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DTSTART;TZID=UTC:20160128T113000
DTEND;TZID=UTC:20160128T123000
DTSTAMP:20260405T225832
CREATED:20160119T140215Z
LAST-MODIFIED:20160119T140338Z
UID:21059-1453980600-1453984200@ibecbarcelona.eu
SUMMARY:IBEC Seminar:  Josep Roca
DESCRIPTION:From Systems Understanding to Personalized Medicine: Lessons and Recommendations based on a multi-disciplinary and translational analysis of COPD \nDr.  Josep Roca\, UB / IDIBAPS / Hospital Clinic\nSystems medicine\, using and adapting methods and approaches as developed within systems biology\, promises to be central in ongoing efforts of realizing and implementing personalized medicine in clinical practice and research. Here we review and critically assess opportunities and challenges using our work on COPD as a case study. We find that there are significant biomedical challenges in how to unravel complex multi-factorial components in disease initiation and progression producing different clinical phenotypes. Yet\, while such a system understanding of COPD is necessary\, there are other auxiliary challenges that need to be addressed in concert with a systems analysis of COPD. These include information and communication technologies (ICT) related issues such as data harmonization\, systematic handling of knowledge\, computational modeling\, and importantly their translation and support of clinical practice. For example\, clinical decision support systems need a seamless integration with new models and knowledge as systems analysis of COPD continues to develop. Our experience with clinical implementation of COPD highlights the need for a change of management including design of appropriate business models\, and adoption of ICT providing and supporting organizational interoperability among professional teams across healthcare tiers\, working around the patient. In conclusion\, in our hands the scope and efforts of systems medicine need to concurrently consider these aspects clinical implementation this driving the selection of most relevant issues and method in a systems analysis of disease.
URL:https://ibecbarcelona.eu/event/ibec-seminar-josep-roca/
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20160128T113000
DTEND;TZID=UTC:20160128T123000
DTSTAMP:20260405T225832
CREATED:20160119T140215Z
LAST-MODIFIED:20160119T140215Z
UID:95889-1453980600-1453984200@ibecbarcelona.eu
SUMMARY:IBEC Seminar:  Josep Roca
DESCRIPTION:From Systems Understanding to Personalized Medicine: Lessons and Recommendations based on a multi-disciplinary and translational analysis of COPD \nDr.  Josep Roca\, UB / IDIBAPS / Hospital Clinic\nSystems medicine\, using and adapting methods and approaches as developed within systems biology\, promises to be central in ongoing efforts of realizing and implementing personalized medicine in clinical practice and research. Here we review and critically assess opportunities and challenges using our work on COPD as a case study. We find that there are significant biomedical challenges in how to unravel complex multi-factorial components in disease initiation and progression producing different clinical phenotypes. Yet\, while such a system understanding of COPD is necessary\, there are other auxiliary challenges that need to be addressed in concert with a systems analysis of COPD. These include information and communication technologies (ICT) related issues such as data harmonization\, systematic handling of knowledge\, computational modeling\, and importantly their translation and support of clinical practice. For example\, clinical decision support systems need a seamless integration with new models and knowledge as systems analysis of COPD continues to develop. Our experience with clinical implementation of COPD highlights the need for a change of management including design of appropriate business models\, and adoption of ICT providing and supporting organizational interoperability among professional teams across healthcare tiers\, working around the patient. In conclusion\, in our hands the scope and efforts of systems medicine need to concurrently consider these aspects clinical implementation this driving the selection of most relevant issues and method in a systems analysis of disease.
URL:https://ibecbarcelona.eu/event/ibec-seminar-josep-roca-2/
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20160205T100000
DTEND;TZID=UTC:20160205T110000
DTSTAMP:20260405T225832
CREATED:20151222T075732Z
LAST-MODIFIED:20151222T075732Z
UID:20385-1454666400-1454670000@ibecbarcelona.eu
SUMMARY:IBEC Seminar:  Josef A. Käs
DESCRIPTION:Why do rigid tumours contain soft cancer cells?\nProf. Dr. Josef A. Käs\, Principal Investigator & Head of the Soft Matter Physics Division · Leipzig University\nAs early as 400 BCE\, the Roman medical encyclopaedist Celsus recognized that solid tumours are stiffer than surrounding tissue. However\, cancer cell lines are softer\, and softer cells facilitate invasion. This paradox raises several questions: Does softness emerge from adaptation to mechanical and chemical cues in the external microenvironment\, or are soft cells already present inside a primary solid tumour? If the latter\, how can a more rígid tissue contain more soft cells? Here we show that in primary tumour samples from patients with mammary and cervix carcinomas\, cells do exhibit a broad distribution of rigidities\, with a higher fraction of softer and more contractile cells compared to normal tissue. Mechanical modelling based on patient data reveals that\, surprisingly\, tumours with a significant fraction of very soft cells can still remain rigid. Moreover\, in tissues with the observed distributions of cell stiffnesses\, softer cells spontaneously self-organize into lines or streams\, possibly facilitating cancer metastasis.
URL:https://ibecbarcelona.eu/event/ibec-seminar-josef-a-kas/
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20160205T100000
DTEND;TZID=UTC:20160205T110000
DTSTAMP:20260405T225832
CREATED:20151222T075732Z
LAST-MODIFIED:20151222T075732Z
UID:95885-1454666400-1454670000@ibecbarcelona.eu
SUMMARY:IBEC Seminar:  Josef A. Käs
DESCRIPTION:Why do rigid tumours contain soft cancer cells?\nProf. Dr. Josef A. Käs\, Principal Investigator & Head of the Soft Matter Physics Division · Leipzig University\nAs early as 400 BCE\, the Roman medical encyclopaedist Celsus recognized that solid tumours are stiffer than surrounding tissue. However\, cancer cell lines are softer\, and softer cells facilitate invasion. This paradox raises several questions: Does softness emerge from adaptation to mechanical and chemical cues in the external microenvironment\, or are soft cells already present inside a primary solid tumour? If the latter\, how can a more rígid tissue contain more soft cells? Here we show that in primary tumour samples from patients with mammary and cervix carcinomas\, cells do exhibit a broad distribution of rigidities\, with a higher fraction of softer and more contractile cells compared to normal tissue. Mechanical modelling based on patient data reveals that\, surprisingly\, tumours with a significant fraction of very soft cells can still remain rigid. Moreover\, in tissues with the observed distributions of cell stiffnesses\, softer cells spontaneously self-organize into lines or streams\, possibly facilitating cancer metastasis.
URL:https://ibecbarcelona.eu/event/ibec-seminar-josef-a-kas-2/
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20160311T100000
DTEND;TZID=UTC:20160311T110000
DTSTAMP:20260405T225832
CREATED:20160229T091313Z
LAST-MODIFIED:20160229T091313Z
UID:21728-1457690400-1457694000@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Samuel Ojosnegros
DESCRIPTION:Imaging Eph/ephrin cell-cell communication through Enhanced Number and Brightness: a novel method for the study of protein aggregation\nDr. Samuel Ojosnegros\, Centre de Medicina Regenerativa de Barcelona (CMRB)\nProteins constantly interact with each other assembling a variety of molecular species\, including small oligomers\, fibers of dynamic polymerization or high-order clusters\, among others. However\, current methods discriminate poorly the stoichiometry of protein interactions in living cells. To overcome these impediments we developed an enhanced version of Number & Brightness (eN&B)\, a powerful live imaging technique with capability to investigate multiple domains of information.  eN&B determines the distribution of protein aggregates present inside every pixel in an image during time-lapse movies. It can reach unprecedented level of space and time resolution compared to FRET-based or FCS-based methods. When studying EphB2 receptor activation\, the eN&B allowed us to resolve simultaneously the aggregation state of 40 different oligomers in 3 dimensions (x\, y\, t) and pixel depth. We found that Eph oligomerization follows a sophisticated dynamics consistent with a nucleated polymerization process\, where activation and clustering are decoupled processes. This decoupling endows the receptor with high sensitivity for low ligand concentrations while at the same time allows to provide a proportional response to a wide range of ligand concentrations. In summary\, I will present a novel imaging tool with capability to determine the stoichiometry of receptor-ligand interactions and potentially\, many other instances or protein aggregation.
URL:https://ibecbarcelona.eu/event/ibec-seminar-samuel-ojosnegros/
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20160311T100000
DTEND;TZID=UTC:20160311T110000
DTSTAMP:20260405T225832
CREATED:20160229T091313Z
LAST-MODIFIED:20160229T091313Z
UID:95898-1457690400-1457694000@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Samuel Ojosnegros
DESCRIPTION:Imaging Eph/ephrin cell-cell communication through Enhanced Number and Brightness: a novel method for the study of protein aggregation\nDr. Samuel Ojosnegros\, Centre de Medicina Regenerativa de Barcelona (CMRB)\nProteins constantly interact with each other assembling a variety of molecular species\, including small oligomers\, fibers of dynamic polymerization or high-order clusters\, among others. However\, current methods discriminate poorly the stoichiometry of protein interactions in living cells. To overcome these impediments we developed an enhanced version of Number & Brightness (eN&B)\, a powerful live imaging technique with capability to investigate multiple domains of information.  eN&B determines the distribution of protein aggregates present inside every pixel in an image during time-lapse movies. It can reach unprecedented level of space and time resolution compared to FRET-based or FCS-based methods. When studying EphB2 receptor activation\, the eN&B allowed us to resolve simultaneously the aggregation state of 40 different oligomers in 3 dimensions (x\, y\, t) and pixel depth. We found that Eph oligomerization follows a sophisticated dynamics consistent with a nucleated polymerization process\, where activation and clustering are decoupled processes. This decoupling endows the receptor with high sensitivity for low ligand concentrations while at the same time allows to provide a proportional response to a wide range of ligand concentrations. In summary\, I will present a novel imaging tool with capability to determine the stoichiometry of receptor-ligand interactions and potentially\, many other instances or protein aggregation.
URL:https://ibecbarcelona.eu/event/ibec-seminar-samuel-ojosnegros-2/
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20160318T100000
DTEND;TZID=UTC:20160318T110000
DTSTAMP:20260405T225832
CREATED:20160229T090903Z
LAST-MODIFIED:20160229T090903Z
UID:95897-1458295200-1458298800@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Mateu Pla
DESCRIPTION:What can we do with our 3D Bioprinter?\nDr. Mateu Pla\, Coordinator of Nanotechnology Platform\nA 3D bioprinter (3D-Discovery from RegenHU ) has recently arrived at IBEC\, and the first training courses have already started. \n3D Bioprinters allow us to generate 3D scaffolds combining biomaterials and cell-laden hydrogels. The applications of this 3D constructs spans from 3D cellular models for drug screening (i.e. dermis)\, scaffolds for regenerative medicine or\, at a more advanced stage\, organ-printing. \nDuring this presentation\, an introduction to bioprinting and the current and future capabilities of IBEC’s 3D bioprinter will be presented.
URL:https://ibecbarcelona.eu/event/ibec-seminar-mateu-pla-2/
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20160318T100000
DTEND;TZID=UTC:20160318T110000
DTSTAMP:20260405T225832
CREATED:20160229T090903Z
LAST-MODIFIED:20160311T103315Z
UID:21726-1458295200-1458298800@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Mateu Pla
DESCRIPTION:What can we do with our 3D Bioprinter?\nDr. Mateu Pla\, Coordinator of Nanotechnology Platform\nA 3D bioprinter (3D-Discovery from RegenHU ) has recently arrived at IBEC\, and the first training courses have already started. \n3D Bioprinters allow us to generate 3D scaffolds combining biomaterials and cell-laden hydrogels. The applications of this 3D constructs spans from 3D cellular models for drug screening (i.e. dermis)\, scaffolds for regenerative medicine or\, at a more advanced stage\, organ-printing. \nDuring this presentation\, an introduction to bioprinting and the current and future capabilities of IBEC’s 3D bioprinter will be presented.
URL:https://ibecbarcelona.eu/event/ibec-seminar-mateu-pla/
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20160406T100000
DTEND;TZID=UTC:20160406T110000
DTSTAMP:20260405T225832
CREATED:20160404T053912Z
LAST-MODIFIED:20160404T053912Z
UID:22120-1459936800-1459940400@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Nick Brown
DESCRIPTION:Linking cell adhesion receptors with the cytoskeleton in morphogenesis\nProf. Nick Brown\, Dept of Physiology\, Development and Neuroscience\, University of Cambridge\nWe use Drosophila development as our test tube to dissect mechanisms of integrin-mediated adhesion to the extracellular matrix\, tackling these questions: \n-How is the adhesion structure built?\n-What are the roles of the many adhesome components?\n-How did the integrin machinery arise during evolution?\n-Can we establish an integrated model of integrin adhesion sites?
URL:https://ibecbarcelona.eu/event/ibec-seminar-nick-brown/
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20160406T100000
DTEND;TZID=UTC:20160406T110000
DTSTAMP:20260405T225832
CREATED:20160404T053912Z
LAST-MODIFIED:20160404T053912Z
UID:95903-1459936800-1459940400@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Nick Brown
DESCRIPTION:Linking cell adhesion receptors with the cytoskeleton in morphogenesis\nProf. Nick Brown\, Dept of Physiology\, Development and Neuroscience\, University of Cambridge\nWe use Drosophila development as our test tube to dissect mechanisms of integrin-mediated adhesion to the extracellular matrix\, tackling these questions: \n-How is the adhesion structure built?\n-What are the roles of the many adhesome components?\n-How did the integrin machinery arise during evolution?\n-Can we establish an integrated model of integrin adhesion sites?
URL:https://ibecbarcelona.eu/event/ibec-seminar-nick-brown-2/
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20160415T100000
DTEND;TZID=UTC:20160415T110000
DTSTAMP:20260405T225832
CREATED:20160216T110305Z
LAST-MODIFIED:20160216T110305Z
UID:21618-1460714400-1460718000@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Jaume Veciana
DESCRIPTION:Multifunctional molecular nanovesicles: A new challenge for drug delivery\nProf. Jaume Veciana\, ICMAB-CSIC and CIBER-BBN\, Campus Universitari de Bellaterra\nIn this lecture a simple one-step and scale-up methodology for preparing multifunctional nanovesicle-drug conjugates will be presented. This method is readily amenable to the integration/encapsulation of multiple bioactive components\, like peptides\, proteins\, enzymes\, into the vesicles in a single-step yielding sufficient quantities for clinical research becoming\, thereby\, nanocarriers to be used in nanomedicine. A couple of examples of novel nanomedicines for solving serious diseases\, prepared by this methodology\, will be presented.
URL:https://ibecbarcelona.eu/event/ibec-seminar-jaume-veciana/
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20160415T100000
DTEND;TZID=UTC:20160415T110000
DTSTAMP:20260405T225832
CREATED:20160216T110305Z
LAST-MODIFIED:20160216T110305Z
UID:95896-1460714400-1460718000@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Jaume Veciana
DESCRIPTION:Multifunctional molecular nanovesicles: A new challenge for drug delivery\nProf. Jaume Veciana\, ICMAB-CSIC and CIBER-BBN\, Campus Universitari de Bellaterra\nIn this lecture a simple one-step and scale-up methodology for preparing multifunctional nanovesicle-drug conjugates will be presented. This method is readily amenable to the integration/encapsulation of multiple bioactive components\, like peptides\, proteins\, enzymes\, into the vesicles in a single-step yielding sufficient quantities for clinical research becoming\, thereby\, nanocarriers to be used in nanomedicine. A couple of examples of novel nanomedicines for solving serious diseases\, prepared by this methodology\, will be presented.
URL:https://ibecbarcelona.eu/event/ibec-seminar-jaume-veciana-2/
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20160426T120000
DTEND;TZID=UTC:20160426T130000
DTSTAMP:20260405T225832
CREATED:20160420T132640Z
LAST-MODIFIED:20160420T132640Z
UID:95910-1461672000-1461675600@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Guy A. Dumont
DESCRIPTION:Signal Processing and Control: From Sleep Apnea to Automated Anesthesia\nDr Guy A. Dumont\, University of British Columbia\, Vancouver\nThis talk will describe a number of key projects undertaken by the Electrical and Computer Engineering for Medicine (ECEM) and the Paediatric Anesthesia Research team (PART) at the University of British Columbia. The commonality between those projects lies in the use of advanced signal processing and control for clinical applications. The applications span mobile health applications for use in both developed and developing word settings for pathologies such as pre-eclampsia\, pneumonia and obstructive sleep apnea as well as automated drug delivery in critical care settings.
URL:https://ibecbarcelona.eu/event/ibec-seminar-guy-a-dumont-2/
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20160426T120000
DTEND;TZID=UTC:20160426T130000
DTSTAMP:20260405T225832
CREATED:20160420T132640Z
LAST-MODIFIED:20160425T090557Z
UID:22522-1461672000-1461675600@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Guy A. Dumont
DESCRIPTION:Signal Processing and Control: From Sleep Apnea to Automated Anesthesia\nDr Guy A. Dumont\, University of British Columbia\, Vancouver\nThis talk will describe a number of key projects undertaken by the Electrical and Computer Engineering for Medicine (ECEM) and the Paediatric Anesthesia Research team (PART) at the University of British Columbia. The commonality between those projects lies in the use of advanced signal processing and control for clinical applications. The applications span mobile health applications for use in both developed and developing word settings for pathologies such as pre-eclampsia\, pneumonia and obstructive sleep apnea as well as automated drug delivery in critical care settings.
URL:https://ibecbarcelona.eu/event/ibec-seminar-guy-a-dumont/
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20160426T160000
DTEND;TZID=UTC:20160426T170000
DTSTAMP:20260405T225832
CREATED:20160415T062040Z
LAST-MODIFIED:20160421T082645Z
UID:22416-1461686400-1461690000@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Wieteke de Boer
DESCRIPTION:Optical activation of neurons through low power two-photon IR excitation of gold nanoparticles\nWieteke de Boer\, Departments of Biological Sciences and Neuroscience\, Columbia University\nSelective optical stimulation of specific classes of excitable cells is a major goal in neurobiology. Here we propose the approach of indirect photostimulation through gold nanoparticles (Au NPs)\, which are conjugated to the neuronal membrane. Au NPs are frequently used in biological research due to their versatile applicability: they have a broad optical tunability\, large absorption cross sections\, can be made chemically stable and biocompatible\, and most importantly they are non-invasive and non-toxic even up to excessively large quantities. We show that these NPs can facilitate reliable optical stimulation of neurons through the plasmonic effect using IR two-photon (2P) excitation\, with extremely low excitation powers. The NPs can be easily tethered to any targeted tissue and are known to be excreted without inducing any permanent damage. Using this approach\, Au NPs are an attractive alternative to genetic modification techniques (such as channelrhodopsins) as it circumvents potential issues often seen in those methods\, e.g. poor signal-to-noise ratio\, photo-instability\, photo-toxicity and expression efficiency.
URL:https://ibecbarcelona.eu/event/ibec-seminar-wieteke-de-boer/
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20160426T160000
DTEND;TZID=UTC:20160426T170000
DTSTAMP:20260405T225832
CREATED:20160415T062040Z
LAST-MODIFIED:20160415T062040Z
UID:95905-1461686400-1461690000@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Wieteke de Boer
DESCRIPTION:Optical activation of neurons through low power two-photon IR excitation of gold nanoparticles\nWieteke de Boer\, Departments of Biological Sciences and Neuroscience\, Columbia University\nSelective optical stimulation of specific classes of excitable cells is a major goal in neurobiology. Here we propose the approach of indirect photostimulation through gold nanoparticles (Au NPs)\, which are conjugated to the neuronal membrane. Au NPs are frequently used in biological research due to their versatile applicability: they have a broad optical tunability\, large absorption cross sections\, can be made chemically stable and biocompatible\, and most importantly they are non-invasive and non-toxic even up to excessively large quantities. We show that these NPs can facilitate reliable optical stimulation of neurons through the plasmonic effect using IR two-photon (2P) excitation\, with extremely low excitation powers. The NPs can be easily tethered to any targeted tissue and are known to be excreted without inducing any permanent damage. Using this approach\, Au NPs are an attractive alternative to genetic modification techniques (such as channelrhodopsins) as it circumvents potential issues often seen in those methods\, e.g. poor signal-to-noise ratio\, photo-instability\, photo-toxicity and expression efficiency.
URL:https://ibecbarcelona.eu/event/ibec-seminar-wieteke-de-boer-2/
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20160512T113000
DTEND;TZID=UTC:20160512T123000
DTSTAMP:20260405T225832
CREATED:20160422T091715Z
LAST-MODIFIED:20160428T115510Z
UID:22547-1463052600-1463056200@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Marina Martínez
DESCRIPTION:How to improve proposals & strategy within Horizon 2020\nMarina Martínez\, The Spanish Office for Science and Technology (SOST-CDT)\nThe aim of this seminar is to advice researchers\, research managers and research support services on how to improve their success ratio on EU proposals application. Moreover\, she will give an overview of all H2020 landscape\, as well as all the stakeholders involved in order to choose the best strategy within EU positioning. \nLimited places available. Register here.
URL:https://ibecbarcelona.eu/event/ibec-seminar-marina-martinez/
LOCATION:Sala 1\, Torre D\, PCB\, Baldiri Reixac 4-8\, 08028 Barcelona
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20160512T113000
DTEND;TZID=UTC:20160512T123000
DTSTAMP:20260405T225832
CREATED:20160422T091715Z
LAST-MODIFIED:20160422T091715Z
UID:95911-1463052600-1463056200@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Marina Martínez
DESCRIPTION:How to improve proposals & strategy within Horizon 2020\nMarina Martínez\, The Spanish Office for Science and Technology (SOST-CDT)\nThe aim of this seminar is to advice researchers\, research managers and research support services on how to improve their success ratio on EU proposals application. Moreover\, she will give an overview of all H2020 landscape\, as well as all the stakeholders involved in order to choose the best strategy within EU positioning. \nLimited places available. Register here.
URL:https://ibecbarcelona.eu/event/ibec-seminar-marina-martinez-2/
LOCATION:Sala 1\, Torre D\, PCB\, Baldiri Reixac 4-8\, 08028 Barcelona
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20160519T120000
DTEND;TZID=UTC:20160519T130000
DTSTAMP:20260405T225832
CREATED:20160504T124456Z
LAST-MODIFIED:20160504T124456Z
UID:22700-1463659200-1463662800@ibecbarcelona.eu
SUMMARY:IBEC Seminar: The new IBEC Bio-AFM system
DESCRIPTION:The new IBEC Bio-AFM system: system’s performance\, applications and users’ guide\nGabriel Gomila\, Group Leader\, Nanoscale Bioelectrical Characterization\, IBEC\nIn this talk I will introduce the new Bio-Atomic Force Microscopy infrastructure of IBEC. I will start describing the components of the infrastructure\, its location at IBEC and its potential performance. Then I will present some examples of application of this system\, and show the first results obtained with it. Finally\, I will explain the special rules for its use by IBEC users.
URL:https://ibecbarcelona.eu/event/ibec-seminar-the-new-ibec-bio-afm-system/
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20160519T120000
DTEND;TZID=UTC:20160519T130000
DTSTAMP:20260405T225832
CREATED:20160504T124456Z
LAST-MODIFIED:20160504T124456Z
UID:95912-1463659200-1463662800@ibecbarcelona.eu
SUMMARY:IBEC Seminar: The new IBEC Bio-AFM system
DESCRIPTION:The new IBEC Bio-AFM system: system’s performance\, applications and users’ guide\nGabriel Gomila\, Group Leader\, Nanoscale Bioelectrical Characterization\, IBEC\nIn this talk I will introduce the new Bio-Atomic Force Microscopy infrastructure of IBEC. I will start describing the components of the infrastructure\, its location at IBEC and its potential performance. Then I will present some examples of application of this system\, and show the first results obtained with it. Finally\, I will explain the special rules for its use by IBEC users.
URL:https://ibecbarcelona.eu/event/ibec-seminar-the-new-ibec-bio-afm-system-2/
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20160520T100000
DTEND;TZID=UTC:20160520T110000
DTSTAMP:20260405T225832
CREATED:20160415T062224Z
LAST-MODIFIED:20160415T062224Z
UID:22417-1463738400-1463742000@ibecbarcelona.eu
SUMMARY:IBEC Seminar:  Xavier Fernández-Busquets
DESCRIPTION:A Short (Hi)story of Malaria\n Xavier Fernández-Busquets\, Nanomalaria Joint Unit (IBEC/Barcelona Institute for Global Health)\nReportedly\, malaria has been the killer of about half of all people who have ever lived\, among which such celebrities as king Tutankhamun\, Alexander the Great\, and Genghis Khan. To commemorate the 2015 Nobel Prize in Physiology or Medicine awarded to Professor Youyou Tu\, we will overview the fascinating history of this murderer disease through the small stories of its sufferers from dinosaurs to humans. From the exorbitant egos of renowned physicians to the shameful experiments in concentration camps and prisons during WWII\, or from the darkest depths of malariotherapy to the shining lights leading to the discovery of some of its remedies\, malaria will keep us in awe of its amazing (hi)story.
URL:https://ibecbarcelona.eu/event/ibec-seminar-xavier-fernandez-busquets/
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20160520T100000
DTEND;TZID=UTC:20160520T110000
DTSTAMP:20260405T225832
CREATED:20160415T062224Z
LAST-MODIFIED:20160415T062224Z
UID:95906-1463738400-1463742000@ibecbarcelona.eu
SUMMARY:IBEC Seminar:  Xavier Fernández-Busquets
DESCRIPTION:A Short (Hi)story of Malaria\n Xavier Fernández-Busquets\, Nanomalaria Joint Unit (IBEC/Barcelona Institute for Global Health)\nReportedly\, malaria has been the killer of about half of all people who have ever lived\, among which such celebrities as king Tutankhamun\, Alexander the Great\, and Genghis Khan. To commemorate the 2015 Nobel Prize in Physiology or Medicine awarded to Professor Youyou Tu\, we will overview the fascinating history of this murderer disease through the small stories of its sufferers from dinosaurs to humans. From the exorbitant egos of renowned physicians to the shameful experiments in concentration camps and prisons during WWII\, or from the darkest depths of malariotherapy to the shining lights leading to the discovery of some of its remedies\, malaria will keep us in awe of its amazing (hi)story.
URL:https://ibecbarcelona.eu/event/ibec-seminar-xavier-fernandez-busquets-2/
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20160526T100000
DTEND;TZID=UTC:20160526T110000
DTSTAMP:20260405T225832
CREATED:20160520T054234Z
LAST-MODIFIED:20160520T054234Z
UID:95914-1464256800-1464260400@ibecbarcelona.eu
SUMMARY:IBEC seminar: Isaac Gállego
DESCRIPTION:DNA Nanotechnology: from its Applications to the Self-Assembly in Alternative Solvents\nIsaac Gállego\, Georgia Institute of Technology\, USA\nDNA nanotechnology is a relatively new field that utilizes the DNA’s programmability and self-assembly properties to build custom-designed shapes at the nanometer scale. A common implementation is the DNA origami method\, in which a M13 single stranded genome (scaffold) is folded by hundreds of complementary base-paired oligonucleotides (staples). DNA nanostructures have been successfully utilized to create two-dimensional and three-dimensional devices with applications in lithography\, photonics\, electronics\, and the fabrication of inorganic materials. Herein\, I will present to you my work on DNA nanotechnology\, which includes: i) the development of a biosensor to dsiplay the DNA repair activity hAGT—an enzyme target for the development of cancer therapeutics;1 ii) the transfer a pre-programmed nanosclae pattern of DNA onto gold surfaces\, a challenging process useful for the fabrication of functional materials; and iii) the first study of self-assembly of DNA nanostructures in a non-aqueous\, alternative solvent\, a deep eutectic solvent composed of glycerol and choline chloride in a 4:1 molar ratio (glycholine).2 Glycholine and its hydrated mixtures facilitate DNA folding by alleviating kinetic traps that are often encountered during the folding of DNA structures in aqueous solvent. \n1. Tintoré\, M.\, Gállego\, I.\, Manning\, B.\, Eritja\, R. & Fàbrega\, C. DNA Origami as a DNA Repair Nanosensor at the Single‐Molecule Level. Angew. Chem. Int. Ed. Engl. 52\, 7747–7750\n2. Gállego\, I.\, Grover\, M. A. & Hud\, N. V. Folding and Imaging of DNA Nanostructures in Anhydrous and Hydrated Deep-Eutectic Solvents. Angew. Chem. Int. Ed. Engl. 54\, 6765–6769 (2015).
URL:https://ibecbarcelona.eu/event/ibec-seminar-isaac-gallego-2/
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20160526T100000
DTEND;TZID=UTC:20160526T110000
DTSTAMP:20260405T225832
CREATED:20160520T054234Z
LAST-MODIFIED:20160520T054234Z
UID:22935-1464256800-1464260400@ibecbarcelona.eu
SUMMARY:IBEC seminar: Isaac Gállego
DESCRIPTION:DNA Nanotechnology: from its Applications to the Self-Assembly in Alternative Solvents\nIsaac Gállego\, Georgia Institute of Technology\, USA\nDNA nanotechnology is a relatively new field that utilizes the DNA’s programmability and self-assembly properties to build custom-designed shapes at the nanometer scale. A common implementation is the DNA origami method\, in which a M13 single stranded genome (scaffold) is folded by hundreds of complementary base-paired oligonucleotides (staples). DNA nanostructures have been successfully utilized to create two-dimensional and three-dimensional devices with applications in lithography\, photonics\, electronics\, and the fabrication of inorganic materials. Herein\, I will present to you my work on DNA nanotechnology\, which includes: i) the development of a biosensor to dsiplay the DNA repair activity hAGT—an enzyme target for the development of cancer therapeutics;1 ii) the transfer a pre-programmed nanosclae pattern of DNA onto gold surfaces\, a challenging process useful for the fabrication of functional materials; and iii) the first study of self-assembly of DNA nanostructures in a non-aqueous\, alternative solvent\, a deep eutectic solvent composed of glycerol and choline chloride in a 4:1 molar ratio (glycholine).2 Glycholine and its hydrated mixtures facilitate DNA folding by alleviating kinetic traps that are often encountered during the folding of DNA structures in aqueous solvent. \n1. Tintoré\, M.\, Gállego\, I.\, Manning\, B.\, Eritja\, R. & Fàbrega\, C. DNA Origami as a DNA Repair Nanosensor at the Single‐Molecule Level. Angew. Chem. Int. Ed. Engl. 52\, 7747–7750\n2. Gállego\, I.\, Grover\, M. A. & Hud\, N. V. Folding and Imaging of DNA Nanostructures in Anhydrous and Hydrated Deep-Eutectic Solvents. Angew. Chem. Int. Ed. Engl. 54\, 6765–6769 (2015).
URL:https://ibecbarcelona.eu/event/ibec-seminar-isaac-gallego/
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20160712T100000
DTEND;TZID=UTC:20160712T230000
DTSTAMP:20260405T225832
CREATED:20160510T055158Z
LAST-MODIFIED:20160510T055158Z
UID:22777-1468317600-1468364400@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Prof. Shulamit Levenberg
DESCRIPTION:Engineering Vascularized Tissue Constructs\nProf. Shulamit Levenberg\, Faculty of Biomedical Engineering\, Technion\, Haifa\, Israel\nVascularization continues to represent a major challenge in the successful implementation of regenerative strategies. Cell organization into 3D tissue vascularized structures involves cell-matrix and cell-cell interactions\, some of which occur between the different tissue cell types. During this process\, cells further differentiate and assemble into structures resembling the final tissue architecture. We have established that vessel network assembly yielding vascularized 3D tissue structures can be induced in-vitro by means of coculturing endothelial cells\, fibroblasts and tissue-specific cells. We have also shown that in vitro pre-vascularization of engineered tissues can promote tissue survival and further vascularization upon implantation\, via anastomosis of the engineered vessels with host vasculature\, forming functional blood vessels in vivo. Vascularization of engineered tissues can be enhanced through coordinated application of improved biomaterial systems with relevant cell types. Moreover\, we have shown that vessel network maturity and morphology can be highly regulated by both matrix composition and by external mechanical stimulations. Our recent studies have focused on investigation of the degree of the in vitro prevascularization required to achieve best postimplantation vascularization of tissue constructs\, as well as on understanding the mechanisms underlying host-implant vessel integration and anastomosis. New co-culture approaches for inducing pre-defined vessel structures in vitro will also be discussed\, as will novel studies on vascularized muscle flaps engineered to reconstruct large soft tissue defects.
URL:https://ibecbarcelona.eu/event/ibec-seminar-prof-shulamit-levenberg/
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=UTC:20160712T100000
DTEND;TZID=UTC:20160712T230000
DTSTAMP:20260405T225832
CREATED:20160510T055158Z
LAST-MODIFIED:20160510T055158Z
UID:95913-1468317600-1468364400@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Prof. Shulamit Levenberg
DESCRIPTION:Engineering Vascularized Tissue Constructs\nProf. Shulamit Levenberg\, Faculty of Biomedical Engineering\, Technion\, Haifa\, Israel\nVascularization continues to represent a major challenge in the successful implementation of regenerative strategies. Cell organization into 3D tissue vascularized structures involves cell-matrix and cell-cell interactions\, some of which occur between the different tissue cell types. During this process\, cells further differentiate and assemble into structures resembling the final tissue architecture. We have established that vessel network assembly yielding vascularized 3D tissue structures can be induced in-vitro by means of coculturing endothelial cells\, fibroblasts and tissue-specific cells. We have also shown that in vitro pre-vascularization of engineered tissues can promote tissue survival and further vascularization upon implantation\, via anastomosis of the engineered vessels with host vasculature\, forming functional blood vessels in vivo. Vascularization of engineered tissues can be enhanced through coordinated application of improved biomaterial systems with relevant cell types. Moreover\, we have shown that vessel network maturity and morphology can be highly regulated by both matrix composition and by external mechanical stimulations. Our recent studies have focused on investigation of the degree of the in vitro prevascularization required to achieve best postimplantation vascularization of tissue constructs\, as well as on understanding the mechanisms underlying host-implant vessel integration and anastomosis. New co-culture approaches for inducing pre-defined vessel structures in vitro will also be discussed\, as will novel studies on vascularized muscle flaps engineered to reconstruct large soft tissue defects.
URL:https://ibecbarcelona.eu/event/ibec-seminar-prof-shulamit-levenberg-2/
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20161010T150000
DTEND;TZID=Europe/Madrid:20161010T160000
DTSTAMP:20260405T225832
CREATED:20160928T191705Z
LAST-MODIFIED:20160930T122011Z
UID:24759-1476111600-1476115200@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Publishing in the Nature journals
DESCRIPTION:IBEC Seminar: Publishing in the Nature journals\nDr. Alexia-Ileana Zaromytidou (Chief Editor\, Nature Cell Biology)\nAlexia-Ileana Zaromytidou\, Chief Editor of Nature Cell Biology will provide an editor’s perspective on the editorial and publishing process in the Nature journals.\nShe received her PhD from the London Research Institute of Cancer Research UK in London\, UK (now the Francis Crick Institute) in January 2007. Her doctoral work with Richard Treisman centered on the molecular interactions between actin-regulated transcription factors and their coactivators in the context of MAPK and Rho signaling responses. She pursued her postdoctoral research in the lab of Joan Massagué at Memorial Sloan-Kettering Cancer Center in New York\, where she studied how different phosphorylation inputs affect TGFβ/BMP pathway activity to achieve distinct biological outcomes. In September 2010 she joined the editorial team of Nature Cell Biology as the editor responsible for the areas of cancer biology\, mechanobiology\, cell adhesion\, migration and the cytoskeleton\, and became Chief editor of the journal in November 2015.
URL:https://ibecbarcelona.eu/event/24759/
LOCATION:Sala Félix Serratossa\, Parc Científic de Barcelona\, Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20161010T150000
DTEND;TZID=Europe/Madrid:20161010T160000
DTSTAMP:20260405T225832
CREATED:20160928T191705Z
LAST-MODIFIED:20160928T191705Z
UID:95918-1476111600-1476115200@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Publishing in the Nature journals
DESCRIPTION:IBEC Seminar: Publishing in the Nature journals\nDr. Alexia-Ileana Zaromytidou (Chief Editor\, Nature Cell Biology)\nAlexia-Ileana Zaromytidou\, Chief Editor of Nature Cell Biology will provide an editor’s perspective on the editorial and publishing process in the Nature journals.\nShe received her PhD from the London Research Institute of Cancer Research UK in London\, UK (now the Francis Crick Institute) in January 2007. Her doctoral work with Richard Treisman centered on the molecular interactions between actin-regulated transcription factors and their coactivators in the context of MAPK and Rho signaling responses. She pursued her postdoctoral research in the lab of Joan Massagué at Memorial Sloan-Kettering Cancer Center in New York\, where she studied how different phosphorylation inputs affect TGFβ/BMP pathway activity to achieve distinct biological outcomes. In September 2010 she joined the editorial team of Nature Cell Biology as the editor responsible for the areas of cancer biology\, mechanobiology\, cell adhesion\, migration and the cytoskeleton\, and became Chief editor of the journal in November 2015.
URL:https://ibecbarcelona.eu/event/24759-2/
LOCATION:Sala Félix Serratossa\, Parc Científic de Barcelona\, Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20161013T100000
DTEND;TZID=Europe/Madrid:20161013T110000
DTSTAMP:20260405T225832
CREATED:20161007T133132Z
LAST-MODIFIED:20161010T161238Z
UID:24827-1476352800-1476356400@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Scaling up in Systems Biology: from a minimal cell to microbiomes
DESCRIPTION:Scaling up in Systems Biology: from a minimal cell to microbiomes\nMaria Lluch Senar\, Design of Biological Systems grup\, Centre for Genomic Regulation (CRG)\nUltra-sequencing technologies have allowed the massive identification of human-associated microbiomes. Genome annotations of microbiomes consider conserved ORFs or those encoding for proteins larger than 100aa. However\, growing evidence highlight the existence of a hidden universe of small genes (smORFs) encoding for small peptides (SEPs; <100aa)\, many of them secreted\, being involved in infection and quorum sensing. Also\, in eukaryotes\, small antimicrobial peptides (AMPs) are secreted in response to infection. The interplay between these secreted SEPs is essential to control the different human microbiomes to ensure coexistence rather than weakening the host against opportunistic infections. Thus\, determining the smORFome of bacterial-host ecosystems and studying its role in homeostasis are essential. In this seminar\, I will explain how by using different system biology approaches we discovered this layer of small peptides in Mycoplasma pneumoniae and our future plans to study their role in human microbiomes focusing in female reproductive tract.
URL:https://ibecbarcelona.eu/event/ibec-seminar-scaling-up-in-systems-biology-from-a-minimal-cell-to-microbiomes/
CATEGORIES:IBEC Seminar
ORGANIZER;CN="IBEC":MAILTO:www.ibecbarcelona.eu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20161013T100000
DTEND;TZID=Europe/Madrid:20161013T110000
DTSTAMP:20260405T225832
CREATED:20161007T133132Z
LAST-MODIFIED:20161007T133132Z
UID:95921-1476352800-1476356400@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Scaling up in Systems Biology: from a minimal cell to microbiomes
DESCRIPTION:Scaling up in Systems Biology: from a minimal cell to microbiomes\nMaria Lluch Senar\, Design of Biological Systems grup\, Centre for Genomic Regulation (CRG)\nUltra-sequencing technologies have allowed the massive identification of human-associated microbiomes. Genome annotations of microbiomes consider conserved ORFs or those encoding for proteins larger than 100aa. However\, growing evidence highlight the existence of a hidden universe of small genes (smORFs) encoding for small peptides (SEPs; <100aa)\, many of them secreted\, being involved in infection and quorum sensing. Also\, in eukaryotes\, small antimicrobial peptides (AMPs) are secreted in response to infection. The interplay between these secreted SEPs is essential to control the different human microbiomes to ensure coexistence rather than weakening the host against opportunistic infections. Thus\, determining the smORFome of bacterial-host ecosystems and studying its role in homeostasis are essential. In this seminar\, I will explain how by using different system biology approaches we discovered this layer of small peptides in Mycoplasma pneumoniae and our future plans to study their role in human microbiomes focusing in female reproductive tract.
URL:https://ibecbarcelona.eu/event/ibec-seminar-scaling-up-in-systems-biology-from-a-minimal-cell-to-microbiomes-2/
CATEGORIES:IBEC Seminar
ORGANIZER;CN="IBEC":MAILTO:www.ibecbarcelona.eu
END:VEVENT
END:VCALENDAR