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DTSTART;TZID=Europe/Madrid:20260612T100000
DTEND;TZID=Europe/Madrid:20260612T110000
DTSTAMP:20260616T155147
CREATED:20260529T063846Z
LAST-MODIFIED:20260529T063846Z
UID:133843-1781258400-1781262000@ibecbarcelona.eu
SUMMARY:Ibec Seminar. Santiago A. Rodríguez-Seguí
DESCRIPTION:Epigenomic Control of Pancreatic β-Cell Development and Fate: Toward Engineering a Vascularized Organoid-on-Chip Platform\nSantiago A. Rodríguez-Seguí1\,2 \n1 Instituto de Fisiología\, Biología Molecular y Neurociencias (IFIBYNE-UBA-CONICET)\, Universidad de Buenos Aires\, Facultad de Ciencias Exactas y Naturales\, Buenos Aires\, Argentina. \n2 Departamento de Fisiología\, Biología Molecular y Celular\, Universidad de Buenos Aires\, Facultad de Ciencias Exactas y Naturales\, Ciudad Universitaria\, Buenos Aires\, Argentina. \nThe human genome encodes the instructions for the vast cellular differentiation required for embryonic development and adult homeostasis. Some developmental programs are reactivated during regeneration upon tissue damage. Decoding this regulatory logic demands integrated approaches: the development of suitable human tissue models\, genomic characterization of transcriptional and epigenetic programs\, and experimental validation. State-of-the-art bioengineering technologies — including microfluidic and biomaterial platforms that recapitulate tissue microenvironments — are enabling insights into human biology that would otherwise be difficult to achieve. \nDiabetes is associated with malfunction of pancreatic β-cells. Our work\, based on pioneering ChIP-seq and scRNA-seq studies in human and mouse pancreatic samples — adult islets\, embryonic pancreas\, and iPSC-derived progenitors — has identified regulatory mechanisms controlling β-cell development and fate. We mapped the enhancer landscape of human islets\, uncovered enhancer mutations causing pancreatic agenesis\, and demonstrated that TEAD and YAP regulate key enhancers during pancreatic development. More recently\, we showed that glucocorticoid receptor activation modulates early differentiation in pancreatic progenitors\, and that HNF1B mutations disrupt this process in iPSC-derived models. From the regenerative angle\, we reported that the peptide INGAP-PP signals to multiple islet cell types\, including β-cells and endothelial cells\, suggesting that its effects depend on multicellular crosstalk poorly captured by conventional culture. \nBuilding on this foundation\, we are now developing a vascularized pancreatic endocrine organoid-on-chip platform that recapitulates the β-cell vascular niche. This platform\, developed in collaboration with the University of Barcelona and IBEC\, integrates human β-cells\, endothelial cells\, and stromal cells in a perfusable microfluidic device. It will enable epigenomic dissection of how vascular niche signals modulate the enhancer landscape underlying β-cell fate in a controlled human microenvironment. Our long-term vision is to translate this mechanistic understanding into precision medicine approaches for diabetes. \nSantiago Rodríguez Seguí is a Principal Investigator at the Institute for Physiology\, Molecular Biology\, and Neurosciences (IFIBYNE)\, affiliated with the National Scientific and Technical Research Council of Argentina (CONICET) and the University of Buenos Aires. He holds a degree in Bioengineering from the University of Entre Ríos\, Argentina\, and a PhD in Biomedicine from the University of Barcelona\, Spain. \nHis research focuses on pancreatic beta cell development and regeneration. He has authored more than 20 publications\, with significant contributions to the field published in high-impact journals such as Nature Genetics\, Nature Cell Biology\, and Development. His work has been recognized with awards from the National Academy of Medicine of Argentina and the Honorable Senate of the Argentine Nation.
URL:https://ibecbarcelona.eu/event/ibec-seminar-santiago-a-rodriguez-segui/
LOCATION:Baobab room\, Floor 11\, Tower 1
CATEGORIES:IBEC Seminar
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DTSTART;TZID=Europe/Madrid:20260612T111500
DTEND;TZID=Europe/Madrid:20260612T121500
DTSTAMP:20260616T155147
CREATED:20260609T065838Z
LAST-MODIFIED:20260609T065838Z
UID:134002-1781262900-1781266500@ibecbarcelona.eu
SUMMARY:Ibec Seminar. Dr. Le Cam
DESCRIPTION:The p53 pathway and metabolism: implications in normal tissue homeostasis\, aging and cancer progression\nDr. Le Cam \, Montpellier Cancer Research Institute (IRCM) \nMutation of the TP53 gene is the most frequent genetic alteration in human cancers. Tumor suppressive functions of p53 have been linked to its ability to control cell division\, cell death and cellular senescence. However growing evidence indicates that the metabolic functions of p53 play important roles in cancer progression. Our team has been studying the metabolic functions of the p53 pathway for many years and highlighted previously unknown functions of several key components of this molecular cascade in pyruvate\, amino-acid\, and nucleotide metabolism. Beyond cancer development\, I will illustrate how deregulation of these metabolic networks impacts on normal physiological responses in the liver\, contributes to cancer development and leads to inborn metabolic disorders. \nRelevant publications: \n1- Riscal R. et al (2016) Chromatin-bound MDM2 regulates serine metabolism and redox homeostasis independently of p53. Mol. Cell. Jun 16;62(6):890-902. \n2- Arena et al. Mitochondrial MDM2 regulates respiratory complex I activity independently of p53. Mol Cell 2018 \n3- Cissé et al. Targeting MDM2-dependent serine metabolism as a new therapeutic strategy for liposarcoma. Sci Trans Med 2020 \n4- Lacroix et al. The multifunctional protein E4F1 links p53 to lipid metabolism in adipocytes. Nat Comms 2021 \n5- Di Michele et al. E4F1 coordinates pyruvate metabolism and the activity of the Elongator Complex to ensure protein translation fidelity. Nat Comms 2025 \n  \nDr. Le Cam earned his Pharmacy thesis and his PhD in Science from Montpellier University (France) in 1999. From 1999 to 2004\, he spent four years as a postdoctoral fellow in Professor Sicinski’s laboratory at the Dana-Farber Cancer Institute in Boston (USA)\, where he studied cell cycle and mouse genetics. He then joined the French National Institute of Health and Medical Research (INSERM) as a researcher at the Institute of Molecular Genetics of Montpellier in Dr. Claude Sardet’s laboratory. In 2008\, he became a group leader at the Montpellier Cancer Research Institute (IRCM)\, where he was appointed deputy director in 2022. His team investigates the metabolic functions of p53\, the most frequently mutated tumor suppressor across many cancer types\, and how their deregulation impinges on metabolic disorders\, aging and cancer progression.
URL:https://ibecbarcelona.eu/event/ibec-seminar-dr-le-cam/
LOCATION:Baobab room\, Floor 11\, Tower 1
CATEGORIES:IBEC Seminar
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DTSTART;TZID=Europe/Madrid:20260619T100000
DTEND;TZID=Europe/Madrid:20260619T110000
DTSTAMP:20260616T155147
CREATED:20260616T123335Z
LAST-MODIFIED:20260616T123335Z
UID:134204-1781863200-1781866800@ibecbarcelona.eu
SUMMARY:Ibec Seminar. Ezequiel Coscueta
DESCRIPTION:Bioactives Beyond Screening: From Molecular Potential to Local Gut Function\nBioactive molecules are often selected through simplified screening assays\, where antioxidant\, antimicrobial\, anti-inflammatory or cytotoxic responses provide an initial indication of biological potential. However\, in the gastrointestinal context\, this potential can be profoundly reshaped by digestion\, solubility\, mucus\, microbiota metabolism\, epithelial interactions and the local biochemical conditions of health or disease. Moving beyond screening therefore requires asking not only whether a molecule is active\, but whether it can remain accessible\, transform into relevant metabolites\, interact with biological barriers and produce function where it is needed. \nThis talk will discuss how bioactives from complex biological matrices can be studied across this transition from molecular potential to gut-relevant function. Drawing on examples involving peptide-rich fractions\, peptidomics\, phenethyl isothiocyanate\, gastrointestinal simulation\, microbiota-oriented assays and delivery systems\, the talk will reflect on the experimental challenges of assigning biological meaning to bioactive molecules intended for local action in the gut. \nThe broader aim is to present a nutraceutical and molecular biotechnology perspective that connects naturally with current questions in gastrointestinal health\, local delivery and human-relevant models. In this context\, emerging biopolymeric and biocatalytic micro/nanosystems will be introduced as part of an ongoing effort to design bioactive-based strategies that respond more closely to the inflammatory gastrointestinal microenvironment. \n  \nEzequiel Coscueta is an Assistant Researcher at the Centro de Biotecnologia e Química Fina (CBQF) and an Invited Assistant Professor at the Faculty of Biotechnology\, Universidade Católica Portuguesa\, in Porto\, Portugal. He is currently undertaking a three-month research mobility at IBEC as a Visiting Researcher in the Smart Nano-Bio-Devices Group\, through an ongoing collaboration with the group leader\, Samuel Sánchez Ordóñez. He holds a PhD in Biological Sciences from Universidad Nacional de Rosario\, Argentina\, and a BSc in Biotechnology from Universidad Nacional del Litoral\, Argentina. His research combines molecular and analytical biotechnology\, peptidomics\, bioactive characterisation\, gastrointestinal digestion and colon fermentation models\, microbiota-oriented assays\, and bio-based delivery systems. \nHis scientific trajectory has evolved from bioprocessing and the study of complex biological matrices toward a broader interest in how bioactive molecules can become functionally relevant within the gastrointestinal environment. Rather than focusing only on simplified bioactivity screening\, his work addresses how digestion\, bioaccessibility\, microbial transformation\, biological barriers and local inflammatory conditions influence the functional potential of bioactives. \nHe is Principal Investigator of gBiOT\, a project funded by FCT\, the Fundação para a Ciência e a Tecnologia\, Portugal’s national public agency for science\, technology and innovation. He was also Co-Principal Investigator of GastroCure\, an ERDF-supported project\, funded through the European Regional Development Fund\, focused on bioactives for gastrointestinal inflammatory disorders. His current research explores bioactive-based strategies\, biopolymeric systems and biocatalytic micro/nanosystems designed for local action in inflammatory gastrointestinal microenvironments. In parallel\, he is working on bioactive peptides as modulators of the gut-skin axis\, with a particular focus on psoriasis\, expanding his research from local gastrointestinal function toward systemic inflammatory communication. Together\, these lines create natural points of contact with human-relevant models\, biological barriers\, local delivery and nanomedicine-oriented research.
URL:https://ibecbarcelona.eu/event/ibec-seminar-ezequiel-coscueta/
LOCATION:Baobab room\, Floor 11\, Tower 1
CATEGORIES:IBEC Seminar
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DTSTART;TZID=Europe/Madrid:20260703T113000
DTEND;TZID=Europe/Madrid:20260703T123000
DTSTAMP:20260616T155147
CREATED:20260615T100943Z
LAST-MODIFIED:20260615T101020Z
UID:134198-1783078200-1783081800@ibecbarcelona.eu
SUMMARY:Ibec seminar. Dr Remy Chiaffarelli
DESCRIPTION:Hybrid PET/MR Imaging of Tumour Physiology: from Perfusion to Extracellular Lactate\nDr Remy Chiaffarelli\, Eberhard Karls University Tübingen \n\nTumour progression is driven by metabolic and vascular changes that shape the tumour microenvironment. We developed new hybrid PET/MRI probes to detect and quantify tumour physiology and its compartmentalization\, with a focus on extracellular lactate and perfusion. By combining responsive CEST MRI contrast agents with PET-based quantification\, these probes provide complementary functional and quantitative information for preclinical metabolic imaging. Our findings demonstrate the value of these approaches for characterising tumour heterogeneity and metabolic dynamics\, providing insights into cancer biology and supporting the development of more precise imaging biomarker.
URL:https://ibecbarcelona.eu/event/ibec-seminar-dr-remy-chiaffarelli/
LOCATION:Baobab room\, Floor 11\, Tower 1
CATEGORIES:IBEC Seminar
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