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DTSTART;TZID=Europe/Madrid:20150917T100000
DTEND;TZID=Europe/Madrid:20150917T110000
DTSTAMP:20260404T224314
CREATED:20150803T122810Z
LAST-MODIFIED:20150803T122810Z
UID:95865-1442484000-1442487600@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Richard Reilly
DESCRIPTION:All a question of Timing:  Sensory processing in Dystonia and Parkinson’s Disease\nProfessor Richard Reilly\, Trinity Centre for Bioengineering · Trinity College Dublin\nThere are many challenges in the diagnosis and management of neurological disorders. Neural Engineering can help address some of these by the development of novel engineering\, computational and experimental methods to help understand the pathogenesis of neurological disorders. This talk will detail results from recent neural engineering studies into understanding cervical dystonia and Parkinson’s disease. \nWhile the pathogenesis of cervical dystonia remains unknown\, recent animal and clinical experimental studies have indicated its probable mechanisms. Human movement involves a complex series of coordinated musculoskeletal but also neural processes. A breakdown in any of these processes can result in irregular movement. The temporal discrimination threshold is the shortest time interval at which two sensory stimuli presented sequentially are detected as asynchronous by the observer. Studies in our group and that of others have shown that abnormal temporal discrimination is a mediational endophenotype of cervical dystonia and informs new concepts of disease pathogenesis. Our hypothesis is that both abnormal temporal discrimination and cervical dystonia are due to a disorder of the midbrain network for covert attentional orienting caused by reduced gamma-aminobutyric acid inhibition\, resulting from\, in turn\, from as yet undetermined\, genetic mutations. Such disinhibition is a) subclinically manifested by abnormal temporal discrimination due to prolonged duration firing of the visual sensory neurons in the superficial laminae of the superior colliculus\, b) clinically manifested by cervical dystonia due to disinhibited burst activity of the cephalomotor neurons of the intermediate and deep laminae of the superior colliculus. Abnormal temporal discrimination in unaffected first-degree relatives of patients with cervical dystonia represents a subclinical manifestation of defective gamma-aminobutyric acid activity both within the superior colliculus and from the substantia nigra pars reticulata. This talk will review some our recent experiments addressing this hypothesis. \nSensory and perceptual disturbances are common in Parkinson’s disease. Subtle deficits of the sensory system\, often not detected by routine examination\, occur in people with Parkinson’s disease. From simple anosmia and impaired kinesthetic perception\, to more complex visual hallucinations and spatiotemporal perceptual abnormalities\, altered sensory processing is found across multiple modalities. Of note\, integration of multiple environmental sensory inputs is crucial for a refined but complex goal-directed motor output (e.g. locomotion through a crowded environment). There is increasing evidence that these sensory deficits contribute to the pathophysiology of some of the abnormal motor features of Parkinson’s disease. This talk will review some of our recent experiments to probe multisensory deficits in Parkinson’s disease and introduce one intervention developed around sensory and cognitive processing.
URL:https://ibecbarcelona.eu/event/ibec-seminar-richard-reilly-2/
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20150917T100000
DTEND;TZID=Europe/Madrid:20150917T110000
DTSTAMP:20260404T224314
CREATED:20150803T122810Z
LAST-MODIFIED:20150803T122810Z
UID:18430-1442484000-1442487600@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Richard Reilly
DESCRIPTION:All a question of Timing:  Sensory processing in Dystonia and Parkinson’s Disease\nProfessor Richard Reilly\, Trinity Centre for Bioengineering · Trinity College Dublin\nThere are many challenges in the diagnosis and management of neurological disorders. Neural Engineering can help address some of these by the development of novel engineering\, computational and experimental methods to help understand the pathogenesis of neurological disorders. This talk will detail results from recent neural engineering studies into understanding cervical dystonia and Parkinson’s disease. \nWhile the pathogenesis of cervical dystonia remains unknown\, recent animal and clinical experimental studies have indicated its probable mechanisms. Human movement involves a complex series of coordinated musculoskeletal but also neural processes. A breakdown in any of these processes can result in irregular movement. The temporal discrimination threshold is the shortest time interval at which two sensory stimuli presented sequentially are detected as asynchronous by the observer. Studies in our group and that of others have shown that abnormal temporal discrimination is a mediational endophenotype of cervical dystonia and informs new concepts of disease pathogenesis. Our hypothesis is that both abnormal temporal discrimination and cervical dystonia are due to a disorder of the midbrain network for covert attentional orienting caused by reduced gamma-aminobutyric acid inhibition\, resulting from\, in turn\, from as yet undetermined\, genetic mutations. Such disinhibition is a) subclinically manifested by abnormal temporal discrimination due to prolonged duration firing of the visual sensory neurons in the superficial laminae of the superior colliculus\, b) clinically manifested by cervical dystonia due to disinhibited burst activity of the cephalomotor neurons of the intermediate and deep laminae of the superior colliculus. Abnormal temporal discrimination in unaffected first-degree relatives of patients with cervical dystonia represents a subclinical manifestation of defective gamma-aminobutyric acid activity both within the superior colliculus and from the substantia nigra pars reticulata. This talk will review some our recent experiments addressing this hypothesis. \nSensory and perceptual disturbances are common in Parkinson’s disease. Subtle deficits of the sensory system\, often not detected by routine examination\, occur in people with Parkinson’s disease. From simple anosmia and impaired kinesthetic perception\, to more complex visual hallucinations and spatiotemporal perceptual abnormalities\, altered sensory processing is found across multiple modalities. Of note\, integration of multiple environmental sensory inputs is crucial for a refined but complex goal-directed motor output (e.g. locomotion through a crowded environment). There is increasing evidence that these sensory deficits contribute to the pathophysiology of some of the abnormal motor features of Parkinson’s disease. This talk will review some of our recent experiments to probe multisensory deficits in Parkinson’s disease and introduce one intervention developed around sensory and cognitive processing.
URL:https://ibecbarcelona.eu/event/ibec-seminar-richard-reilly/
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20150918T100000
DTEND;TZID=Europe/Madrid:20150918T110000
DTSTAMP:20260404T224314
CREATED:20150629T072320Z
LAST-MODIFIED:20150629T072320Z
UID:95859-1442570400-1442574000@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Marc Martí-Renom
DESCRIPTION:Structure determination of genomes and genomic domains by satisfaction of spatial restraints\nMarc Martí-Renom\, ICREA Research Professor / CNAG / CRG\nThe genome three-dimensional (3D) organization plays important\, yet poorly understood roles in gene regulation. Chromosomes assume multiple distinct conformations in relation to the expression status of resident genes and undergo dramatic alterations in higher order structure through the cell cycle. Despite advances in microscopy\, a general technique to determine the 3D conformation of chromatin has been lacking. We developed a new method for the determination of the 3D conformation of chromatin domains in the interphase nucleus\, which combines 3C-based experiments with the computational Integrative Modeling Platform (IMP). The general approach of our method\, which has been applied to study the 3D conformation of the alpha-globin domain in the human genome [1]\, the Caulobacter crescentus whole genome [2]\, and the dynamic response of Topologically Associating Domains (TADs) to hormone treatment in breast cancer cell lines [3]\, opens the field for comprehensive studies of the 3D conformation of chromosomal domains and contributes to a more complete characterization of genome regulation.\n[1] D. Baù et al. Nat Struct Mol Biol (2011) 18:107.\n[2] M.A. Umbarger\, et al. Molecular Cell (2011) 44:252\n[3] Le Dily\, et al. Genes & Dev (2014) 28:2151
URL:https://ibecbarcelona.eu/event/ibec-seminar-marc-marti-renom-2/
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20150918T100000
DTEND;TZID=Europe/Madrid:20150918T110000
DTSTAMP:20260404T224314
CREATED:20150629T072320Z
LAST-MODIFIED:20150629T072320Z
UID:17667-1442570400-1442574000@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Marc Martí-Renom
DESCRIPTION:Structure determination of genomes and genomic domains by satisfaction of spatial restraints\nMarc Martí-Renom\, ICREA Research Professor / CNAG / CRG\nThe genome three-dimensional (3D) organization plays important\, yet poorly understood roles in gene regulation. Chromosomes assume multiple distinct conformations in relation to the expression status of resident genes and undergo dramatic alterations in higher order structure through the cell cycle. Despite advances in microscopy\, a general technique to determine the 3D conformation of chromatin has been lacking. We developed a new method for the determination of the 3D conformation of chromatin domains in the interphase nucleus\, which combines 3C-based experiments with the computational Integrative Modeling Platform (IMP). The general approach of our method\, which has been applied to study the 3D conformation of the alpha-globin domain in the human genome [1]\, the Caulobacter crescentus whole genome [2]\, and the dynamic response of Topologically Associating Domains (TADs) to hormone treatment in breast cancer cell lines [3]\, opens the field for comprehensive studies of the 3D conformation of chromosomal domains and contributes to a more complete characterization of genome regulation.\n[1] D. Baù et al. Nat Struct Mol Biol (2011) 18:107.\n[2] M.A. Umbarger\, et al. Molecular Cell (2011) 44:252\n[3] Le Dily\, et al. Genes & Dev (2014) 28:2151
URL:https://ibecbarcelona.eu/event/ibec-seminar-marc-marti-renom/
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20150922T000000
DTEND;TZID=Europe/Madrid:20150922T130000
DTSTAMP:20260404T224314
CREATED:20150918T102346Z
LAST-MODIFIED:20150918T102346Z
UID:95868-1442880000-1442926800@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Albert Folch
DESCRIPTION:Print-and-Play Microfluidics\nAlbert Folch\, Associate Professor\, University of Washington\nBiologists and clinicians typically do not have access to microfluidic technology because they do not have the engineering expertise or equipment required to fabricate and/or operate microfluidic devices. Furthermore\, the present commercialization path for microfluidic devices is usually restricted to high-volume applications in order to recover the large investment needed to develop the plastic molding processes. We are developing microfluidic devices through stereolithography\, a form of 3D printing\, in order to make microfluidic technology readily available via the web to biomedical scientists. Our lab presently focuses on developing 3D-printable microdevices that facilitate the advancement of basic neuroscience and translational cancer applications. The lab’s long-term mission is to make microfluidic devices as easy to use as smartphones and make them easily available to clinicians in order to enable novel cancer diagnostics and therapies.
URL:https://ibecbarcelona.eu/event/ibec-seminar-albert-folch-2/
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20150922T000000
DTEND;TZID=Europe/Madrid:20150922T130000
DTSTAMP:20260404T224314
CREATED:20150918T102346Z
LAST-MODIFIED:20150918T102346Z
UID:18953-1442880000-1442926800@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Albert Folch
DESCRIPTION:Print-and-Play Microfluidics\nAlbert Folch\, Associate Professor\, University of Washington\nBiologists and clinicians typically do not have access to microfluidic technology because they do not have the engineering expertise or equipment required to fabricate and/or operate microfluidic devices. Furthermore\, the present commercialization path for microfluidic devices is usually restricted to high-volume applications in order to recover the large investment needed to develop the plastic molding processes. We are developing microfluidic devices through stereolithography\, a form of 3D printing\, in order to make microfluidic technology readily available via the web to biomedical scientists. Our lab presently focuses on developing 3D-printable microdevices that facilitate the advancement of basic neuroscience and translational cancer applications. The lab’s long-term mission is to make microfluidic devices as easy to use as smartphones and make them easily available to clinicians in order to enable novel cancer diagnostics and therapies.
URL:https://ibecbarcelona.eu/event/ibec-seminar-albert-folch/
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20151016T100000
DTEND;TZID=Europe/Madrid:20151016T110000
DTSTAMP:20260404T224314
CREATED:20150713T060412Z
LAST-MODIFIED:20150713T060412Z
UID:18096-1444989600-1444993200@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Lorenzo Albertazzi
DESCRIPTION:Nanoscopy for Nanomedicine: looking at nanomaterials in action one molecule at a time\nLorenzo Albertazzi\, IBEC\nThe use of nanomaterials for biomedical purposes such as drug or gene delivery is one of the key applications of nanotechnology. In this framework a variety of materials have been fabricated\, evaluated in cells and in vivo and\, in some cases\, successfully translated into clinical applications. A crucial factor limiting the design of effective nanocarriers is the lack of knowledge about materials-cell interactions that severely limit the rational design of nanosized devices.\nHere I’ll show how advanced optical microscopy techniques can shine a light on nanomaterials behavior in the biological environment\, helping us to understand structure-activity relationships and to design improved and more effective therapeutic devices. In particular I’ll discuss the ability of super resolution microscopy to image with nanometric resolution nanomaterials interactions with target cells. The potential and the applications of the technique will be discussed\, with particular emphasis on the study of self-assembled bio-inspired materials.
URL:https://ibecbarcelona.eu/event/ibec-seminar-lorenzo-albertazzi/
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20151016T100000
DTEND;TZID=Europe/Madrid:20151016T110000
DTSTAMP:20260404T224314
CREATED:20150713T060412Z
LAST-MODIFIED:20150713T060412Z
UID:95862-1444989600-1444993200@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Lorenzo Albertazzi
DESCRIPTION:Nanoscopy for Nanomedicine: looking at nanomaterials in action one molecule at a time\nLorenzo Albertazzi\, IBEC\nThe use of nanomaterials for biomedical purposes such as drug or gene delivery is one of the key applications of nanotechnology. In this framework a variety of materials have been fabricated\, evaluated in cells and in vivo and\, in some cases\, successfully translated into clinical applications. A crucial factor limiting the design of effective nanocarriers is the lack of knowledge about materials-cell interactions that severely limit the rational design of nanosized devices.\nHere I’ll show how advanced optical microscopy techniques can shine a light on nanomaterials behavior in the biological environment\, helping us to understand structure-activity relationships and to design improved and more effective therapeutic devices. In particular I’ll discuss the ability of super resolution microscopy to image with nanometric resolution nanomaterials interactions with target cells. The potential and the applications of the technique will be discussed\, with particular emphasis on the study of self-assembled bio-inspired materials.
URL:https://ibecbarcelona.eu/event/ibec-seminar-lorenzo-albertazzi-2/
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20151019T100000
DTEND;TZID=UTC:20151019T120000
DTSTAMP:20260404T224314
CREATED:20151006T054804Z
LAST-MODIFIED:20151006T054804Z
UID:19129-1445248800-1445256000@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Cell Imaging Day - Molecular Probes
DESCRIPTION:Cell Imaging Day – Molecular Probes\nClara Streiff\, Senior Technical Specialist · Molecular Probes – ThermoFisher Scientific\nSeminar:\n•	Marcaje de estructuras celulares en células vivas (Bacmam Cellight)\n•	Proliferación celular (Click-iT® EdU)\n•	Estrés oxidativo (CellROX®)\n•	Fagocitosis (PHrodo)\n•	Apoptosis (Cellevent Caspase 3 and 7)\n•	Mejorando la señal fluorescente en células vivas y fijadas (ReadyProbes reactivos “ready to use”)\n•	Ventajas de la citometría por focalización acústica (Attune®NxT acoustic focusing cytometer)  \nAl final del seminario podrás pasar tus muestras en el microscopio EVOS® FL AUTO y prueba nuestros reactivos ReadyProbes de Molecular Probes sin compromiso\, reactivos para imaging que permiten marcar tus células sin necesidad de hacer calculos\, diluciones ni pipetear.
URL:https://ibecbarcelona.eu/event/ibec-seminar-cell-imaging-day-molecular-probes/
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20151019T100000
DTEND;TZID=UTC:20151019T120000
DTSTAMP:20260404T224314
CREATED:20151006T054804Z
LAST-MODIFIED:20151006T054804Z
UID:95869-1445248800-1445256000@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Cell Imaging Day - Molecular Probes
DESCRIPTION:Cell Imaging Day – Molecular Probes\nClara Streiff\, Senior Technical Specialist · Molecular Probes – ThermoFisher Scientific\nSeminar:\n•	Marcaje de estructuras celulares en células vivas (Bacmam Cellight)\n•	Proliferación celular (Click-iT® EdU)\n•	Estrés oxidativo (CellROX®)\n•	Fagocitosis (PHrodo)\n•	Apoptosis (Cellevent Caspase 3 and 7)\n•	Mejorando la señal fluorescente en células vivas y fijadas (ReadyProbes reactivos “ready to use”)\n•	Ventajas de la citometría por focalización acústica (Attune®NxT acoustic focusing cytometer)  \nAl final del seminario podrás pasar tus muestras en el microscopio EVOS® FL AUTO y prueba nuestros reactivos ReadyProbes de Molecular Probes sin compromiso\, reactivos para imaging que permiten marcar tus células sin necesidad de hacer calculos\, diluciones ni pipetear.
URL:https://ibecbarcelona.eu/event/ibec-seminar-cell-imaging-day-molecular-probes-2/
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20151023T100000
DTEND;TZID=Europe/Madrid:20151023T110000
DTSTAMP:20260404T224314
CREATED:20150803T123423Z
LAST-MODIFIED:20150803T123423Z
UID:95866-1445594400-1445598000@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Miquel Bosch Pita
DESCRIPTION:The molecular mechanisms of memory persistence: imaging how single synapses learn in real time\nMiquel Bosch Pita\, Nanoprobes and nanoswitches group\, IBEC\nMemories are stored in our brain through the ability of synaptic connections to modify their structure and function in a long-lasting way. However\, nobody has ever observed how these changes occur in a single synapse in real time.\nI will explain how we used a new combination of optical technologies to reveal the molecular remodeling that takes place inside a synapse during the creation of a memory. We used two-photon microscopy to stimulate individual synapses and to visualize protein trafficking in real time. We identified a unique protein that is rapidly and persistently captured in potentiated synapses\, forming a new macromolecule that could serve as a memory tag. We developed a novel photo-marking technique that allowed us to localize the same synapses under both two-photon and electron microscopies. This way we observed how different synaptic structures evolve asynchronously in three temporal phases during synaptic potentiation.
URL:https://ibecbarcelona.eu/event/ibec-seminar-miquel-bosch-pita-2/
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20151023T100000
DTEND;TZID=Europe/Madrid:20151023T110000
DTSTAMP:20260404T224314
CREATED:20150803T123423Z
LAST-MODIFIED:20150803T123423Z
UID:18434-1445594400-1445598000@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Miquel Bosch Pita
DESCRIPTION:The molecular mechanisms of memory persistence: imaging how single synapses learn in real time\nMiquel Bosch Pita\, Nanoprobes and nanoswitches group\, IBEC\nMemories are stored in our brain through the ability of synaptic connections to modify their structure and function in a long-lasting way. However\, nobody has ever observed how these changes occur in a single synapse in real time.\nI will explain how we used a new combination of optical technologies to reveal the molecular remodeling that takes place inside a synapse during the creation of a memory. We used two-photon microscopy to stimulate individual synapses and to visualize protein trafficking in real time. We identified a unique protein that is rapidly and persistently captured in potentiated synapses\, forming a new macromolecule that could serve as a memory tag. We developed a novel photo-marking technique that allowed us to localize the same synapses under both two-photon and electron microscopies. This way we observed how different synaptic structures evolve asynchronously in three temporal phases during synaptic potentiation.
URL:https://ibecbarcelona.eu/event/ibec-seminar-miquel-bosch-pita/
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20151119T120000
DTEND;TZID=UTC:20151119T130000
DTSTAMP:20260404T224314
CREATED:20151109T154810Z
LAST-MODIFIED:20151109T154810Z
UID:95878-1447934400-1447938000@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Luis de Lecea
DESCRIPTION:Optogenetic control of arousal\nLuis de Lecea\, Department of Psychiatry and Behavioral Sciences\, Stanford University School of Medicine\nChanges in arousal states are at the core of most neuropsychiatric disorders. Several groups of monoaminergic neurons have long been known to facilitate arousal state transitions. Here we will review the role of hypocretin/orexin neurons in the dynamics of sleep-to-wake transitions. I will also show data demonstrating that dopaminergic neurons of the ventral tegmental area (VTA) directly and causally control the generation and maintenance of electrocortical and behavioral arousal. Combining chemogenetic and optogenetic tools with polysomnographic recordings in mice\, we show that activity in VTA-dopaminergic neurons is necessary for arousal\, and that their chemogenetic inhibition suppresses wakefulness to promote both non-rapid eye movement (NREM) and REM sleep. Moreover\, chemogenetic inhibition of VTA-dopaminergic neurons suppresses wakefulness even in the face of highly salient stimuli related to reproduction\, feeding and predation. Nevertheless\, prior to inducing sleep\, chemogenetic inhibition of VTA-dopaminergic neurons promotes goal-directed and sleep-related nest building behavior. Optogenetic stimulation\, in contrast\, initiates and maintains long-term wakefulness and suppresses sleep and sleep-related nesting behavior. We further show that the nucleus accumbens (NAc) circuit\, and not the medial prefrontal cortex (mPFC)\, mediates most of VTA-dopaminergic effects on arousal. After collecting data from multiple brain structures involved in arousal states\, we propose a computational model that assigns probabilities to optogenetically-induced arousal state transitions in individual brain structures. We identify feedback\, redundancy\, and gating hierarchy as three fundamental aspects of this model. Incorporation of conductance-based models of neuronal ensembles into this model and existing models of cortical excitability will provide more comprehensive insight into arousal state dynamics as well as arousal-related disorders.
URL:https://ibecbarcelona.eu/event/ibec-seminar-luis-de-lecea-2/
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20151119T120000
DTEND;TZID=UTC:20151119T130000
DTSTAMP:20260404T224314
CREATED:20151109T154810Z
LAST-MODIFIED:20151113T074152Z
UID:19587-1447934400-1447938000@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Luis de Lecea
DESCRIPTION:Optogenetic control of arousal\nLuis de Lecea\, Department of Psychiatry and Behavioral Sciences\, Stanford University School of Medicine\nChanges in arousal states are at the core of most neuropsychiatric disorders. Several groups of monoaminergic neurons have long been known to facilitate arousal state transitions. Here we will review the role of hypocretin/orexin neurons in the dynamics of sleep-to-wake transitions. I will also show data demonstrating that dopaminergic neurons of the ventral tegmental area (VTA) directly and causally control the generation and maintenance of electrocortical and behavioral arousal. Combining chemogenetic and optogenetic tools with polysomnographic recordings in mice\, we show that activity in VTA-dopaminergic neurons is necessary for arousal\, and that their chemogenetic inhibition suppresses wakefulness to promote both non-rapid eye movement (NREM) and REM sleep. Moreover\, chemogenetic inhibition of VTA-dopaminergic neurons suppresses wakefulness even in the face of highly salient stimuli related to reproduction\, feeding and predation. Nevertheless\, prior to inducing sleep\, chemogenetic inhibition of VTA-dopaminergic neurons promotes goal-directed and sleep-related nest building behavior. Optogenetic stimulation\, in contrast\, initiates and maintains long-term wakefulness and suppresses sleep and sleep-related nesting behavior. We further show that the nucleus accumbens (NAc) circuit\, and not the medial prefrontal cortex (mPFC)\, mediates most of VTA-dopaminergic effects on arousal. After collecting data from multiple brain structures involved in arousal states\, we propose a computational model that assigns probabilities to optogenetically-induced arousal state transitions in individual brain structures. We identify feedback\, redundancy\, and gating hierarchy as three fundamental aspects of this model. Incorporation of conductance-based models of neuronal ensembles into this model and existing models of cortical excitability will provide more comprehensive insight into arousal state dynamics as well as arousal-related disorders.
URL:https://ibecbarcelona.eu/event/ibec-seminar-luis-de-lecea/
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20151127T120000
DTEND;TZID=UTC:20151127T130000
DTSTAMP:20260404T224314
CREATED:20151106T080207Z
LAST-MODIFIED:20151106T080207Z
UID:95877-1448625600-1448629200@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Chia-Fu Chou
DESCRIPTION:Low-copy number biomolecular analysis with dielectrophoretic enrichment /trapping via molecular dam and plasmonic electrode nanogaps\nChia-Fu Chou\, Senior Research Fellow/Professor\, Institute of Physics\, Academia Sinica\, Taiwan\nNanoscale structures\, such as electrode nanogap and nanofluidic confinement\, given its simplicity in geometry\, nevertheless offer unique platforms for the study of molecular and cellular biophysics\, with the potential for bioanalytical applications [1-5]. For low-copy number molecule detection\, we developed two versatile analysis platforms for the manipulation and sensing of biomolecules. In the first scenario\, sub-30 nm insulating nanoconstriction operating under the balance of negative dielectrophoresis (DEP)\, electrophoresis\, and electroosmosis\, serves as molecular dam\, enables protein enrichment of 105-fold in 20 seconds [6]\, which can then be coupled with graphene-modified electrode for sensitive electrochemical detection of proteins and peptides [7\, 8]. In the second scenario\, an array of Ti/Au electrode nanogaps with sub-10 nm gap size function as templates for AC DEP-based molecular trapping\, plasmonic hot spots for surface-enhanced Raman spectroscopy as well as electronic measurements\, and fluorescence imaging. During molecular trapping\, recorded Raman spectra\, conductance measurements across the nanogaps and fluorescence imaging show unambiguously the presence and characteristics of the trapped molecules\, demonstrated with R-phycoerythrin [9] and Alzheimer’s disease associated biomarkers A-beta 40 and 42 peptides. Our platforms open up simple ways for multifunctional low-concentration heterogeneous sample analysis.\n[1] L.J. Guo\, X. Cheng\, C.F. Chou\, Nano Lett. 4\, 69 (2004).\n[2] J. Gu\, R. Gupta\, C.F. Chou\, Q. Wei\, F. Zenhausern\, Lab Chip 7\, 1198 (2007).\n[3] J.W. Yeh\, A. Taloni\, Y.L. Chen\, C.F. Chou\, Nano Lett. 12\, 1597 (2012). [Research Highlights\, Nature 482\, 442 (2012)].\n[4] J.P. Shen and C.F. Chou\, Biomicrofluidics 8\, 041103 (2014).\n[5] K.K. Sriram\, J.W. Yeh\, Y.L. Lin\, Y.R. Chang\, C.F. Chou\, Nucleic Acids Res. 42\, e85 (2014).\n[6] K.T. Liao\, C.F. Chou\, J. Am. Chem. Soc. 134\, 8742 (2012). [JACS Spotlights: JACS 134\, 10307 (2012)]\n[7] B. Sanghavi\, W. Varhue\, J. Chávez\, C.F. Chou\, N. S. Swami\, Anal. Chem. 86\, 4120 (2014\,).\n[8] B.J. Sanghavi\, W. Varhue\, A. Rohani\, K.T. Liao\, L. Bazydlo\, C.F. Chou\, N. S. Swami\, Lab Chip 2015\, DOI: 10.1039/c5lc00840a.\n[9] L. Lesser-Rojas\, P. Ebbinghaus\, G. Vasan\, M.L. Chu\, A. Erbe\, C.F. Chou\, Nano Lett. 14\, 2242 (2014).
URL:https://ibecbarcelona.eu/event/ibec-seminar-chia-fu-chou-2/
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20151127T120000
DTEND;TZID=UTC:20151127T130000
DTSTAMP:20260404T224314
CREATED:20151106T080207Z
LAST-MODIFIED:20151123T092950Z
UID:19561-1448625600-1448629200@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Chia-Fu Chou
DESCRIPTION:Low-copy number biomolecular analysis with dielectrophoretic enrichment /trapping via molecular dam and plasmonic electrode nanogaps\nChia-Fu Chou\, Senior Research Fellow/Professor\, Institute of Physics\, Academia Sinica\, Taiwan\nNanoscale structures\, such as electrode nanogap and nanofluidic confinement\, given its simplicity in geometry\, nevertheless offer unique platforms for the study of molecular and cellular biophysics\, with the potential for bioanalytical applications [1-5]. For low-copy number molecule detection\, we developed two versatile analysis platforms for the manipulation and sensing of biomolecules. In the first scenario\, sub-30 nm insulating nanoconstriction operating under the balance of negative dielectrophoresis (DEP)\, electrophoresis\, and electroosmosis\, serves as molecular dam\, enables protein enrichment of 105-fold in 20 seconds [6]\, which can then be coupled with graphene-modified electrode for sensitive electrochemical detection of proteins and peptides [7\, 8]. In the second scenario\, an array of Ti/Au electrode nanogaps with sub-10 nm gap size function as templates for AC DEP-based molecular trapping\, plasmonic hot spots for surface-enhanced Raman spectroscopy as well as electronic measurements\, and fluorescence imaging. During molecular trapping\, recorded Raman spectra\, conductance measurements across the nanogaps and fluorescence imaging show unambiguously the presence and characteristics of the trapped molecules\, demonstrated with R-phycoerythrin [9] and Alzheimer’s disease associated biomarkers A-beta 40 and 42 peptides. Our platforms open up simple ways for multifunctional low-concentration heterogeneous sample analysis.\n[1] L.J. Guo\, X. Cheng\, C.F. Chou\, Nano Lett. 4\, 69 (2004).\n[2] J. Gu\, R. Gupta\, C.F. Chou\, Q. Wei\, F. Zenhausern\, Lab Chip 7\, 1198 (2007).\n[3] J.W. Yeh\, A. Taloni\, Y.L. Chen\, C.F. Chou\, Nano Lett. 12\, 1597 (2012). [Research Highlights\, Nature 482\, 442 (2012)].\n[4] J.P. Shen and C.F. Chou\, Biomicrofluidics 8\, 041103 (2014).\n[5] K.K. Sriram\, J.W. Yeh\, Y.L. Lin\, Y.R. Chang\, C.F. Chou\, Nucleic Acids Res. 42\, e85 (2014).\n[6] K.T. Liao\, C.F. Chou\, J. Am. Chem. Soc. 134\, 8742 (2012). [JACS Spotlights: JACS 134\, 10307 (2012)]\n[7] B. Sanghavi\, W. Varhue\, J. Chávez\, C.F. Chou\, N. S. Swami\, Anal. Chem. 86\, 4120 (2014\,).\n[8] B.J. Sanghavi\, W. Varhue\, A. Rohani\, K.T. Liao\, L. Bazydlo\, C.F. Chou\, N. S. Swami\, Lab Chip 2015\, DOI: 10.1039/c5lc00840a.\n[9] L. Lesser-Rojas\, P. Ebbinghaus\, G. Vasan\, M.L. Chu\, A. Erbe\, C.F. Chou\, Nano Lett. 14\, 2242 (2014).
URL:https://ibecbarcelona.eu/event/ibec-seminar-chia-fu-chou/
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20151203T100000
DTEND;TZID=UTC:20151203T230000
DTSTAMP:20260404T224314
CREATED:20151126T075237Z
LAST-MODIFIED:20151126T075237Z
UID:95882-1449136800-1449183600@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Alexandre Perera
DESCRIPTION:Data evaluation in Metabolomics\, preprocessing\, analysis and biological enrichment\nAlexandre Perera\, B2SLab Bioinformatics and Biomedical Signals Laboratory\, UPC\nThis talk will depict the last efforts by the B2Slab on the processing of LC/MS metabolomics data. First\, we describe a new method to solve known issues of peak intensity drifts in metabolomics datasets. This method is based on a two-step approach in which intensity drift effects are modelled through Common Principal Components Analysis and removed from original data. Secondly\, we propose a new processing workflow based on peak aggregation techniques. We show that the predictive power of the data is improved when the peak aggregation techniques are used regardless of the prediction technique used. We also describe a new computational tool to perform end-to-end analysis (MAIT) coded under the R environment. MAIT package is highly modular and programmable which allow the users to perform their personalised LC/MS data analysis workflows. MAIT is able to take the raw output files from an LC/MS instrument as an input and\, by applying a set of functions\, provide a metabolite identification table as a result. Finally\, we introduce FELLA\, a set of algorithms for biological interpretation of metabolomic data in light of existing knowledge extracted from annotation databases\, extending the concept of pathway enrichment into metabolomics. FELLA is based on diffusion process on a graph representation of a knowledge base\, while statistically testing solutions against analytical null diffusion distributions. Results are provided comparing the tools with sate of the art methods on different network types.\n\n[1] Fernández-Albert F.\, Llorach R.\, Andrés-Lacueva C.\, Perera-Lluna A. Peak Aggregation as an Innovative Strategy for Improving the Predictive Power of LC-MS Metabolomic Profiles. Analytical Chemistry 86 (5)\, 2320–5 (2014).\n[2] Fernández-Albert F.\, Llorach R.\, Andrés-Lacueva C.\, Perera-Lluna A. An R package to analyse LC/MS metabolomic data: MAIT (Metabolite Automatic Identification Toolkit). Bioinformatics 30(13):1937-9 (2014).\n[3] Fernández-Albert F.\, Llorach R.\, Garcia-Aloy M\, Ziyatdinov A\, Andrés-Lacueva C.\, Perera-Lluna A. Intensity drift removal in LC/MS metabolomics by Common Variance Compensation. Bioinformatics 30(20)\, 2898-2905 (2014)\n[4] Domingo-Almenara\, X.\, Perera\, A.\, Ramírez\, N.\, Cañellas\, N.\, Correig\, X.\, & Brezmes\, J. (2015). Compound identification in gas chromatography/mass spectrometry-based metabolomics by blind source separation. Journal of Chromatography A\, 1409\, 226-233\n[5] Ziyatdinov\, A.; Marco\, S.; Chaudry\, A.; Persaud\, K.; Caminal\, P.; Perera\, A. Drift compensation of gas sensor array data by common principal component analysis. Sensors and Actuators B: Chemical 146\, 460-5 (2010).
URL:https://ibecbarcelona.eu/event/ibec-seminar-alexandre-perera-2/
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20151203T100000
DTEND;TZID=UTC:20151203T230000
DTSTAMP:20260404T224314
CREATED:20151126T075237Z
LAST-MODIFIED:20151126T075237Z
UID:19883-1449136800-1449183600@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Alexandre Perera
DESCRIPTION:Data evaluation in Metabolomics\, preprocessing\, analysis and biological enrichment\nAlexandre Perera\, B2SLab Bioinformatics and Biomedical Signals Laboratory\, UPC\nThis talk will depict the last efforts by the B2Slab on the processing of LC/MS metabolomics data. First\, we describe a new method to solve known issues of peak intensity drifts in metabolomics datasets. This method is based on a two-step approach in which intensity drift effects are modelled through Common Principal Components Analysis and removed from original data. Secondly\, we propose a new processing workflow based on peak aggregation techniques. We show that the predictive power of the data is improved when the peak aggregation techniques are used regardless of the prediction technique used. We also describe a new computational tool to perform end-to-end analysis (MAIT) coded under the R environment. MAIT package is highly modular and programmable which allow the users to perform their personalised LC/MS data analysis workflows. MAIT is able to take the raw output files from an LC/MS instrument as an input and\, by applying a set of functions\, provide a metabolite identification table as a result. Finally\, we introduce FELLA\, a set of algorithms for biological interpretation of metabolomic data in light of existing knowledge extracted from annotation databases\, extending the concept of pathway enrichment into metabolomics. FELLA is based on diffusion process on a graph representation of a knowledge base\, while statistically testing solutions against analytical null diffusion distributions. Results are provided comparing the tools with sate of the art methods on different network types.\n\n[1] Fernández-Albert F.\, Llorach R.\, Andrés-Lacueva C.\, Perera-Lluna A. Peak Aggregation as an Innovative Strategy for Improving the Predictive Power of LC-MS Metabolomic Profiles. Analytical Chemistry 86 (5)\, 2320–5 (2014).\n[2] Fernández-Albert F.\, Llorach R.\, Andrés-Lacueva C.\, Perera-Lluna A. An R package to analyse LC/MS metabolomic data: MAIT (Metabolite Automatic Identification Toolkit). Bioinformatics 30(13):1937-9 (2014).\n[3] Fernández-Albert F.\, Llorach R.\, Garcia-Aloy M\, Ziyatdinov A\, Andrés-Lacueva C.\, Perera-Lluna A. Intensity drift removal in LC/MS metabolomics by Common Variance Compensation. Bioinformatics 30(20)\, 2898-2905 (2014)\n[4] Domingo-Almenara\, X.\, Perera\, A.\, Ramírez\, N.\, Cañellas\, N.\, Correig\, X.\, & Brezmes\, J. (2015). Compound identification in gas chromatography/mass spectrometry-based metabolomics by blind source separation. Journal of Chromatography A\, 1409\, 226-233\n[5] Ziyatdinov\, A.; Marco\, S.; Chaudry\, A.; Persaud\, K.; Caminal\, P.; Perera\, A. Drift compensation of gas sensor array data by common principal component analysis. Sensors and Actuators B: Chemical 146\, 460-5 (2010).
URL:https://ibecbarcelona.eu/event/ibec-seminar-alexandre-perera/
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20151211T120000
DTEND;TZID=UTC:20151211T130000
DTSTAMP:20260404T224314
CREATED:20151029T093053Z
LAST-MODIFIED:20151029T093053Z
UID:95876-1449835200-1449838800@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Roberto de la Rica
DESCRIPTION:Bioplasmonics in nanofabrication\, biosensing and nanomedicine\nRoberto de la Rica\, University of Strathclyde\nIn this talk I will show several bio-enabled and bio-inspired approaches for growing and assembling plasmonic nanoparticles and their applications in biosensing and nanomedicine. I will explain how to use enzyme nanoreactors to guide the growth of plasmonic nanoparticles with different morphologies\, an approach that can be used to design ultrasensitive biosensors and new nanolithography tools. [1-4] \nI will also show a method for assembling nanoparticle superstructures with crystallographically aligned building blocks5 that possess improved plasmonic properties derived from their 3D organization. When assembled on magnetic supports these plasmonic superstructures can be used for as multifunctional intracellular sensors as well as for heat generation in thermal therapy. \n[1] Nat. Mater. 11\, 604 (2012);[2] Nat. Nanotechnol. 7\, 821\, 2012; [3] Nat. Protocol. 8\, 1759 (2013); [4] Adv. Funct. Mater. 24\, 3692 (2104); [5] JACS 133\, 2875 (2011)
URL:https://ibecbarcelona.eu/event/ibec-seminar-roberto-de-la-rica-2/
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20151211T120000
DTEND;TZID=UTC:20151211T130000
DTSTAMP:20260404T224314
CREATED:20151029T093053Z
LAST-MODIFIED:20151029T093053Z
UID:19457-1449835200-1449838800@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Roberto de la Rica
DESCRIPTION:Bioplasmonics in nanofabrication\, biosensing and nanomedicine\nRoberto de la Rica\, University of Strathclyde\nIn this talk I will show several bio-enabled and bio-inspired approaches for growing and assembling plasmonic nanoparticles and their applications in biosensing and nanomedicine. I will explain how to use enzyme nanoreactors to guide the growth of plasmonic nanoparticles with different morphologies\, an approach that can be used to design ultrasensitive biosensors and new nanolithography tools. [1-4] \nI will also show a method for assembling nanoparticle superstructures with crystallographically aligned building blocks5 that possess improved plasmonic properties derived from their 3D organization. When assembled on magnetic supports these plasmonic superstructures can be used for as multifunctional intracellular sensors as well as for heat generation in thermal therapy. \n[1] Nat. Mater. 11\, 604 (2012);[2] Nat. Nanotechnol. 7\, 821\, 2012; [3] Nat. Protocol. 8\, 1759 (2013); [4] Adv. Funct. Mater. 24\, 3692 (2104); [5] JACS 133\, 2875 (2011)
URL:https://ibecbarcelona.eu/event/ibec-seminar-roberto-de-la-rica/
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20160122T150000
DTEND;TZID=UTC:20160122T160000
DTSTAMP:20260404T224314
CREATED:20160114T100133Z
LAST-MODIFIED:20160114T100133Z
UID:95887-1453474800-1453478400@ibecbarcelona.eu
SUMMARY:IBEC Seminar (Bellvitge): Martin Lohse\, University of Würzburg
DESCRIPTION:Optical studies of receptor activation and signaling\nProf. Dr. Martin Lohse\, Chairman of the Rudolf Virchow Center for Experimental Biomedicine\, University of Würzburg\, Germany\nCyclic nucleotides (cAMP and cGMP) belong to the most ubiquitous intracellular messengers\, are produced in response to multiple stimuli\, act on several intracellular targets\, and regulate a vast array of biological functions. \nHowever\, in spite of the fundamental importance of these signaling systems\, very little is known about the temporal and spatial patterns of their production and action. In fact\, space and time seem to play almost no role in current concepts of intracellular signaling. To gain an insight into these dimensions\, we develop methods to create images of these second messengers in intact cells\, and to resolve these intracellular signals in space and in time.
URL:https://ibecbarcelona.eu/event/ibec-seminar-bellvitge-martin-lohse-university-of-wurzburg-2/
LOCATION:Aulari Nou de Bellvitge\, Sala de Graus (room 001\, ground floor)\, Campus de Bellvitge\, c/ Feixa Llarga s/n\, L'Hospitalet de Llobregat\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20160122T150000
DTEND;TZID=UTC:20160122T160000
DTSTAMP:20260404T224314
CREATED:20160114T100133Z
LAST-MODIFIED:20160118T093027Z
UID:20905-1453474800-1453478400@ibecbarcelona.eu
SUMMARY:IBEC Seminar (Bellvitge): Martin Lohse\, University of Würzburg
DESCRIPTION:Optical studies of receptor activation and signaling\nProf. Dr. Martin Lohse\, Chairman of the Rudolf Virchow Center for Experimental Biomedicine\, University of Würzburg\, Germany\nCyclic nucleotides (cAMP and cGMP) belong to the most ubiquitous intracellular messengers\, are produced in response to multiple stimuli\, act on several intracellular targets\, and regulate a vast array of biological functions. \nHowever\, in spite of the fundamental importance of these signaling systems\, very little is known about the temporal and spatial patterns of their production and action. In fact\, space and time seem to play almost no role in current concepts of intracellular signaling. To gain an insight into these dimensions\, we develop methods to create images of these second messengers in intact cells\, and to resolve these intracellular signals in space and in time.
URL:https://ibecbarcelona.eu/event/ibec-seminar-bellvitge-martin-lohse-university-of-wurzburg/
LOCATION:Aulari Nou de Bellvitge\, Sala de Graus (room 001\, ground floor)\, Campus de Bellvitge\, c/ Feixa Llarga s/n\, L'Hospitalet de Llobregat\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20160126T100000
DTEND;TZID=UTC:20160126T230000
DTSTAMP:20260404T224314
CREATED:20160120T140644Z
LAST-MODIFIED:20160120T140644Z
UID:95890-1453802400-1453849200@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Michael Schmuker
DESCRIPTION:Neural computation in odour space\nDr. Michael Schmuker\, School of Engineering and Informatics\, University of Sussex\, UK\nOur sense of smell enables us to explore the world of chemical information. Yet\, our knowledge on the structure of chemical stimulus space still lacks far behind other modalities like vision or hearing. This lack of knowledge currently presents a major roadblock for understanding how the brain efficiently encodes chemical information. Moreover\, a better understanding of odour space\, and how it is processed in the brain\, may also enable bio-inspired design of efficient technical solutions for chemical sensing. \nIn this presentation\, I will give an overview on our research on how the olfactory systems of insects and vertebrates encode and transform chemical information on its way from the primary sensors to higher brain areas. These investigations inspired us to implement the key concepts of olfactory processing on a neuromorphic hardware system that uses spiking neuronal networks to perform pattern recognition in high-dimensional feature spaces. I will also present our recent findings on how to extract information about source distance from the fine-structure of gas plumes.
URL:https://ibecbarcelona.eu/event/ibec-seminar-michael-schmuker-2/
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20160126T100000
DTEND;TZID=UTC:20160126T230000
DTSTAMP:20260404T224314
CREATED:20160120T140644Z
LAST-MODIFIED:20160120T140644Z
UID:21092-1453802400-1453849200@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Michael Schmuker
DESCRIPTION:Neural computation in odour space\nDr. Michael Schmuker\, School of Engineering and Informatics\, University of Sussex\, UK\nOur sense of smell enables us to explore the world of chemical information. Yet\, our knowledge on the structure of chemical stimulus space still lacks far behind other modalities like vision or hearing. This lack of knowledge currently presents a major roadblock for understanding how the brain efficiently encodes chemical information. Moreover\, a better understanding of odour space\, and how it is processed in the brain\, may also enable bio-inspired design of efficient technical solutions for chemical sensing. \nIn this presentation\, I will give an overview on our research on how the olfactory systems of insects and vertebrates encode and transform chemical information on its way from the primary sensors to higher brain areas. These investigations inspired us to implement the key concepts of olfactory processing on a neuromorphic hardware system that uses spiking neuronal networks to perform pattern recognition in high-dimensional feature spaces. I will also present our recent findings on how to extract information about source distance from the fine-structure of gas plumes.
URL:https://ibecbarcelona.eu/event/ibec-seminar-michael-schmuker/
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20160128T113000
DTEND;TZID=UTC:20160128T123000
DTSTAMP:20260404T224314
CREATED:20160119T140215Z
LAST-MODIFIED:20160119T140215Z
UID:95889-1453980600-1453984200@ibecbarcelona.eu
SUMMARY:IBEC Seminar:  Josep Roca
DESCRIPTION:From Systems Understanding to Personalized Medicine: Lessons and Recommendations based on a multi-disciplinary and translational analysis of COPD \nDr.  Josep Roca\, UB / IDIBAPS / Hospital Clinic\nSystems medicine\, using and adapting methods and approaches as developed within systems biology\, promises to be central in ongoing efforts of realizing and implementing personalized medicine in clinical practice and research. Here we review and critically assess opportunities and challenges using our work on COPD as a case study. We find that there are significant biomedical challenges in how to unravel complex multi-factorial components in disease initiation and progression producing different clinical phenotypes. Yet\, while such a system understanding of COPD is necessary\, there are other auxiliary challenges that need to be addressed in concert with a systems analysis of COPD. These include information and communication technologies (ICT) related issues such as data harmonization\, systematic handling of knowledge\, computational modeling\, and importantly their translation and support of clinical practice. For example\, clinical decision support systems need a seamless integration with new models and knowledge as systems analysis of COPD continues to develop. Our experience with clinical implementation of COPD highlights the need for a change of management including design of appropriate business models\, and adoption of ICT providing and supporting organizational interoperability among professional teams across healthcare tiers\, working around the patient. In conclusion\, in our hands the scope and efforts of systems medicine need to concurrently consider these aspects clinical implementation this driving the selection of most relevant issues and method in a systems analysis of disease.
URL:https://ibecbarcelona.eu/event/ibec-seminar-josep-roca-2/
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20160128T113000
DTEND;TZID=UTC:20160128T123000
DTSTAMP:20260404T224314
CREATED:20160119T140215Z
LAST-MODIFIED:20160119T140338Z
UID:21059-1453980600-1453984200@ibecbarcelona.eu
SUMMARY:IBEC Seminar:  Josep Roca
DESCRIPTION:From Systems Understanding to Personalized Medicine: Lessons and Recommendations based on a multi-disciplinary and translational analysis of COPD \nDr.  Josep Roca\, UB / IDIBAPS / Hospital Clinic\nSystems medicine\, using and adapting methods and approaches as developed within systems biology\, promises to be central in ongoing efforts of realizing and implementing personalized medicine in clinical practice and research. Here we review and critically assess opportunities and challenges using our work on COPD as a case study. We find that there are significant biomedical challenges in how to unravel complex multi-factorial components in disease initiation and progression producing different clinical phenotypes. Yet\, while such a system understanding of COPD is necessary\, there are other auxiliary challenges that need to be addressed in concert with a systems analysis of COPD. These include information and communication technologies (ICT) related issues such as data harmonization\, systematic handling of knowledge\, computational modeling\, and importantly their translation and support of clinical practice. For example\, clinical decision support systems need a seamless integration with new models and knowledge as systems analysis of COPD continues to develop. Our experience with clinical implementation of COPD highlights the need for a change of management including design of appropriate business models\, and adoption of ICT providing and supporting organizational interoperability among professional teams across healthcare tiers\, working around the patient. In conclusion\, in our hands the scope and efforts of systems medicine need to concurrently consider these aspects clinical implementation this driving the selection of most relevant issues and method in a systems analysis of disease.
URL:https://ibecbarcelona.eu/event/ibec-seminar-josep-roca/
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20160205T100000
DTEND;TZID=UTC:20160205T110000
DTSTAMP:20260404T224314
CREATED:20151222T075732Z
LAST-MODIFIED:20151222T075732Z
UID:20385-1454666400-1454670000@ibecbarcelona.eu
SUMMARY:IBEC Seminar:  Josef A. Käs
DESCRIPTION:Why do rigid tumours contain soft cancer cells?\nProf. Dr. Josef A. Käs\, Principal Investigator & Head of the Soft Matter Physics Division · Leipzig University\nAs early as 400 BCE\, the Roman medical encyclopaedist Celsus recognized that solid tumours are stiffer than surrounding tissue. However\, cancer cell lines are softer\, and softer cells facilitate invasion. This paradox raises several questions: Does softness emerge from adaptation to mechanical and chemical cues in the external microenvironment\, or are soft cells already present inside a primary solid tumour? If the latter\, how can a more rígid tissue contain more soft cells? Here we show that in primary tumour samples from patients with mammary and cervix carcinomas\, cells do exhibit a broad distribution of rigidities\, with a higher fraction of softer and more contractile cells compared to normal tissue. Mechanical modelling based on patient data reveals that\, surprisingly\, tumours with a significant fraction of very soft cells can still remain rigid. Moreover\, in tissues with the observed distributions of cell stiffnesses\, softer cells spontaneously self-organize into lines or streams\, possibly facilitating cancer metastasis.
URL:https://ibecbarcelona.eu/event/ibec-seminar-josef-a-kas/
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20160205T100000
DTEND;TZID=UTC:20160205T110000
DTSTAMP:20260404T224314
CREATED:20151222T075732Z
LAST-MODIFIED:20151222T075732Z
UID:95885-1454666400-1454670000@ibecbarcelona.eu
SUMMARY:IBEC Seminar:  Josef A. Käs
DESCRIPTION:Why do rigid tumours contain soft cancer cells?\nProf. Dr. Josef A. Käs\, Principal Investigator & Head of the Soft Matter Physics Division · Leipzig University\nAs early as 400 BCE\, the Roman medical encyclopaedist Celsus recognized that solid tumours are stiffer than surrounding tissue. However\, cancer cell lines are softer\, and softer cells facilitate invasion. This paradox raises several questions: Does softness emerge from adaptation to mechanical and chemical cues in the external microenvironment\, or are soft cells already present inside a primary solid tumour? If the latter\, how can a more rígid tissue contain more soft cells? Here we show that in primary tumour samples from patients with mammary and cervix carcinomas\, cells do exhibit a broad distribution of rigidities\, with a higher fraction of softer and more contractile cells compared to normal tissue. Mechanical modelling based on patient data reveals that\, surprisingly\, tumours with a significant fraction of very soft cells can still remain rigid. Moreover\, in tissues with the observed distributions of cell stiffnesses\, softer cells spontaneously self-organize into lines or streams\, possibly facilitating cancer metastasis.
URL:https://ibecbarcelona.eu/event/ibec-seminar-josef-a-kas-2/
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20160311T100000
DTEND;TZID=UTC:20160311T110000
DTSTAMP:20260404T224314
CREATED:20160229T091313Z
LAST-MODIFIED:20160229T091313Z
UID:95898-1457690400-1457694000@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Samuel Ojosnegros
DESCRIPTION:Imaging Eph/ephrin cell-cell communication through Enhanced Number and Brightness: a novel method for the study of protein aggregation\nDr. Samuel Ojosnegros\, Centre de Medicina Regenerativa de Barcelona (CMRB)\nProteins constantly interact with each other assembling a variety of molecular species\, including small oligomers\, fibers of dynamic polymerization or high-order clusters\, among others. However\, current methods discriminate poorly the stoichiometry of protein interactions in living cells. To overcome these impediments we developed an enhanced version of Number & Brightness (eN&B)\, a powerful live imaging technique with capability to investigate multiple domains of information.  eN&B determines the distribution of protein aggregates present inside every pixel in an image during time-lapse movies. It can reach unprecedented level of space and time resolution compared to FRET-based or FCS-based methods. When studying EphB2 receptor activation\, the eN&B allowed us to resolve simultaneously the aggregation state of 40 different oligomers in 3 dimensions (x\, y\, t) and pixel depth. We found that Eph oligomerization follows a sophisticated dynamics consistent with a nucleated polymerization process\, where activation and clustering are decoupled processes. This decoupling endows the receptor with high sensitivity for low ligand concentrations while at the same time allows to provide a proportional response to a wide range of ligand concentrations. In summary\, I will present a novel imaging tool with capability to determine the stoichiometry of receptor-ligand interactions and potentially\, many other instances or protein aggregation.
URL:https://ibecbarcelona.eu/event/ibec-seminar-samuel-ojosnegros-2/
CATEGORIES:IBEC Seminar
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DTSTART;TZID=UTC:20160311T100000
DTEND;TZID=UTC:20160311T110000
DTSTAMP:20260404T224314
CREATED:20160229T091313Z
LAST-MODIFIED:20160229T091313Z
UID:21728-1457690400-1457694000@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Samuel Ojosnegros
DESCRIPTION:Imaging Eph/ephrin cell-cell communication through Enhanced Number and Brightness: a novel method for the study of protein aggregation\nDr. Samuel Ojosnegros\, Centre de Medicina Regenerativa de Barcelona (CMRB)\nProteins constantly interact with each other assembling a variety of molecular species\, including small oligomers\, fibers of dynamic polymerization or high-order clusters\, among others. However\, current methods discriminate poorly the stoichiometry of protein interactions in living cells. To overcome these impediments we developed an enhanced version of Number & Brightness (eN&B)\, a powerful live imaging technique with capability to investigate multiple domains of information.  eN&B determines the distribution of protein aggregates present inside every pixel in an image during time-lapse movies. It can reach unprecedented level of space and time resolution compared to FRET-based or FCS-based methods. When studying EphB2 receptor activation\, the eN&B allowed us to resolve simultaneously the aggregation state of 40 different oligomers in 3 dimensions (x\, y\, t) and pixel depth. We found that Eph oligomerization follows a sophisticated dynamics consistent with a nucleated polymerization process\, where activation and clustering are decoupled processes. This decoupling endows the receptor with high sensitivity for low ligand concentrations while at the same time allows to provide a proportional response to a wide range of ligand concentrations. In summary\, I will present a novel imaging tool with capability to determine the stoichiometry of receptor-ligand interactions and potentially\, many other instances or protein aggregation.
URL:https://ibecbarcelona.eu/event/ibec-seminar-samuel-ojosnegros/
CATEGORIES:IBEC Seminar
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