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BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20200515T100000
DTEND;TZID=Europe/Madrid:20200515T120000
DTSTAMP:20260406T000359
CREATED:20200504T102025Z
LAST-MODIFIED:20200508T102953Z
UID:73823-1589536800-1589544000@ibecbarcelona.eu
SUMMARY:Online IBEC Seminar: Gabriel Gomila
DESCRIPTION:Multiscale approach to bioelectricity\n \nGabriel Gomila \, IBEC \nUnderstanding how electricity is generated and propagated in living systems is key to understand many physiological processes and to develop medical instruments for diagnosis\, monitoring and therapy. \nIn this seminar I will present the multiscale approach to bioelectricity developed in our research group at IBEC\, which covers from multicellular systems to single biomolecules\, with an emphasis on passive electrical properties. Topics will include novel devices for electrophysiological recordings\, novel routes and structures for extracellular electron transfer in bacterial cells\, on-chip impedance flow cytometry\, label-free electrical methods for microbiology and nanoscale electrical mapping of single cells. \nThe seminar will take place online at the GoToMeeting Platform \nKnow more about Gabriel Gomila’s research here
URL:https://ibecbarcelona.eu/event/online-ibec-seminar-gabriel-gomila/
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20200529T100000
DTEND;TZID=Europe/Madrid:20200529T120000
DTSTAMP:20260406T000359
CREATED:20200504T102344Z
LAST-MODIFIED:20200525T070522Z
UID:73832-1590746400-1590753600@ibecbarcelona.eu
SUMMARY:Online IBEC Seminar: Giuseppe Battaglia
DESCRIPTION:Bionics at the molecular level: copying Nature to control Nature\n\n\nGiuseppe Battaglia \, IBEC \n\nA very established approach in medicine involves the replacement of organs or other malfunctioning body parts by synthetic versions\, engineered to mimic (or even augment it\, if you allow the sci-fi digression) the original function. Bionics is a very established medical discipline where engineering spouses the life sciences\, creating exquisite combinations. With the help of nanoscience and nanotechnology\, we can now push such an effort down to the molecular level. In our group\, we fabricate synthetic surrogates of trafficking vesicles\, viruses and\, one day perhaps\, even a whole cell. Such molecular bionic units offer more efficient solutions to deliver drugs\, to probe life at the nanoscale\, and to act as a model to understand biological complexity. \n\n\nOur efforts are intrinsically multidisciplinary\, and we mix chemistry\, physics and biology in all we do. We typically start studying biological complexity\, with a strong focus on transport\, trafficking and multivalent interactions (Physical Biology). To help this\, we develop new tools to look at biological systems in four dimensions capturing life’s spatiotemporal patterns (Microscopy). We thus apply a constructionist approach where we mimic biological complexity in the form of design principles such as compartmentalisation\, multivalency and taxis\, to produce functional units from simple building blocks and their interactions (Molecular Engineering).​ Finally\, we apply the resulting constructs to tackle disorders such as cancer\, neurodegeneration\, inflammation\, and infections (Nanomedicine). \n\n\nToday\, I start introducing our research activities giving a few examples of each segment\, to eventually focus my seminar on one of the latest and most exciting developments\, our understanding of multivalent interaction and how these control crucial biological processes\, such as cellular selectivity and trafficking. \n\nThe seminar will take place online at the GoToMeeting Platform \nKnow more about Giuseppe Battaglia’s research here
URL:https://ibecbarcelona.eu/event/online-ibec-seminar-giuseppe-battaglia/
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20200605T100000
DTEND;TZID=Europe/Madrid:20200605T120000
DTSTAMP:20260406T000359
CREATED:20200504T102718Z
LAST-MODIFIED:20200602T070514Z
UID:73835-1591351200-1591358400@ibecbarcelona.eu
SUMMARY:Online IBEC Seminar: Benedetta Bolognesi
DESCRIPTION:Deep mutagenesis to understand Protein Phase Transitions\n \nBenedetta Bolognesi \, IBEC \nSpecific insoluble protein aggregates are the hallmarks of many neurodegenerative diseases. Whether the protein aggregates themselves or other forms of the proteins are toxic to cells is still unclear in many of these diseases. This lack of understanding of the causes of cellular toxicity is reflected in the general failure of multiple therapeutic approaches so far attempted. The causes of this rely mainly on the lack of systematic approaches able to estimate in parallel the effect of mutations on cell viability as well as on protein conformation. Our lab uses deep mutagenesis as a systematic and unbiased approach to identify and investigate the toxic species of proteins. \nIn this seminar I will explain how we used this approach to report on the toxicity of thousands of protein sequences and how\, more recently\, we adapted this method to track more specific biochemical processes\, such as amyloid nucleation. Overall\, the results I will discuss demonstrate that deep mutagenesis is a powerful approach to study intrinsically disordered proteins and also illustrate that it can be used to genetically validate assays as discovery platforms. \nThe seminar will take place online at the GoToMeeting Platform \nKnow more about Benedetta Bolognesi’s research here
URL:https://ibecbarcelona.eu/event/online-ibec-seminar-benedetta-bolognesi/
CATEGORIES:IBEC Seminar
ORGANIZER;CN="IBEC":MAILTO:www.ibecbarcelona.eu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20200626T100000
DTEND;TZID=Europe/Madrid:20200626T120000
DTSTAMP:20260406T000359
CREATED:20200605T081203Z
LAST-MODIFIED:20200618T100739Z
UID:74893-1593165600-1593172800@ibecbarcelona.eu
SUMMARY:Online IBEC Seminar: Pere Roca-Cusachs
DESCRIPTION:Sensing the matrix: transducing mechanical signals from integrins to the nucleus\n \nPere Roca-Cusachs \, IBEC \nCell proliferation and differentiation\, as well as key processes in development\, tumorigenesis\, and wound healing\, are strongly determined by the properties of the extracellular matrix (ECM)\, including its mechanical rigidity and the density and distribution of its ligands. In this talk\, I will explain how we combine molecular biology\, biophysical measurements\, and theoretical modelling to understand the mechanisms by which cells sense and respond to matrix properties. \nI will discuss how the properties under force of integrin-ECM bonds\, and of the adaptor protein talin\, drive and regulate matrix sensing. I will further discuss how this sensing can be understood through a computational molecular clutch model\, which can quantitatively predict the role of integrins\, talin\, myosin\, and ECM receptors\, and their effect on cell response. Finally\, I will analyze how signals triggered by rigidity at cell-ECM adhesions are transmitted to the nucleus\, leading to transcriptional regulation. \nThe seminar will take place online at the GoToMeeting Platform \nKnow more about Pere Roca-Cusachs’ research here
URL:https://ibecbarcelona.eu/event/online-ibec-seminar-pere-roca-cusachs/
LOCATION:IBEC
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20200703T100000
DTEND;TZID=Europe/Madrid:20200703T120000
DTSTAMP:20260406T000359
CREATED:20200605T081640Z
LAST-MODIFIED:20200605T081640Z
UID:74896-1593770400-1593777600@ibecbarcelona.eu
SUMMARY:Online IBEC Seminar: Santiago Marco
DESCRIPTION:Signal and Data Processing Workflows for Untargeted Chemical Analysis: Sensor Array and Mass Spectrometry Analysis of Complex Gas Samples\nSantiago Marco \, IBEC \nIn diverse sectors such as health\, food\, environment\, complex natural gas samples are analysed. Those samples can contain hundreds or thousands of compounds. In many cases\, the question to be answered does not require full separation\, quantification\, and identification of all compounds. Instead detection of abnormal samples (normal/ faulty)\, assignation of classes to samples (e.g.healthy/disease)\, or evaluation of global quantitative indexes (e.g odour intensity) is required. \nThe analysis of gas phase samples can be carried out with high-end lab equipment based on Chromatography-Mass Spectrometry or lower cost systems based on chemical sensors. In all cases\, the resulting raw signals/data need substantial efforts to extract the hidden information. In health applications the problem of biomarker discovery becomes like finding a needle in a haystack. Intimate knowledge of the instrumental problems and the sampling conditions is key for the correct interpretation of the results. \nThese problems are often addressed by building mega-variate predictive models using tools from machine learning. However\, in small sample conditions the possibilities to obtain overoptimistic results abound due to the curse of dimensionality. Careful model validation and statement of model validity domains is needed. \nThe seminar will take place online at the GoToMeeting Platform \nKnow more about Santiago Marco’s research here \n 
URL:https://ibecbarcelona.eu/event/online-ibec-seminar-santiago-marco/
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20201113T100000
DTEND;TZID=Europe/Madrid:20201113T120000
DTSTAMP:20260406T000359
CREATED:20201030T121221Z
LAST-MODIFIED:20201110T121400Z
UID:78766-1605261600-1605268800@ibecbarcelona.eu
SUMMARY:Online IBEC Seminar: Xavier Trepat
DESCRIPTION:Mechanobiology of intestinal organoids\n \nXavier Trepat\, IBEC \nIntestinal organoids capture essential features of the intestinal epithelium such as folding of the crypt\, spatial compartmentalization of different cell types\, and cellular movements from crypt to villus-like domains. Each of these processes and their coordination in time and space requires patterned physical forces that are currently unknown. In this study\, we map the three-dimensional cell-ECM and cell-cell forces in mouse intestinal organoids grown on soft hydrogels. We show that these organoids exhibit a non-monotonic stress distribution that defines mechanical and functional compartments. The stem cell compartment pushes the ECM and folds through apical constriction\, whereas the transit amplifying zone pulls the ECM and elongates through basal constriction. Tension measurements establish that the transit amplifying zone isolates mechanically the stem cell compartment and the villus-like domain. A 3D vertex model shows that the shape and force distribution of the crypt can be largely explained by cell surface tensions following the measured apical and basal actomyosin density. Finally\, we show that cells are pulled out of the crypt along a gradient of increasing tension\, rather than pushed by a compressive stress downstream of mitotic pressure as previously assumed. Our study unveils how patterned forces enable folding and collective migration in the intestinal crypt. \nThis seminar will take place online at the Microsoft Teams Platform \nKnow more about Xavier Trepat’s research here
URL:https://ibecbarcelona.eu/event/online-ibec-seminar-xavier-trepat/
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20201204T100000
DTEND;TZID=Europe/Madrid:20201204T120000
DTSTAMP:20260406T000359
CREATED:20201116T153209Z
LAST-MODIFIED:20201127T110248Z
UID:79750-1607076000-1607083200@ibecbarcelona.eu
SUMMARY:Online IBEC Seminar: Paul Verschure
DESCRIPTION:The volitional brain in action: counterfactual error and the virtualization of memory\n \nVolitional motor control can be seen as the result of a gradual replacement of feedback by feedforward control. We have addressed this question from the perspective of an integrated architecture called the Distributed Adaptive Control (DAC) theory of mind and brain. DAC proposes that the brain is a multi-layer control system which optimizes the how of action by considering why (motivation)\, what (objects)\, where (space)\, when (time) and who (agents) or the H5W problem. We have shown that for DAC to realize optimal solutions in foraging problems\, its decision-making renders policies that simultaneously optimize perceptual evidence\, memory bias\, goals\, and utility. This raises the question of what the principles are that underlie the processing and adaptation of these factors. In this presentation\, I will focus on a link between volition\, policy adaptation and perceptual learning we have recently advanced. The dominant model of anticipatory motor control relies on the notion of an inverse model that by learning from encountered errors acquires corrective responses that supersede feedback control. However\, these models are predicated on a Markovian world assumption and thus by necessity face problems in handling exceptions\, such as observed in probe trials\, where fast feedback control is required. We solve this challenge by proposing that adaptive motor control can also be obtained by relying on a cascade of purely sensory predictions that drive feedback control via counterfactual errors or Hierarchical Sensory Predictive Control. Using robot experiments\, we have demonstrated the robustness of this solution. I will present further supporting evidence for the relevance of counterfactual error in the physiology of motor learning\, the neurophysiology of human memory as obtained with intracranial recordings and in the rehabilitation of stroke patients.  In conclusion Paul will comment on the challenges involved in bringing science to society. \n\nPaul Verschure is Catalan Institute of Advanced Studies (ICREA) Research Professor\, Director of the Synthetic Perceptive\, Emotive and Cognitive Systems Laboratory at the Institute for Bioengineering of Catalunya and the Barcelona Institute of Science and Technology. Paul has received his MA and Ph.D. in Psychology\, and has worked in Neuroscience\, Cognitive Science\, Robotics and Artificial Intelligence and his scientific aim is to develop a unified theory of mind and brain\, to validate it using synthetic methods and to apply it to quality of life enhancing technologies. To achieve the latter goal\, Paul is founder/CEO of Eodyne Systems S.L. (Eodyne.com)\, which is commercializing novel science grounded neurorehabilitation\, education and cultural heritage technologies. Paul is founder/Chairman of the Future Memory Foundation (futurememoryfoundation.org) which aims at supporting the development of new tools and paradigms for the conservation\, presentation\, and education of the history of Nazi crimes. Paul is founder/Chairman of the Convergent Science Network Foundation which hosts the annual Living Machines conference for which Paul also hosts the Convergent Science Network podcast. Paul chairs the annual Barcelona Cognition\, Brain and Technology summer school. Paul manages a multidisciplinary team of about 30 researchers with whom he has published over 400 articles in leading journals and conferences in a range of disciplines and has completed 15 Ironman races. \nThis seminar will take place online at the GoToMeeting platform \nKnow more about Paul Verschure’s research here
URL:https://ibecbarcelona.eu/event/online-ibec-seminar-paul-verschure/
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20210115T100000
DTEND;TZID=Europe/Madrid:20210115T120000
DTSTAMP:20260406T000359
CREATED:20201116T152332Z
LAST-MODIFIED:20210108T115741Z
UID:79746-1610704800-1610712000@ibecbarcelona.eu
SUMMARY:Online IBEC Seminar: Silvia Muro
DESCRIPTION:Targeted drug delivery: fundamental aspects and translational applications\n \nSilvia Muro\, IBEC \nThe design of strategies to enable efficient and safe delivery of therapeutic agents to areas of the body requiring intervention is an active research field. Therapeutic targets are often confined to specific regions or tissues in the body\, where access may require active transport from the administration site into a subjacent or far-away tissue. Once within the tissue or body compartment of interest\, most targets for therapeutic intervention relate to particular sub-cellular environments\, e.g.\, the cell surface versus different intracellular compartments\, requiring strategies to achieve the final destination of interest. Using polymer nanocarriers functionalized with affinity moieties against single or combined cell-surface receptors\, along with additional biological signaling moieties\, my laboratory focuses on understanding the parameters that regulate transport of drug delivery vehicles across cellular barriers and/or into compartments of subjacent tissues. We examine these aspects using cell culture models with subsequent validation in laboratory animals to correlate molecular/cellular mechanisms with in vivo outcomes. We investigate the influence exerted on targeting and transport by drug carrier design parameters (size\, shape\, avidity\, combination targeting\, etc.) and parameters that are intrinsic to the physiological system (disease states\, flow\, receptor epitopes being targeted\, modulation of regulatory molecules\, etc.). \nIn this presentation\, I will focus on reviewing some of our most recent efforts in this field. The characterization of these complex physiological and design parameters\, along with the understanding of the mechanisms governing the interaction of drugs carriers with the surrounding biological environment\, are necessary steps toward achieving efficient drug delivery systems. \nThis seminar will take place online at the GoToMeeting platform \nKnow more about Silvia Muro’s research here
URL:https://ibecbarcelona.eu/event/online-ibec-seminar-silvia-muro/
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20210205T100000
DTEND;TZID=Europe/Madrid:20210205T120000
DTSTAMP:20260406T000359
CREATED:20210107T101425Z
LAST-MODIFIED:20210203T120455Z
UID:80728-1612519200-1612526400@ibecbarcelona.eu
SUMMARY:Online IBEC Seminar: Jordi Alcaraz
DESCRIPTION:Improving lung cancer management by reengineering tumor-associated fibroblasts\nJordi Alcaraz\, UB facultat de Medicina & IBEC Associated Researcher \nLung cancer is the leading cause of cancer death due in part to subtoptimal patient responses to current therapies\, which have been largely designed to targeting cancer cell abnormalities. However\, there is a paradigm shift in cancer research that considers tumors as abnormal organs\, thereby acknowledging the key contribution to tumor progression provided by fibroblasts and other non-cancerous stromal cells that shape the tumor mechanical and biochemical ecosystem. \nOur group pioneered the study of tumor-associated fibroblasts (TAFs) in lung cancer in Spain in collaboration with oncologists at the Hospital Clínic. I will provide an overview of our efforts in unveiling how TAFs contribute to tumor progression in major lung cancer subtypes and in identifying how can we target such contributions with new therapeutic strategies\, including the development of novel preclinical models. Moreover\, I will describe our efforts to define novel TAF-related prognostic and/or diagnostic biomarkers. Part of this work is carried out in collaboration with pharmaceutical companies. I will also briefly summarize ongoing collaborations with IBEC groups in these topics. \nThis seminar will take place online at the GoToMeeting platform \nKnow more about Jordi Alcaraz’s research here
URL:https://ibecbarcelona.eu/event/online-ibec-seminar-jordi-alcaraz/
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20210310T120000
DTEND;TZID=Europe/Madrid:20210310T140000
DTSTAMP:20260406T000359
CREATED:20210218T161413Z
LAST-MODIFIED:20210301T092607Z
UID:81895-1615377600-1615384800@ibecbarcelona.eu
SUMMARY:Online IBEC Seminar: Ester Caffarel
DESCRIPTION:Breaking Paradigms: Delivering insulin orally\nEster Caffarel\, MIT \nBiologics have revolutionized disease treatment; however\, their rapid degradation and poor absorption in the gastrointestinal (GI) tract generally limit their administration to parenteral routes. Devices for the oral delivery of biologics must aid in both localization and permeation to achieve systemic drug uptake. For this purpose\, we have developed various ingestible devices that rapidly propel drug-loaded posts into the tissue wall of the different organs of the GI tract.
URL:https://ibecbarcelona.eu/event/online-ibec-seminar-ester-caffarel/
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20210312T100000
DTEND;TZID=Europe/Madrid:20210312T120000
DTSTAMP:20260406T000359
CREATED:20210203T123720Z
LAST-MODIFIED:20210303T105835Z
UID:81355-1615543200-1615550400@ibecbarcelona.eu
SUMMARY:Online IBEC Seminar: Paolo Arosio
DESCRIPTION:Membraneless compartments based on intrinsically disordered proteins: from biology towards new protein materials\nPaolo Arosio\, Institute for Chemical and Bioengineering\, ETH Zurich \nIn the last few years\, discoveries in biology are revealing that a class of intrinsically disordered protein sequences plays an important role in the formation of cellular membraneless compartments by spontaneous liquid-liquid phase separation of proteins and nucleic acids. These compartments underlie several important functions and can act as microreactors\, in which environment and composition are carefully regulated in space and time. These observations inspired us to exploit these biological sequences to mimic these membraneless compartments on the bench\, towards the development of high-performance open microreactors\, with applications for instance in biocatalysis. With these sequences we can regulate not only the dynamic process of phase separation but also several properties of the resulting compartments\, including uptake of client molecules\, polarity and material properties. With this control we can\, in turn\, regulate biochemical reactions occurring within the compartments. \nWe further show the development of droplet microfluidic platforms to characterize multiple properties of the open compartments\, including both thermodynamics and dynamics of phase separation. We illustrate these concepts by investigating an established in vitro model of Processing bodies consisting of the phase separation of the DEAD-box protein ATPase Dhh1 in the presence of ATP and RNA. \nThis seminar will take place online \nKnow more about Paolo Arosio’s research here
URL:https://ibecbarcelona.eu/event/online-ibec-seminar-paolo-arosio/
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20210319T100000
DTEND;TZID=Europe/Madrid:20210319T120000
DTSTAMP:20260406T000359
CREATED:20210203T121424Z
LAST-MODIFIED:20210315T124852Z
UID:81339-1616148000-1616155200@ibecbarcelona.eu
SUMMARY:Clinical Colloquia: Anna Novials
DESCRIPTION:Diabetes\, where are we?\nAnna Novials\, PI of the group “Pathogenesis and Prevention of Diabetes” at IDIBAPS/Clinic Hospital of Barcelona and member of CIBERDEM network. \nDiabetes mellitus (DM) is a group of chronic metabolic disorders all characterized by hyperglycemia. It occurs either when the pancreas does not produce enough insulin or when the peripheral tissues cannot effectively use the insulin it produces. The global prevalence of diabetes and impaired glucose tolerance (the intermediate transition between normal blood glucose levels and diabetes) has been increasing over recent decades. The International Diabetes Federation (IDF) reported that in 2019 there were 463 million people between 20-79 years worldwide with diabetes\, accounting for the 9.3 % of the global adult population. If this trend continues\, it is expected to increase to 700 million by 2045. Furthermore persistent high blood glucose levels cause generalized vascular damage affecting the kidneys (nephropathy)\, the eyes (retinopathy)\, the nerves (neuropathy) and the heart (cardiovascular disease)\, leading to disabilities and premature death. The World Health Organization (WHO) reported diabetes to be the seventh leading cause of death. As a consequence the economic burden of diabetes has a high impact on the global health-care system. \nThe first national study in Spain published in 2012 (the Di@bet.es Study) revealed that the overall prevalence of DM in individuals ≥18 years old in our country was 13.8% and\, about a half of them (6%) had unknown diabetes. In addition to this alarming values\, the prevalence rates of isolated impaired fasting glucose (IFG)  and isolated impaired glucose tolerance (IGT)  3.4% and 9.2%\, respectively (2). Taken together\, this study uncovered that almost 30% of the study population had some carbohydrate disturbance. \nType 2 Diabetes (T2D) accounts for the vast majority (around 90%) of diabetes worldwide. It can be effectively managed through education\, adoption of healthy lifestyles\, combined with medication as required. The pathogeny of T2D is extremely complex and comprises all the organs that work coordinately to maintain energy and glucose homeostasis.  It is established that when the cross-talk between organs (pancreas\, liver\, muscle\, adipose tissue\, brain \,etc )is altered\, then the main pathogenic events which are insulin secretory defects and insulin resistance appear as a hallmark of T2D. All current treatment for T2D are adressed to  target molecular pathways in different tissues. \nType 1 diabetes (T1D) is the major cause of diabetes in childhood. Patients need an uninterrupted supply of insulin for life. The pathogeny of diabetes consists in alteration in the autoinmunity. The main cause is not yet been stablished. The advances in the treatment remain  dissapointing . Although technology applied to diabetes is in continuos progress\, patients are still using the same treatment as 100 years ago\, when insulin was discovered. \nCollectively\, these results  evidence the need for more clinical and preventive intervention programs and highlight the importance of carrying out more basic research in order to understand the underlying mechanisms of the disease. \n\nDr. Anna Novials is endocrinologist at Hospital Clinic de Barcelona and  leader group of research at IDIBAPS. She received her PhD from the University of Barcelona\, in 1989\, focusing her studies on the chronic effect of glucotoxicity on pancreatic function in patients with type 2 diabetes. A postdoctoral stay at the University of Cambridge and collaborations with the University of Oxford enriched her scientific and technical knowledge of molecular biology\, turning her research objectives toward the molecular mechanisms that affect pancreatic islet function in diabetes\, which she would then develop at the Hospital Clinic de Barcelona\, going on to lead her own research group. \nFrom 1998 to 2008\, Dr. Novials conducted her clinical activity at the Sardà Farriol Foundation in Barcelona\, first as Head of the Diabetology Unit and later as Executive Director. Here she devoted her efforts to promoting educational tools to help patients adhere to exercise programs as part of their diabetes treatment plan. In 2008\, she rejoined the IDIBAPS as leader of a clinical and basic research team. Since 2010\, she has also served as an Executive Committee member of the Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders (CIBERDEM). Finally\, Dr. Novials is the former  President of the Spanish Diabetes Society and as served as member of the EASD-EU Committee of the European Association for the Study of Diabetes to advocate for diabetes research. \nThis clinical colloquia will take place online at the GoToMeeting platform
URL:https://ibecbarcelona.eu/event/clinical-colloquia-anna-novials/
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20210416T100000
DTEND;TZID=Europe/Madrid:20210416T120000
DTSTAMP:20260406T000359
CREATED:20210329T143157Z
LAST-MODIFIED:20210407T090510Z
UID:83098-1618567200-1618574400@ibecbarcelona.eu
SUMMARY:Online IBEC Seminar: Núria Montserrat
DESCRIPTION:Study on the of the interplay between glucose metabolism and SARS-CoV-2 infection exploiting human kidney organoids\n \nNúria Montserrat\, group leader “Pluripotency for organ regeneration” at IBEC \nSevere acute respiratory syndrome 2 (SARS-CoV-2) infection leads to a high risk of hospitalization and mortality in diabetic patients. SARS-CoV-2 binds to angiotensin-converting enzyme 2 (ACE2) receptor\, which is expressed in key metabolic organs such as pancreas\, muscle\, heart\, adipose tissue\, the small intestine\, and the kidneys. As a result\, it is likely that SARS-CoV-2 may cause alterations of glucose metabolism that could complicate the pathophysiology of pre-existing diabetes or lead to new mechanisms of disease. \nThanks to an international collaboration we have previously shown that SARS-CoV-2 can directly infect engineered human blood vessel organoids and human kidney organoids. In these last months we have started to collectively addressed how to study on the interplay between glucose metabolism and SARS-CoV-2 infections making use of kidney organoid technology. We have first developed culture regime conditions in human kidney organoids mirroring cellular responses similar to those encountered in the human diabetic kidney. Through an exhaustive characterization including single cell RNA profiling and ulterior validation in organoids and kidney patient cells we are starting to dissect the different transcriptional programs that are differently regulated in these different contexts. To further assess on the key role of ACE2 in these processes we have make use of CRISPR/Cas9 technology to generate human pluripotent stem cells lines knock out (KO) for ACE2. Kidney organoids ACE2KO have been further subjected to SARS-CoV-2 infections in normoglycemic and oscillatory glucose conditions further demonstrating the central role of ACE2 in early steps of infection in these organoid model systems. Thanks to our international collaborators we have also explored on the role of ACE2 in early steps of SARS-CoV-2 infection in other organoid platforms including gastric and vascular organoids. \nTogether\, our results provide evidence that SARS-CoV-2 infection altered glucose metabolism and support the use of kidney organoids as a platform to investigate the cellular susceptibility\, disease mechanisms\, and treatment strategies for SARS-CoV-2 infection in hyperglycaemic condition. \nMore information about Núria Montserrat’s research here \nThis seminar will be held using the GoToMeeting Platform
URL:https://ibecbarcelona.eu/event/online-ibec-seminar-nuria-montserrat/
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20210514T100000
DTEND;TZID=Europe/Madrid:20210514T120000
DTSTAMP:20260406T000359
CREATED:20210506T071033Z
LAST-MODIFIED:20210506T074133Z
UID:84141-1620986400-1620993600@ibecbarcelona.eu
SUMMARY:Online IBEC Seminar: Mónica Marro
DESCRIPTION:A new molecular dimension: exploiting Raman spectroscopy in Biomedicine\nMónica Marro\, ICFO\, The Institute of Photonic Sciences\n \nRaman spectroscopy is a promising optical technique that enables the investigation of the molecular content of biological samples in a rapid\, non-invasive\, label-free and multiplexed approach. In the biomedical field\, it is of special interest because the device can be portable and cost-effective. \nIn this seminar\, I will show my work exploiting Raman spectroscopy in a broad range of biomedical applications from the molecular\, to cellular and tissue level. I will present how Raman spectroscopy can represent a step forward into different fields\, namely: cancer diagnosis\, patient stratification\, and personalized medicine; neurodegeneration; and mechanobiology. I will show also optical developments that can improve Raman spectroscopy in the speed of image acquisition\, like the Raman light sheet approach\, or Surface Enhanced Raman spectroscopy. \nOverall\, I will show how Raman spectroscopy coupled with data science and developments in photonics and nano-engineering could revolutionize the biomedical field in the next years\, providing new and other-wise inaccessible molecular information\, and giving an unprecedented step towards a more rapid\, accurate\, personalized diagnosis and treatments.
URL:https://ibecbarcelona.eu/event/online-ibec-seminar-monica-marro/
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20210618T100000
DTEND;TZID=Europe/Madrid:20210618T120000
DTSTAMP:20260406T000359
CREATED:20210611T070229Z
LAST-MODIFIED:20210611T070255Z
UID:84958-1624010400-1624017600@ibecbarcelona.eu
SUMMARY:IBEC Online Seminar: Jessica Ilenburg
DESCRIPTION:Tissue Engineering in Microgravity\nJessica Ilenburg\, Gravitational Biotechnologist at Yuri gravity \nTissue Engineering and regenerative medicine are two fast growing and fast moving research fields. With the invention of bioprinting and tissue chips two breakthrough innovations have been made and now research in microgravity (for example on the ISS) promises even more and faster progress. A lot of advantages\, like less contact inhibition and unrestrained growth in all 3 dimensions make the cell structures grow bigger and more complex. This presentation focuses on the qualities of the unique research environment of microgravity and introduces a couple of research findings. \nJessica Ilenburg is doing her master studies in molecular biotechnology at Bielefeld University in Germany. Currently she is working at yuri GmbH as a gravitational biotechnologist focusing on Tissue Engineering\, bioprinting and protein crystal growth in microgravity. Previously she has worked at the Novo Nordisk Foundation Center for Biosustainability in Copenhagen working with thermophilic organisms and isolating proteins of the butanol pathway.
URL:https://ibecbarcelona.eu/event/ibec-online-seminar-jessica-ilenburg/
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20210709T100000
DTEND;TZID=Europe/Madrid:20210709T120000
DTSTAMP:20260406T000359
CREATED:20210628T090521Z
LAST-MODIFIED:20210628T105718Z
UID:85638-1625824800-1625832000@ibecbarcelona.eu
SUMMARY:Online IBEC Seminar: Xavier Fernàndez-Busquets
DESCRIPTION:Nanomalaria group: 20 years at IBEC\nXavier Fernàndez-Busques\, group leader of the Nanomalaria group at IBEC \nWe will start by briefly looking at the origins of our group back in 2001 as part of IBEC’s embryo\, the Research Center for Bioelectronics and Nanobioscience. Our current activities integrate two decades of cumulative research oriented to the development of targeted nanocarriers for parasitic diseases with focus on malaria but currently expanding to leishmaniasis. \nBecause eventual antimalarial nanomedicines need to be deployed in low per capita income regions\, their final components must take into account this particular economic landscape. Liposomes and polymeric nanocarriers offer advantages and suffer from limitations depending on the severity of the disease in each particular clinical case. Entering erythrocytes\, the host cell of Plasmodium in the blood circulation\, is a challenge in itself due to their lack of endocytic processes. Antibodies\, polysaccharides like heparin\, synthetic polymers and DNA aptamers have been used to target and eventually penetrate red blood cells. \nFinally\, we have recently launched an effort to discover new antimalarial drugs that should constitute the third and final element in the design of targeted nanocarriers for malaria. The know-how acquired in the development of nanocapsules\, targeting elements and drugs has the capacity of being exported to other infectious diseases. Because\, no matter how cost-efficient you can make a nanomedicine\, clinical trials will significantly increase its cost\, we are exploring a radical alternative: designing nanocarriers to target the parasites in their arthropod vectors. \nMore information about Xavier’s research here \nThis seminar will be held using the TEAMS app \n 
URL:https://ibecbarcelona.eu/event/online-ibec-seminar-xavier-fernandez-busquets/
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20210716T100000
DTEND;TZID=Europe/Madrid:20210716T120000
DTSTAMP:20260406T000359
CREATED:20210628T090824Z
LAST-MODIFIED:20210628T105106Z
UID:85642-1626429600-1626436800@ibecbarcelona.eu
SUMMARY:Online IBEC Seminar: Pau Gorostiza
DESCRIPTION:Electrochemically Gated Charge Transport in Redox Proteins and Photosynthetic Complexes\n\nPau Gorostiza\, group leader of the Nanoprobes and nanoswitches group at IBEC \nInterprotein electron transport is an essential process in cell respiration and photosynthesis. It takes place between redox proteins and complexes\, and it displays an outstanding efficiency and environmental adaptability. Although the biochemistry of electron transport processes is well characterized\, nanoscale experimental methods are needed to understand electronic pathways in these redox protein structures\, both for fundamental and for technological purposes. Electrochemical scanning tunneling microscopy (ECSTM) is an excellent tool to study electronic materials and redox molecules including proteins. It offers single molecule resolution and allows working in aqueous solution\, in nearly physiological conditions in the case of proteins\, and under full electrochemical control. ECSTM also allows performing conductance measurements by current-potential and current-distance tunneling spectroscopy. An overview of these methods and current projects in the laboratory will be presented\, with special emphasis on cytochromes of the respiratory chain and on photosystem I complexes. \nMore information about Pau Gorostiza’s research here \nThis seminar will be held using the TEAMS app
URL:https://ibecbarcelona.eu/event/online-ibec-seminar-pau-gorostiza/
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20210917T100000
DTEND;TZID=Europe/Madrid:20210917T120000
DTSTAMP:20260406T000359
CREATED:20210901T145722Z
LAST-MODIFIED:20210909T072941Z
UID:86914-1631872800-1631880000@ibecbarcelona.eu
SUMMARY:Online IBEC Seminar: Daniel Gonzalez-Carter
DESCRIPTION:Delivering Nanoparticles Specifically to the Brain by Generating Artificial Brain Targets\nDaniel Gonzalez-Carter\, Molecular Bionics group at IBEC \nAchieving efficient therapy delivery to the brain is one of the most pressing medical issues today. Therapy brain delivery is severely hampered by the protective blood-brain barrier (BBB)\, composed of the highly impermeable endothelial cells lining the brain vasculature.  To overcome the BBB\, therapies may be loaded onto nanoparticles functionalized with ligands which bind to target proteins expressed at the surface of brain endothelial cells (BEC)\, thereby increasing brain uptake. However\, such strategies have inherent brain-specificity limitations\, as the target proteins are also expressed on the vasculature of other organs\, resulting in increased ‘off-target’ nanoparticle accumulation. \nTo achieve truly selective brain targeting\, our group is developing a strategy to generate artificial targets exclusively at the BBB. This is done by exploiting the low endocytic rate of BEC\, a key requirement for their high impermeability\, to selectively retain exogenous targets on their surface. By generating nanoparticles capable of efficiently recognizing the artificial targets\, we hope to increase nanoparticle delivery exclusively to the brain with minimal ‘off-target’ nanoparticle accumulation. Furthermore\, we are developing an mRNA delivery platform to continuously re-generate the artificial targets from within the BEC to allow for repeated dosing in chronic diseases like Alzheimer’s disease.
URL:https://ibecbarcelona.eu/event/online-ibec-seminar-daniel-gonzalez-carter/
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20211008T100000
DTEND;TZID=Europe/Madrid:20211008T120000
DTSTAMP:20260406T000359
CREATED:20210917T110652Z
LAST-MODIFIED:20210929T075522Z
UID:87233-1633687200-1633694400@ibecbarcelona.eu
SUMMARY:Online IBEC Seminar: Veronika Magdanz
DESCRIPTION:Development of biohybrid and bioinspired microrobots toward biomedical applications\nVeronika Magdanz\, Smart Nano-Bio-Devices \nAutonomous motion and precise control on the microscale is one of the main challenges in developing non-invasive medical microrobots. In this seminar\, I present my approaches of how to develop artificial\, biomimetic and biohybrid microrobots. We can be inspired by nature’s solutions to achieve such propulsion on the microscale. Specifically\, sperm cells offer beneficial features as components of microrobots: as propulsion sources\, as templates and as cargo. By combining smart microstructures with spermatozoa\, new ways to control and manipulate sperm cells emerge. \nThis seminar will be held using the GoToMeeting app \n 
URL:https://ibecbarcelona.eu/event/online-ibec-seminar-veronika-magdanz/
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20211015T100000
DTEND;TZID=Europe/Madrid:20211015T120000
DTSTAMP:20260406T000359
CREATED:20210909T072358Z
LAST-MODIFIED:20211005T101926Z
UID:87071-1634292000-1634299200@ibecbarcelona.eu
SUMMARY:Online IBEC Seminar: Mohit Kumar
DESCRIPTION:Peptide based nanomaterials with life-like functions\nMohit Kumar\, Molecular Bionics group at IBEC \nChemists’ curiosity to create life de novo has sought inspiration from biological systems. In nature\, self-assembled nanostructures constantly form and degrade which provides unique features like on-demand function\, adaptation\, temporal and spatial control. Such processes are enabled by the metabolism and the ability to consume chemical energy to perform useful work. However\, these features are not trivial to obtain in synthetic systems. My talk will show that now peptide based self-assembled materials can also form and degrade over time and their nanostructures and functions can be regulated in time by consuming chemical fuel. Furthermore\, by using super-resolution imaging dynamic transformations in solution can be probed in real-time\, in situ. \nThis seminar will be held using the GoToMeeting app
URL:https://ibecbarcelona.eu/event/online-ibec-seminar-mohit-kumar/
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20211022T100000
DTEND;TZID=Europe/Madrid:20211022T120000
DTSTAMP:20260406T000359
CREATED:20211005T153325Z
LAST-MODIFIED:20211013T073030Z
UID:87598-1634896800-1634904000@ibecbarcelona.eu
SUMMARY:Hybrid IBEC Seminar: Cesar Rodriguez-Emmenegger
DESCRIPTION:Bio-inspired soft matter at the service of interactive biointerfaces and synthetic cells\nCesar Rodriguez-Emmenegger\, Group Leader\, DWI-Leibniz Institute for Interactive Materials \nNature achieves unmatched functionality by the self-assembly of (macro)molecular building blocks in a hierarchical manner. All information necessary for the function is encoded at the molecular level. Unraveling such blueprints serves as a powerful paradigm in the bio-inspired synthesis of materials that can seamlessly interface with living matter or perform non-natural functions. In this talk\, I will present a selection of research studies from my lab addressing the overarching task of developing bio-inspired interactive materials and their application in the biomedical field. Three themes will be considered. Firstly\, I will present hydrophilic arborescent polymers\, a new class of quasi-dendritic macromolecules in which the topology codes for extreme flexibility and enables a myriad of multivalent interactions. Secondly\, I will present highlights of the antimicrobial Kill&Repel and Adaptive hemocompatible nanocoatings and our efforts in translating them to medical devices. The last part of the talk will focus on the development of Membrane Machines\, tailor-made synthetic vesicles capable of recapitulating some fundamental biological properties and performing specific tasks. We take advantage of these systems to study how biological selectivity can emerge from the lateral organization of ligand in static and dynamic systems such as the bacterial divisome. We are also developing synthetic macrophage-mimetic microrobots capable of endocytosing bacteria and viruses\, including SARS-CoV-2. \nThis seminar will be hybrid\, using the GoToMeeting app and also at the Baobab meeting room located at Tower I\, 11th floor. Very few people will be able to attend this seminar in person due to the capacity of the meeting room.  If you wish to attend this seminar please write an email to ibeccommunications@ibecbarcelona.eu the free spots will be assigned on a first come first served basis.. The seminar will also be available on streaming\, by using the GoToMeeting app\, available in this link. \nMore information about his research team here
URL:https://ibecbarcelona.eu/event/hybrid-ibec-seminar-cesar-rodriguez-emmenegger/
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20211119T100000
DTEND;TZID=Europe/Madrid:20211119T120000
DTSTAMP:20260406T000359
CREATED:20210901T151522Z
LAST-MODIFIED:20211110T120644Z
UID:86930-1637316000-1637323200@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Cristina Mayor-Ruiz
DESCRIPTION:Targeted protein degradation: genetic determinants and drug discovery opportunities\nCristina Mayor-Ruiz\, IRBarcelona \nTargeted protein degradation is a new therapeutic modality based on drugs that destabilize proteins by inducing their proximity to E3 ubiquitin ligases. Of particular interest are “molecular glue degraders”: compounds that can degrade otherwise unligandable proteins by orchestrating direct interactions between target and E3. However\, their discovery has been serendipitous\, thus hampering broad translational efforts. I will present a scalable target-agnostic strategy toward glue degrader discovery. This approach is based on differential chemical screening coupled to a multi-omics target deconvolution campaign. Collectively\, our data outline a versatile and broadly applicable strategy to identify degraders and thus empower future drug discovery efforts. \n\nThis seminar will be held at Tower I\, 11th floor Baobab room\, there will be 30 avialable seats\, the free spots will be assigned on a first come first served basis. If you wish to attend this seminar online\, please write to ibeccommunications@ibecbarcelona.eu. \nMore information about Cristina Mayor-Ruiz’s research here \nCristina Mayor-Ruiz obtained her PhD in 2017 at the CNIO (Madrid) under the supervision of Óscar Fernández-Capetillo. There\, she explored mechanisms of resistance to anticancer therapies. In 2018\, she joined the group of Georg Winter at CeMM (Vienna) supported by EMBO and Marie Curie postdoctoral fellowships\, where her interests focused on different aspects of chemical biology and drug screening. Since January 2021\, she leads the “Targeted Protein Degradation & Drug discovery” lab at IRB Barcelona. Her research focuses on: \n(1) Developing screening strategies for early drug discovery. In particular\,  to identify monovalent degraders and other proximity-inducing drugs with therapeutic interest. \n(2) Tackling exciting biological questions that either benefit from the high kinetic resolution provided by targeted protein degradation\, or that involve E3 (dys)regulation dynamics. \n 
URL:https://ibecbarcelona.eu/event/online-ibec-seminar-cristina-mayor-ruiz/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
ORGANIZER;CN="IBEC":MAILTO:www.ibecbarcelona.eu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20211130T160000
DTEND;TZID=Europe/Madrid:20211130T170000
DTSTAMP:20260406T000359
CREATED:20211110T120518Z
LAST-MODIFIED:20211124T114657Z
UID:88450-1638288000-1638291600@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Rob Jelier
DESCRIPTION:The effect of gene loss on adaptation | 3D cell shape analysis in embryos\nRob Jelier\, CMPG – Predictive Genetics and Multicellular Systems University of Leuven \nIn this talk I will summarize two research projects. First\, I will report on a large-scale experimental evolution study into the effect of gene deletion on adaptation. We found gene deletion can speed up adaptation. Further\, tracking adaptation after the systematic perturbation of genes involved in a complex trait informs on the genetic architecture of the trait. Second\, we have developed a segmentation-pipeline for membrane tagged cells from fluorescent microscopy timelapses. The pipeline uses a biophysical DEM model of cell shape to constrain the possible cell shapes. The retrieved accurate cell shapes are subsequently used for very sensitive characterization of cell shapes\, for example to identify changes after perturbations. \nThis seminar will be held at Tower I\, 11th floor Baobab room\, there will be 30 avialable seats\, the free spots will be assigned on a first come first served basis. If you wish to attend this seminar online\, please write to ibeccommunications@ibecbarcelona.eu.
URL:https://ibecbarcelona.eu/event/ibec-seminar-rob-jelier/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20211203T100000
DTEND;TZID=Europe/Madrid:20211203T120000
DTSTAMP:20260406T000359
CREATED:20210917T110911Z
LAST-MODIFIED:20211123T152952Z
UID:87237-1638525600-1638532800@ibecbarcelona.eu
SUMMARY:Online IBEC Seminar: Arnau Hervera
DESCRIPTION:Therapeutic effects of HDAC3 inhibition on spinal injuries and autoimmune demyelinating diseases\nArnau Hervera\, Molecular and Cellular Neurobiotechnology \nThe molecular mechanisms discriminating between regenerative failure and success remain elusive. While a regeneration-competent peripheral nerve injury mounts a regenerative gene expression response in bipolar dorsal root ganglia (DRG) sensory neurons\, a regeneration-incompetent central spinal cord injury does not. This dichotomic response offered us a unique opportunity to investigate the fundamental biological mechanisms underpinning this regenerative ability. Following a pharmacological screen with small molecule inhibitors targeting key epigenetic enzymes in DRG neurons we identified HDAC3 signaling as a novel candidate\, that hindered axonal regenerative growth. In vivo\, we found that only a peripheral but not a central axonal injury induced an increase in calcium\, activating protein phosphatase 4 (PP4) who in turn dephosphorylates HDAC3 thus impairing its activity and enhancing histone acetylation. Bioinformatics analysis of ex vivo H3K9ac ChIPseq and RNAseq from DRG followed by promoter acetylation and protein expression studies implicated HDAC3 in the regulation of multiple regenerative pathways. Additionally\, we and others have found that\, HDAC3 inhibition is able to modulate the neuroinflammatory environment in the CNS after injury. In that sense\, after CNS injury\, inflammatory phase transitions are poorly orchestrated leading to unresolved exaggerated inflammation that triggers secondary damage and functional deficits. We found that HDAC3 inhibition also altered the cytokinome after SCI\, and we are currently characterizing the effects of this inhibition on the functions of different immune cells after SCI. Additionally\, HDAC3 inhibition has been also previously described to play important roles in neuronal survival\, lymphocyte differentiation and myelination\, together with neuroinflammation\, all these processes are essential regulators on the development and outcome of autoimmune demyelinating diseases\, such as MS. In this direction\, we are also currently studying the potential therapeutic effects of HDAC3 inhibition in the multiple sclerosis mouse model Experimental Autoimmune Encephalitis (EAE)\, as well as their underlying mechanisms\, in neuroinflammation autoantigen presentation\, lymphocyte differentiation\, demyelination\, remyelination and oligodendrocyte survival and differentiation. \nThis seminar will be held using the GoToMeeting app
URL:https://ibecbarcelona.eu/event/online-ibec-seminar-arnau-hervera/
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20211210T100000
DTEND;TZID=Europe/Madrid:20211210T120000
DTSTAMP:20260406T000359
CREATED:20210901T150722Z
LAST-MODIFIED:20211129T105836Z
UID:86922-1639130400-1639137600@ibecbarcelona.eu
SUMMARY:Online IBEC Seminar: Irene Marco
DESCRIPTION:Updates on a new lab at IBEC: hyperpolarised magnetic resonance for real-time\, in situ monitoring of cell metabolism\nIrene Marco\, Molecular Imaging for Precision Medicine group at IBEC \nThere is a clinical need for non-invasive and reliable markers to diagnose\, stage and evaluate treatment response in many diseases such as cancer or non-alcoholic fatty liver disease. \nMagnetic resonance (MR) methods now have the potential to revolutionise in the identification of such biomarkers in real time.  Spectroscopic identification and quantitation of metabolites via carbon-13 chemical shifts can be combined with imaging (MRI) to simultaneously probe spatial (biodistribution) and temporal (kinetics) aspects of metabolism in vivo. These capabilities are enabled by so-called hyperpolarised (HP) MR techniques\, including Dynamic Nuclear Polarisation (DNP)\, which can transiently boost the carbon-13 MR signals by several orders of magnitude\, compared to traditional methods. DNP enables real-time measurement of enzymatic reactions in cell suspensions and in vivo. Multiple HP 13C-labelled substrates have provided insights in several metabolic pathways\, including glycolysis\, the pentose-phosphate pathway and the cellular redox state. I will present the potential of DNP to study metabolism in cell suspensions\, tissue ex vivo and animals in vivo. Also\, I will talk about the progress we have made at IBEC in the past couple of months and how we plan to implement HP MR to monitor metabolism in organs-in-chips. \nThis seminar will be held at Tower I\, 11th floor Baobab room\, there will be 30 avialable seats\, the free spots will be assigned on a first come first served basis. If you wish to attend this seminar online\, please write to ibeccommunications@ibecbarcelona.eu. \nMore information about Irene Marco’s research here
URL:https://ibecbarcelona.eu/event/online-ibec-seminar-irene-marco/
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20220121T100000
DTEND;TZID=Europe/Madrid:20220121T120000
DTSTAMP:20260406T000359
CREATED:20210901T151240Z
LAST-MODIFIED:20220111T080313Z
UID:86926-1642759200-1642766400@ibecbarcelona.eu
SUMMARY:Online IBEC Seminar: Carlos Aleman
DESCRIPTION:Smart and multifunctional artificial materials for bioengineering\nCarlos Aleman\, Universitat Politècnica de Catalunta (UPC) \nThe research of the ” Innovation\, Modeling & Engineering in Materials” group in the field of multifunctional materials. Three\, different examples of multifunctional systems will be presented: 1) Magnetic electroconductive and self-healing PEDOT:alginate hydrogels for sensing\, drug-delivery and energy storage; 2) Self-standing PLA/PEDOT films as artificial muscles\, controlled lactate release and selective ion transport; and 3) Permanently polarized hydroxyapatite a biocatalyst for carbon and nitrogen fixation. \nCarlos Alemán graduated in Chemistry from the University of Barcelona (Spain). He received his Ph.D. from the Polytechnic University of Catalonia (UPC) in 1994\, where he was promoted to the position of Full Professor of Physical Chemistry. He was postdoctoral researcher at the ETH in Zürich (Switzerland) and visiting professor at the Università di Napoli Federico II (Italy)\, University of Twente (Holland) and Universidade Federal do Rio Grande do Sul (Brazil). Since 2003 he is the leader of the ‘‘Innovation\, Modeling & Engineering in Materials’’ (IMEM) group. His main research interests focus on conducting polymers and biopolymers with biomedical and technological (energy) applications. \nThis seminar will take place online\, using the go to meeting app
URL:https://ibecbarcelona.eu/event/online-ibec-seminar-carlos-aleman/
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20220304T100000
DTEND;TZID=Europe/Madrid:20220304T120000
DTSTAMP:20260406T000359
CREATED:20220222T141809Z
LAST-MODIFIED:20220222T141809Z
UID:90595-1646388000-1646395200@ibecbarcelona.eu
SUMMARY:Online IBEC Seminar: Stefano Pulchino
DESCRIPTION:Regenerative Neuroimmunology – new generation molecular approaches to restore maladaptive inflammatory responses in the persistently inflamed CNS\nStefano Pulchino\, University of Cambridge \nThere are currently no approved therapies to slow down the accumulation of neurological disability that occurs independently of relapses in multiple sclerosis (MS). International agencies are engaging to expedite the development of novel strategies capable of modifying disease progression\, abrogating persistent CNS inflammation\, and support degenerating axons in people with persistent inflammation of the\, such as that occurring in progressive MS. \nUnderstanding why regeneration fails in the progressive MS brain and developing new regenerative approaches is a key priority for the Pluchino Lab. \nIn particular\, we aim to elucidate how the immune system\, in particular its cells called myeloid cells\, affects brain structure and function under normal healthy conditions and in disease. \nOur objective is to find how myeloid cells communicate with the central nervous system and affect tissue healing and functional recovery by stimulating mechanisms of brain plasticity mechanisms such as the generation of new nerve cells and the reduction of scar formation. \nApplying combination of state-of-the-art omic technologies\, and molecular approaches to study murine and human disease models of inflammation and neurodegeneration\, we aim to develop experimental molecular medicines\, including those with stem cells and gene therapy vectors\, which slow down the accumulation of irreversible disabilities and improve functional recovery after progressive multiple sclerosis\, stroke and traumatic injuries. \nBy understanding the mechanisms of intercellular (neuro-immune) signalling\, diseases of the brain and spinal cord may be treated more effectively\, and significant neuroprotection may be achieved with new tailored molecular therapeutics. \n\nI have received my MD and PhD degrees at the University of Siena\, Italy\, and additional training at Cambridge University\, UK. I am currently Professor of Regenerative Neuroimmunology and Honorary Consultant in Neurology\, within the Department of Clinical Neurosciences at Cambridge University. \nI have a strong interest in Regenerative Neuroimmunology\, and my research over the last 20 years has recalibrated the classical view that cellular grafts only function through structural cell replacement and opened up a new therapeutic avenue by which to use exogenously delivered stem cells\, or even stem cell-derived acellular therapies that include extracellular vesicles and exosomes. \nThe Pluchino team studies whether the accumulation of neurological disability observed in patients with chronic inflammatory neurological conditions can be slowed down using next generation molecular therapies. The overarching aim is to understand the basic mechanisms that allow exogenously delivered stem cells\, gene therapy vectors and/or exosomes to create an environment that preserves damaged axons or prevents neurons from dying. Such mechanisms may be harnessed and used to modulate disease states in an effort to repair and/or regenerate critical components of the nervous system. \nI am recipient of numerous national and international awards\, among which the Italian Multiple Sclerosis Foundation (FISM) Rita Levi-Montalcini prize for outstanding research in MS (2007)\, the 2009 Italian Ministry of Health Young Investigator Award and the 2010 European Research Council (ERC) Starting Independent Award. \nMy laboratory research on Regenerative Neuroimmunology is documented in >230 publications in international journals\, including many recent articles in highly prestigious journals\, such as Nature\, Cell\, Cell Stem Cell\, Nat Cell Biol\, Nat Chem Biol\, PNAS\, PLoS Med\, Brain\, Ann Neurol\, and J Neurosci\, as well as invited review articles in Nat Rev Neurosci\, Physiol Reviews\, Trends in Mol Med and Trends Immunol. My publications have to date received >14.000 citations (ISI-WOK)\, having a Hirsch Factor of 52. \n\nThis seminar will take place online\, using the go to meeting app
URL:https://ibecbarcelona.eu/event/online-ibec-seminar-stefano-pulchino-2/
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20220304T100000
DTEND;TZID=Europe/Madrid:20220304T120000
DTSTAMP:20260406T000359
CREATED:20220429T090715Z
LAST-MODIFIED:20220429T090716Z
UID:93913-1646388000-1646395200@ibecbarcelona.eu
SUMMARY:Online IBEC Seminar: Stefano Pulchino
DESCRIPTION:Regenerative Neuroimmunology – new generation molecular approaches to restore maladaptive inflammatory responses in the persistently inflamed CNS\n\n\n\nStefano Pulchino\, University of Cambridge \n\n\n\nThere are currently no approved therapies to slow down the accumulation of neurological disability that occurs independently of relapses in multiple sclerosis (MS). International agencies are engaging to expedite the development of novel strategies capable of modifying disease progression\, abrogating persistent CNS inflammation\, and support degenerating axons in people with persistent inflammation of the\, such as that occurring in progressive MS. \n\n\n\nUnderstanding why regeneration fails in the progressive MS brain and developing new regenerative approaches is a key priority for the Pluchino Lab. \n\n\n\nIn particular\, we aim to elucidate how the immune system\, in particular its cells called myeloid cells\, affects brain structure and function under normal healthy conditions and in disease. \n\n\n\nOur objective is to find how myeloid cells communicate with the central nervous system and affect tissue healing and functional recovery by stimulating mechanisms of brain plasticity mechanisms such as the generation of new nerve cells and the reduction of scar formation. \n\n\n\nApplying combination of state-of-the-art omic technologies\, and molecular approaches to study murine and human disease models of inflammation and neurodegeneration\, we aim to develop experimental molecular medicines\, including those with stem cells and gene therapy vectors\, which slow down the accumulation of irreversible disabilities and improve functional recovery after progressive multiple sclerosis\, stroke and traumatic injuries. \n\n\n\nBy understanding the mechanisms of intercellular (neuro-immune) signalling\, diseases of the brain and spinal cord may be treated more effectively\, and significant neuroprotection may be achieved with new tailored molecular therapeutics. \n\n\n\n\n\n\n\nI have received my MD and PhD degrees at the University of Siena\, Italy\, and additional training at Cambridge University\, UK. I am currently Professor of Regenerative Neuroimmunology and Honorary Consultant in Neurology\, within the Department of Clinical Neurosciences at Cambridge University. \n\n\n\nI have a strong interest in Regenerative Neuroimmunology\, and my research over the last 20 years has recalibrated the classical view that cellular grafts only function through structural cell replacement and opened up a new therapeutic avenue by which to use exogenously delivered stem cells\, or even stem cell-derived acellular therapies that include extracellular vesicles and exosomes. \n\n\n\nThe Pluchino team studies whether the accumulation of neurological disability observed in patients with chronic inflammatory neurological conditions can be slowed down using next generation molecular therapies. The overarching aim is to understand the basic mechanisms that allow exogenously delivered stem cells\, gene therapy vectors and/or exosomes to create an environment that preserves damaged axons or prevents neurons from dying. Such mechanisms may be harnessed and used to modulate disease states in an effort to repair and/or regenerate critical components of the nervous system. \n\n\n\nI am recipient of numerous national and international awards\, among which the Italian Multiple Sclerosis Foundation (FISM) Rita Levi-Montalcini prize for outstanding research in MS (2007)\, the 2009 Italian Ministry of Health Young Investigator Award and the 2010 European Research Council (ERC) Starting Independent Award. \n\n\n\nMy laboratory research on Regenerative Neuroimmunology is documented in >230 publications in international journals\, including many recent articles in highly prestigious journals\, such as Nature\, Cell\, Cell Stem Cell\, Nat Cell Biol\, Nat Chem Biol\, PNAS\, PLoS Med\, Brain\, Ann Neurol\, and J Neurosci\, as well as invited review articles in Nat Rev Neurosci\, Physiol Reviews\, Trends in Mol Med and Trends Immunol. My publications have to date received >14.000 citations (ISI-WOK)\, having a Hirsch Factor of 52. \n\n\n\n\n\n\n\nThis seminar will take place online\, using the go to meeting app
URL:https://ibecbarcelona.eu/event/online-ibec-seminar-stefano-pulchino/
CATEGORIES:IBEC Seminar
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BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20220314T160000
DTEND;TZID=Europe/Madrid:20220314T170000
DTSTAMP:20260406T000359
CREATED:20220309T092904Z
LAST-MODIFIED:20220309T092904Z
UID:90888-1647273600-1647277200@ibecbarcelona.eu
SUMMARY:IBEC Seminar: André Körnig
DESCRIPTION:NanoWizard® V BioScience – The latest Generation AFM for Automated Structural and Mechanical Analysis & NanoRacer® – High-Speed AFM for dynamical processes\nAndré Körnig\, JPK BioAFM\, Bruker Nano GmbH \nThe ability of atomic force microscopy (AFM) to obtain three-dimensional topography images of biological molecules and complexes with nanometer resolution and under near-physiological conditions remains unmatched by other imaging techniques. Bruker BioAFM has recently launched the NanoWizard® V BioScience AFM that combines high spatio-temporal resolution with a large scan area\, flexible experiment design\, and outstanding integration with advanced optical microscope systems. \nThis talk will focus on how the advances in Bruker’s latest BioAFM can be applied to study a wide-range of biological samples: from individual biomolecules to mammalian cells and tissues in-situ. It will be presented how we are able to resolve the nanoscale structure of individual biomolecules\, at high-speed scan rates (400 lines/sec)\, follow the dynamic reorganization of the membrane-associated cytoskeleton of living cells at high temporal and spatial resolution. It will be highlighted\, how the topography of cells across the entire area of the microscope stage can be automatically mapped. Special part will be dedicated to the suite of BioAFM modes\, probes and accessories for studying nanomechanical properties of cells and tissues\, including direct correlation with super-resolution microscopy techniques (STED). \nIn the past\, investigating large and rough samples such as tissues and hydrogels using AFM was challenging due to the limited z-axis of the AFM. Using osteoarthritic cartilage as an example\, we will demonstrate how a newly developed hybrid of a motorized and piezo stage enables multi-region AFM probing over a large\, rough sample area while providing additional correlative optical data sets. \nThe newly developed NanoRacer® High-Speed AFM enables scanning speeds of up to 50 frames per second. In this way\, the high-speed study of the time-resolved dynamics associated with cellular processes and the binding mechanisms of individual biomolecules is possible\, e.g. the dynamics of single molecule binding behavior\, two-dimensional protein assemblies\, motor proteins and membrane trafficking. \nWe will present data on DNA origami nanostructures containing biotin binding sites\, imaged in fluid in the presence of streptavidin\, as well as data on DNA metastable bubble formation and closure (~30 nm in length)\, imaged in fluid in closed-loop at 2000 lines per second. \n\nThis seminar will be held at Tower I\, 11th floor Baobab room\, there will be 30 avialable seats\, the free spots will be assigned on a first come first served basis.
URL:https://ibecbarcelona.eu/event/ibec-seminar-andre-kornig-2/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
ORGANIZER;CN="IBEC":MAILTO:www.ibecbarcelona.eu
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BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20220314T160000
DTEND;TZID=Europe/Madrid:20220314T170000
DTSTAMP:20260406T000359
CREATED:20220503T134023Z
LAST-MODIFIED:20220503T134024Z
UID:93989-1647273600-1647277200@ibecbarcelona.eu
SUMMARY:IBEC Seminar: André Körnig
DESCRIPTION:NanoWizard® V BioScience – The latest Generation AFM for Automated Structural and Mechanical Analysis & NanoRacer® – High-Speed AFM for dynamical processes\n\n\n\nAndré Körnig\, JPK BioAFM\, Bruker Nano GmbH \n\n\n\nThe ability of atomic force microscopy (AFM) to obtain three-dimensional topography images of biological molecules and complexes with nanometer resolution and under near-physiological conditions remains unmatched by other imaging techniques. Bruker BioAFM has recently launched the NanoWizard® V BioScience AFM that combines high spatio-temporal resolution with a large scan area\, flexible experiment design\, and outstanding integration with advanced optical microscope systems. \n\n\n\nThis talk will focus on how the advances in Bruker’s latest BioAFM can be applied to study a wide-range of biological samples: from individual biomolecules to mammalian cells and tissues in-situ. It will be presented how we are able to resolve the nanoscale structure of individual biomolecules\, at high-speed scan rates (400 lines/sec)\, follow the dynamic reorganization of the membrane-associated cytoskeleton of living cells at high temporal and spatial resolution. It will be highlighted\, how the topography of cells across the entire area of the microscope stage can be automatically mapped. Special part will be dedicated to the suite of BioAFM modes\, probes and accessories for studying nanomechanical properties of cells and tissues\, including direct correlation with super-resolution microscopy techniques (STED). \n\n\n\nIn the past\, investigating large and rough samples such as tissues and hydrogels using AFM was challenging due to the limited z-axis of the AFM. Using osteoarthritic cartilage as an example\, we will demonstrate how a newly developed hybrid of a motorized and piezo stage enables multi-region AFM probing over a large\, rough sample area while providing additional correlative optical data sets. \n\n\n\nThe newly developed NanoRacer® High-Speed AFM enables scanning speeds of up to 50 frames per second. In this way\, the high-speed study of the time-resolved dynamics associated with cellular processes and the binding mechanisms of individual biomolecules is possible\, e.g. the dynamics of single molecule binding behavior\, two-dimensional protein assemblies\, motor proteins and membrane trafficking. \n\n\n\nWe will present data on DNA origami nanostructures containing biotin binding sites\, imaged in fluid in the presence of streptavidin\, as well as data on DNA metastable bubble formation and closure (~30 nm in length)\, imaged in fluid in closed-loop at 2000 lines per second. \n\n\n\n\n\n\n\nThis seminar will be held at Tower I\, 11th floor Baobab room\, there will be 30 avialable seats\, the free spots will be assigned on a first come first served basis.
URL:https://ibecbarcelona.eu/event/ibec-seminar-andre-kornig/
LOCATION:IBEC\, floor 11\, Tower i
CATEGORIES:IBEC Seminar
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