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DTSTART;TZID=Europe/Madrid:20231201T120000
DTEND;TZID=Europe/Madrid:20231201T130000
DTSTAMP:20260418T193602
CREATED:20231122T092220Z
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SUMMARY:IBEC Seminar: Dr. Neil Lin
DESCRIPTION:Epithelial Cell Variability is Governed by Physics Principles and Has Mechanobiology Impacts\nDr. Neil Lin\,  Assistant Professor of Mechanical Engineering and Bioengineering at University of California\, Los Angeles (UCLA). \nBiological systems inherently exhibit variability\, seen in diverse cell shapes\, sizes\, and mechanical properties. Despite its prevalence\, our understanding of the role of phenotypic heterogeneity in cell biology is incomplete. This talk explores how basic physics governs cell-to-cell variability in epithelial monolayers and its impact on biological processes. The first part covers how cell shape heterogeneity influences chromatin organization during crowding. The second part demonstrates that in deformed epithelial layers\, nucleo-cytoskeleton coupling regulates intracellular strain distribution\, influencing cellular mechanoresponse and gene expression. Overall\, cell-cell variability significantly shapes tissue development and remodeling. \n\nDr. Neil Lin is an Assistant Professor of Mechanical Engineering and Bioengineering at University of California\, Los Angeles (UCLA). He obtained his Ph.D. in physics at Cornell University\, studying the microscopic mechanisms that underlie the non-Newtonian suspension flow property. From there\, he went on to do a postdoctoral fellowship at Harvard University\, studying approaches to recreate microenvironment cues for recapitulating kidney functions in vitro. He joined UCLA in 2019\, and his research is to utilize mechanobiology principles to engineer epithelial tissues. His honors include an NIH MIRA\, Prostate Cancer Foundation Young Investigator Award\, and BMES CMBE Rising Star Award.
URL:https://ibecbarcelona.eu/event/ibec-seminar-dr-neil-lin/
LOCATION:Sala Dolors Aleu\, Cluster II\, IBEC\, Baldiri i Reixac\, Barcelona
CATEGORIES:IBEC Seminar
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DTSTART;TZID=Europe/Madrid:20231215T140000
DTEND;TZID=Europe/Madrid:20231215T150000
DTSTAMP:20260418T193602
CREATED:20231211T113708Z
LAST-MODIFIED:20231211T113913Z
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SUMMARY:IBEC Seminar: Pavan Kumar Bosukonda
DESCRIPTION:Smart artificial microcompartments: motility and communication\nPavan Kumar Bosukonda\, Assistant Professor at the Department of Chemistry\, Indian Institute of Technology Roorkee \n  \nNature is a continuous source of inspiration for the design of smart and intelligent materials. In particular\, cells which are the building blocks of life display a complex symphony of various chemical/physical processes which make “life” possible and give it the characteristics which enable life to flourish and sustain. The topology of control systems in place within living cells offer many lessons in design of smart artificial microcompartments or microbots. In this talk\, I will be discussing examples of microcompartments which are capable of smart adaptive motility\, self-assembly and chemical-mediated communication with each other. We use simple buoyancy forces to regulate movement of our microcapsules and use antagonistic control to design relatively complex autonomous behavior by employing stratified chemical environments. The motile microcapsules can turn on/off chemical reactions and carry out logistics of molecular cargo. Also\, I will discuss how we can use the combination of a stimuli responsive hydrogel and stratified environments to design a chemo-mechanical oscillator.  Another focus will be our results on multiphase coacervates and how they formulate a pathway for self-assembly of microdroplets into clusters or tissue-like structures and trigger chemical communication between them. \n\nBrief Bio: Dr. Pavan Kumar Bosukonda is an Assistant Professor at the Department of Chemistry\, Indian Institute of Technology Roorkee. He carried out his doctoral studies at Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR)\, Bangalore\, in the field of porous materials wherein his specific interest was to use supramolecular strategies for pore engineering in mesoporous silica. After completing his Ph.D. in 2015\, he moved to the University of Bristol\, UK\, to work with Prof. Stephen Mann as a Marie-Sklodowska-Curie Postdoctoral Fellow in the field of protocells. His current research interests are focused on developing strategies to fabricate motile microcompartments\, study of multiphase dynamics in liquid-liquid phase separation and designing strategies for regulating chemical communication between microcompartments.
URL:https://ibecbarcelona.eu/event/ibec-seminar-pavan-kumar-bosukonda/
LOCATION:Sala Olivera\, Tower I\, Floor 11
CATEGORIES:IBEC Seminar
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DTSTART;TZID=Europe/Madrid:20231219T100000
DTEND;TZID=Europe/Madrid:20231219T110000
DTSTAMP:20260418T193602
CREATED:20231212T123816Z
LAST-MODIFIED:20231215T121923Z
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SUMMARY:IBEC Seminar: Prof. Aitor Aguirre
DESCRIPTION:Reverse engineering human heart  development with pluripotent stem cells\nProf. Aitor Aguirre\, Institute for Quantitative Health Science and Engineering (IQ) and the Department of Biomedical Engineering at Michigan State University  \nDuring development\, an exquisitely orchestrated series of biological processes lay down the map for the entirety of our bodies and carry it out to perfection. However\, occasional errors occur (due to mutations\, environmental factors\, and other causes) and lead to congenital defects\, the most common birth defect in humans affecting 1% of all newborns. Certain conditions such as obesity\, diabetes\, infections or drug use can increase this risk much further.\nTo tackle CHDs\, we are reverse engineering human heart development on a dish with the use of pluripotent stem cells\, creating heart organoids or synthetic mini-hearts. By recapitulating  aspects of heart development in vitro\, under fully controlled conditions\, we can dissect gene networks and morphological changes that give rise to specific parts of the heart to understand and prevent CHD\, such as single ventricle defects. Furthermore\, we can also use these mini-hearts as models to study the exposure to environmental conditions and other factors that are very poorly known. \n\nDr. Aguirre obtained his B.S. in Biology and M.S. in Biochemistry and Molecular Biology at the University of the Basque Country and his Ph.D. in Material Science at the Institute for Bioengineering of Catalonia (IBEC). For his postdoctoral training Dr. Aguirre joined The Salk Institute under the supervision of J.C. Izpisua-Belmonte\, where he explored in vivo reprogramming applied to cardiac regeneration\, making significant contributions to non-coding RNA biology in human cardiac development (Cell Stem Cell\, 2014; Circulation\, 2015). Dr. Aguirre became Assistant Professor of Medicine at the University of California\, San Diego in 2017 and joined the Institute for Quantitative Health Science and Engineering (IQ) and the Department of Biomedical Engineering at Michigan State University one year later. He became associate professor in 2023 and is currently the Chief of IQ’s Developmental and Stem Cell Biology Division and the Director of MSU’s Stem Cell Core Facility. Dr. Aguirre has extensive experience in cardiac development\, cardiovascular disease\, tissue engineering and -omic approaches. Dr. Aguirre has received numerous awards and nominations including the Hispanic Center of Excellence award at the University of California\, a career development NHLBI K01 award and frequently serves in grant review panels for the NIH and European Commission\, among others.
URL:https://ibecbarcelona.eu/event/ibec-seminar-prof-aitor-aguirre/
LOCATION:Sala Dolors Aleu\, Cluster II\, IBEC\, Baldiri i Reixac\, Barcelona
CATEGORIES:IBEC Seminar
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