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DTSTART;TZID=Europe/Madrid:20240503T100000
DTEND;TZID=Europe/Madrid:20240503T110000
DTSTAMP:20260418T130924
CREATED:20240429T130247Z
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SUMMARY:IBEC Seminar: Ovijit Chaudhuri
DESCRIPTION:Cell migration and morphogenesis in viscoelastic matrices\nOvijit Chaudhuri\, University of Standford \nThe extracellular matrix (ECM) is a complex assembly of structural proteins that provides physical support and biochemical signaling to cells in tissues. Over the last two decades\, studies have revealed the important role that ECM elasticity plays in regulating a variety of biological processes in cells\, including stem cell differentiation and cancer progression. However\, tissues and ECM are often viscoelastic\, displaying stress relaxation over time in response to a deformation\, and viscoplastic\, exhibiting irreversible deformations in response to mechanical stress.  In this talk\, I will discuss our recent findings on how matrix viscoelasticity regulates various biological processes\, including collective invasion by cancer cells\, morphogenesis of pluripotent stem cells\, and monocyte migration.
URL:https://ibecbarcelona.eu/event/ibec-seminar-ovijit-chaudhuri/
LOCATION:Sala Dolors Aleu\, Cluster II\, IBEC\, Baldiri i Reixac\, Barcelona
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20240507T124500
DTEND;TZID=Europe/Madrid:20240507T133000
DTSTAMP:20260418T130924
CREATED:20240409T125915Z
LAST-MODIFIED:20240415T140034Z
UID:116840-1715085900-1715088600@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Aurora Hernandez-Machado
DESCRIPTION:Biomicrofluidic analysis of hematological diseases by means of mathematical biomechanical models and statistical analysis: Cells and hydrogels in microchannels and microrheometers\nAurora Hernandez-Machado\, Departament de Fisica de la Materia Condensada\, Universitat de Barcelona \nWe have developed microfluidic devices for precise characterization of hematological diseases. By means of one drop of blood and mathematical models based on biomechanics\, we analyze the properties of cells and microrheological properties such as the viscosity of blood. We will present a microrheometer to determine in a fast\, chip and sensitive way the viscosity of a drop of blood. Experimental results of malaria infected red blood cells in microchannels with endothelial slits and hydrogels with organ-on-a-chip will be discussed. Sprouting is a fundamental cellular behavior that plays an essential role in vascular development and angiogenesis. Due to its relevance to many aspects of human health\, the ability to accurately reproduce cell sprouting is of broad and multidisciplinary interest. We will present microfluidic experiments and compare with theoretical models in which endothelial cells chemotactically migrate into a fibrin-based porous hydrogel which mimics the extracellular matrix. By means of statistical analysis we improve the diagnosis of the hematological diseases. We predict if a sample of blood corresponds to healthy blood or to blood with a hematological disease. We have obtained different performance for the different methods\, some of them with very good results and an accuracy of 94%.
URL:https://ibecbarcelona.eu/event/ibec-seminar-aurora-hernandez-machado/
LOCATION:Sala Dolors Aleu\, Cluster II\, IBEC\, Baldiri i Reixac\, Barcelona
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20240509T120000
DTEND;TZID=Europe/Madrid:20240509T130000
DTSTAMP:20260418T130924
CREATED:20240426T080635Z
LAST-MODIFIED:20240429T132435Z
UID:117301-1715256000-1715259600@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Nicolò Accanto
DESCRIPTION:2P-BRAINSCOPY: pushing the boundaries of two-photon microscopy to study large neuronal networks in behaving mice.\nNicolò Accanto\, Inserm researcher at the in Insitut de la Vision (IDV)\, in the group of Valentina Emiliani\, Paris  \nIn the past 15 years\, the synergy of two-photon (2P) microscopy and optogenetics has transformed neuroscience\, enabling high-resolution imaging and precise photostimulation of neuronal activity. Today\, understanding how neuronal networks in the brain interact to generate perception\, memory and behaviour\, or in other words\, deciphering the neuronal code\, requires to push the limits of 2P microscopy. \nThis involves studying the brain of freely moving animals engaged in natural tasks and accessing thousands of neurons on a very fast (100 ms) timescale\, across large (> 5 mm) brain regions\, while keeping individual neuron (5 µm) spatial resolutions. \n  \nIn this presentation I will outline our recent endeavours towards these goals. I will first show how 2P holographic photostimulation based on spatial light modulators is capable to precisely target individual neurons within a large volume [1]. I will then describe how we can use minimally invasive GRIN lenses to access deeper brain regions [2]\, below the scattering limit. Finally\, I will detail our most advanced technique: a novel fiber-based miniaturized microscope to image and photostimulate neuronal activity in freely moving mice [3\,4]. In the last part of the talk\, I will present future directions for further developments and applications in neuroscience. \n  \nReferences \n[1] Accanto\, N. et al. Multiplexed temporally focused light shaping for high-resolution multi-cell targeting. Optica 5\, 1478 (2018). \n[2] Accanto\, N. et al. Multiplexed temporally focused light shaping through a gradient index lens for precise in-depth optogenetic photostimulation. Sci. Rep. 9\, 7603 (2019). \n[3] Accanto\, N. et al. A flexible two-photon fiberscope for fast activity imaging and precise optogenetic photostimulation of neurons in freely moving mice. Neuron 111\, 176-189.e6 (2023). \n[4] Lorca-Cámara\, Antonio\, Blot\, Francois & Accanto\, N. Recent advances in light patterned optogenetic photostimulation in freely moving mice. Neurophotonics In press\, 11\, S11508 (2024).
URL:https://ibecbarcelona.eu/event/ibec-seminar-nicolo-accanto/
LOCATION:Sala Dolors Aleu\, Cluster II\, IBEC\, Baldiri i Reixac\, Barcelona
CATEGORIES:IBEC Seminar
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DTSTART;TZID=Europe/Madrid:20240514T150000
DTEND;TZID=Europe/Madrid:20240514T170000
DTSTAMP:20260418T130924
CREATED:20240509T120306Z
LAST-MODIFIED:20240509T120306Z
UID:117486-1715698800-1715706000@ibecbarcelona.eu
SUMMARY:Seminar “The Canadian health research following COVID-19 pandemic – artificial intelligence (AI)\, generative systems\, quantum computing and beyond"
DESCRIPTION:We are glad to invite you to this seminar organized by IBEC where Marek W. Radomski\, Vice-Dean Research College of Medicine\, University of Saskatchewan\, Saskatoon\, Canada will talk about the Canadian health research following COVID-19 pandemic\, the next Tuesday 14th of May at 15h at the Faculty of Medicine Clinic (UB). \nMarek W. Radomski\,\nVice-Dean of Investigation College of Medicine\, University of Saskatchwan\, Saskatoon\, Canada and President of The Association of Faculties of Medicine of Canada\, Vice-Deans Research Committee.   \nHe has developed his research career in Poland\, the United Kingdom and Ireland (both in a pharmaceutical company and at Trinity College in Dublin)\, at the University of Houston and in Canada (in two universities) \nThe Canadian health research following COVID-19 pandemic – artificial intelligence (AI)\, generative systems\, quantum computing and beyond. \nThe COVID-19 pandemic claimed millions of lives worldwide and greatly disrupted societal fabric across the globe. \nDespite amazing achievements of vaccine research and development many areas of health research have been adversely affected by limitations caused by pandemic. \nHowever\, AI\, generative systems and quantum computing are examples of a postpandemic research acceleration with substantial health research and service potentials. \nThe presentation will focus on these challenges and opportunities through the lens of the College of Medicine University of Saskatchewan and of the Association of Faculties of Medicine of Canada. \n  \n\n\n\n  \n\n\n\n\n14/05/2024 · 15h\n\n\n\nAula Manuel Corachan  (5th floor) · UB Faculty of Medicine Clinic (Carrer de Casanova\, 143\, Eixample\, 08036 Barcelona)\n\n\n\nIBEC\n\n\n\nNo registration needed
URL:https://ibecbarcelona.eu/event/seminar-the-canadian-health-research-following-covid-19-pandemic-artificial-intelligence-ai-generative-systems-quantum-computing-and-beyond/
LOCATION:Aula Manuel Corachan  (5th floor) · UB Faculty of Medicine Clinic (Carrer de Casanova\, 143\, Eixample\, 08036 Barcelona)
CATEGORIES:IBEC Seminar
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DTSTART;TZID=Europe/Madrid:20240517T100000
DTEND;TZID=Europe/Madrid:20240517T110000
DTSTAMP:20260418T130924
CREATED:20240408T072307Z
LAST-MODIFIED:20240410T115407Z
UID:116794-1715940000-1715943600@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Erika Ferrari
DESCRIPTION:Beating Organs-on-Chip: leveraging on motion to mimic human organ physiological/diseased states in vitro\nErika Ferrari\, Commercial Science Leader\, BiomimX Srl \nBeating Organs-on-Chip are in vitro miniaturized models developed within the uBeat® platform\, which integrates microfluidics\, 3D human cell culture and controlled mechanical stimulation to recapitulate\,\nwith unprecedented precision and predictability\, clinically relevant models reflective of human pathophysiology and complex diseases. Every tissue in the body is subject motion and this motion can be mimicked within the uBeat® platformplatforms\, which provides 3D microtissues with controlled mechanical stimulation (e.g.\, stretching or compression) resulting in more reliable\, responsive\, and predictive in vitro model models to investigate new therapies. BiomimX lead model is uHeart Visone\, Tox Sciences\, 2023; +4 additional cardiac publications )\, a functional beating heart on a chip for cardiotoxicity and safety testing. uHeart was recently qualified with 12 drugs as a predictor of functional cardiotoxicity\, showing 83.3% sensitivity\, 100% specificity\, a nd 91.6% accuracy. BiomimX pipeline consists of predictive physiological and pathological models\, engineered solely through mechanical stimulation\, without the need for introducing exogenous compounds (e.g.\, cytokines) into the cell culture chamber. uKnee the first in vitro model of human osteoarthritis; Occhetta\, Nature Biomed Eng\, 2019 ) has successfully supported a recent IND application. Other key models include uScar cardiac fibrosis; Visone\, Adv Healthcare Mat\, 202 2023)\, uGut a barrier model of the intestinal epithelium & endothelium; Ballerini\, Nature Biomed Eng\, under review )\, uLung and uLiver Heart a multiorgan platform used to study the off-target cardiotoxicity of liver-metabolized drugs; Ferrari\, Adv Mat Tech\, 2023 ).
URL:https://ibecbarcelona.eu/event/ibec-seminar-erika-ferrari/
LOCATION:Sala Dolors Aleu\, Cluster II\, IBEC\, Baldiri i Reixac\, Barcelona
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20240524T100000
DTEND;TZID=Europe/Madrid:20240524T110000
DTSTAMP:20260418T130924
CREATED:20240507T151701Z
LAST-MODIFIED:20240513T084437Z
UID:117479-1716544800-1716548400@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Sergi Garcia-Manyes
DESCRIPTION:Single molecule insights into cellular mechanotransduction\nSergi Garcia-Manyes\, Single Molecule Mechanobiology laboratory\, The Francis Crick Institute and King’s College London \n  \nCellular mechanostransduction relies on the conversion of mechanical cues into chemical signals\, which propagate from the focal adhesion hub through the cytoskeleton to ultimately reach the nucleus through the Nuclear Pore Complex (NPC)\, and switch on specific force-dependent transcriptional programmes. However\, how cellular mechanotransduction is regulated by the nanomechanical properties of the underpinning force-bearing proteins remains largely unknown. Here we first used a newly developed single-molecule magnetic tweezers combined with UV-light to demonstrate that oxidation of a previously cryptic methionine in the talin mechanosensor impairs vinculin binding. When translating the single-molecule findings into the cellular context\, we found a loss in talin/vinculin co-localisation at focal adhesions of NIH3T3 mouse fibroblasts when exposed to µM concentrations of H2O2 and a decrease in the nuclear localisation of the YAP transcription factor (TF). In this vein\, how the nuclear shuttling of mechanosensitive TFs is regulated by their mechanical properties remains also unclear.  By using a combination of single-molecule mechanics and single-cell optogenetics\, we discovered that proteins with locally soft regions in the vicinity of the nuclear-localization sequence exhibit higher nuclear-import rates. Inspired by these findings\, we designed a short and easy-to-express unstructured peptide tag that accelerates the nuclear-import rate of stiff protein cargos. Altogether\, our cross-scale experiments provide a single molecule perspective onto cellular mechanotransduction. \n  \n 
URL:https://ibecbarcelona.eu/event/ibec-seminar-sergi-garcia-manyes/
LOCATION:Sala Dolors Aleu\, Cluster II\, IBEC\, Baldiri i Reixac\, Barcelona
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20240531T100000
DTEND;TZID=Europe/Madrid:20240531T120000
DTSTAMP:20260418T130924
CREATED:20240517T085223Z
LAST-MODIFIED:20240517T085303Z
UID:117772-1717149600-1717156800@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Wenting Zhao
DESCRIPTION:Engineering the Nanoscale Membrane Topography in Cells\nWenting Zhao\, School of Chemistry\, Chemical Engineering and Biotechnology\, Nanyang Technological University\, Singapore and Institute for Digital Molecular Analytics and Science (IDMxS)\, Singapore  \nAbstract. \nCell membranes serve as a central platform to host a variety of proteins essential for cellular activities such as cell signaling\, morphogenesis\, and membrane trafficking. At the same time\, the membranes also undergo drastic morphological changes in a number of essential processes\, such as endocytosis\, intracellular trafficking\, and cytokinesis\, etc. An intriguing yet challenging question to answer is whether and how the shapes of the membrane impact the dynamics of membrane proteins or the periphery proteins interacting with the membrane. However\, membrane shape changes often happen at sub-micro to the nanoscale\, which is approaching the limit of conventional microscopy imaging resolution and difficult to examine quantitatively. In this work\, we will introduce our efforts in employing vertically aligned nanostructures to generate defined membrane topography in live cells and in vitro. We will discuss our findings on the membrane curvature-guided accumulation of membrane proteins\, including oncogenic Ras proteins and viral proteins\, as well as the membrane-associated protein condensation. In addition to plasma membrane\, we also explore the nanoscale topography guidance on nuclear membrane and its implication in differentiating malignant cancer cells. We envision more new insights would be revealed by bridging advanced nanotechnology to nanoscale dynamics at cell surfaces. \n\nShort Bio \nDr. Wenting Zhao is currently an assistant professor in the School of Chemistry\, Chemical Engineering\, and Biotechnology at Nanyang Technological University\, Singapore. She received her Ph.D. degree in Bioengineering at the Hong Kong University of Science and Technology\, and completed her postdoc training at Stanford University. Her research group aims to reveal the nanoscale interplay between membrane morphology and protein assembly using advance nanofabrication and nanomaterials. Specific focuses of her studies are on the nanoscale topography-guided protein clustering and complex assembly\, and their impacts on disease progression\, such as cancer progression\, viral replication\, and immune activation. \nGroup website: www.wtzhaolab.com.
URL:https://ibecbarcelona.eu/event/ibec-seminar-wenting-zhao/
LOCATION:Sala Dolors Aleu\, Cluster II\, IBEC\, Baldiri i Reixac\, Barcelona
CATEGORIES:IBEC Seminar
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