BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Institute for Bioengineering of Catalonia - ECPv6.15.20//NONSGML v1.0//EN
CALSCALE:GREGORIAN
METHOD:PUBLISH
X-ORIGINAL-URL:https://ibecbarcelona.eu
X-WR-CALDESC:Events for Institute for Bioengineering of Catalonia
REFRESH-INTERVAL;VALUE=DURATION:PT1H
X-Robots-Tag:noindex
X-PUBLISHED-TTL:PT1H
BEGIN:VTIMEZONE
TZID:Europe/Madrid
BEGIN:DAYLIGHT
TZOFFSETFROM:+0100
TZOFFSETTO:+0200
TZNAME:CEST
DTSTART:20220327T010000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:+0200
TZOFFSETTO:+0100
TZNAME:CET
DTSTART:20221030T010000
END:STANDARD
BEGIN:DAYLIGHT
TZOFFSETFROM:+0100
TZOFFSETTO:+0200
TZNAME:CEST
DTSTART:20230326T010000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:+0200
TZOFFSETTO:+0100
TZNAME:CET
DTSTART:20231029T010000
END:STANDARD
BEGIN:DAYLIGHT
TZOFFSETFROM:+0100
TZOFFSETTO:+0200
TZNAME:CEST
DTSTART:20240331T010000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:+0200
TZOFFSETTO:+0100
TZNAME:CET
DTSTART:20241027T010000
END:STANDARD
END:VTIMEZONE
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20231002T120000
DTEND;TZID=Europe/Madrid:20231002T130000
DTSTAMP:20260419T001803
CREATED:20230912T132001Z
LAST-MODIFIED:20230912T132001Z
UID:110817-1696248000-1696251600@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Simone Reber
DESCRIPTION:Conserved nucleocytoplasmic density homeostasis drives cellular organization across eukaryotes\nSimone Reber\, Max Planck Institut for Infection Biology\, Berlin (invited by Pere Roca-Cusachs) \nThe packing and confinement of macromolecules in the cytoplasm and nucleoplasm has profound implications for cellular biochemistry. How intracellular density distributions vary and affect cellular physiology remains largely unknown. We show that the nucleus is less dense than the cytoplasm and that living systems establish and maintain a constant density ratio between these compartments. Using label-free biophotonics and theory\, we show that nuclear density is set by a pressure balance across the nuclear envelope in vitro\, in vivo and during early development. Nuclear transport establishes a specific nuclear proteome that exerts a colloid osmotic pressure\, which\, assisted by entropic chromatin pressure\, draws water into the nucleus. Using C. elegans\, we show that while nuclear-to-cytoplasmic (N/C) volume ratios change during early development\, the N/C density ratio is robustly maintained. We propose that the maintenance of a constant N/C density ratio is the biophysical driver of one of the oldest tenets of cell biology: the N/C volume ratio. In summary\, this study reveals a previously unidentified homeostatic coupling of macromolecular densities that drives cellular organization.
URL:https://ibecbarcelona.eu/event/ibec-seminar-simone-reber/
LOCATION:Sala Dolors Aleu\, Cluster II\, IBEC\, Baldiri i Reixac\, Barcelona
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20231011T110000
DTEND;TZID=Europe/Madrid:20231011T130000
DTSTAMP:20260419T001803
CREATED:20231004T102504Z
LAST-MODIFIED:20231004T102504Z
UID:111446-1697022000-1697029200@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Jaap den Toonder
DESCRIPTION:Microfluidic technology enabling biomedical applications\nJaap den Toonder\, Microsystems Research Section\, Department of Mechanical Engineering\, and Institute for Complex Molecular Systems\, Eindhoven University of Technology.  \nCurrently\, visiting professor at IBEC\, Barcelona \nMicrofluidics is the science and technology of manipulating and analyzing fluid flow at small scales\, typically from millimeters down to micrometers. At these scales\, fluid flow is almost always laminar which enables excellent control over the flow. Microfluidic devices can be made using a range of microfabrication approaches and materials\, and these enable to integrate tailored electronic or mechanical functions. These unique properties of microfluidic technologies\, and the ongoing further development of the technology\, enable a range of new biomedical applications\, including diagnostic and monitoring devices\, medical implants\, and organ-on-chip. \nIn this lecture\, I will present recent developments within three research lines of our lab. (1) Bio-inspired microfluidics: A novel microfluidic flow generation concept inspired by nature\, which is based on magnetic nano- and micro-actuators we call “artificial cilia”; integrated in microfluidic devices\, these can be used to induce flow\, to manipulate particles\, and as actuators in cellular mechano-transduction research. (2) Microfluidic devices for health: Examples of microfluidic devices for health applications\, specifically a sweat sensing device for non-invasive semi-continuous monitoring of hospitalized patients\, and a smart eye implant to control eye pressure in glaucoma patients after surgery. (3) Organ-on-chip: A game-changing technology in which human cells are cultured in microfluidic chips simulating and predicting the response of healthy and diseased human tissues. I will focus on cancer-on-chip approaches to understand initial stages of cancer metastasis\, and on our lumen-based organ-on-chip models that are enabled by a 3D sugar printing technique we developed.
URL:https://ibecbarcelona.eu/event/ibec-seminar-jaap-den-toonder/
LOCATION:Sala Dolors Aleu\, Cluster II\, IBEC\, Baldiri i Reixac\, Barcelona
CATEGORIES:IBEC Seminar
END:VEVENT
END:VCALENDAR