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DTSTART;TZID=Europe/Madrid:20171018T100000
DTEND;TZID=Europe/Madrid:20171018T110000
DTSTAMP:20260405T213641
CREATED:20170926T130337Z
LAST-MODIFIED:20170926T130337Z
UID:96106-1508320800-1508324400@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Arpita Upadhyaya
DESCRIPTION:Push\, pull and sense: Forces and mechanosensing in immune cells\nArpita Upadhyaya\, Associate Professor\, Department of Physics\, IPST\, University of Maryland\nThe activation of lymphocytes is an essential step in the adaptive immune response. Lymphocyte activation involves the binding of specialized receptors (TCR in T cells and BCR in B cells) with antigen on the surface of antigen presenting cells. This leads to changes in cell morphology and the movement and assembly of receptors\, scaffold proteins and enzymes into signaling microclusters\, which are essential for immune cell activation. During this process\, cells of the immune system interact with structures that possess a diverse range of physical properties. I will summarize our recent studies from a biophysical perspective that examine how T cells and B cells respond to physical cues such as stiffness\, topography and ligand mobility. Specifically\, I will highlight the distinct roles of the actin and microtubule cytoskeleton in the exertion of mechanical stresses that support signaling activation\, microcluster assembly and receptor movement in T and B lymphocytes.
URL:https://ibecbarcelona.eu/event/ibec-seminar-arpita-upadhyaya-2/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20171018T100000
DTEND;TZID=Europe/Madrid:20171018T110000
DTSTAMP:20260405T213641
CREATED:20170926T130337Z
LAST-MODIFIED:20170926T130337Z
UID:31495-1508320800-1508324400@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Arpita Upadhyaya
DESCRIPTION:Push\, pull and sense: Forces and mechanosensing in immune cells\nArpita Upadhyaya\, Associate Professor\, Department of Physics\, IPST\, University of Maryland\nThe activation of lymphocytes is an essential step in the adaptive immune response. Lymphocyte activation involves the binding of specialized receptors (TCR in T cells and BCR in B cells) with antigen on the surface of antigen presenting cells. This leads to changes in cell morphology and the movement and assembly of receptors\, scaffold proteins and enzymes into signaling microclusters\, which are essential for immune cell activation. During this process\, cells of the immune system interact with structures that possess a diverse range of physical properties. I will summarize our recent studies from a biophysical perspective that examine how T cells and B cells respond to physical cues such as stiffness\, topography and ligand mobility. Specifically\, I will highlight the distinct roles of the actin and microtubule cytoskeleton in the exertion of mechanical stresses that support signaling activation\, microcluster assembly and receptor movement in T and B lymphocytes.
URL:https://ibecbarcelona.eu/event/ibec-seminar-arpita-upadhyaya/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20171218T120000
DTEND;TZID=Europe/Madrid:20171218T130000
DTSTAMP:20260405T213641
CREATED:20171123T104034Z
LAST-MODIFIED:20171123T104034Z
UID:96138-1513598400-1513602000@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Jonel Trebicka
DESCRIPTION:Liver fibrosis and Portal hypertension\nProf. Jonel Trebicka\, Laboratory for Liver Fibrosis and Portal Hypertension\, Dept of Internal Medicine\, University of Bonn\nIn patients with chronic liver disease\, portal hypertension and progressive fibrosis are concomitant pathological processes interacting with each-other and leading to severe complications. The mechanics of matrix and the distinct response of different hepatic cell types contribute in the development of liver injury and cancer. Moreover\, cellular mechanics play a crucial role on the remodeling of matrix in chronic liver disease. Interruption of the liver injury either by treating the initial liver injury and addressing the perpetuating risk factors will improve both fibrosis and prevent or ameliorate portal hypertension. Currently\, after the successful cure of viral hepatitis\, lifestyle-related liver damage due to chronic alcoholism or morbid obesity will remain the main factor leading to liver fibrosis and portal hypertension. Even though\, the basic pathogenetic mechanisms of development of fibrosis and portal hypertension are similar. Especially RhoA/Rho-kinase pathway is crucially involved in the pathogenetic processes inside and outside the liver. RhoA/Rho-kinase is crucial in mechanics of cells\, and the modulation of these targets has been evaluated in different animal models. Also\, some well-established drugs\, which are used in humans for other indications (for example\, statins)\, are promising if applied early and concomitantly to standard therapy. In the future\, more cell-specific targeting and personalized strategies must be considered to avoid progression of disease and complications.
URL:https://ibecbarcelona.eu/event/ibec-seminar-jonel-trebicka-4/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20171218T120000
DTEND;TZID=Europe/Madrid:20171218T130000
DTSTAMP:20260405T213641
CREATED:20171123T104034Z
LAST-MODIFIED:20171127T103555Z
UID:56469-1513598400-1513602000@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Jonel Trebicka
DESCRIPTION:Liver fibrosis and Portal hypertension\nProf. Jonel Trebicka\, Laboratory for Liver Fibrosis and Portal Hypertension\, Dept of Internal Medicine\, University of Bonn\nIn patients with chronic liver disease\, portal hypertension and progressive fibrosis are concomitant pathological processes interacting with each-other and leading to severe complications. The mechanics of matrix and the distinct response of different hepatic cell types contribute in the development of liver injury and cancer. Moreover\, cellular mechanics play a crucial role on the remodeling of matrix in chronic liver disease. Interruption of the liver injury either by treating the initial liver injury and addressing the perpetuating risk factors will improve both fibrosis and prevent or ameliorate portal hypertension. Currently\, after the successful cure of viral hepatitis\, lifestyle-related liver damage due to chronic alcoholism or morbid obesity will remain the main factor leading to liver fibrosis and portal hypertension. Even though\, the basic pathogenetic mechanisms of development of fibrosis and portal hypertension are similar. Especially RhoA/Rho-kinase pathway is crucially involved in the pathogenetic processes inside and outside the liver. RhoA/Rho-kinase is crucial in mechanics of cells\, and the modulation of these targets has been evaluated in different animal models. Also\, some well-established drugs\, which are used in humans for other indications (for example\, statins)\, are promising if applied early and concomitantly to standard therapy. In the future\, more cell-specific targeting and personalized strategies must be considered to avoid progression of disease and complications.
URL:https://ibecbarcelona.eu/event/ibec-seminar-jonel-trebicka/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20180112T100000
DTEND;TZID=Europe/Madrid:20180112T110000
DTSTAMP:20260405T213641
CREATED:20171228T101943Z
LAST-MODIFIED:20171228T101943Z
UID:96148-1515751200-1515754800@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Dong-Pyo Kim
DESCRIPTION:Advances in Microfluidic Technology Driven by Materials\nDong-Pyo Kim\, POSTECH (Pohang University of Science & Technology)\, Korea\nAdvanced microreaction technologies have been achieved the best by chemistry and engineering together\, rather than either alone. This talk shows typical cases of innovative microreactor systems and process intensification by adopting multifunctional phenomena of materials and the specialty as well as by embracing newly emerging fabrication methods. \nDong-Pyo Kim is a professor of POSTECH and director of Center for Intelligent Microprocess of Pharmaceutical Synthesis. He obtained PhD in Chemistry at Temple University in 1991\, then post-doctoral research in University of Illinois at Urbana-Champaign (Materials S.E.)\, and came to Korea Research Institute of Chemical Technology as a senior researcher. Prior to POSTECH at 2012\, he had worked in Applied Chemistry at Chungnam National University for 17 years. His research has been based on materials chemistry of silicon-based resin. Since 2004\, he has devoted to a microreaction field\, currently covered the reactor design\, fabrication as well as continuous-flow syntheses in organics\, polymers and nanomaterials. He has published > 250 peer-reviewed papers and 30 patents. He received Academic Excellence Award by Korean Chemical Society (2017)\, POSTECHian Scientist of the Year (2016)\, The Great Scientist Award (2016) and Best 100 Scientific Achievement (2014\, 2007) by National Research Foundation.
URL:https://ibecbarcelona.eu/event/ibec-seminar-dong-pyo-kim-2/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20180112T100000
DTEND;TZID=Europe/Madrid:20180112T110000
DTSTAMP:20260405T213641
CREATED:20171228T101943Z
LAST-MODIFIED:20171228T101943Z
UID:57061-1515751200-1515754800@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Dong-Pyo Kim
DESCRIPTION:Advances in Microfluidic Technology Driven by Materials\nDong-Pyo Kim\, POSTECH (Pohang University of Science & Technology)\, Korea\nAdvanced microreaction technologies have been achieved the best by chemistry and engineering together\, rather than either alone. This talk shows typical cases of innovative microreactor systems and process intensification by adopting multifunctional phenomena of materials and the specialty as well as by embracing newly emerging fabrication methods. \nDong-Pyo Kim is a professor of POSTECH and director of Center for Intelligent Microprocess of Pharmaceutical Synthesis. He obtained PhD in Chemistry at Temple University in 1991\, then post-doctoral research in University of Illinois at Urbana-Champaign (Materials S.E.)\, and came to Korea Research Institute of Chemical Technology as a senior researcher. Prior to POSTECH at 2012\, he had worked in Applied Chemistry at Chungnam National University for 17 years. His research has been based on materials chemistry of silicon-based resin. Since 2004\, he has devoted to a microreaction field\, currently covered the reactor design\, fabrication as well as continuous-flow syntheses in organics\, polymers and nanomaterials. He has published > 250 peer-reviewed papers and 30 patents. He received Academic Excellence Award by Korean Chemical Society (2017)\, POSTECHian Scientist of the Year (2016)\, The Great Scientist Award (2016) and Best 100 Scientific Achievement (2014\, 2007) by National Research Foundation.
URL:https://ibecbarcelona.eu/event/ibec-seminar-dong-pyo-kim/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20180118T150000
DTEND;TZID=Europe/Madrid:20180118T160000
DTSTAMP:20260405T213641
CREATED:20180115T090716Z
LAST-MODIFIED:20180115T090716Z
UID:96154-1516287600-1516291200@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Gopi Shah
DESCRIPTION:Prospects of light sheet microscopy in developmental biology and cancer research\nGopi Shah (CRUK Cambridge Institute\, University of Cambridge)\nLight sheet microscopy is one of the fastest fluorescence imaging technologies available today. In the last decade\, it has emerged as an ideal technique for visualizing biological processes occurring at various time and length scales: rapid three-dimensional processes such as the beating zebrafish heart can be captured at >400 frames/sec\, large samples such as the developing zebrafish embryo (~0.7-1mm) can be imaged in toto at high resolution through multi-view imaging and delicate samples such as in vitro cultured 3D organoids can be monitored over days owing to its non-invasive nature. \nNonetheless\, most biological studies demand a higher imaging throughput in terms of sample size\, which has been a challenge for light sheet microscopy both in terms of microscope design and the volume of data generated. To address this\, we have developed customised light sheet microscopes with real-time image-processing engine that projects the 3D image volume onto a 2D map\, drastically reducing the amount of data generated as well as providing a panoramic view of the sample for ease of downstream analyses. We also designed a fluidic sample delivery system to pump embryos through the microscope\, enabling time-lapse imaging and screening of several samples simultaneously. Together\, these tools harness the high-speed imaging capability of a light sheet system to obtain multi-dimensional data from many samples\, essential for systematic population analysis. In my talk\, I will discuss how this work (a) has enabled integration of whole-sample live imaging\, genetic information and analysis of an ensemble of specimen to understand large-scale tissue movements during zebrafish embryogenesis and (b) facilitates my vision of establishing high-throughput imaging of organoids for understanding tumor cell dynamics and developing organoids as a model for image-based screening and therapeutics.
URL:https://ibecbarcelona.eu/event/ibec-seminar-gopi-shah-2/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20180118T150000
DTEND;TZID=Europe/Madrid:20180118T160000
DTSTAMP:20260405T213641
CREATED:20180115T090716Z
LAST-MODIFIED:20180115T090716Z
UID:57187-1516287600-1516291200@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Gopi Shah
DESCRIPTION:Prospects of light sheet microscopy in developmental biology and cancer research\nGopi Shah (CRUK Cambridge Institute\, University of Cambridge)\nLight sheet microscopy is one of the fastest fluorescence imaging technologies available today. In the last decade\, it has emerged as an ideal technique for visualizing biological processes occurring at various time and length scales: rapid three-dimensional processes such as the beating zebrafish heart can be captured at >400 frames/sec\, large samples such as the developing zebrafish embryo (~0.7-1mm) can be imaged in toto at high resolution through multi-view imaging and delicate samples such as in vitro cultured 3D organoids can be monitored over days owing to its non-invasive nature. \nNonetheless\, most biological studies demand a higher imaging throughput in terms of sample size\, which has been a challenge for light sheet microscopy both in terms of microscope design and the volume of data generated. To address this\, we have developed customised light sheet microscopes with real-time image-processing engine that projects the 3D image volume onto a 2D map\, drastically reducing the amount of data generated as well as providing a panoramic view of the sample for ease of downstream analyses. We also designed a fluidic sample delivery system to pump embryos through the microscope\, enabling time-lapse imaging and screening of several samples simultaneously. Together\, these tools harness the high-speed imaging capability of a light sheet system to obtain multi-dimensional data from many samples\, essential for systematic population analysis. In my talk\, I will discuss how this work (a) has enabled integration of whole-sample live imaging\, genetic information and analysis of an ensemble of specimen to understand large-scale tissue movements during zebrafish embryogenesis and (b) facilitates my vision of establishing high-throughput imaging of organoids for understanding tumor cell dynamics and developing organoids as a model for image-based screening and therapeutics.
URL:https://ibecbarcelona.eu/event/ibec-seminar-gopi-shah/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20180131T153000
DTEND;TZID=Europe/Madrid:20180131T163000
DTSTAMP:20260405T213641
CREATED:20180125T121920Z
LAST-MODIFIED:20180125T121920Z
UID:96160-1517412600-1517416200@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Gregory Lanza
DESCRIPTION:IBEC Seminar: Gregory Lanza\nGregory Lanza (Professor of Medicine\, Biomedical Engineering and Biology & Biomedical Sciences; Washington University)\nDr. Lanza is a full Professor of Medicine in the Cardiovascular Division of the School of Medicine\, with affiliations in the Department of Biomedical Engineering\, as well as Biology & Biomedical Sciences\, in Washington University.  He received a B.A. from Colby College\, both an M.S. and a Ph.D. from the Department of Poultry Science in University of Georgia Athens\, an M.D. from Northwest University\, and conducted his medical residency and cardiology specialization in Washington University Medical Center.  Dr. Lanza has been the recipient for a Searle Career Development Award\, as well as NCI Unconventional Innovation Program Awards in 2000\, 2002\, and 2003\, among several other recognitions.  He is also a Fellow of the American College of Cardiology.  Dr. Lanza is the Co-founder and Chief Scientific Officer for Kereos\, Inc.  He serves in the editorial board of Nanomedicine: Nanotechnology\, Biology\, & Medicine\, the International Journal of Green Nanotechnology: Biomedicine\, WIREs: Nanomedicine\, and Theranostics.
URL:https://ibecbarcelona.eu/event/ibec-seminar-gregory-lanza-2/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
ORGANIZER;CN="IBEC":MAILTO:www.ibecbarcelona.eu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20180131T153000
DTEND;TZID=Europe/Madrid:20180131T163000
DTSTAMP:20260405T213641
CREATED:20180125T121920Z
LAST-MODIFIED:20180129T101234Z
UID:57400-1517412600-1517416200@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Gregory Lanza
DESCRIPTION:IBEC Seminar: Gregory Lanza\nGregory Lanza (Professor of Medicine\, Biomedical Engineering and Biology & Biomedical Sciences; Washington University)\nDr. Lanza is a full Professor of Medicine in the Cardiovascular Division of the School of Medicine\, with affiliations in the Department of Biomedical Engineering\, as well as Biology & Biomedical Sciences\, in Washington University.  He received a B.A. from Colby College\, both an M.S. and a Ph.D. from the Department of Poultry Science in University of Georgia Athens\, an M.D. from Northwest University\, and conducted his medical residency and cardiology specialization in Washington University Medical Center.  Dr. Lanza has been the recipient for a Searle Career Development Award\, as well as NCI Unconventional Innovation Program Awards in 2000\, 2002\, and 2003\, among several other recognitions.  He is also a Fellow of the American College of Cardiology.  Dr. Lanza is the Co-founder and Chief Scientific Officer for Kereos\, Inc.  He serves in the editorial board of Nanomedicine: Nanotechnology\, Biology\, & Medicine\, the International Journal of Green Nanotechnology: Biomedicine\, WIREs: Nanomedicine\, and Theranostics.
URL:https://ibecbarcelona.eu/event/ibec-seminar-gregory-lanza/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
ORGANIZER;CN="IBEC":MAILTO:www.ibecbarcelona.eu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20180228T100000
DTEND;TZID=Europe/Madrid:20180228T110000
DTSTAMP:20260405T213641
CREATED:20180201T164138Z
LAST-MODIFIED:20180201T164138Z
UID:96163-1519812000-1519815600@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Johanna Ivaska
DESCRIPTION:Mechanosensitive regulation of cancer and pluripotency\nJohanna Ivaska\, Turku Centre for Biotechnology\, University of Turku\, Finland\nTissue homeostasis is dependent on the spatially controlled localization of specific cell types and the correct composition of the extracellular stroma. Integrin mediated adhesions\, in conjunction with the actin cytoskeleton\, allow cells to sense the stiffness of the surrounding extra-cellular matrix (ECM). Conversely\, cells exert acto-myosin and integrin dependent forces to remodel and organize the surrounding ECM. In cancer\, stiffening of the tumor stroma is considered as an instrumental contributor to tumor progression. However\, the mechanisms how stromal ECM regulates cancer progression is not fully understood. I will describe our recent findings on the interrelationship between cancer cell mediated ECM remodelling and ECM induced mechanochemical signals regulating transcription of growth promoting pathways in cancer cells. Reprogramming and survival of human pluripotent stem cells is heavily influenced by their adhesion to the underlying ECM. We have recently investigated the link between ECM-adhesion\, the actin cytoskeleton and cell contractility in maintenance of pluripotency. I will describe our recent efforts to define the stem-cell adhesion structure in nanoscale and how it contributes to maintenance of pluripotency.
URL:https://ibecbarcelona.eu/event/ibec-seminar-johanna-ivaska-2/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20180228T100000
DTEND;TZID=Europe/Madrid:20180228T110000
DTSTAMP:20260405T213641
CREATED:20180201T164138Z
LAST-MODIFIED:20180201T164148Z
UID:57497-1519812000-1519815600@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Johanna Ivaska
DESCRIPTION:Mechanosensitive regulation of cancer and pluripotency\nJohanna Ivaska\, Turku Centre for Biotechnology\, University of Turku\, Finland\nTissue homeostasis is dependent on the spatially controlled localization of specific cell types and the correct composition of the extracellular stroma. Integrin mediated adhesions\, in conjunction with the actin cytoskeleton\, allow cells to sense the stiffness of the surrounding extra-cellular matrix (ECM). Conversely\, cells exert acto-myosin and integrin dependent forces to remodel and organize the surrounding ECM. In cancer\, stiffening of the tumor stroma is considered as an instrumental contributor to tumor progression. However\, the mechanisms how stromal ECM regulates cancer progression is not fully understood. I will describe our recent findings on the interrelationship between cancer cell mediated ECM remodelling and ECM induced mechanochemical signals regulating transcription of growth promoting pathways in cancer cells. Reprogramming and survival of human pluripotent stem cells is heavily influenced by their adhesion to the underlying ECM. We have recently investigated the link between ECM-adhesion\, the actin cytoskeleton and cell contractility in maintenance of pluripotency. I will describe our recent efforts to define the stem-cell adhesion structure in nanoscale and how it contributes to maintenance of pluripotency.
URL:https://ibecbarcelona.eu/event/ibec-seminar-johanna-ivaska/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20180320T160000
DTEND;TZID=Europe/Madrid:20180320T170000
DTSTAMP:20260405T213641
CREATED:20180312T101441Z
LAST-MODIFIED:20180312T101441Z
UID:96186-1521561600-1521565200@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Carlo A. Bortolotti
DESCRIPTION:Monitoring biorecognition with organic bioelectronic transistors\nCarlo A. Bortolotti\, Dipartimento di Scienze della Vita\, Universita di Modena ed Regio Emilia\, Italy\nElectrolyte-gated OFETs (EGOFETs) and Organic Electrochemical transistors (OECTs) are emerging as an important class of chemo- and biosensors to meet the main requirements of healthcare diagnostics: portability\, manufacturing with low cost\, miniaturization\, low-temperature processing. These devices can be operated either in accumulation (EGOFETs) or in depletion mode (OECTs). Devices that allow transduction of protein/protein interactions can be used not only for analytical purposes\, but also for real time monitoring of surface adsorption and recognition events\, and may therefore provide insights into both the kinetics and thermodynamics of biomolecular interactions. These devices provide a real-time\, label-free response and the ultra-low sensitivity arising from the capacitive coupling between the electrolyte solution and the channel. We are currently investigating a wide range of biorecognition events\, differing in terms of size of the surface bound biomolecule and of the chemical nature and lateral dimensions of the biological partner in solution\, ranging from receptor/ligand interactions to antibody/antigene (protein) and antibody/virus couples. I will present a few examples of the EGOFET-based and OECT-based detection of detection of biorecognition events. Different surface functionalization strategies\, aiming at reducing non-specific binding\, increasing sensitivity and ensuring re-usability of the electrodes with immobilized sensing units will be described. I will also present our latest achievements in the development of a multigate lab-on-a-chip device\, aiming at the multiplexed detection of different analytes in a biological fluid\, also including an internal reference electrode.
URL:https://ibecbarcelona.eu/event/ibec-seminar-carlo-a-bortolotti-2/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20180320T160000
DTEND;TZID=Europe/Madrid:20180320T170000
DTSTAMP:20260405T213641
CREATED:20180312T101441Z
LAST-MODIFIED:20180312T101441Z
UID:57987-1521561600-1521565200@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Carlo A. Bortolotti
DESCRIPTION:Monitoring biorecognition with organic bioelectronic transistors\nCarlo A. Bortolotti\, Dipartimento di Scienze della Vita\, Universita di Modena ed Regio Emilia\, Italy\nElectrolyte-gated OFETs (EGOFETs) and Organic Electrochemical transistors (OECTs) are emerging as an important class of chemo- and biosensors to meet the main requirements of healthcare diagnostics: portability\, manufacturing with low cost\, miniaturization\, low-temperature processing. These devices can be operated either in accumulation (EGOFETs) or in depletion mode (OECTs). Devices that allow transduction of protein/protein interactions can be used not only for analytical purposes\, but also for real time monitoring of surface adsorption and recognition events\, and may therefore provide insights into both the kinetics and thermodynamics of biomolecular interactions. These devices provide a real-time\, label-free response and the ultra-low sensitivity arising from the capacitive coupling between the electrolyte solution and the channel. We are currently investigating a wide range of biorecognition events\, differing in terms of size of the surface bound biomolecule and of the chemical nature and lateral dimensions of the biological partner in solution\, ranging from receptor/ligand interactions to antibody/antigene (protein) and antibody/virus couples. I will present a few examples of the EGOFET-based and OECT-based detection of detection of biorecognition events. Different surface functionalization strategies\, aiming at reducing non-specific binding\, increasing sensitivity and ensuring re-usability of the electrodes with immobilized sensing units will be described. I will also present our latest achievements in the development of a multigate lab-on-a-chip device\, aiming at the multiplexed detection of different analytes in a biological fluid\, also including an internal reference electrode.
URL:https://ibecbarcelona.eu/event/ibec-seminar-carlo-a-bortolotti/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20180328T100000
DTEND;TZID=Europe/Madrid:20180328T110000
DTSTAMP:20260405T213641
CREATED:20180322T115517Z
LAST-MODIFIED:20180322T115517Z
UID:96199-1522231200-1522234800@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Aurélien Bancaud
DESCRIPTION:µLAS technology for DNA processing: setting up elementary functions (concentration\, separation\, purification\, identification) and application in oncology and targeted sequencing\nAurélien Bancaud\, LAAS-CNRS\, Toulouse\, France\nWe recently developed the µLAS technology for nucleic acids processing. Its operating principle relies on the monitoring of DNA transport in a viscoelastic liquid under the combined action of hydrodynamic and electrophoretic forces (1). DNA molecules are dragged toward the walls of microchannels by a transverse force proportional to their contour length. Because the hydrodynamic decreases near the wall\, DNA molecules are sorted according to their molecular weight. Furthermore\, by tailoring the geometry of a channel with a constriction\, we can tune the amplitude of transverse forces and stop molecules to design a concentrator that achieves enrichment rates of 100 to 1000 fold per minute. \nWe will derive a quantitative model of DNA transport in µLAS that relies on 1 fitting parameter and perform rational optimizations of the technology. We will then exploit µLAS for sizing cell-free circulating DNA (cfDNA) in the blood (2)\, and demonstrate that cfDNA profiling is a promissing biomarker for the follow-up of cancer patients. Finally\, we will present the principle of a DNA size-selective valve for the purification and sequencing of target genomic regions by combining µLAS with Cas9 endonuclease. \n(1) Ranchon et al.\, Lab Chip (2016)\n (2) Andriamanampisoa et al.\, Anal Chem (2018)
URL:https://ibecbarcelona.eu/event/ibec-seminar-aurelien-bancaud-2/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20180328T100000
DTEND;TZID=Europe/Madrid:20180328T110000
DTSTAMP:20260405T213641
CREATED:20180322T115517Z
LAST-MODIFIED:20180322T115517Z
UID:58142-1522231200-1522234800@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Aurélien Bancaud
DESCRIPTION:µLAS technology for DNA processing: setting up elementary functions (concentration\, separation\, purification\, identification) and application in oncology and targeted sequencing\nAurélien Bancaud\, LAAS-CNRS\, Toulouse\, France\nWe recently developed the µLAS technology for nucleic acids processing. Its operating principle relies on the monitoring of DNA transport in a viscoelastic liquid under the combined action of hydrodynamic and electrophoretic forces (1). DNA molecules are dragged toward the walls of microchannels by a transverse force proportional to their contour length. Because the hydrodynamic decreases near the wall\, DNA molecules are sorted according to their molecular weight. Furthermore\, by tailoring the geometry of a channel with a constriction\, we can tune the amplitude of transverse forces and stop molecules to design a concentrator that achieves enrichment rates of 100 to 1000 fold per minute. \nWe will derive a quantitative model of DNA transport in µLAS that relies on 1 fitting parameter and perform rational optimizations of the technology. We will then exploit µLAS for sizing cell-free circulating DNA (cfDNA) in the blood (2)\, and demonstrate that cfDNA profiling is a promissing biomarker for the follow-up of cancer patients. Finally\, we will present the principle of a DNA size-selective valve for the purification and sequencing of target genomic regions by combining µLAS with Cas9 endonuclease. \n(1) Ranchon et al.\, Lab Chip (2016)\n (2) Andriamanampisoa et al.\, Anal Chem (2018)
URL:https://ibecbarcelona.eu/event/ibec-seminar-aurelien-bancaud/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20180404T120000
DTEND;TZID=Europe/Madrid:20180404T130000
DTSTAMP:20260405T213641
CREATED:20180222T110811Z
LAST-MODIFIED:20180222T110811Z
UID:57824-1522843200-1522846800@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Fernando López-Gallego
DESCRIPTION:Immobilization of multi-enzyme systems; an avenue to fabricate self-sufficient heterogeneous biocatalysts\nFernando López-Gallego\, Heterogeneous Biocatalysis Lab\, University of Zaragoza (iQSCH-CSIC) / ARAID\, Science Foundation of Aragón\nIn the last decade\, the chemists have been delighted by the catalytic orchestration found in vivo\, and have isolated multi-enzyme system to work ex-vivo in both natural and non-natural tandem reactions creating a new concept: systems biocatalysis. These systems are the pioneers of the cell-free synthetic biology; an emerging discipline that seeks the simplest biology to make the most complex chemistry. We have paid our attention to the heterogenization of multi-enzyme system to catalyze tandem reactions. Co-immobilization of multi-enzyme systems improve: 1) the kinetics of the chemical cascades due to the spatial localization of the different biocatalytic modules that avoids intermediate accumulation and increases cofactor recycling efficiency\, 2) the stability of the biocatalysts due to both structural rigidification and in situ elimination of toxic by-products\, 3) the biocatalyst recycle and 4) the biocatalyst adaptation to continuous processes. Nevertheless\, the co-immobilization of several enzymes to carry out synthetic cascades is challenging because there is no a universal immobilization chemistry that optimally attaches all the enzymes to the same surface. We have recently developed different immobilized multi-enzyme systems formed by a 3-enzyme cascade for oxidizing phenol derivatives with in situ H2O2 supply\, a 3-enzyme cascade for synthesizing 1\,3-dihydroxyacetone with both in situ cofactor recycling and H2O2 elimination\, a 4-enzyme cascade for quantitatively synthesizing pro-chiral ketones starting from racemic esters and a 2-enzyme cascades to synthesize optically pure secondary alcohols integrating the cofactor recycling in the solid-phase. The optimal design of the immobilization protocols enables co-immobilizing several enzymes and cofactors on the porous carrier to optimize their spatial localization across the carrier microstructure and preserve both global activity and stability of the multi-enzyme systems.
URL:https://ibecbarcelona.eu/event/ibec-seminar-fernando-lopez-gallego/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20180404T120000
DTEND;TZID=Europe/Madrid:20180404T130000
DTSTAMP:20260405T213641
CREATED:20180222T110811Z
LAST-MODIFIED:20180222T110811Z
UID:96178-1522843200-1522846800@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Fernando López-Gallego
DESCRIPTION:Immobilization of multi-enzyme systems; an avenue to fabricate self-sufficient heterogeneous biocatalysts\nFernando López-Gallego\, Heterogeneous Biocatalysis Lab\, University of Zaragoza (iQSCH-CSIC) / ARAID\, Science Foundation of Aragón\nIn the last decade\, the chemists have been delighted by the catalytic orchestration found in vivo\, and have isolated multi-enzyme system to work ex-vivo in both natural and non-natural tandem reactions creating a new concept: systems biocatalysis. These systems are the pioneers of the cell-free synthetic biology; an emerging discipline that seeks the simplest biology to make the most complex chemistry. We have paid our attention to the heterogenization of multi-enzyme system to catalyze tandem reactions. Co-immobilization of multi-enzyme systems improve: 1) the kinetics of the chemical cascades due to the spatial localization of the different biocatalytic modules that avoids intermediate accumulation and increases cofactor recycling efficiency\, 2) the stability of the biocatalysts due to both structural rigidification and in situ elimination of toxic by-products\, 3) the biocatalyst recycle and 4) the biocatalyst adaptation to continuous processes. Nevertheless\, the co-immobilization of several enzymes to carry out synthetic cascades is challenging because there is no a universal immobilization chemistry that optimally attaches all the enzymes to the same surface. We have recently developed different immobilized multi-enzyme systems formed by a 3-enzyme cascade for oxidizing phenol derivatives with in situ H2O2 supply\, a 3-enzyme cascade for synthesizing 1\,3-dihydroxyacetone with both in situ cofactor recycling and H2O2 elimination\, a 4-enzyme cascade for quantitatively synthesizing pro-chiral ketones starting from racemic esters and a 2-enzyme cascades to synthesize optically pure secondary alcohols integrating the cofactor recycling in the solid-phase. The optimal design of the immobilization protocols enables co-immobilizing several enzymes and cofactors on the porous carrier to optimize their spatial localization across the carrier microstructure and preserve both global activity and stability of the multi-enzyme systems.
URL:https://ibecbarcelona.eu/event/ibec-seminar-fernando-lopez-gallego-2/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20180413T100000
DTEND;TZID=Europe/Madrid:20180413T110000
DTSTAMP:20260405T213641
CREATED:20180226T153414Z
LAST-MODIFIED:20180226T153414Z
UID:96181-1523613600-1523617200@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Joan Seoane
DESCRIPTION:Intratumor heterogeneity in brain cancer\nJoan Seoane\, Group Leader / Director of Translational Research at Vall d’Hebron Institute of Oncology (VHIO)\nJoan Seoane is a Group Leader and Director of the Translational Research program at the Vall d’Hebron Institute of Oncology (VHIO) within the Vall d’Hebron University Hospital since 2011. \nIn 1998\, Joan obtained his PhD in Biochemistry and Molecular Biology from the University of Barcelona. Previously\, in 1993\, he obtained his BSc degree in Chemistry. Joan joined the Memorial Sloan-Kettering Cancer Center (MSKCC) in New York as a post-doctoral fellow in 1998. \nFrom 1998 to 2001\, he worked as a Research Fellow and subsequently\, from 2001 to 2003\, as a Research Associate. He was appointed ICREA Research Professor in 2004 and joined VHIO. \nIn 2007\, he became a member of the EMBO Young Investigator program and the recipient of a European Research Council (ERC) grant in 2008. Later\, he obtained two ERC Proof of Concept grants (2011\, 2013). In 2008\, he became Board member of the European Association of Cancer Research (EACR) and Professor of the Autonomous University of Barcelona. \nIn 2012\, founded Mosaic Biomedicals as a spin-off company from his lab and\, in 2013\, he was the recipient of the Dr. Josef Steiner Award. In 2016\, he became Secretary General of the EACR.
URL:https://ibecbarcelona.eu/event/ibec-seminar-joan-seoane-2/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20180413T100000
DTEND;TZID=Europe/Madrid:20180413T110000
DTSTAMP:20260405T213641
CREATED:20180226T153414Z
LAST-MODIFIED:20180409T075629Z
UID:57830-1523613600-1523617200@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Joan Seoane
DESCRIPTION:Intratumor heterogeneity in brain cancer\nJoan Seoane\, Group Leader / Director of Translational Research at Vall d’Hebron Institute of Oncology (VHIO)\nJoan Seoane is a Group Leader and Director of the Translational Research program at the Vall d’Hebron Institute of Oncology (VHIO) within the Vall d’Hebron University Hospital since 2011. \nIn 1998\, Joan obtained his PhD in Biochemistry and Molecular Biology from the University of Barcelona. Previously\, in 1993\, he obtained his BSc degree in Chemistry. Joan joined the Memorial Sloan-Kettering Cancer Center (MSKCC) in New York as a post-doctoral fellow in 1998. \nFrom 1998 to 2001\, he worked as a Research Fellow and subsequently\, from 2001 to 2003\, as a Research Associate. He was appointed ICREA Research Professor in 2004 and joined VHIO. \nIn 2007\, he became a member of the EMBO Young Investigator program and the recipient of a European Research Council (ERC) grant in 2008. Later\, he obtained two ERC Proof of Concept grants (2011\, 2013). In 2008\, he became Board member of the European Association of Cancer Research (EACR) and Professor of the Autonomous University of Barcelona. \nIn 2012\, founded Mosaic Biomedicals as a spin-off company from his lab and\, in 2013\, he was the recipient of the Dr. Josef Steiner Award. In 2016\, he became Secretary General of the EACR.
URL:https://ibecbarcelona.eu/event/ibec-seminar-joan-seoane/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20180420T100000
DTEND;TZID=Europe/Madrid:20180420T110000
DTSTAMP:20260405T213641
CREATED:20180403T074519Z
LAST-MODIFIED:20180403T074519Z
UID:96200-1524218400-1524222000@ibecbarcelona.eu
SUMMARY:IBEC Seminar: (David) Dagan Feng
DESCRIPTION:Biomedical Engineering and Technology Research at USYD and beyond\n(David) Dagan Feng\, PhD\, FACS\, FATSE\, FHKIE\, FIEEE\, & FIET\nRecent advances in engineering\, information technology and imaging have revolutionized biotechnology\, biomedical research and healthcare. This talk will initially focus on some of his core theories and enabling techniques research in molecular imaging for E-Healthcare and its impact to clinical practice\, in particular in cancer and metabolic diseases. This talk will then give an overview of the Biomedical Engineering and Technology research at the University of Sydney and beyond\, in particular several University new initiatives and the USYD-SJTU Joint Research Alliance.
URL:https://ibecbarcelona.eu/event/ibec-seminar-david-dagan-feng-2/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20180420T100000
DTEND;TZID=Europe/Madrid:20180420T110000
DTSTAMP:20260405T213641
CREATED:20180403T074519Z
LAST-MODIFIED:20180403T074519Z
UID:58189-1524218400-1524222000@ibecbarcelona.eu
SUMMARY:IBEC Seminar: (David) Dagan Feng
DESCRIPTION:Biomedical Engineering and Technology Research at USYD and beyond\n(David) Dagan Feng\, PhD\, FACS\, FATSE\, FHKIE\, FIEEE\, & FIET\nRecent advances in engineering\, information technology and imaging have revolutionized biotechnology\, biomedical research and healthcare. This talk will initially focus on some of his core theories and enabling techniques research in molecular imaging for E-Healthcare and its impact to clinical practice\, in particular in cancer and metabolic diseases. This talk will then give an overview of the Biomedical Engineering and Technology research at the University of Sydney and beyond\, in particular several University new initiatives and the USYD-SJTU Joint Research Alliance.
URL:https://ibecbarcelona.eu/event/ibec-seminar-david-dagan-feng/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20180502T120000
DTEND;TZID=Europe/Madrid:20180502T130000
DTSTAMP:20260405T213641
CREATED:20180406T090351Z
LAST-MODIFIED:20180406T090351Z
UID:96216-1525262400-1525266000@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Francesco Ricci
DESCRIPTION:DNA-based nanodevices for diagnostic and drug-delivery applications\nFrancesco Ricci\, Chemistry Department\, University of Rome\, Tor Vergata\, Rome\, Italy\nDNA nanotechnology uses DNA (or nucleic acids) as a versatile material to rationally engineer tools and molecular devices that can find a multitude of different applications (e.g.\, in-vivo and in-vitro diagnostics\, drug delivery\, genetic circuits etc.). \nDuring this presentation I will introduce the field of DNA nanotechnology and I will talk about some of the most exciting examples of the last decade. \nI will show how to exploit the “designability” of DNA to fabricate nature-inspired DNA-based nanoswitches and nanodevices that are specifically designed to undergo a conformational change (switch) upon binding to a specific input (i.e. target). This input-triggered conformational change can be used for diagnostic\, drug-delivery or synthetic-biology applications. \nI will demonstrate how to characterize and recreate in-vitro several mechanisms to control the response of DNA-based nanodevices (1-2) and how to regulate their activity with different chemical and environmental stimuli including pH (3-8)\, antibodies (2-3)\, enzymes (9)\, small molecules (10) and electronic inputs (11). \nReferences\n[1] Porchetta. A.\, et al.\, J. Am. Chem. Soc.\, 2013\, 135\, 13238.\n[2] Ranallo\, S. et al.\, Angew. Chem.\, 2015\, 54\, 13214.\n[3] Ranallo\, S. et al.\, Nat. Commun.\, 2017\, 8\, 15150.\n[4] Idili\, A. et al.\, Nano Lett.\, 2015\, 15\, 5539.\n[5] Porchetta\, A\, et al. Nano Lett.\, 2015\, 15\, 4467.\n[6] Amodio\, A. et al.\, J. Am. Chem. Soc.\, 2014\, 136\, 16469.\n[7] Idili\, A. et al.\, J. Am. Chem. Soc.\, 2014\, 136\, 5836.\n[8] Mariottini\, D. et al.\, Nano Lett.\, 2017\, 17\, 3225.\n[9] Amodio\, A. et al.\, J. Am. Chem. Soc.\, 2016\, \, 138\, 12735.\n[10] Del Grosso\, E. et al.\, Nano Lett.\, 2015\, 15\, 8407.\n[11] Ranallo\, S. et al.\, Chem. Sc.\, 2016\, 7\, 66-71.
URL:https://ibecbarcelona.eu/event/ibec-seminar-francesco-ricci-2/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20180502T120000
DTEND;TZID=Europe/Madrid:20180502T130000
DTSTAMP:20260405T213641
CREATED:20180406T090351Z
LAST-MODIFIED:20180427T111212Z
UID:58285-1525262400-1525266000@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Francesco Ricci
DESCRIPTION:DNA-based nanodevices for diagnostic and drug-delivery applications\nFrancesco Ricci\, Chemistry Department\, University of Rome\, Tor Vergata\, Rome\, Italy\nDNA nanotechnology uses DNA (or nucleic acids) as a versatile material to rationally engineer tools and molecular devices that can find a multitude of different applications (e.g.\, in-vivo and in-vitro diagnostics\, drug delivery\, genetic circuits etc.). \nDuring this presentation I will introduce the field of DNA nanotechnology and I will talk about some of the most exciting examples of the last decade. \nI will show how to exploit the “designability” of DNA to fabricate nature-inspired DNA-based nanoswitches and nanodevices that are specifically designed to undergo a conformational change (switch) upon binding to a specific input (i.e. target). This input-triggered conformational change can be used for diagnostic\, drug-delivery or synthetic-biology applications. \nI will demonstrate how to characterize and recreate in-vitro several mechanisms to control the response of DNA-based nanodevices (1-2) and how to regulate their activity with different chemical and environmental stimuli including pH (3-8)\, antibodies (2-3)\, enzymes (9)\, small molecules (10) and electronic inputs (11). \nReferences\n[1] Porchetta. A.\, et al.\, J. Am. Chem. Soc.\, 2013\, 135\, 13238.\n[2] Ranallo\, S. et al.\, Angew. Chem.\, 2015\, 54\, 13214.\n[3] Ranallo\, S. et al.\, Nat. Commun.\, 2017\, 8\, 15150.\n[4] Idili\, A. et al.\, Nano Lett.\, 2015\, 15\, 5539.\n[5] Porchetta\, A\, et al. Nano Lett.\, 2015\, 15\, 4467.\n[6] Amodio\, A. et al.\, J. Am. Chem. Soc.\, 2014\, 136\, 16469.\n[7] Idili\, A. et al.\, J. Am. Chem. Soc.\, 2014\, 136\, 5836.\n[8] Mariottini\, D. et al.\, Nano Lett.\, 2017\, 17\, 3225.\n[9] Amodio\, A. et al.\, J. Am. Chem. Soc.\, 2016\, \, 138\, 12735.\n[10] Del Grosso\, E. et al.\, Nano Lett.\, 2015\, 15\, 8407.\n[11] Ranallo\, S. et al.\, Chem. Sc.\, 2016\, 7\, 66-71.
URL:https://ibecbarcelona.eu/event/ibec-seminar-francesco-ricci/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20180608T100000
DTEND;TZID=Europe/Madrid:20180608T110000
DTSTAMP:20260405T213641
CREATED:20180604T083617Z
LAST-MODIFIED:20180604T083617Z
UID:96259-1528452000-1528455600@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Mar Alvarez
DESCRIPTION:Organ-on-chip monitoring\nMar Alvarez\, Ramon y Cajal researcher\, Biomedical Applications Group\, IMB-CNM\nOrgan-on-chip (OOC) is the term used to define a microfluidic 3D culture model that contains continuously perfused chambers inhabited by living cells. The development of the OOC technology has been possible thanks to the advancement in micro- and nanotechnologies. The engineered cellular microenvironments reproduce more accurately the in vivo structure and physiological conditions\, and allow simulating the activities\, mechanics and physiological response of tissues and organs. OOC are considered as very promising tools for investigating many aspects of human physiology and pathophysiology as well as drug testing platforms with future progressions to be used for precision medicine. As the complexity of OOC systems increases\, the necessity to integrate relevant assessment methods to provide information about cell physiology\, secreted metabolites as well as pharmacodynamics drug responses also increases. \nIn this talk\, I will focus on the different engineering approaches that we have used to develop physical and chemical sensors that can be integrated into OOC. I will describe our recent works on biological barrier models\, including blood-retinal barrier\, renal tubule and liver sinusoid. In particular\, I will talk about compartmentalization strategies and integration of transepithelial electrical resistance electrodes into these models\, fabricated by standard photolithographic processes\, for the on-line quantification of ion permeability and continuous evaluation of the barrier functioning. I will as well describe the integration of inkjet-printed electrodes into the culture porous membrane for the monitorization in real-time of the dissolved oxygen levels.
URL:https://ibecbarcelona.eu/event/ibec-seminar-mar-alvarez-2/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20180608T100000
DTEND;TZID=Europe/Madrid:20180608T110000
DTSTAMP:20260405T213641
CREATED:20180604T083617Z
LAST-MODIFIED:20180604T083617Z
UID:59409-1528452000-1528455600@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Mar Alvarez
DESCRIPTION:Organ-on-chip monitoring\nMar Alvarez\, Ramon y Cajal researcher\, Biomedical Applications Group\, IMB-CNM\nOrgan-on-chip (OOC) is the term used to define a microfluidic 3D culture model that contains continuously perfused chambers inhabited by living cells. The development of the OOC technology has been possible thanks to the advancement in micro- and nanotechnologies. The engineered cellular microenvironments reproduce more accurately the in vivo structure and physiological conditions\, and allow simulating the activities\, mechanics and physiological response of tissues and organs. OOC are considered as very promising tools for investigating many aspects of human physiology and pathophysiology as well as drug testing platforms with future progressions to be used for precision medicine. As the complexity of OOC systems increases\, the necessity to integrate relevant assessment methods to provide information about cell physiology\, secreted metabolites as well as pharmacodynamics drug responses also increases. \nIn this talk\, I will focus on the different engineering approaches that we have used to develop physical and chemical sensors that can be integrated into OOC. I will describe our recent works on biological barrier models\, including blood-retinal barrier\, renal tubule and liver sinusoid. In particular\, I will talk about compartmentalization strategies and integration of transepithelial electrical resistance electrodes into these models\, fabricated by standard photolithographic processes\, for the on-line quantification of ion permeability and continuous evaluation of the barrier functioning. I will as well describe the integration of inkjet-printed electrodes into the culture porous membrane for the monitorization in real-time of the dissolved oxygen levels.
URL:https://ibecbarcelona.eu/event/ibec-seminar-mar-alvarez/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20180615T100000
DTEND;TZID=Europe/Madrid:20180615T110000
DTSTAMP:20260405T213641
CREATED:20180517T085601Z
LAST-MODIFIED:20180517T085601Z
UID:96251-1529056800-1529060400@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Vivek Shenoy
DESCRIPTION:Cell-Matrix Interactions in Fibrosis and Cancer: Multiscale mechano-chemical models\nVivek Shenoy\, University of Pennsylvania\nMuch of our understanding of the biological mechanisms that underlie cellular functions\, such as migration\, differentiation and force sensing has been garnered from studying cells cultured on two-dimensional (2D) substrates. In the recent years there has been intense interest and effort to understand cell mechanics in three-dimensional (3D) cultures\, which more closely resemble the in vivo microenvironment. However\, a major challenge unique to 3D settings is the dynamic feedback between cells and their surroundings. In many 3D matrices\, cells remodel and reorient local extracellular microenvironment\, which in turn alters the active mechanics and in many cases\, the cell phenotype. Most models for matrices to date do not account for such positive feedback. Such models\, validated by experiments\, can provide a quantitative framework to study how injury related factors (in pathological conditions such as fibrosis and cancer metastasis) alter extracellular matrix (ECM) mechanics. They can also be used to analyze tissue morphology in complex 3D environments such as during morphogenesis and organogenesis\, and guide such processes in engineered 3D tissues. In this talk\, I will present discrete network simulations to study how cells remodel matrices and how this remodeling can lead to force transmission over large distances in cells. I will also discuss an active tissue model to quantitatively study the influence of mechanical constraints and matrix stiffness on contractility and stability of micropatterned tissues.
URL:https://ibecbarcelona.eu/event/ibec-seminar-vivek-shenoy-2/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20180615T100000
DTEND;TZID=Europe/Madrid:20180615T110000
DTSTAMP:20260405T213641
CREATED:20180517T085601Z
LAST-MODIFIED:20180517T085601Z
UID:59170-1529056800-1529060400@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Vivek Shenoy
DESCRIPTION:Cell-Matrix Interactions in Fibrosis and Cancer: Multiscale mechano-chemical models\nVivek Shenoy\, University of Pennsylvania\nMuch of our understanding of the biological mechanisms that underlie cellular functions\, such as migration\, differentiation and force sensing has been garnered from studying cells cultured on two-dimensional (2D) substrates. In the recent years there has been intense interest and effort to understand cell mechanics in three-dimensional (3D) cultures\, which more closely resemble the in vivo microenvironment. However\, a major challenge unique to 3D settings is the dynamic feedback between cells and their surroundings. In many 3D matrices\, cells remodel and reorient local extracellular microenvironment\, which in turn alters the active mechanics and in many cases\, the cell phenotype. Most models for matrices to date do not account for such positive feedback. Such models\, validated by experiments\, can provide a quantitative framework to study how injury related factors (in pathological conditions such as fibrosis and cancer metastasis) alter extracellular matrix (ECM) mechanics. They can also be used to analyze tissue morphology in complex 3D environments such as during morphogenesis and organogenesis\, and guide such processes in engineered 3D tissues. In this talk\, I will present discrete network simulations to study how cells remodel matrices and how this remodeling can lead to force transmission over large distances in cells. I will also discuss an active tissue model to quantitatively study the influence of mechanical constraints and matrix stiffness on contractility and stability of micropatterned tissues.
URL:https://ibecbarcelona.eu/event/ibec-seminar-vivek-shenoy/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20180706T100000
DTEND;TZID=Europe/Madrid:20180706T110000
DTSTAMP:20260405T213641
CREATED:20180702T090609Z
LAST-MODIFIED:20180702T090609Z
UID:96274-1530871200-1530874800@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Cristina Canal
DESCRIPTION:Cold atmospheric plasma: a novel potential therapy for cancer treatment\nCristina Canal\, Biomaterials\, Biomechanics and Tissue Engineering (BBT)\, UPC\nOver the last few years\, significant attention has been paid to biomedical applications of Atmospheric Pressure Plasmas (APP). Plasma chemistry leads to the generation of an abundance of reactive species which are suspected to play a key role in selective cancer cell death [1] without damaging surrounding healthy tissues [2]. The anti-cancer properties of the APP have been described in many cancer cell lines\, such as breast\, skin\, lung\, pancreas\, cervix and brain cancers and only more recently in bone cancer cells [3-4]. Although the cell death mechanisms are not yet precisely known\, this selectivity towards cancer cells is associated in literature to the reactive oxygen and nitrogen species (RONS) generated by the plasma treatment\, among other potential actors. In this talk we will introduce different plasma oncology concepts and will discuss some of our first results related to plasma treatment and plasma activated medium treatment of osteosarcoma and the selectivity of the treatment.
URL:https://ibecbarcelona.eu/event/ibec-seminar-cristina-canal-2/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20180706T100000
DTEND;TZID=Europe/Madrid:20180706T110000
DTSTAMP:20260405T213641
CREATED:20180702T090609Z
LAST-MODIFIED:20180702T090615Z
UID:59823-1530871200-1530874800@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Cristina Canal
DESCRIPTION:Cold atmospheric plasma: a novel potential therapy for cancer treatment\nCristina Canal\, Biomaterials\, Biomechanics and Tissue Engineering (BBT)\, UPC\nOver the last few years\, significant attention has been paid to biomedical applications of Atmospheric Pressure Plasmas (APP). Plasma chemistry leads to the generation of an abundance of reactive species which are suspected to play a key role in selective cancer cell death [1] without damaging surrounding healthy tissues [2]. The anti-cancer properties of the APP have been described in many cancer cell lines\, such as breast\, skin\, lung\, pancreas\, cervix and brain cancers and only more recently in bone cancer cells [3-4]. Although the cell death mechanisms are not yet precisely known\, this selectivity towards cancer cells is associated in literature to the reactive oxygen and nitrogen species (RONS) generated by the plasma treatment\, among other potential actors. In this talk we will introduce different plasma oncology concepts and will discuss some of our first results related to plasma treatment and plasma activated medium treatment of osteosarcoma and the selectivity of the treatment.
URL:https://ibecbarcelona.eu/event/ibec-seminar-cristina-canal/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
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