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DTSTART;TZID=Europe/Madrid:20221005T100000
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DTSTAMP:20260403T213250
CREATED:20220919T080717Z
LAST-MODIFIED:20220927T081412Z
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SUMMARY:IBEC Seminar: David Odde
DESCRIPTION:Differential migration mechanics and immune response of glioblastoma subtypes\nDavid Odde\, Dept. of Biomedical Eng.\, U. Minnesota \nGlioblastoma remains a deadly cancer driven by invasion of tumor cells into the brain. Transcriptomic analyses have revealed distinct molecular subtypes\, but mechanistic and targetable differences that explain clinical differences are not clear. Using a state-of-the-art immunocompetent mouse model for glioblastoma – where tumors are induced by injection of plasmids containing human glioblastoma subtype-defining genetic drivers in a wild-type background – we found that\, as predicted by the motor-clutch model for cell migration (Klank et al.\, Cell Rep\, 2017)\, mesenchymal glioma cells are more spread\, generate larger traction forces\, and migrate faster in brain tissue compared to proneural cells. Despite their fast migration and comparable proliferation rate in vitro\, mice with mesenchymal tumors live longer than mice with proneural tumors\, which was correlated with an immune response in the mesenchymal mice that included T cell-mediated killing of cancer cells\, similar to human tumors. Thus\, mesenchymal tumors have aggressive migration\, but are relatively immunologically ‘hot’ which suppresses net proliferation\, features which are captured by our Brownian Dynamics tumor simulator (Klank et al.\, Conv Sci Phys Oncol\, 2018). These two features counteract each other and may explain the lack of a strong survival difference between subtypes clinically\, while also opening up new opportunities for subtype-specific therapies. \n  \n\nDavid Odde is the Medtronic Professor of Engineering in Medicine at the University of Minnesota. Trained as a chemical engineer at the University of Minnesota and Rutgers University\, Odde joined the newly created Department of Biomedical Engineering at the University of Minnesota in 1999 where he is a professor and Associate Director for Strategic Research Initiatives in the Institute for Engineering in Medicine. In his research\, Odde’s group builds computer models of cellular and molecular self-assembly and force-generation-dissipation dynamics\, and tests the models experimentally using digital microscopic imaging of living cells ex vivo and in engineered microenvironments. His group seeks to bring an engineering approach that uses physics-based modeling and analysis to understand\, predict\, and control disease outcomes (oddelab.umn.edu). Dr. Odde is an elected Fellow of the American Institute for Medical and Biological Engineering (AIMBE)\, the Biomedical Engineering Society (BMES)\, the International Academy of Medical and Biological Engineering (IAMBE)\, and the American Association for the Advancement of Science (AAAS) and is the Director of the Physical Sciences in Oncology Center at the University of Minnesota (psoc.umn.edu)\, which is focused on modeling the mechanics of cancer cell migration in biologically relevant contexts.
URL:https://ibecbarcelona.eu/event/ibec-seminar-david-odde/
CATEGORIES:IBEC Seminar
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DTSTART;TZID=Europe/Madrid:20221014T100000
DTEND;TZID=Europe/Madrid:20221014T120000
DTSTAMP:20260403T213250
CREATED:20220513T064645Z
LAST-MODIFIED:20221004T083638Z
UID:96615-1665741600-1665748800@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Conrado Aparicio
DESCRIPTION:Peptides and bioinstructive polymers on surfaces for prevention of oral infections\nConrado Aparicio\, Faculty of Odontology\, UIC Barcelona and Associated Researcher – IBEC \nOral infections are the most prevalent infectious diseases worldwide. We have explored bioinspired modification of surfaces of restorative/regenerative materials and implants as well as dental tissues to address oral infections by harnessing the biomolecular toolbox –oligopeptides\, proteins\, recombinamers\, … and thus\, mitigating the worldwide threat of antimicrobial resistance. \nOne of our strategies aimed at exploiting secondary structure and self-assembly of anti-biofilm peptides and recombinamers to increase anti-biofilm potency vs relevant oral biofilms and to form highly hydrophobic interfaces to obtain dual-action surfaces to address infection in dental peri-tisular and peri-implant sites. \nAlternatively\, we have found inspiration in the natural junction at the tooth-oral mucosa interface. Teeth\, long-lasting percutaneous organs\, feature soft tissue attachment through adhesive structures\, hemidesmosomes\, in the junctional epithelium basement membrane adjacent to teeth. This soft tissue attachment prevents bacterial infection of the tooth despite the rich – and harsh – microbial composition of the oral cavity. Consequently\, we have tapped basement membrane peptides known to engage specific integrins as well as synthesized new bioinstructive photocurable resins that stimulate formation of hemidesmosomes on synthetic and natural surfaces. \nWe recently have also combined those strategies with immunomodulatory regulation to reduce inflammation triggered by pathogenic biofilms causing oral infections. \n\nDr. Conrado Aparicio is Professor at the Department of Odontology of UIC Barcelona – Universitat International de Catalunya\, Spain. He is associated researcher at IBEC-Institute for BioEngineering of Catalonia and elected fellow of the AIMBE-American Institute for Medical and Biological Engineering. \nDr. Aparicio is a materials scientist and engineer by training. After starting his academic career at the Technical University of Catalonia (UPC) he moved to the University of Minnesota (UMN) where he spent 12+ years in the Department of Restorative Sciences\, and was the Deputy Director of the MDRCBB-Minnesota Dental Research Center for Biomaterials and Biomechanics. Last year Professor Aparicio returned to his hometown\, Barcelona\, as FBA-BIST-UIC fellow. \nFor two decades he has carried out multidisciplinary research on bioinspired biomaterials and interfaces for directing biological responses to repair/regenerate bone and oral mucosa as well as to prevent bacterial infections for dental applications. Using inspiration from nature’s molecules and structures\, his team designs and develops bioactive surfaces using supramolecular assembly and enabling spatial-temporal control of bioactive responses. \nHe has published 130+ research papers and has lectured around the World on bioactivation of synthetic biomaterials for reparative and regenerative dentistry and medicine. He is co-inventor of multiple patents\, one of them licensed and marketed by a dental implant company. He has been awarded multiple national and international research projects from US and EC agencies\, foundations and corporations\, in interdisciplinary collaborations between academic and corporate engineers\, biologists\, and clinicians.
URL:https://ibecbarcelona.eu/event/ibec-seminar-conrado-aparicio-2/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
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