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DTSTART;TZID=Europe/Madrid:20240119T100000
DTEND;TZID=Europe/Madrid:20240119T110000
DTSTAMP:20260418T174923
CREATED:20240104T082933Z
LAST-MODIFIED:20240104T083058Z
UID:113766-1705658400-1705662000@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Al Jord
DESCRIPTION:Mechanisms of Organelle Remodeling for Cellular Function\nAl Jord\, Group leader of Mechanisc of organelle remodeling group\, Centre for Genomic Regulation\, Barcelona \nTo function\, organisms rely on vital organs which\, in turn\, rely on specialized cells. At the subcellular scale\, cell specialization is notably driven by robust mechanisms of organelle remodeling. Thus\, discovering these mechanisms is key for the fundamental understanding of organisms in health and disease\, as well as for improved organ engineering. In this seminar\, I will discuss my research on organelle remodeling in somatic and female germ cells. I will first show how multiciliated cells – critical for nervous\, respiratory and reproductive organs – repurpose conserved mechanisms of cell division to remodel organelles for motile ciliogenesis. I will then talk about how oocytes deploy a biophysical mechanism\, based on cytoplasmic force tuning\, to mechanically remodel nuclear RNA-processing organelles for reproductive success. I will conclude with some future research plans\, blending my past and present interests into an interdisciplinary project that will venture into unexplored grounds of nuclear organelle mechano-regulation in somatic cells to deepen our understanding of organ development and homeostasis. \n\nKey relevant publications : \n  \nAl Jord\, A. et al. Centriole amplification by mother and daughter centrioles differs in multiciliated cells. Nature 516\, 104–107 (2014). \n  \nAl Jord\, A. et al. Calibrated mitotic oscillator drives motile ciliogenesis. Science 358\, 803–806 (2017). \n  \nAl Jord\, A. et al. Cytoplasmic forces functionally reorganize nuclear condensates in oocytes. Nat. Commun. 13:5070\, 1–19 (2022).
URL:https://ibecbarcelona.eu/event/ibec-seminar-al-jord/
LOCATION:Sala Dolors Aleu\, Cluster II\, IBEC\, Baldiri i Reixac\, Barcelona
CATEGORIES:IBEC Seminar
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DTSTART;TZID=Europe/Madrid:20240131T120000
DTEND;TZID=Europe/Madrid:20240131T130000
DTSTAMP:20260418T174923
CREATED:20231220T093851Z
LAST-MODIFIED:20240117T143436Z
UID:113528-1706702400-1706706000@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Marc Suarez Calvet
DESCRIPTION:Blood biomarkers for Alzheimer’s disease: advancing diagnosis and patient care\nMarc Suárez-Calvet\, Barcelonabeta Brain Research Center\, Fundació Pasqual Maragall\, Servei de Neurologia\, Hospital del Mar. \n  \nIn recent years\, one of the most significant breakthroughs in Alzheimer’s disease research has been the emergence of blood biomarkers that offer accurate detection of AD. Our research group has successfully demonstrated the utility of these blood biomarkers not only in patients presenting with cognitive impairement but also in individuals at the preclinical stage of Alzheimer’s. Moving forward\, our focus lies in establishing the routine application of these biomarkers in clinical settings\, with a keen eye on assessing their positive impact on patient outcomes. Furthermore\, our ongoing efforts are dedicated to the exploration of novel blood biomarkers that can furnish valuable insights into the prognosis of Alzheimer’s patients.
URL:https://ibecbarcelona.eu/event/ibec-seminar-marc-suarez-calvet/
LOCATION:Sala Dolors Aleu\, Cluster II\, IBEC\, Baldiri i Reixac\, Barcelona
CATEGORIES:IBEC Seminar
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