/Madrid:20200417T120000
DTSTAMP:20260426T011400
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SUMMARY:Online IBEC Seminar: Javier Ramón
DESCRIPTION:Bioprinting methods for organ-on-a-chip applications\n \nJavier Ramón \, IBEC \nEngineered tissues in three-dimensional (3D) cell culture platforms that resemble the complex native structure and organization can be used as in vitro models to study tissues physiology and metabolism. Our technology allows us to develop a new platform to model metabolic and muscle diseases in vitro in order to study its response to candidate therapeutics and to better understand disease mechanisms of pathogenesis. To this end\, we monitor the secretion of disease-associated biomarker proteins and metabolites. \nHere\, we present 3D skeletal muscle constructs\, fabricated by encapsulating C2C12 cells and pancreatic mouse islets in a photocrosslinkable Gelatin Methacrylate (GelMA) and Carboxymethylcellulose Methacrylate (GelMA:CMCMA) hydrogel and cryogel scaffolds. These scaffolds present a microgrooved topography that promotes cell alignment and differentiation. These 3D tissues are integrated with biosensors for in situ monitorization of cytokines and hormones released under different external stimuli\, toxins\, drugs or electrical stimulation. \nWe have obtained a new platform to study the evolution of congenital muscle diseases\, specifically myotonic dystrophy 1 and evaluate the functional tissues by metabolic and gene expression analysis. Monitor the secretion of biomarkers proteins\, metabolites\, and the glycolysis pathway of muscle tissues for different drug candidates. Discussion: This platform has been tested with different drugs assays and represent a step toward the goal of producing in vitro drug testing systems for medical and pharmaceutical industry applications. Finally\, such “multi tissue-on-a-chip” devices can be fabricated using patient’s own cells as a major step toward personalized medicine. \nThe seminar will take place online at the GoToMeeting Platform \nKnow more about Javier Ramón’s research here
URL:https://ibecbarcelona.eu/event/online-ibec-seminar-javier-ramon/
CATEGORIES:IBEC Seminar
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DTSTART;TZID=Europe/Madrid:20200421T160000
DTEND;TZID=Europe/Madrid:20200421T170000
DTSTAMP:20260426T011400
CREATED:20200415T101113Z
LAST-MODIFIED:20200415T101223Z
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SUMMARY:Online IBEC Seminar: Lorenzo Albertazzi
DESCRIPTION:A super-resolved look at nanomedicine\n \nLorenzo Albertazzi \, IBEC \nNanomaterials revolutionized the field of biomedicine introducing innovative approaches towards drug delivery\, molecular imaging\, regenerative medicine and biosensing. However\, despite the large investments in nanotechnology the translation into clinical applications is still unsatisfactory. One of the main reasons is the lack of knowledge about the behavior of nanostructures in the biological environment that makes the rational design of effective materials extremely challenging. \nThe main aim of our group is to use advanced microscopy techniques to understand the interactions of nanomaterials with living matter and to exploit this information to design novel devices for biomedical applications with a particular focus on drug delivery. To this goal we employ innovative optical imaging techniques such as super resolution microscopy to visualize and understand the molecular interactions of nanomaterials with their cellular targets in unprecedented detail. Super resolution microscopy techniques such as stochastic optical reconstruction microscopy (STORM) and point accumulation for imaging in nanoscale topography (PAINT) offer nanometric resolution and multicolor ability\, therefore they are ideal tools to study nano-sized multicomponent functional objects in vitro and in cells. This allows to get a closer “look” at the mechanisms of the key phenomena responsible for device performances such as particle stability\, protein corona and targeting. The fundamental knowledge acquired will pave the way towards the “microscopy-guided” design of novel nanomaterials for drug and gene delivery. \nThe seminar will take place online at the GoToMeeting Platform \nKnow more about Lorenzo Albertazzi’s research here
URL:https://ibecbarcelona.eu/event/online-ibec-seminar-lorenzo-albertazzi/
CATEGORIES:IBEC Seminar
ORGANIZER;CN="IBEC":MAILTO:www.ibecbarcelona.eu
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BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20200428T160000
DTEND;TZID=Europe/Madrid:20200428T180000
DTSTAMP:20260426T011400
CREATED:20200421T075141Z
LAST-MODIFIED:20200421T075153Z
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SUMMARY:Online IBEC Seminar: Samuel Sánchez
DESCRIPTION:BioEngineering Hybrid Robotic Machines: from nanobots to 3D Bioprinted Robots\n \nSamuel Sánchez \, IBEC \nThe combination of biological components and artificial ones emerges into what we called hybrid machines/bots/robots. Here\, I will present two types of hybrid systems that we are currently developing in our lab which span across different length scales\, from a few nanometers to centimeters. \nAlike bacteria or small swimmers found in nature\, these artificial nanobots convert bio-available fuels to generate propulsion force to swim at the nanoscale. One of the dreams in nanotechnology is to engineer small vehicles which can eventually be applied in vivo for medical purposes. In the first part of my talk\, I will present how we bioengineer our hybrid nanobots combining the best from the two worlds: biology (enzymes) and (nano)technology (nano- micro-particles) providing swimming capabilities\, biocompatibility\, remote control\, multifunctionality and actuation. I will present some of the proof-of-concept applications such as the efficient transport of drugs into cancer cells and spheroids\, sensing capabilities and the use of molecular imaging techniques for their tracking and localization both in vitro and in vivo. \nIn the second part of my talk\, I will present the 3D bioprinting technique to fabricate hybrid 3D BIOBOTS which provides flexibility\, scalability\, rapid prototyping and simplicity. This technique has emerged as a powerful tool for the development of functional three-dimensional tissues and\, in particular\, skeletal muscle. By electrical stimulation\, we studied the adaptability of 3D hybrid Robots after long-term trainings and the force evolution during the trainings together with the dynamic gene expression. Two types of devices are bioengineered in our lab: (i) 3D Actuators which useful force measurement platform for drug screening against dystrophies and (ii) 3D BIOBOTS that can be a next generation of living soft robotics systems with swimming capabilities. \nThe seminar will take place online at the GoToMeeting Platform \nKnow more about Samuel Sánchez’s research here
URL:https://ibecbarcelona.eu/event/online-ibec-seminar-samuel-sanchez/
CATEGORIES:IBEC Seminar
ORGANIZER;CN="IBEC":MAILTO:www.ibecbarcelona.eu
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