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DTSTART;TZID=Europe/Madrid:20221102T153000
DTEND;TZID=Europe/Madrid:20221102T173000
DTSTAMP:20260404T105843
CREATED:20221025T111442Z
LAST-MODIFIED:20221031T092456Z
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SUMMARY:IBEC Seminar: Felipe Galvez-Cancino (canceled)
DESCRIPTION:
URL:https://ibecbarcelona.eu/event/ibec-seminar-felipe-galvez-cancino/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
ORGANIZER;CN="IBEC":MAILTO:www.ibecbarcelona.eu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20221109T160000
DTEND;TZID=Europe/Madrid:20221109T180000
DTSTAMP:20260404T105843
CREATED:20221028T104835Z
LAST-MODIFIED:20221028T104906Z
UID:100158-1668009600-1668016800@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Takashi Hiiragi
DESCRIPTION:Multicellular coordination in context\nTakashi Hiiragi\, Hubrecht Institute\, The Netherlands \nA defining feature of living systems is the capacity to break symmetry and generate well-defined forms and patterns through self-organisation. Our group aims to understand the design principle of multicellular living systems using early mouse embryos as a model system. We developed an experimental framework that integrates biology\, physics and mathematics\, to understand how molecular\, cellular and physical signals are dynamically coupled across the scales for self-organisation. I will discuss our ongoing work investigating the coordination of developmental programmes in space and time. \n\nTakashi Hiiragi is group leader at the Hubrecht Institute.  The Hiiragi group aims to understand what defines multi-cellular living systems. In particular\, the group studies the design principle of tissue self-organization\, using early mammalian embryos as a model system. To this end\, they developed an experimental framework that integrates biology\, physics and mathematics. Their recent studies led to a model in which feedback between cell fate\, polarity\, and cell and tissue mechanics underlies multi-cellular self-organization. The group adopts a wide variety of experimental strategies including embryology\, genetics\, advanced microscopy\, biophysics\, engineering and theoretical modelling\, in order to address fundamental questions in cell and developmental biology.
URL:https://ibecbarcelona.eu/event/ibec-seminar-takashi-hiiragi/
LOCATION:Sala Baobab\, Tower I - 11th floor
CATEGORIES:IBEC Seminar
ORGANIZER;CN="IBEC":MAILTO:www.ibecbarcelona.eu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20221111T100000
DTEND;TZID=Europe/Madrid:20221111T120000
DTSTAMP:20260404T105843
CREATED:20221104T105722Z
LAST-MODIFIED:20221104T105722Z
UID:100305-1668160800-1668168000@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Astrid Viciano
DESCRIPTION:Is the price of pharmaceutical drugs justified?\nAstrid Viciano\, IBEC \n10 euros\, 1000 euros\, or rather 1 million? Many new medicines that have recently reached the market are prohibitively expensive. But are these prices justified? Science reporter Astrid Viciano has investigated the high prices of innovative therapies. For these investigations\, she received a number of European journalism stipends. \nViciano will explain how the pharmaceutical industry calculates prices for new drugs\, and who currently determines the costs for new medications in different healthcare systems. Looking into different\, concrete examples such as the drug Zolgensma for the treatment of spinal muscular atrophy\, she will point out how drugs are currently developed and approved\, and how medications for orphan diseases are developed. Moreover\, looking into historic examples such as insulin\, she will look into why access to potentially life-saving drugs is still not guaranteed in all regions of the world\, an urgent problem the Covid-19 pandemic has highlighted in the past two years. \n\nDr. Astrid Viciano has been working as a science journalist for German national media such as Süddeutsche Zeitung\, Die Zeit\, Spiegel\, and GEO for more than 20 years. \nShe has worked in a variety of European cross-border teams\, focusing on in-depth investigative science reporting.  From 2012 to 2016\, she worked as a freelance reporter from Paris\, and from 2009 and 2011 in Los Angeles. She has published articles in German\, English\, Dutch and Spanish. Viciano has won several national and international journalism awards\, grants\, and fellowships. \nAstrid Viciano is a medical doctor with a doctorate in immunology and virology and also has an M.A. in Specialized Journalism (USC Annenberg ’11). Currently she is „journalist-in-residence“ at IBEC. She holds the Spanish and German nationalities.
URL:https://ibecbarcelona.eu/event/ibec-seminar-astrid-viciano/
LOCATION:Sala Dolors Aleu\, Cluster II\, IBEC\, Baldiri i Reixac\, Barcelona
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20221202T100000
DTEND;TZID=Europe/Madrid:20221202T140000
DTSTAMP:20260404T105843
CREATED:20221124T124127Z
LAST-MODIFIED:20221124T124856Z
UID:102173-1669975200-1669989600@ibecbarcelona.eu
SUMMARY:Sostenibilidad en el PCB (spanish)
DESCRIPTION:En este seminario\, Glòria Pladellorens\, jefa de Calidad\, Seguridad y Medio Ambiente del PCB\, nos explicará todas las acciones que se están llevando a cabo desde PCB para avanzar hacia un parque científico más sostenible. \nEl comité de sostenibilidad ha invitado a Glòria a dar esta charla que será una muy buena oportunidad para resolver todas esas dudas que nos planteamos y compartir nuestras inquietudes e ideas para tener un entorno de trabajo más sostenible. \n  \nThis seminar will be in Spanish\, a translated report will be prepared and distributed among the non-Spanish speakers. \nAll members of research groups in the process of My green lab certification are strongly encouraged to attend.
URL:https://ibecbarcelona.eu/event/sostenibilidad-en-el-pcb-spanish/
LOCATION:Sala Dolors Aleu\, Cluster II\, IBEC\, Baldiri i Reixac\, Barcelona
CATEGORIES:IBEC Seminar
ORGANIZER;CN="IBEC":MAILTO:www.ibecbarcelona.eu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20221221T113000
DTEND;TZID=Europe/Madrid:20221221T133000
DTSTAMP:20260404T105843
CREATED:20221214T140135Z
LAST-MODIFIED:20221214T140135Z
UID:102662-1671622200-1671629400@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Xavier Rovira-Clavé
DESCRIPTION:Epitope barcoding and subcellular high-plex imaging reveal clonal tumor patch behaviors\nXavier Rovira-Clavé\, PhD \nIntratumoral heterogeneity is a seminal feature of human tumors contributing to tumor progression and response to treatment. Current technologies are still largely unsuitable to accurately track phenotypes and clonal evolution within tumors\, especially in response to genetic manipulations. In this seminar I will present our recent development of epitopes for imaging using combinatorial tagging (EpicTags)\, which we coupled to multiplexed ion beam imaging (EpicMIBI)\, for in situ tracking of barcodes within tissue microenvironments. Using EpicMIBI\, we dissected the spatial component of cell lineages and phenotypes in xenograft models of small-cell lung cancer. We observed emergent properties from mixed clones leading to the preferential expansion of clonal patches for both neuroendocrine and non-neuroendocrine cancer cell states in these models. In a tumor model harboring a fraction of PTEN-deficient cancer cells\, we observed a non-autonomous increase of clonal patch size in PTEN wild-type cancer cells. Thus\, EpicMIBI facilitates in situ interrogation of cell-intrinsic and cell-extrinsic processes involved in intratumoral heterogeneity and it is posed to help reveal principles and mechanisms of tissue developmental processes\, in both normal and malignant growth\, that will thus accelerate therapeutic discoveries. \n\nDr. Xavier Rovira-Clavé is an instructor in the laboratory of Professor Garry Nolan in the Department of Microbiology and Immunology at Stanford University\, where he develops and applies multiparameter technologies to study tissue biology in models of cancer and infectious diseases. In 2016\, he received his PhD in Immunology from the University of Barcelona under the supervision of Dr. Enric Espel and Dr. Manuel Reina. He also trained for a year in cancer biology studies as a visiting PhD student in the group of Dr. Gregory Emery at the University of Montreal. He has published 12 articles\, including some in leading journals such as Cancer Cell and Immunity. He holds 3 granted patents. He has received 5 competitive fellowships\, including the prestigious LLS Career Development Award and the EMBO postdoctoral fellowship. His areas of research include cancer\, the immune system\, and infectious diseases. His technical expertise includes highly multiplexed tissue imaging (spatial proteomics)\, single-cell assays\, molecular biology approaches\, cell culture\, in vitro co-culture systems\, engineered tumors\, murine models\, genome editing\, bioconjugation strategies\, assay automation\, and single-cell spatial data analysis. His recent research efforts have been focused in the development of imaging technologies to subcellularly locate structurally unmodified drugs at the nanometer scale\, track subclonal growth in situ\, and co-detect multiple biomolecular species (RNA\, DNA\, and protein) to enable new understanding of spatial structures at the molecular\, cellular and tissue levels with the long-term goal to improve disease management. \n 
URL:https://ibecbarcelona.eu/event/ibec-seminar-xavier-rovira-clave/
LOCATION:Sala Dolors Aleu\, Cluster II\, IBEC\, Baldiri i Reixac\, Barcelona
CATEGORIES:IBEC Seminar
ORGANIZER;CN="IBEC":MAILTO:www.ibecbarcelona.eu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20230111T120000
DTEND;TZID=Europe/Madrid:20230111T130000
DTSTAMP:20260404T105843
CREATED:20230109T085957Z
LAST-MODIFIED:20230109T102957Z
UID:103479-1673438400-1673442000@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Manuel Valero
DESCRIPTION:The role of inhibition in hippocampal coding\nManuel Valero\, PhD NYU Neuroscience Institute\, New York University (US) \nThe fundamental computation a single neuron performs is to integrate incoming excitatory and inhibitory inputs to decide whether to fire an action potential and feedback its activity into the network. Investigation of this synaptic computation requires access to the neuron subthreshold dynamics\, whose state-of-art methodologies have remained unaltered for decades and are unrealistic for cell assemblies and behaving animals.\nInstead of intracellular recording\, we propose a method to optogenetically probe the membrane polarization of the cells with short depolarizing pulses using chronically implanted µLED probes (4 shanks with 3 µLED/shank). Light-sensitive neurons responded to one or more µLEDs and the spike numbers were used as a proxy for estimating relative changes in the membrane potential dynamics. Strikingly\, induced spike responses gain sharply increased several-folds inside the preferred position (place fields) of the responsive cells. These results are compatible with a tuning curve model in the CA1 pyramidal cells where excitation and inhibition display a concerted and reciprocal relationship. When optogenetic stimulation was probed on non-place cells\, majority of the putative non-place cells showed place-related activity. Finally\, we optically probed neurons around sharp wave-ripples (SPW-Rs)\, hippocampal events considered a key mechanism for memory consolidation and action planning. In the short time window of SPW-R\, excitatory and inhibitory neurons increased in parallel. As expected\, optogenetic probing of the CA1 networks showed that\, in contrast to the large gain within place fields\, responsivity of pyramidal cells showed a robust decrease during SPW-Rs.\nWe have developed a method for studying the subthreshold dynamics of individual cells in chronic recordings using novel high-resolution optical stimulation as a proxy for membrane polarization. These experiments disclosed a reciprocal interaction between inhibition and excitation along the place fields of CA1 and demonstrated that the same exact perturbation can bring about opposite responses during exploration and transient SPW-Rs. \n\n  \n 
URL:https://ibecbarcelona.eu/event/ibec-seminar-manuel-valero/
LOCATION:Sala Dolors Aleu\, Cluster II\, IBEC\, Baldiri i Reixac\, Barcelona
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20230120T100000
DTEND;TZID=Europe/Madrid:20230120T120000
DTSTAMP:20260404T105843
CREATED:20230109T095712Z
LAST-MODIFIED:20230109T095712Z
UID:103484-1674208800-1674216000@ibecbarcelona.eu
SUMMARY:IBEC Seminar (online): Sam Hall
DESCRIPTION:Presentation of Open Research Europe publishing plataform\nSam Hall\, from Open Research Euorpe \nOpen Research Europe is the European Commission’s open access publishing platform for research stemming from Horizon 2020 and Horizon Europe funding. In this webinar Senior Content Acquisition Editor Sam Hall will show how the platform enables the rapid dissemination of results and facilitates open and constructive research discussion\, and maximizes the discoverability and credit for researchers and their work. Sam will also explain the funder-pays model which means that all publication fees are met by the European Commission at no cost to the researcher or the project. \n\nSam Hall is a Senior Content Acquisition Editor for F1000\, commissioning articles and Collections for Open Research Europe. Launched in March 2021\, Open Research Europe is an open access publishing Platform for research stemming from Horizon 2020\, Horizon Europe and/or Euratom funding across all subject areas. Within this broad remit\, Sam focusses on the research area of Engineering and Technology\, and most recently the Data Note article type. Sam has almost 10 years of experience working in publishing\, and in this time has worked in contrasting companies and settings. This has included society publishers\, start-ups\, and international governmental organizations. \nLink Teams here
URL:https://ibecbarcelona.eu/event/ibec-seminar-online-sam-hall/
LOCATION:Online
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20230217T100000
DTEND;TZID=Europe/Madrid:20230217T120000
DTSTAMP:20260404T105843
CREATED:20230202T144717Z
LAST-MODIFIED:20230202T144717Z
UID:103953-1676628000-1676635200@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Presentation of the new Programme of ”la Caixa” Foundation on Innovation in Biomedicine and Health
DESCRIPTION:Alexandre Esteban\, Programme Manager at ”la Caixa” Foundation\nDuring the event\, all the details of the new Innovation programme will be presented\, with which the “la Caixa” Foundation reinforces its commitment to innovation and knowledge transfer in Spain and Portugal. \nThis new programme will fund breakthrough technologies with high market potential.
URL:https://ibecbarcelona.eu/event/ibec-seminar-presentation-of-the-new-programme-of-la-caixa-foundation-on-innovation-in-biomedicine-and-health/
LOCATION:Sala Dolors Aleu\, Cluster II\, IBEC\, Baldiri i Reixac\, Barcelona
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20230413T150000
DTEND;TZID=Europe/Madrid:20230413T170000
DTSTAMP:20260404T105843
CREATED:20230328T155642Z
LAST-MODIFIED:20230328T155642Z
UID:106462-1681398000-1681405200@ibecbarcelona.eu
SUMMARY:IBEC Seminar: David Caballero
DESCRIPTION:Engineering the cancer: from biomaterials to on-chip solutions\nDavid Caballero; Research Institute on Biomaterials\, Biodegradables and Biomimetics\, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine\, University of Minho\, Portugal. \nCancer is a complex and multifaceted pathology\, which is influenced by numerous factors\, including the tumor microenvironment (TME). This environment is composed of various of components that interact in a tightly regulated manner\, affecting cancer cell behavior and response to treatment. Building realistic models of the TME is therefore essential for improving our knowledge of cancer pathophysiology and developing more effective therapies. In recent years\, there has been growing interest in using precisely-engineered biomaterials and microphysiological systems to create accurate 3D in vitro models of the TME. These models can provide a more physiologically-relevant habitat for studying fundamental aspects of cancer biology and for performing drug screening. Additionally\, when combined with organ-on-a-chip technology\, these models offer a high degree of biomimicry and control\, allowing for a precise recreation and better understanding of key biological functions of the native TME\, surpassing what traditional platforms can achieve. In this lecture\, I will present our latest works utilizing biomimetic materials and on-chip systems as powerful preclinical tools for engineering realistic in vitro models of the TME to study key aspects of tumorigenesis\, for drug screening/discovery purposes\, and for disease diagnosis applications.
URL:https://ibecbarcelona.eu/event/ibec-seminar-david-caballero/
LOCATION:Sala Dolors Aleu\, Cluster II\, IBEC\, Baldiri i Reixac\, Barcelona
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20230426T110000
DTEND;TZID=Europe/Madrid:20230426T110000
DTSTAMP:20260404T105843
CREATED:20230412T131424Z
LAST-MODIFIED:20230412T131618Z
UID:107088-1682506800-1682506800@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Dr. Ubaka Ogbogu
DESCRIPTION:Foregrounding justice\, equity and inclusion as determinants of access to precision medicine: an ethical case study of patient-derived tissue organoids.\nDr. Ubaka Ogbogu\, Professor and the Associate Dean Research in the Faculty of Law from the University of Alberta\, Canada.  \nUbaka Ogbogu is a Professor and the Associate Dean Research in the Faculty of Law. He is also the Chair of the University of Alberta Research Ethics Board 2 and the Katz Research Fellow in Health Law and Science Policy. Dr. Ogbogu is a recipient of the Confederation of Alberta Faculty Associations Distinguished Academic Early Career Award. He holds a doctorate in law from the University of Toronto\, a Master of Laws degree from the University of Alberta and undergraduate degrees in law from the University of Benin\, Nigeria and the Nigerian Law School. \nOgbogu’s scholarly work is focused broadly on the ethical\, legal and societal implications of novel and emerging biotechnologies and associated research. His publications have explored a diverse range of issues in this field\, including the ethical and legal issues associated with stem cell research\, gene and engineered cell therapies\, biobanks\, germline gene editing. In his talk\, Prof. Obgobu will reflect about these issues and also discuss how foregrounding justice\, equity and inclusion are elements that impact on access to precise medicine. \nHe has been invited to IBEC by Nuria Montserrat. \n  \n 
URL:https://ibecbarcelona.eu/event/ibec-seminar-dr-ubaka-ogbogu/
LOCATION:Sala Dolors Aleu\, Parc Científic de Barcelona\, Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20230428T120000
DTEND;TZID=Europe/Madrid:20230428T133000
DTSTAMP:20260404T105843
CREATED:20230309T155632Z
LAST-MODIFIED:20230426T104601Z
UID:105698-1682683200-1682688600@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Charles Baroud
DESCRIPTION:Modeling immune-cancer interactions using a microfluidic 3D culture approach\nCharles Baroud\, Professor at Ecole Polytechnique\, France\nLab head at Institut Pasteur\, Paris\, France \nCancer immunotherapy is emerging as a transformative approach for treating cancer patients. This approach\, which has shown some remarkable successes\, leverages the patient’s own immune cells to locate and attack the tumor cells. However the method suffers from large heterogeneities in outcomes between different patients\, in part due to the the number\, phenotype\, and distribution of cytotoxic T cells (CTLs) around the tumor cells. For this reason decoding the collective behavior of CTLs\, as they recognize and attack cancer cells\, is a major challenge that requires advanced in vitro models. This seminar will present a microfluidic platform that enables quantitative measurements of the spatiotemporal dynamics of individual CTLs as they migrate in three-dimensional (3D) environments and attack cancer spheroids. The method provides access to the trajectories of thousands of cells around hundreds of spheroids\, which in turn enables probabilistic modeling of the trajectories. Analysis of the migration and killing events allows us to dissect the different phases of interactions and to identify limiting steps for different conditions. The talk will present the microfluidics and then shift focus to different biological models\, with implications for both fundamental biology and for personalized medicine. \n\n 
URL:https://ibecbarcelona.eu/event/ibec-seminar-charles-baroud/
LOCATION:Sala Dolors Aleu\, Cluster II\, IBEC\, Baldiri i Reixac\, Barcelona
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20230526T110000
DTEND;TZID=Europe/Madrid:20230526T130000
DTSTAMP:20260404T105843
CREATED:20230315T112426Z
LAST-MODIFIED:20230315T113622Z
UID:105907-1685098800-1685106000@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Raphael Voituriez
DESCRIPTION:Cellular footprints : examples of emergent memory effects in cell migration.\nRaphael Voituriez\, Laboratoire Jean Perrin / Laboratoire de Physique Théorique de la Matière Condensée CNRS / Sorbonne Université\n \nLiving cells actively migrate in their environment to perform key biological functions—from unicellular organisms looking for food to single cells such as fibroblasts\, leukocytes or cancer cells that can shape\, patrol or invade tissues. Cell migration results from complex intracellular processes that enable cell self-propulsion\, and has been shown to also integrate various chemical or physical extracellular signals. While it is established that cells can modify their environment by depositing biochemical signals or mechanically remodelling the extracellular matrix\, the impact of such self-induced environmental perturbations on cell trajectories at various scales remains broadly unexplored. I will discuss examples where such interactions with the environment can have deep consequences on the large scale cell dynamics\, and show that they can effectively endow cells with a memory of their past trajectory.
URL:https://ibecbarcelona.eu/event/ibec-seminar-raphael-voituriez/
LOCATION:Sala Dolors Aleu\, Cluster II\, IBEC\, Baldiri i Reixac\, Barcelona
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20230529T123000
DTEND;TZID=Europe/Madrid:20230529T140000
DTSTAMP:20260404T105843
CREATED:20230515T084601Z
LAST-MODIFIED:20230518T115408Z
UID:107973-1685363400-1685368800@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Anthony J. Ryan OBE
DESCRIPTION:Making Science Work for Refugees and Refugees Work for Science\nProf Anthony J. Ryan\, OBE\, University of Sheffield\, UK \nAt Zaatari refugee camp\, 80\,000 people face daily struggles that many of us cannot imagine are squeezed into six square kilometres. With highly qualified jobs at home\, they are forcibly unemployed at the camp but embody values that are often forgotten by those of us in more privileged parts of the world: an adaptable approach to solving problems\, an aversion to waste\, a sense of community. Our research on hydroponics is focussed on the production of high-value crops close to market (urban farming) with a low carbon and water footprint using polyurethane foam as synthetic soil. I will show how a design of experiments approach can predict the productivity of crops from the reagents used in polyurethane synthesis through the properties of the foam.\nWe connected our work on synthetic soils with a waste disposal problem posed by UNHCR – the UN’s refugee agency. Where they saw dirty unused mattresses\, we saw an alternative growth substrate. In doing so we developed small-scale hydroponics at the household and community scale. We responded to the frequent cry of the Syrian refugees – that they miss the colour green – not only did we find a technical fix\, but also an impact on well-being. This benefits our work in Sheffield\, we now have an urban farm built using the low-cost technology developed in Zaatari with farmers from Syria. \n\nProfessor Tony Ryan OBE is The Professor of Physical Chemistry at the University of Sheffield and the founding Director of the Grantham Centre for Sustainable Futures.\nTony’s research interests include sustainable synthesis\, structure\, processing\, and applications of polymers using advanced analytical and measurement techniques. Recent research projects included renewable sources for polyurethane synthesis\, organic photovoltaics\, maximising the properties of polymers and biopolymers through flow-induced crystallisation\, formulation of home and personal care products and polymer foams for high-intensity urban agriculture. He has co-authored more than 300 papers and patents and 2 books\, “Polymer Processing and Structure Development” and “The Solar Revolution: One Planet\, 10 Billion People\, One Solution.”\nMore recently\, Tony has been focussing on the global challenge of the food\, water\, and energy nexus; feeding a growing world population. Tony is very active in translational research\, disseminating evidence-based science to both experts and non-experts and has been a regular contributor to TV\, Radio\, National Press and learned societies from The Royal Society of Chemistry to Chatham House\, The Royal Institute of International Affairs. He presented evidence at the UNFCCC COP21 in Paris in 2015 and returned to COP22 in Marrakech in 2016. Tony delivered the televised Royal Institution Christmas Lectures in 2002 and was awarded an OBE in 2006 for ‘Services to Science’.\nTony holds a BSc and PhD from the University of Manchester and a DSc from UMIST. He held a NATO Research Fellowship at the University of Minnesota\, was a Lecturer\, Senior Lecturer and Reader in Materials Science at The University of Manchester and was seconded to the Synchrotron Radiation Source at Daresbury. In 1997 he moved to Sheffield and served as Head of Chemistry before becoming the Pro Vice Chancellor for the Faculty of Science in 2008\, a role which he fulfilled until 2016.
URL:https://ibecbarcelona.eu/event/ibec-seminar-anthony-j-ryan/
LOCATION:Sala Dolors Aleu\, Cluster II\, IBEC\, Baldiri i Reixac\, Barcelona
CATEGORIES:IBEC Seminar
ORGANIZER;CN="IBEC":MAILTO:www.ibecbarcelona.eu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20230606T093000
DTEND;TZID=Europe/Madrid:20230606T110000
DTSTAMP:20260404T105843
CREATED:20230503T152810Z
LAST-MODIFIED:20230503T152810Z
UID:107647-1686043800-1686049200@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Danny Hatters
DESCRIPTION:Protein interactions gone awry in neurodegenerative disease\nDanny Hatters\, Department of Biochemistry and Pharmacology | Faculty of Medicine\, Dentistry and Health Sciences\nThe University of Melbourne\,  Australia\n \nThe Hatters lab studies impacts of protein misfolding and aggregation in cultured cell models of neurodegenerative diseases. We have developed approaches to examine principles governing how proteins inappropriately aggregate and new approaches with chemical reagents to monitor cysteine reactivity to probe changes in proteome foldedness and conformation. I will discuss recent findings from our laboratory that provide insight to the consequences of protein aggregation by globular proteins\, and how we can model the types of protein-protein interactions that are involved. I will also discuss how we can monitor changes in protein structure and function in response to stresses and stimuli\, and under conditions of disease in Huntington Disease.
URL:https://ibecbarcelona.eu/event/ibec-seminar-danny-hatters/
LOCATION:Sala Dolors Aleu\, Cluster II\, IBEC\, Baldiri i Reixac\, Barcelona
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20230619T123000
DTEND;TZID=Europe/Madrid:20230619T133000
DTSTAMP:20260404T105843
CREATED:20230502T111657Z
LAST-MODIFIED:20230607T134735Z
UID:107616-1687177800-1687181400@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Amnon Buxboim
DESCRIPTION:How does ageing-related stiffening of brain tissue microenvironments affect the regenerative capacity of cns progenitor cells\nProfessor of biology and bioengineering\, the Hebrew University of Jerusalem\, Israel. \nAgeing-related stiffening of neuronal microenvironments in the brain generates potent signals that attenuate the regenerative capacity of oligodendrocyte progenitor cells (OPCs) to proliferate and differentiate. We find that ageing drives substantial remolding of the nuclear lamina in OPCs\, in which A-type lamin levels increase and B-type lamin expression decreases. Owing to the ubiquitous role of lamins in anchoring mostly heterochromatic sections at the nuclear envelope known as lamina associated domains (LAD’s)\, we hypothesized that ageing effects are mediated via altered genomic organization and regulation. In this study\, we isolate OPCs from neonate and aged rats and study the effects of ageing-related tissue stiffening by designing and optimizing hydrogel-based matrices that mimic the extracellular elasticity and adhesion signals of neonate and aged microenvironments. Indeed\, the differences in cellular morphologies and lamina compositions between neonate and aged cells are recapitulated by matrix elasticity. To characterize differences in the structural organization of the nuclear lamina\, we combine high-resolution optical and electron microscopies and perform micropipette aspiration based rheology to define the viscoelastic properties of OPC nuclei within intact cells. LAD mapping is performed using optimized CUT&RUN assays that target endogenous lamin-B1\, thus avoiding the effects of ectopic expression of nuclear envelope proteins\, which is a prerequisite by standard methodologies. Downstream effects on transcriptional regulation are studied via single-cell RNA sequencing (scRNA-seq)\, thus providing insight into cell-to-cell variations. In summary\, our work-in-progress highlights the mechanobiological component of ageing on progenitor cells of the CNS that can stimulate potential therapeutic strategies. \n\nDr. Amnon Buxboim is a professor of biology and bioengineering\, the Hebrew University of Jerusalem\, Israel. Trained as a biophysicist\, he opened the Buxboim Lab for Mechanobiology in 2013. Dr. Buxboim research aims at understanding how physical and mechanical inputs combine with parallel signaling pathways to direct cell-fate decision-making processes. The Buxboim Lab studies oocyte maturation\, preimplantation embryo development\, stromal bone marrow immunomodulation\, and CNS stem/progenitor cell ageing. Dr. Buxboim also studies mechanisms of nuclear mechanotransduction\, as mediated via nuclear lamins and associated nuclear envelope proteins. The Buxboim Lab combines established assays\, advanced computational tools\, newly designed device-based technologies\, and integrates single-cell level genomics with micro-rheological measurements. Based on his research findings\, Dr. Buxboim develops assisted reproductive technologies to advance and improve medical care.
URL:https://ibecbarcelona.eu/event/ibec-seminar-amnon-buxboim/
LOCATION:Sala Dolors Aleu\, Cluster II\, IBEC\, Baldiri i Reixac\, Barcelona
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20230620T113000
DTEND;TZID=Europe/Madrid:20230620T133000
DTSTAMP:20260404T105843
CREATED:20230502T111443Z
LAST-MODIFIED:20230607T134316Z
UID:107614-1687260600-1687267800@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Magali Suzanne
DESCRIPTION:Mechanical impact of cell delamination on tissue dynamics\, in developmental and tumoral contexts\nCentre de Biologie Intégrative\, CNRS/UMR 5088\, Université Toulouse III\, Toulouse\, France \nHow mechanical forces drive morphogenesis is a fundamental question in the field of biomechanics. Combining imaging\, genetics\, biophysical and modeling approaches\, we found that apoptotic cells\, far from being eliminated passively\, exert a force before dying and thus actively participate in tissue remodeling. This transient force\, generated in the depth of the epithelium\, constitute a mechanical signal involved in tissue folding. Comparing apoptotic cell dynamics to cells undergoing EMT\, we found that a very similar apico-basal force is generated at the onset of EMT.\nWe further deciphered how these forces are transmitted at the tissue scale through the characterization of a specific mechanical state favoring directional force transmission and developed a new method that offers the opportunity to extract automatically\, in strongly deformed epithelia\, a precise characterization of the spatial organization of a given cytoskeletal network combined to morphological quantifications in highly remodeled 3D epithelial tissues.\nIn parallel\, we turned to cancer mechanics\, focusing particularly in tumor progression. Cancer is a largely widespread pathology that corresponds to an overproliferation of cells that could finally invade others tissues. Tumors develop through three increasingly aggressive steps: (1) hyperplasia\, which corresponds to cells overproliferation; (2) dysplasia\, during which cells can acquire a more mesenchymal phenotype\, and finally (3) metastasis. Tumor development can be influenced by mutations but also by external factors\, such as extracellular matrix rigidity. However\, a comprehensive understanding of the intrinsic factors driving tumor evolution is still lacking. Our recent unpublished work identifies unexpected factors that could influence tumor development\, and more specifically the hyperplasia/dysplasia transition\, a critical step in tumor aggressiveness. This work highlights puzzling differences between developmental and tumoral mechanics.
URL:https://ibecbarcelona.eu/event/ibec-seminar-magali-suzanne/
LOCATION:Sala Dolors Aleu\, Cluster II\, IBEC\, Baldiri i Reixac\, Barcelona
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20230628T120000
DTEND;TZID=Europe/Madrid:20230628T130000
DTSTAMP:20260404T105843
CREATED:20230626T100738Z
LAST-MODIFIED:20230626T103836Z
UID:109214-1687953600-1687957200@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Dr. Benjami Oller-Salvia
DESCRIPTION:Development of chemical and synthetic biology tools to generate biotherapeutics and to tackle brain diseases\nDr. Benjami Oller-Salvia\, IQS \nIn our group we develop chemical and synthetic biology tools to generate biotherapeutics and to tackle brain diseases. In the first part of the talk\, I will report our efforts toward developing strategies to construct conditionally-active biotherapeutics that target antigens considered undruggable. In the second part of the talk\, I will present our work on peptides for drug delivery across the blood brain barrier. There\, I will highlight the recent development of a new family of bicyclic brain shuttles and provide a hint toward new ways of exploring brain transport. .
URL:https://ibecbarcelona.eu/event/ibec-seminar-dr-benjami-oller-salvia/
LOCATION:Sala Dolors Aleu\, Cluster II\, IBEC\, Baldiri i Reixac\, Barcelona
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20230705T100000
DTEND;TZID=Europe/Madrid:20230705T110000
DTSTAMP:20260404T105843
CREATED:20230615T143306Z
LAST-MODIFIED:20230615T143306Z
UID:108630-1688551200-1688554800@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Theodore Alexandrov
DESCRIPTION:Spatial single-cell metabolomics reveals metabolic cell states\nEMBL \nRecent discoveries put metabolism into the spotlight. Metabolism not only fuels cells but also plays key roles in health and disease. In parallel\, emerging single-cell technologies opened a new world of cell types and states previously hidden beneath population averages. Yet\, methods for discovering links between metabolism\, cell states\, metabolic plasticity and reprogramming on the single-cell level and in situ are crucially lacking. Our research aims to contribute bridging this gap. First\, we will present how the emerging technology of imaging mass spectrometry can be used for the spatial profiling of metabolites\, lipids\, and drugs in tissues. These efforts are enabled by our big data community cloud platform METASPACE which is increasingly used across the world. Next\, we will present method SpaceM for spatial single-cell metabolomics. SpaceM detects 100+ metabolites or 500+ lipids from thousands of individual cells together with fluorescence and morpho-spatial features. We used SpaceM to characterize how stimulating human hepatocytes with fatty acids led to the emergence of two co-existing subpopulations outlined by distinct cellular metabolic states. Inducing inflammation with the cytokine IL-17A perturbs the balance of these states in a process dependent on NF-κB signalling. We will show how a high-throughput version of the SpaceM method helps discover and characterize metabolic states of activated CD4+ T cells from peripheral human blood. Finally\, we will present how spatial multi-omics can reveal the relationships between cell types and cell states in tissues. Overall\, such methods can open novel avenues for understanding metabolism in tissues and cell cultures on the single-cell level.
URL:https://ibecbarcelona.eu/event/ibec-seminar-theodore-alexandrov/
LOCATION:Sala Dolors Aleu\, Cluster II\, IBEC\, Baldiri i Reixac\, Barcelona
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20230712T120000
DTEND;TZID=Europe/Madrid:20230712T130000
DTSTAMP:20260404T105843
CREATED:20230705T112820Z
LAST-MODIFIED:20230705T112820Z
UID:109532-1689163200-1689166800@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Loris Rizzello
DESCRIPTION:Towards an evolutionary-driven universal therapy against (intracellular) pathogens\nUniversità degli Studi di Milano \nWe are living a time where we believe antibiotics are the cornerstone of any infectious disease-based therapy. It is definitely out of question that antibiotics saved millions of people worldwide in the last century\, and that they are still doing it very efficiently. Nevertheless\, their extensive abuse\, especially for zoonic applications\, contributed to the rise of antibiotic resistance (AMR). AMR is one of the biggest threats in the current human history because it is estimated that the majority of the antibiotics\, currently used in the clinics\, will be completely ineffective for the eradication of infectious disease. This has been defined as “The New Dark Ages of Antibiotics”\, which is expected to start in the next decades if no actions will be taken now. There are several causes behind AMR\, but one of the most relevant is the exposure of bacteria to sub-lethal doses of the antimicrobials. One of the big aim of our research efforts is to design of a new generation of therapy that counteract this issue. It is inspired on solutions already provided by Nature\, and it is based on the strategy exploited by a specific class of viruses that infect and kill bacteria only\, called as bacteriophages\, which are completely safe and unharmful to humans. The development of a new therapy possessing the requirements to avoid the rise in AMR represents a new legacy for the future generation in terms of anitibacterial therapies\, exaclty in the same way antibiotics changed the human history in the 20th century.
URL:https://ibecbarcelona.eu/event/ibec-seminar-loris-rizzello/
LOCATION:Sala Dolors Aleu\, Cluster II\, IBEC\, Baldiri i Reixac\, Barcelona
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20230712T150000
DTEND;TZID=Europe/Madrid:20230712T170000
DTSTAMP:20260404T105843
CREATED:20230705T111505Z
LAST-MODIFIED:20230706T123428Z
UID:109529-1689174000-1689181200@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Zev Gartner
DESCRIPTION:Building tissues to understand how tissues build themselves\nZev Gartner\, UCSF \nCells assemble into tissues and organs through an active process termed self-organization. Harnessing tissue self-organization will ultimately advance applications as diverse as disease modeling and regenerative medicine\, while revealing new strategies for fighting disease. However\, progress towards these applications is limited by our incomplete understanding of how the properties of tissues emerge from their cellular building blocks.  I will discuss two recent projects that aim to address this knowledge gap.  In a first project\, we use human mammary organoids to make the remarkable observation that tissues can behave as dynamic structural ensembles. We model the ensemble using a maximum entropy framework\, and demonstrate the probability distribution of tissue structures is a function of the entropy associated with cell arrangements\, the energy associated with cell interfaces\, and mechanical fluctuations associated with cell motility.  We map these parameters back to measurable molecular and mechanical properties of cells and their microenvironment\, allowing us to engineer the structural ensemble quantitatively and systematically.  In a second project we use the morphogenesis of mouse intestinal villi to reveal that tuning the geometry and active mechanics of the epithelial/mesenchymal interface is sufficient to sculpt a diversity of tissue forms. In the gut\, MMP and Myosin-II dependent fluidization of a contractile and adhesive sub-epithelial mesenchyme results in a dynamic monolayer of cells with a high surface tension. Minimization of surface energy results in a process we call “mesenchymal de-wetting\,”  which results in the formation of an array of multicellular condensates that act to pattern and fold the overlying epithelium. Manipulating the properties of the cells or the interface results in predictable changes to the pattern and shape of the folds. These studies have some important implications for tissue engineering\, disease progression\, and our understanding of tissue self-organization in other contexts.
URL:https://ibecbarcelona.eu/event/ibec-seminar-zev-gartner/
LOCATION:Sala Dolors Aleu\, Cluster II\, IBEC\, Baldiri i Reixac\, Barcelona
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20230712T160000
DTEND;TZID=Europe/Madrid:20230712T170000
DTSTAMP:20260404T105843
CREATED:20230706T124124Z
LAST-MODIFIED:20230706T124124Z
UID:109536-1689177600-1689181200@ibecbarcelona.eu
SUMMARY:IBEC-IFIBYNE Webinar Cycle (online) 12th July 2023 at 16:00 Javier Ramon
DESCRIPTION:Organ on a chip models to emulate multi systemic metabolic diseases\nJavier Ramon\, IBEC \nExisting on-chip tissue models typically represent a single organ\, limiting systemic drug investigations. Microscale tissue analog systems aim to improve drug and toxicity predictions across various organs. However\, multi-organ devices are limited\, and none have explored skeletal muscle and pancreatic islets. We developed a novel multi-organ-on-a-chip platform for real-time\, sensitive monitoring of cross-talk between two organs. Unlike previous electrochemical platforms\, our sensing system offers cost-effectiveness\, label-free detection\, easy integration\, multiplexing\, and real-time monitoring. This platform quantifies secreted proteins with high sensitivity\, crucial for understanding the relationship between skeletal muscle and the pancreas. Our work shows promise for disease modeling\, drug screening\, and personalized medicine. \n\nDoctor Javier Ramon is an ICREA Professor since 2021 and the leader of the Biosensors for Bioengineering group at the Institute of Bioengineering of Catalonia. Javier studied Chemistry at the University of Catalonia and completed his PhD at the CSIC in the Institute of Advanced Chemistry of Catalonia. He conducted his postdoctoral research in Japan at the Advanced Institute of Materials and returned to Spain in 2016 as a Ramon y Cajal researcher. His research is focused on tissue engineering\, biomaterials\, biosensors\, and integrating these technologies into organ-on-chip devices to study diseases and drug screening.
URL:https://ibecbarcelona.eu/event/ibec-ifibyne-webinar-cycle-online-12th-july-2023-at-1600-javier-ramon/
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20230718T100000
DTEND;TZID=Europe/Madrid:20230718T113000
DTSTAMP:20260404T105843
CREATED:20230712T092151Z
LAST-MODIFIED:20230712T092151Z
UID:109754-1689674400-1689679800@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Dan Vigneron
DESCRIPTION:Translation and Initial Patient and Volunteer Studies with Hyperpolarized Carbon-13 MR Molecular Imaging\nDan Vigneron\, Department of Radiology & Biomedical Imaging\, University of California San Francisco \n“Hyperpolarized (HP) carbon-13 MRI is an emerging molecular imaging method to monitor enzymatic conversions through key\, previously-inaccessible biochemical pathways. Over 1000 human HP carbon-13 MR studies to date have shown outstanding research and potential clinical value. Just as MRI has shown value for medical imaging providing information beyond CT/X-ray\, HP C-13 MRI can provide new isotope imaging biomarker information in addition to what PET & SPECT do. HP C13 MRI is safe\, ~2min\, non-radioactive addition to standard-of-care MRI exams\, at costs less than separate PET exam. At the UCSF Hyperpolarized MRI Technology Resource Center\, we are developing new techniques for rapid dynamic acquisitions to measure HP conversion rates for [1-13C]pyruvate to [1-13C]lactate\, [1-13C]alanine and 13C-bicarbonate in the abdomen\, pelvis\, heart and brain to monitor cellular metabolism in normal tissues and pathologies. We are conducting over 15 clinical trials of HP C-13 MRI and have translated 4 different HP probes into first human studies: [1-13C]pyruvate\, [2-13C]pyruvate\, [1-13C]alpha-ketoglutarate\, and 13C-urea. Initial results demonstrate the ability to detect cancer aggressiveness\, response to therapy\, cardiac disease and brain bioenergetics. \n\nDr. Daniel B. Vigneron Ph.D. is a Professor in the Department of Radiology & Biomedical Imaging and at the University of California\, San Francisco. He also has joint appointments in the Departments of Bioengineering & Therapeutic Sciences and Neurological Surgery at UCSF and is a member of the UCB/UCSF Bioengineering graduate group. He directs the UCSF Human Imaging Core and the Advanced Imaging Technologies Resource Group that facilitates imaging technique development in the Department of Radiology & Biomedical Imaging including: Hyperpolarized Carbon-13\, PET-MR\, and 7T MR. He also is the Director of the NIH NIBIB-funded Hyperpolarized C-13 MRI Technology Resource Center at UCSF that was recently renewed till 2027 with 20 external collaborative and service projects. This UCSF Hyperpolarized MRI Technology Resource Center also sponsors numerous training and education opportunities including symposia/workshops focused on the development and dissemination of new HP-MRI techniques. Dr. Vigneron was elected Fellow of the International Society of Magnetic Resonance in Medicine in 2009 and to the College of Fellows of the American Institute for Medical and Biological Engineering in 2007. He received the Academy of Radiology Research Distinguished Investigator Award in 2013 and with colleagues was awarded the Gold Medal of the World Molecular Imaging Society in 2014. \nDr. Vigneron obtained his BA in Chemistry from Wesleyan University in Middletown\, Connecticut in 1983\, and he completed his PhD research in Pharmaceutical Chemistry from UCSF in 1988 and then conducted post-doctoral research at the Fox Chase Cancer Center in Philadelphia and at UCSF developing new MRI techniques for characterizing disease and therapy response. Prof. Vigneron’s research is focused on the development of metabolic MRI techniques for research and clinical assessments of human diseases. This research has been reported in over 350 total publications resulting in over 39\,000 citations with an h-index of 109 and an i10-index of 339 and has been funded by 25 NIH grant awards including as PI: 3 P41\, 1 P01 2 U01\, 18 R01 and 1 S10 grant awards. Also\, he has served as the Primary Mentor on 6 NIH career mentored awards. Dr. Vigneron leads the technical development aspects of the hyperpolarized carbon-13 MR program at UCSF and is the Principal Investigator of seven current NIH funded projects focused on new HP metabolic MRI techniques applied to clinical research studies of prostate cancer\, metastatic cancers\, brain disorders and CNS tumors.
URL:https://ibecbarcelona.eu/event/ibec-seminar-dan-vigneron/
LOCATION:Sala Dolors Aleu\, Cluster II\, IBEC\, Baldiri i Reixac\, Barcelona
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20230726T120000
DTEND;TZID=Europe/Madrid:20230726T130000
DTSTAMP:20260404T105843
CREATED:20230724T071319Z
LAST-MODIFIED:20230724T071618Z
UID:110268-1690372800-1690376400@ibecbarcelona.eu
SUMMARY:IBEC Seminar: MDr Joanna Sierpowska
DESCRIPTION:Awake brain surgery mapping – a way to mitigate postsurgical impairments and a door to understanding human cognition\nMDr Joanna Sierpowska from the Department of Cognition\, Development and Educational Psychology\, Institute of Neurosciences\, University of Barcelona \nBrain mapping for language and cognition during awake brain surgeries helps neurosurgeons to mitigate postsurgical impairments. At the same time\, it uncovers the truth about brain functional organization. While the cortical procedures are very well studied and widely implemented since the ’50 of the XX century confirming the classical models of language production\, the work on mapping the white matter pathways has developed very recently. The dual pathway model for language introduces the importance of the perisylvian white matter in the processing of speech sounds and word meaning. In the present talk\, I will explain if the model was successfully confirmed by intraoperative language testing. Furthermore\, I will explain how we assess language function associated with the model perioperatively in a large sample of brain tumor patients. 
URL:https://ibecbarcelona.eu/event/ibec-seminar-mdr-joanna-sierpowska/
LOCATION:Sala Dolors Aleu\, Cluster II\, IBEC\, Baldiri i Reixac\, Barcelona
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20230726T150000
DTEND;TZID=Europe/Madrid:20230726T170000
DTSTAMP:20260404T105843
CREATED:20230712T082101Z
LAST-MODIFIED:20230712T082101Z
UID:109742-1690383600-1690390800@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Matthias Schulze
DESCRIPTION:Highlights of 20 years DNP with Merck as partner\nMatthias Schulze\, Merck \nIntroduction of Merck’s capabilities to supply specifically labeled tracers in different grades.\nDescribing the milestones of DNP towards establishing that method as a powerful tool in cancer diagnostics. Outlining the challenges and the scope on projects utilizing 13 C labeled reagents. \n\nMatthias Schulze studied chemistry at the TU Berlin and gained his PhD in 1991 for research in natural product synthesis. Subsequent stays at various sites abroad (Norman\, Oklahoma and Columbus\, Ohio) extended his expertise in analytical and synthetical techniques. Later\, he worked as a group leader at the University Bonn on mechanistic questions in metal-organic chemistry and new ways to access cyclic natural products. He has 20 years of experience in stable isotopes and its applications in a corporate environment. His current role is that of a technology manager for stable isotopes in EMEA. Ever since he worked with numerous researchers to support them in a broad range of fields\, focusing on biochemical and medicinal topics \n 
URL:https://ibecbarcelona.eu/event/ibec-seminar-matthias-schulze/
LOCATION:Sala Dolors Aleu\, Cluster II\, IBEC\, Baldiri i Reixac\, Barcelona
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20230905T100000
DTEND;TZID=Europe/Madrid:20230905T120000
DTSTAMP:20260404T105843
CREATED:20230724T080449Z
LAST-MODIFIED:20230724T080449Z
UID:110271-1693908000-1693915200@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Virgil Percec
DESCRIPTION:Reprogramming the Factory of Life to Target the Delivery of mRNA via Helical Chirality\nVirgil Percec\, Roy & Diana Vagelos Laboratories\, Department of Chemistry\, University of Pennsylvania\, Philadelphia \nHomochiral helical self-organizations are known at the macroscopic level in nature\, art\, architecture and science for thousands of years [1a\,b]. However\, molecular helicity was discovered in proteins and DNA [2] only in the early 1950th and in molecular\, macromolecular and supramolecular complex nanosystems emerged soon after [1c\,d\,e\,f]. Our ability to program functions at the supramolecular level based on helical chirality is less advanced than the same process at the macroscopic level during Archimedes and Leonardo da Vinci times. The principles “discover-elucidate mechanism-predict programmed primary structure” elaborated in our laboratory and aided by synthetic methodologies developed also in our laboratory for accelerated modular-orthogonal synthesis of programmed structures such us Ni-catalyzed cross-coupling\, mixed-ligand\, thio-bromo click\, SET-organic and polymerizarion reactions\, self-accelerated and self-interrupted synthesis including selected examples of homochiral helical self-organizations and functions together with the molecular factory of life will be briefly explained. The origins of helical homochirality is equivalent to the origins of life although the origins and the rational of biological membranes homochirality continues to be debated [3]. Inspiration from amphiphilic Janus dendrimers [4a] and Janus glycodendrimers [4b] discovered in our laboratory allowed to transit from the commercial viral and four-component lipid nanoparticle synthetic vectors for delivery of mRNA to the one-component ionizable multifunctional sequence-defined amphiphilic Janus dendrimers (IAJDs) delivery vector [5]. The current status of the molecular design principles providing the least expensive and the simplest access to targeted delivery of mRNA with programmed IAJDs will be discussed in great details. Targeted delivery of mRNA to all organs is expected to change the field of nanomedicine at the most fundamental level by providing unprecedented avenues to new vaccines and therapeutics. \nReferences \n\n(a) Percec\, V.; Xiao\, Q. Bull. Chem. Soc. Jpn. 2021\, 94\, 900-928. (b) Percec\, V.; Adamson\, J.; Gianti\, E. Supramolecular Nanotechnology\, Wiley-VCH\, 2023\, Azzaroni\, O.; Conda-Sheridan\, M. Eds. Vol.1\, p. 1-123. (c) Percec\, V. Lab. Science 1997\, 278\, 449-452. (d) Nature 1998\, 391\,161-164. (e) Nature 2002\, 419\, 384-387. (f) Nature 2004\, 430\, 764-768.\n(a) Pauling\, L.; Corey\, J. Am. Chem. Soc. 1950\, 72\, 5349-5349; (b) Watson\, J. D.; Crick\, F.H.C. Nature 1953\, 171\, 737-738; (c) Percec\, V.; Xiao\, Q. CHEM 2021\, 7\, 529-536; (d) Percec\, V. CHEM 2023\, August issue.\nPercec\, V. Lab. J. Am. Chem. Soc. 2023\, 145\, 4311-4323.\n(a) Percec\, V. Lab. Science\, 2010\, 328\, 1009-1014; (b) Percec\, V. Lab. J. Am. Chem. Soc. 2013\, 135\, 9055-9077.\n(a) Percec\, V. and Weissman D. Labs. J. Am. Chem. Soc. 2021\, 143\, 12315-12325; (b) J. Am. Chem. Soc. 2021\, 143\, 18803-12325; (c) J. Am. Chem. Soc. 2022\, 144\, 4746-4753; (d) Pharmaceutics 2023\, 15\, 1572; (e) J. Am. Chem. Soc. Submitted.\n\n\nVirgil Percec was born and educated in Romania (BS in Organic and Macromolecular Chemistry at the Polytechnic University in Iasi\, PhD in 1976 with C. I. Simionescu. In 1981 he defected his native country and after short postdoctoral stays at the University of Freiburg in Germany (July 1981 with H. -J. Cantow) and University of Akron\, US (August 1981 to March 1982 with J. P. Kennedy) he joined the Department of Macromolecular Science of Case Western Reserve University in Cleveland\, US in March 1982 as an Assistant Professor. He was promoted to Associate Professor in 1984 and to Professor in 1986. In 1993 he was awarded the Leonard Case Jr. Chair at Case Western Reserve University and in 1999 he was invited and moved to the University of Pennsylvania in Philadelphia as P. Roy Vagelos Chair and Professor of Chemistry. He has been repeatedly a Visiting Professor at the Universities of Freiburg\, Ulm and at the Max Planck Institute for Polymer Research in Mainz (all in Germany) and at the Royal Institute of Technology in Stockholm. His research interest is at the interface between organic\, supramolecular\, macromolecular chemistries\, liquid crystals\, nanoscience and biology where he contributed over 820 refereed publications\, 80 patents\, edited 20 books and presented over 1300 endowed\, invited and plenary lectures. He educated over 3509 students and postdocs over 70 of them being in university professors all over the world.
URL:https://ibecbarcelona.eu/event/ibec-seminar-virgil-percec/
LOCATION:Sala Dolors Aleu\, Cluster II\, IBEC\, Baldiri i Reixac\, Barcelona
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20230915T100000
DTEND;TZID=Europe/Madrid:20230915T113000
DTSTAMP:20260404T105843
CREATED:20230710T085202Z
LAST-MODIFIED:20230710T085202Z
UID:109584-1694772000-1694777400@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Dr. Andy Tay
DESCRIPTION:Biomaterials for cancer study and accelerate wound healing\nDr. Andy Tay \, Assistant Professor\, Presidential Young Professor\, Department of Biomedical Engineering \nMagnetic hydrogels are materials containing magnetic microparticles which help transduce magnetic fields into mechanical forces. In the presence of a static magnet\, the stiffness of magnetic hydrogels can be altered to investigate the reversible effects of matrix softening and stiffening on cellular behaviours. Here\, I will describe how we exploit this unique feature of our material for cancer study. \nThe World Health Organization estimates that 10% of the world’s population suffers from diabetes\, and diabetic patients has a 15-25% lifetime risk of getting diabetic foot ulcers. Every 20s\, there is a lower extremity amputation worldwide. In the second half of my talk\, I will describe the use of magnetic hydrogel for mechanical stimulation of cells to synergistically accelerate diabetic wound healing. \n\nAndy Tay graduated in 2014 from NUS with a First-Class Honours in Biomedical Engineering. He later headed to the University of California\, Los Angeles for his PhD studies and graduated in 2017 as the recipient of the Harry M Showman Commencement Award. Andy next received his postdoctoral training at Stanford University before heading to Imperial College London as an 1851 Royal Commission Brunel Research Fellow. He is currently a Presidential Young Professor in NUS. \nAndy is a recipient of international awards including the Interstellar Initiative Early-Career Faculty Award\, Christopher Hewitt Outstanding Young Investigator Award\, Terasaki Young Innovator Award. He is listed as a 2019 Forbes 30 Under 30 (US/Canada\, Science)\, 2020 World Economic Forum Young Scientist\, 2020 The Straits Times ‘30 and Under’ Young Singaporeans to Watch and 2022 Top 2% Scientist in the World by Stanford University. \n 
URL:https://ibecbarcelona.eu/event/ibec-seminar-dr-andy-tay/
LOCATION:Sala Dolors Aleu\, Cluster II\, IBEC\, Baldiri i Reixac\, Barcelona
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20230927T120000
DTEND;TZID=Europe/Madrid:20230927T130000
DTSTAMP:20260404T105843
CREATED:20230803T110925Z
LAST-MODIFIED:20230803T110925Z
UID:110580-1695816000-1695819600@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Mariano Vázquez
DESCRIPTION:Supercomputer-based virtual humans: the future of medicine NOW\nMariano Vázquez\, ELEM Biotech & Barcelona Supercomputing Center \nIn this talk we are going to address the potential of supercomputer-based virtual humans for the biomedical realm. Virtual Humans are computational “avatars” of a patient\, which combines data with a mathematical model which are used to predict (as opposed to measure with experiments) some quantities of interest\, under a context of use and used to support medical decisions. We will show examples of Populations of Virtual Humans used as cohorts for in-silico clinical trials to optimize drug or devise-based therapies. \nOur examples are mostly of the cardiovascular and respiratory domains.
URL:https://ibecbarcelona.eu/event/ibec-seminar-mariano-vazquez/
LOCATION:Sala Dolors Aleu\, Cluster II\, IBEC\, Baldiri i Reixac\, Barcelona
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20230929T100000
DTEND;TZID=Europe/Madrid:20230929T113000
DTSTAMP:20260404T105843
CREATED:20230912T131744Z
LAST-MODIFIED:20230912T131744Z
UID:110815-1695981600-1695987000@ibecbarcelona.eu
SUMMARY:IBEC Seminar: New technologies for accelerating drug discovery and preclinical testing
DESCRIPTION:New technologies for accelerating drug discovery and preclinical testing\nMaria Majellaro\, Chief Scientific Officer of Celtarys. \nAbi J Vazquez. Co-founder and COO of DIVERSA Technologies SL.\nBruno K Rodiño-Janeiro\, Chief Scientific Officer of BFlow. \n  \nCeltarys\, DIVERSA and BFlow belong to the Galician biotechnology ecosystem and are dedicated to provide cutting-edge technologies applied in different and complementary phases of preclinical drug screening\, accelerating the drug development process and reducing the time to market of new therapies. \nThe three companies emerge from technologies developed at public research centers and transferred to the market after participation in validation programs. The speakers will explain their experiences in the process of going from an idea in the laboratory to the final technology transfer as spin-off companies. \nCeltarys is a spin-off of the University of Santiago de Compostela\, focused on the development of innovative fluorescent tools to improve the efficiency of the drug discovery process. In addition to its fluorescent ligand portfolio\, Celtarys specializes in customized fluorescent ligands for target-based drug discovery\, utilizing its proprietary conjugation technology. This unique approach allows to quickly design and develop libraries of different tailor-made fluorescent ligands with their own linkers covering wide chemical architectures for any target of interest. \nDIVERSA is a spin-off from the Santiago de Compostela Health Research Institute (IDIS) and the Galician Health Service (SERGAS)\, devoted to drive the translation of new therapeutic molecules to the clinic through the application of patented safe-by-design lipid nanoemulsions that can efficiently improve the delivery of drugs and biomolecules (RNAs\, proteins and peptides ) to their target\, and thus efficacy. DIVERSA commercialize ready-to-use reagents\, and also provides customized services for the development of tailored and unique formulations that can accomplish all requirements for a specific molecule\, indication\, and route of administration. We also conduct comprehensive R&D activities to advance our own nanomedicines towards the clinic\, answering to current unmet clinical needs. \n  \nBFlow is a spin-off from the University of Santiago de Compostela (USC) and the Health Research Institute of Santiago de Compostela (IDIS)\, which offers advanced Organ-on-a-chip models to improve the physiological relevance of cell cultures. BFlow products are designed to cover the urgent need to improve the data in both research laboratories and the pharmaceutical industry. Regarding the latter\, Organ-on-a-chip models will have a relevant role reducing the cost\, time and use of experimental animal models in the preclinical drug screening process\, accelerating the discovery of new drugs. \n  \nThe seminar will consist of 15 minute talks from each company with 15 minutes of questions and answers.
URL:https://ibecbarcelona.eu/event/ibec-seminar-new-technologies-for-accelerating-drug-discovery-and-preclinical-testing/
LOCATION:Sala Dolors Aleu\, Cluster II\, IBEC\, Baldiri i Reixac\, Barcelona
CATEGORIES:IBEC Seminar
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DTSTART;TZID=Europe/Madrid:20231002T120000
DTEND;TZID=Europe/Madrid:20231002T130000
DTSTAMP:20260404T105843
CREATED:20230912T132001Z
LAST-MODIFIED:20230912T132001Z
UID:110817-1696248000-1696251600@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Simone Reber
DESCRIPTION:Conserved nucleocytoplasmic density homeostasis drives cellular organization across eukaryotes\nSimone Reber\, Max Planck Institut for Infection Biology\, Berlin (invited by Pere Roca-Cusachs) \nThe packing and confinement of macromolecules in the cytoplasm and nucleoplasm has profound implications for cellular biochemistry. How intracellular density distributions vary and affect cellular physiology remains largely unknown. We show that the nucleus is less dense than the cytoplasm and that living systems establish and maintain a constant density ratio between these compartments. Using label-free biophotonics and theory\, we show that nuclear density is set by a pressure balance across the nuclear envelope in vitro\, in vivo and during early development. Nuclear transport establishes a specific nuclear proteome that exerts a colloid osmotic pressure\, which\, assisted by entropic chromatin pressure\, draws water into the nucleus. Using C. elegans\, we show that while nuclear-to-cytoplasmic (N/C) volume ratios change during early development\, the N/C density ratio is robustly maintained. We propose that the maintenance of a constant N/C density ratio is the biophysical driver of one of the oldest tenets of cell biology: the N/C volume ratio. In summary\, this study reveals a previously unidentified homeostatic coupling of macromolecular densities that drives cellular organization.
URL:https://ibecbarcelona.eu/event/ibec-seminar-simone-reber/
LOCATION:Sala Dolors Aleu\, Cluster II\, IBEC\, Baldiri i Reixac\, Barcelona
CATEGORIES:IBEC Seminar
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BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20231011T110000
DTEND;TZID=Europe/Madrid:20231011T130000
DTSTAMP:20260404T105843
CREATED:20231004T102504Z
LAST-MODIFIED:20231004T102504Z
UID:111446-1697022000-1697029200@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Jaap den Toonder
DESCRIPTION:Microfluidic technology enabling biomedical applications\nJaap den Toonder\, Microsystems Research Section\, Department of Mechanical Engineering\, and Institute for Complex Molecular Systems\, Eindhoven University of Technology.  \nCurrently\, visiting professor at IBEC\, Barcelona \nMicrofluidics is the science and technology of manipulating and analyzing fluid flow at small scales\, typically from millimeters down to micrometers. At these scales\, fluid flow is almost always laminar which enables excellent control over the flow. Microfluidic devices can be made using a range of microfabrication approaches and materials\, and these enable to integrate tailored electronic or mechanical functions. These unique properties of microfluidic technologies\, and the ongoing further development of the technology\, enable a range of new biomedical applications\, including diagnostic and monitoring devices\, medical implants\, and organ-on-chip. \nIn this lecture\, I will present recent developments within three research lines of our lab. (1) Bio-inspired microfluidics: A novel microfluidic flow generation concept inspired by nature\, which is based on magnetic nano- and micro-actuators we call “artificial cilia”; integrated in microfluidic devices\, these can be used to induce flow\, to manipulate particles\, and as actuators in cellular mechano-transduction research. (2) Microfluidic devices for health: Examples of microfluidic devices for health applications\, specifically a sweat sensing device for non-invasive semi-continuous monitoring of hospitalized patients\, and a smart eye implant to control eye pressure in glaucoma patients after surgery. (3) Organ-on-chip: A game-changing technology in which human cells are cultured in microfluidic chips simulating and predicting the response of healthy and diseased human tissues. I will focus on cancer-on-chip approaches to understand initial stages of cancer metastasis\, and on our lumen-based organ-on-chip models that are enabled by a 3D sugar printing technique we developed.
URL:https://ibecbarcelona.eu/event/ibec-seminar-jaap-den-toonder/
LOCATION:Sala Dolors Aleu\, Cluster II\, IBEC\, Baldiri i Reixac\, Barcelona
CATEGORIES:IBEC Seminar
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