BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Institute for Bioengineering of Catalonia - ECPv6.15.18//NONSGML v1.0//EN
CALSCALE:GREGORIAN
METHOD:PUBLISH
X-ORIGINAL-URL:https://ibecbarcelona.eu
X-WR-CALDESC:Events for Institute for Bioengineering of Catalonia
REFRESH-INTERVAL;VALUE=DURATION:PT1H
X-Robots-Tag:noindex
X-PUBLISHED-TTL:PT1H
BEGIN:VTIMEZONE
TZID:Europe/Madrid
BEGIN:DAYLIGHT
TZOFFSETFROM:+0100
TZOFFSETTO:+0200
TZNAME:CEST
DTSTART:20170326T010000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:+0200
TZOFFSETTO:+0100
TZNAME:CET
DTSTART:20171029T010000
END:STANDARD
BEGIN:DAYLIGHT
TZOFFSETFROM:+0100
TZOFFSETTO:+0200
TZNAME:CEST
DTSTART:20180325T010000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:+0200
TZOFFSETTO:+0100
TZNAME:CET
DTSTART:20181028T010000
END:STANDARD
BEGIN:DAYLIGHT
TZOFFSETFROM:+0100
TZOFFSETTO:+0200
TZNAME:CEST
DTSTART:20190331T010000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:+0200
TZOFFSETTO:+0100
TZNAME:CET
DTSTART:20191027T010000
END:STANDARD
BEGIN:DAYLIGHT
TZOFFSETFROM:+0100
TZOFFSETTO:+0200
TZNAME:CEST
DTSTART:20200329T010000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:+0200
TZOFFSETTO:+0100
TZNAME:CET
DTSTART:20201025T010000
END:STANDARD
END:VTIMEZONE
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20180716T120000
DTEND;TZID=Europe/Madrid:20180716T130000
DTSTAMP:20260406T022624
CREATED:20180710T132144Z
LAST-MODIFIED:20180710T132144Z
UID:96279-1531742400-1531746000@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Ina Meiser\, Cryobiotechnology group manager\, IBMT
DESCRIPTION:Application oriented cryopreservation and banking of stem cells and stem cell derivates\nDr. Ina Meiser\, Cryobiotechnology group manager\, Fraunhofer Institute for Biomedical Engineering (IBMT)\nCryopreservation is still the only possibility to store viable cells for long periods. In general\, conventional slow freezing methods are efficient enough to preserve single cells in suspension for subsequent expansion (e.g. human induced pluripotent stem cells\, hiPSCs). Here\, several aspects have to be taken into account for safe long-term storage regarding infrastructure and handling according to planned purpose. However\, in case of preservation of adherent cells or multicellular systems that are increasingly relevant for biomedical research and application (e.g. hiPSC-derived neuronal cells)\, slow freezing shows major limitations. (1) Usually the adherent cells have to be enzymatically or mechanically dissociated to single cells or small aggregates prior to freezing\, (2) crystallization-induced damaging mechanisms additionally disrupt cadherin- and integrin-mediated cellular contacts\, and especially for hiPSC\, (3) the recovered viable cell numbers is dramatically reduced compared to the control. Besides application of sophisticated scaffolds in slow freezing approaches\, the method of ice-free cryopreservation (vitrification) provides the possibility to overcome these limitations\, but requires skilled handling especially regarding sterile procedures\, implies small sample sizes and therefore is considered as unsuitable for routine handling or bulk storage. To launch vitrification for large cell numbers and thus enabling ready-to-use cryopreserved adherent cell systems\, a sophisticated multi-usage cell culture disposable covering comprehensive cell-based workflows from cultivation/differentiation to sterile vitrification will be introduced.
URL:https://ibecbarcelona.eu/event/ibec-seminar-ina-meiser-cryobiotechnology-group-manager-ibmt-2/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20180716T120000
DTEND;TZID=Europe/Madrid:20180716T130000
DTSTAMP:20260406T022624
CREATED:20180710T132144Z
LAST-MODIFIED:20180710T132203Z
UID:60379-1531742400-1531746000@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Ina Meiser\, Cryobiotechnology group manager\, IBMT
DESCRIPTION:Application oriented cryopreservation and banking of stem cells and stem cell derivates\nDr. Ina Meiser\, Cryobiotechnology group manager\, Fraunhofer Institute for Biomedical Engineering (IBMT)\nCryopreservation is still the only possibility to store viable cells for long periods. In general\, conventional slow freezing methods are efficient enough to preserve single cells in suspension for subsequent expansion (e.g. human induced pluripotent stem cells\, hiPSCs). Here\, several aspects have to be taken into account for safe long-term storage regarding infrastructure and handling according to planned purpose. However\, in case of preservation of adherent cells or multicellular systems that are increasingly relevant for biomedical research and application (e.g. hiPSC-derived neuronal cells)\, slow freezing shows major limitations. (1) Usually the adherent cells have to be enzymatically or mechanically dissociated to single cells or small aggregates prior to freezing\, (2) crystallization-induced damaging mechanisms additionally disrupt cadherin- and integrin-mediated cellular contacts\, and especially for hiPSC\, (3) the recovered viable cell numbers is dramatically reduced compared to the control. Besides application of sophisticated scaffolds in slow freezing approaches\, the method of ice-free cryopreservation (vitrification) provides the possibility to overcome these limitations\, but requires skilled handling especially regarding sterile procedures\, implies small sample sizes and therefore is considered as unsuitable for routine handling or bulk storage. To launch vitrification for large cell numbers and thus enabling ready-to-use cryopreserved adherent cell systems\, a sophisticated multi-usage cell culture disposable covering comprehensive cell-based workflows from cultivation/differentiation to sterile vitrification will be introduced.
URL:https://ibecbarcelona.eu/event/ibec-seminar-ina-meiser-cryobiotechnology-group-manager-ibmt/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20180720T100000
DTEND;TZID=Europe/Madrid:20180720T110000
DTSTAMP:20260406T022624
CREATED:20180710T132333Z
LAST-MODIFIED:20180710T132333Z
UID:96280-1532080800-1532084400@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Hiroshi Ishida\, Tokyo University of Agriculture and Technology
DESCRIPTION:Active Flow Generation for Mobile Robot Olfaction and Olfactory Assisting Devices\nProf. Hiroshi Ishida\, Graduate School of Bio-Applications and Systems Engineering\, Tokyo University of Agriculture and Technology\nMobile robots can be used as moving platforms for various gas sensing tasks in the field\, e.g.\, gas source localization and gas distribution mapping. In the presentation\, it will be shown that actively generated airflow can be used to facilitate such robotic gas sensing tasks. Reception of chemical substances at the chemical sensors on a robot can be significantly enhanced by generating a carefully designed airflow field around the sensors. Olfactory assist systems that allow the user to sense smells with amplified sensitivities are also reported.
URL:https://ibecbarcelona.eu/event/ibec-seminar-hiroshi-ishida-tokyo-university-of-agriculture-and-technology-2/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20180720T100000
DTEND;TZID=Europe/Madrid:20180720T110000
DTSTAMP:20260406T022624
CREATED:20180710T132333Z
LAST-MODIFIED:20180710T132333Z
UID:60381-1532080800-1532084400@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Hiroshi Ishida\, Tokyo University of Agriculture and Technology
DESCRIPTION:Active Flow Generation for Mobile Robot Olfaction and Olfactory Assisting Devices\nProf. Hiroshi Ishida\, Graduate School of Bio-Applications and Systems Engineering\, Tokyo University of Agriculture and Technology\nMobile robots can be used as moving platforms for various gas sensing tasks in the field\, e.g.\, gas source localization and gas distribution mapping. In the presentation\, it will be shown that actively generated airflow can be used to facilitate such robotic gas sensing tasks. Reception of chemical substances at the chemical sensors on a robot can be significantly enhanced by generating a carefully designed airflow field around the sensors. Olfactory assist systems that allow the user to sense smells with amplified sensitivities are also reported.
URL:https://ibecbarcelona.eu/event/ibec-seminar-hiroshi-ishida-tokyo-university-of-agriculture-and-technology/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20180723T110000
DTEND;TZID=Europe/Madrid:20180723T120000
DTSTAMP:20260406T022624
CREATED:20180719T071723Z
LAST-MODIFIED:20180719T071723Z
UID:96285-1532343600-1532347200@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Dr. Kevin Chalut\, Cambridge Stem Cell Institute
DESCRIPTION:Mechanical signaling and cell fate\nDr. Kevin Chalut\, Cambridge Stem Cell Institute\nThe role of mechanical signaling in cell fate choice has been largely overlooked; however\, it plays a significant role in tuning cellular response to signals. My lab is investigating the interplay between biochemical signaling and mechanical signaling in cell fate decisions. I will show first in the mouse embryo that biochemical signaling modulates cytoskeletal contractility to influence spatial positioning and solidify cell fate choice. I will then show that mechanics tunes the response of the cell to biochemical signaling to steer fate choice. This hypothetical feedback loop between mechanics and biochemical signaling likely has significant impact on cellular plasticity both in development and stem cells. I will also present an example demonstrating the functional impact of mechanics on stem cell function. In this example\, we have shown that we can reverse the loss of plasticity associated with ageing by controlling the mechanical microenvironment. Ultimately\, I will advance the hypothesis that mechanical sensing acts as a switch to modulate growth factor signaling to modulate cell fate choice.
URL:https://ibecbarcelona.eu/event/ibec-seminar-dr-kevin-chalut-cambridge-stem-cell-institute-2/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20180723T110000
DTEND;TZID=Europe/Madrid:20180723T120000
DTSTAMP:20260406T022624
CREATED:20180719T071723Z
LAST-MODIFIED:20180719T071723Z
UID:60609-1532343600-1532347200@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Dr. Kevin Chalut\, Cambridge Stem Cell Institute
DESCRIPTION:Mechanical signaling and cell fate\nDr. Kevin Chalut\, Cambridge Stem Cell Institute\nThe role of mechanical signaling in cell fate choice has been largely overlooked; however\, it plays a significant role in tuning cellular response to signals. My lab is investigating the interplay between biochemical signaling and mechanical signaling in cell fate decisions. I will show first in the mouse embryo that biochemical signaling modulates cytoskeletal contractility to influence spatial positioning and solidify cell fate choice. I will then show that mechanics tunes the response of the cell to biochemical signaling to steer fate choice. This hypothetical feedback loop between mechanics and biochemical signaling likely has significant impact on cellular plasticity both in development and stem cells. I will also present an example demonstrating the functional impact of mechanics on stem cell function. In this example\, we have shown that we can reverse the loss of plasticity associated with ageing by controlling the mechanical microenvironment. Ultimately\, I will advance the hypothesis that mechanical sensing acts as a switch to modulate growth factor signaling to modulate cell fate choice.
URL:https://ibecbarcelona.eu/event/ibec-seminar-dr-kevin-chalut-cambridge-stem-cell-institute/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20180921T100000
DTEND;TZID=Europe/Madrid:20180921T110000
DTSTAMP:20260406T022624
CREATED:20180823T084554Z
LAST-MODIFIED:20180823T084554Z
UID:96290-1537524000-1537527600@ibecbarcelona.eu
SUMMARY:IBEC seminar: Yunuen Avalos
DESCRIPTION:GUVs as biomimetic systems to study pathogenic-related mechanisms of human parasites\nDr. Yunuen Avalos\, BEST Cofund postdoc\, Nanomalaria group\, IBEC\nMembrane models such as Giant Unilamellar Vesicles (GUVs) are a powerful tool for studying reactions occurring in living cells. The main advantage of using these biomimetic systems is the vast possibility of controlling the conditions such as membrane composition\, surrounding media and temperature; therefore\, minimizing the complexity occurring in normal circumstances and allowing us to understand the mechanism of the membrane-related reactions. \nIn this talk I will focus on the use of GUVs for the reconstitution of the Endosomal Sorting Complex Required for Transport (ESCRT) machinery whose transitory nature on living membranes makes it difficult to study via in vivo systems. The ESCRT machinery is involved in important membrane-remodeling processes in eukaryotes such as cytokinesis\, virus budding\, plasma membrane repair\, neuron pruning\, etc. In all of these reactions\, the ESCRT machinery orchestrates the fusion of buds that forms away from the cytosol\, contrary to the process regulated by clathrin-coated vesicles. In protozoan parasites such as Plasmodium facilparum and Entamoeba histolytica (causative agents of Malaria and Amebiasis\, respectively)\, the ESCRT machinery controls processes involved in the pathogenic mechanisms\, such as exosome generation for Plasmodium and endosome maturation in Entamoeba. By using GUVs as a model system\, the action of the ESCRT machinery from these and other organisms has been successfully reconstituted. The GUVs system allowed us to unveil the assembly sequence and the function of the proteins at the membrane. Moreover\, we have recreated the topology occurring in living cells by a femto-injection approach. The results derived from these experiments can be used to find new therapeutic targets for the eradication of these parasitic diseases.
URL:https://ibecbarcelona.eu/event/ibec-seminar-yunuen-avalo-2/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20180921T100000
DTEND;TZID=Europe/Madrid:20180921T110000
DTSTAMP:20260406T022624
CREATED:20180823T084554Z
LAST-MODIFIED:20180917T075818Z
UID:60917-1537524000-1537527600@ibecbarcelona.eu
SUMMARY:IBEC seminar: Yunuen Avalos
DESCRIPTION:GUVs as biomimetic systems to study pathogenic-related mechanisms of human parasites\nDr. Yunuen Avalos\, BEST Cofund postdoc\, Nanomalaria group\, IBEC\nMembrane models such as Giant Unilamellar Vesicles (GUVs) are a powerful tool for studying reactions occurring in living cells. The main advantage of using these biomimetic systems is the vast possibility of controlling the conditions such as membrane composition\, surrounding media and temperature; therefore\, minimizing the complexity occurring in normal circumstances and allowing us to understand the mechanism of the membrane-related reactions. \nIn this talk I will focus on the use of GUVs for the reconstitution of the Endosomal Sorting Complex Required for Transport (ESCRT) machinery whose transitory nature on living membranes makes it difficult to study via in vivo systems. The ESCRT machinery is involved in important membrane-remodeling processes in eukaryotes such as cytokinesis\, virus budding\, plasma membrane repair\, neuron pruning\, etc. In all of these reactions\, the ESCRT machinery orchestrates the fusion of buds that forms away from the cytosol\, contrary to the process regulated by clathrin-coated vesicles. In protozoan parasites such as Plasmodium facilparum and Entamoeba histolytica (causative agents of Malaria and Amebiasis\, respectively)\, the ESCRT machinery controls processes involved in the pathogenic mechanisms\, such as exosome generation for Plasmodium and endosome maturation in Entamoeba. By using GUVs as a model system\, the action of the ESCRT machinery from these and other organisms has been successfully reconstituted. The GUVs system allowed us to unveil the assembly sequence and the function of the proteins at the membrane. Moreover\, we have recreated the topology occurring in living cells by a femto-injection approach. The results derived from these experiments can be used to find new therapeutic targets for the eradication of these parasitic diseases.
URL:https://ibecbarcelona.eu/event/ibec-seminar-yunuen-avalo/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20181008T120000
DTEND;TZID=Europe/Madrid:20181008T130000
DTSTAMP:20260406T022624
CREATED:20181004T075235Z
LAST-MODIFIED:20181004T075235Z
UID:96309-1539000000-1539003600@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Prof. Rui L. Reis
DESCRIPTION:New Approaches\, combining natural materials and stem cells\, for the Engineering of Different Types of Tissues\nProf. Rui L. Reis\, University of Minho\nThe selection of a proper material to be used as a scaffold or as a hydrogel to support\, hold or encapsulate cells is both a critical and a difficult choice that will determine the success of failure of any tissue engineering and regenerative medicine (TERM) strategy.\nWe believe that the use of natural origin polymers\, including a wide range of marine origin materials\, is the best option for many different approaches that allow for the regeneration of different tissues. In addition to the selection of appropriate material systems it is of utmost importance the development of processing methodologies that allow for the production of adequate scaffolds/matrices\, in many cases incorporating bioactive/differentiation agents in their structures. \nFurthermore an adequate cell source should be selected. In many cases efficient cell isolation\, expansion and differentiation\, and in many cases the selection of a specific sub-population\, methodologies should be developed and optimized. We have been using different human cell sources namely: mesenchymal stem cells from bone marrow\, mesenchymal stem cells from human adipose tissue\, human cells from amniotic fluids and membranes and cells obtained from human umbilical cords. \nThe development of dynamic ways to culture the cells and of distinct ways to stimulate their differentiation in 3D environments\, as well as the use of nano-based systems to induce their differentiation and internalization into cells\, is also a key part of some of the strategies that are being developed in our research group. \nThe potential of each combination materials/cells\, to be used to develop novel useful regeneration therapies will be discussed. The use of different cells and their interactions with different natural origin degradable scaffolds and smart hydrogels will be described. Several examples of TERM strategies to regenerate different types of tissues will be presented. This will include the use of original high-throughput methodologies to look at materials/cell interactions. \n 
URL:https://ibecbarcelona.eu/event/ibec-seminar-prof-rui-l-reis-4/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20181008T120000
DTEND;TZID=Europe/Madrid:20181008T130000
DTSTAMP:20260406T022624
CREATED:20181004T075235Z
LAST-MODIFIED:20181004T075235Z
UID:61875-1539000000-1539003600@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Prof. Rui L. Reis
DESCRIPTION:New Approaches\, combining natural materials and stem cells\, for the Engineering of Different Types of Tissues\nProf. Rui L. Reis\, University of Minho\nThe selection of a proper material to be used as a scaffold or as a hydrogel to support\, hold or encapsulate cells is both a critical and a difficult choice that will determine the success of failure of any tissue engineering and regenerative medicine (TERM) strategy.\nWe believe that the use of natural origin polymers\, including a wide range of marine origin materials\, is the best option for many different approaches that allow for the regeneration of different tissues. In addition to the selection of appropriate material systems it is of utmost importance the development of processing methodologies that allow for the production of adequate scaffolds/matrices\, in many cases incorporating bioactive/differentiation agents in their structures. \nFurthermore an adequate cell source should be selected. In many cases efficient cell isolation\, expansion and differentiation\, and in many cases the selection of a specific sub-population\, methodologies should be developed and optimized. We have been using different human cell sources namely: mesenchymal stem cells from bone marrow\, mesenchymal stem cells from human adipose tissue\, human cells from amniotic fluids and membranes and cells obtained from human umbilical cords. \nThe development of dynamic ways to culture the cells and of distinct ways to stimulate their differentiation in 3D environments\, as well as the use of nano-based systems to induce their differentiation and internalization into cells\, is also a key part of some of the strategies that are being developed in our research group. \nThe potential of each combination materials/cells\, to be used to develop novel useful regeneration therapies will be discussed. The use of different cells and their interactions with different natural origin degradable scaffolds and smart hydrogels will be described. Several examples of TERM strategies to regenerate different types of tissues will be presented. This will include the use of original high-throughput methodologies to look at materials/cell interactions. \n 
URL:https://ibecbarcelona.eu/event/ibec-seminar-prof-rui-l-reis/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20181019T100000
DTEND;TZID=Europe/Madrid:20181019T110000
DTSTAMP:20260406T022624
CREATED:20181004T075517Z
LAST-MODIFIED:20181011T080137Z
UID:61876-1539943200-1539946800@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Alvaro Aytés\, IDIBELL
DESCRIPTION:Cross-species analysis of gene regulatory networks during prostate cancer progression\nAlvaro Aytés\, IDIBELL\nAnalysis of gene regulatory networks is a powerful tool to decipher drivers of phenotypic transitions\, oncogenic dependencies and potential vulnerabilities that can be exploited for therapeutic intervention. By modeling prostate cancer progression in genetically engineered mice we have been able to perform cross-species studies between mouse and human\, facilitating the identification and functional validation of cancer mechanisms. In particular we have a strong interest in understanding how aberrant control of transcriptional programs leads to treatment failure and resistance in prostate cancer. Whether this results in the emergence of new dependencies and vulnerabilities is also key to envision new treatment paradigms in the era of personalized medicine. \n 
URL:https://ibecbarcelona.eu/event/ibec-seminar-alvaro-aytes-idibell-2/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20181019T100000
DTEND;TZID=Europe/Madrid:20181019T110000
DTSTAMP:20260406T022624
CREATED:20181004T075517Z
LAST-MODIFIED:20181004T075517Z
UID:96310-1539943200-1539946800@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Alvaro Aytés\, IDIBELL
DESCRIPTION:Cross-species analysis of gene regulatory networks during prostate cancer progression\nAlvaro Aytés\, IDIBELL\nAnalysis of gene regulatory networks is a powerful tool to decipher drivers of phenotypic transitions\, oncogenic dependencies and potential vulnerabilities that can be exploited for therapeutic intervention. By modeling prostate cancer progression in genetically engineered mice we have been able to perform cross-species studies between mouse and human\, facilitating the identification and functional validation of cancer mechanisms. In particular we have a strong interest in understanding how aberrant control of transcriptional programs leads to treatment failure and resistance in prostate cancer. Whether this results in the emergence of new dependencies and vulnerabilities is also key to envision new treatment paradigms in the era of personalized medicine. \n 
URL:https://ibecbarcelona.eu/event/ibec-seminar-alvaro-aytes-idibell-2-2/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20181116T100000
DTEND;TZID=Europe/Madrid:20181116T110000
DTSTAMP:20260406T022624
CREATED:20181004T075934Z
LAST-MODIFIED:20181004T075934Z
UID:96320-1542362400-1542366000@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Benedetta Bolognesi
DESCRIPTION:The mutational landscape of a prion-like domain\nBenedetta Bolognesi\, IBEC\nAt least 70 human RNA-binding proteins (RBPs) contain a prion-like domain (PrLD). PrLDs are low complexity domains which resemble in composition the infectious yeast prions. Mutations in PrLDs are associated to the onset of many neurodegenerative conditions\, such as Amyotrophic Lateral Sclerosis (ALS). PrLDs are able to populate multiple physical states: diffuse\, liquid de-mixed\, insoluble amyloid. Pathological mutations affect these equilibria in ways we cannot yet fully understand\, or predict. The TAR DNA binding protein TDP-43 contains a 140 aa long PrLD and forms cytoplasmic aggregates in most cases of ALS. We use deep mutational scanning to understand how sequence determines the toxicity of TDP-43 in a yeast model. I will present the first “genotype-to-phenotype” map of TDP-43 where we quantify the effect of all possible amino acid substitutions in the PrLD on cellular fitness. While allowing us to understand the impact of mutations within low-complexity regions\, these data provide the basis to understand by which mechanism protein inclusions drive pathogenesis. \n 
URL:https://ibecbarcelona.eu/event/ibec-seminar-new-junior-group-leader-benedetta-bolognesi-2/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20181116T100000
DTEND;TZID=Europe/Madrid:20181116T110000
DTSTAMP:20260406T022624
CREATED:20181004T075934Z
LAST-MODIFIED:20181030T112433Z
UID:61884-1542362400-1542366000@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Benedetta Bolognesi
DESCRIPTION:The mutational landscape of a prion-like domain\nBenedetta Bolognesi\, IBEC\nAt least 70 human RNA-binding proteins (RBPs) contain a prion-like domain (PrLD). PrLDs are low complexity domains which resemble in composition the infectious yeast prions. Mutations in PrLDs are associated to the onset of many neurodegenerative conditions\, such as Amyotrophic Lateral Sclerosis (ALS). PrLDs are able to populate multiple physical states: diffuse\, liquid de-mixed\, insoluble amyloid. Pathological mutations affect these equilibria in ways we cannot yet fully understand\, or predict. The TAR DNA binding protein TDP-43 contains a 140 aa long PrLD and forms cytoplasmic aggregates in most cases of ALS. We use deep mutational scanning to understand how sequence determines the toxicity of TDP-43 in a yeast model. I will present the first “genotype-to-phenotype” map of TDP-43 where we quantify the effect of all possible amino acid substitutions in the PrLD on cellular fitness. While allowing us to understand the impact of mutations within low-complexity regions\, these data provide the basis to understand by which mechanism protein inclusions drive pathogenesis. \n 
URL:https://ibecbarcelona.eu/event/ibec-seminar-new-junior-group-leader-benedetta-bolognesi/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20181123T100000
DTEND;TZID=Europe/Madrid:20181123T110000
DTSTAMP:20260406T022624
CREATED:20181004T075739Z
LAST-MODIFIED:20181004T075739Z
UID:96317-1542967200-1542970800@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Rubén Moreno-Bote
DESCRIPTION:Aligned neuronal encoding of sensory information\, biases and choices in perceptual decision making\nRubén Moreno-Bote\, Serra Hunter Associate Professor\, UPF\nIdentifying what aspects of neuronal population activity are relevant for the encoding of information and choices is a crucial step toward understanding the neural code. Several statistical features of the neuronal population responses\, such as tuning\, synchronization and global activity could affect the amount of information encoded and modulate behavioral performance. Here we show\, however\, that only two of these features correlate wtih information: the length of the vector joining the mean responses across conditions and the inverse trial-by-trial variability of the responses projected along that vector. We find that modulations of the two statistical features are correlated with fluctuations of behavioral performance in various tasks. In contrast\, modulations in mean correlations among neurons and global activity have negligible or no consistent effects on information encoding and behavioral performance. These results suggest that the neuronal representation of sensory information and choices are aligned. Interestingly\, we also find that harmful\, intrinsically generated behavioral biases are aligned with the choice representation in neuronal populations in the prefrontal cortex. I will describe a recently published sequential theory of decision making that could explain why these variables are represented along aligned axes in neuronal activity space. \n 
URL:https://ibecbarcelona.eu/event/ibec-seminar-ruben-moreno-bote-2/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20181123T100000
DTEND;TZID=Europe/Madrid:20181123T110000
DTSTAMP:20260406T022624
CREATED:20181004T075739Z
LAST-MODIFIED:20181004T075739Z
UID:61880-1542967200-1542970800@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Rubén Moreno-Bote
DESCRIPTION:Aligned neuronal encoding of sensory information\, biases and choices in perceptual decision making\nRubén Moreno-Bote\, Serra Hunter Associate Professor\, UPF\nIdentifying what aspects of neuronal population activity are relevant for the encoding of information and choices is a crucial step toward understanding the neural code. Several statistical features of the neuronal population responses\, such as tuning\, synchronization and global activity could affect the amount of information encoded and modulate behavioral performance. Here we show\, however\, that only two of these features correlate wtih information: the length of the vector joining the mean responses across conditions and the inverse trial-by-trial variability of the responses projected along that vector. We find that modulations of the two statistical features are correlated with fluctuations of behavioral performance in various tasks. In contrast\, modulations in mean correlations among neurons and global activity have negligible or no consistent effects on information encoding and behavioral performance. These results suggest that the neuronal representation of sensory information and choices are aligned. Interestingly\, we also find that harmful\, intrinsically generated behavioral biases are aligned with the choice representation in neuronal populations in the prefrontal cortex. I will describe a recently published sequential theory of decision making that could explain why these variables are represented along aligned axes in neuronal activity space. \n 
URL:https://ibecbarcelona.eu/event/ibec-seminar-ruben-moreno-bote/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20190111T100000
DTEND;TZID=Europe/Madrid:20190111T110000
DTSTAMP:20260406T022624
CREATED:20181127T104913Z
LAST-MODIFIED:20181127T104913Z
UID:96350-1547200800-1547204400@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Dominque Martínez\, Lorraine Laboratory of Research in Informatics and its Applications - CNRS
DESCRIPTION:Neural computations of olfactory navigation\nDominque Martínez\, Lorraine Laboratory of Research in Informatics and its Applications – CNRS\nI will present my work in computational neuroscience and neuro-robotics aiming at understanding the odour-guided behaviour of animals\, especially insects. At the application level\, the challenge is to create innovative olfactory sensors and robots that reproduce certain aspects of animal behaviour. A virtuous circle is created where biological models benefit from robotic experiments and inspire them in return. The most demonstrative result concerns a hybrid robot with insect antennae as biosensors for the detection and localization of chemical sources. If time allows\, I will also present another project carried out at our laboratory about modelling the brain oscillatory activity in Parkinson’s disease.\n \nDominque is a visiting researcher in the Signal and information processing for sensing systems group at IBEC \n 
URL:https://ibecbarcelona.eu/event/ibec-seminar-dominque-martinez-lorraine-laboratory-of-research-in-informatics-and-its-applications-cnrs-2/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20190111T100000
DTEND;TZID=Europe/Madrid:20190111T110000
DTSTAMP:20260406T022624
CREATED:20181127T104913Z
LAST-MODIFIED:20181211T083944Z
UID:63562-1547200800-1547204400@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Dominque Martínez\, Lorraine Laboratory of Research in Informatics and its Applications - CNRS
DESCRIPTION:Neural computations of olfactory navigation\nDominque Martínez\, Lorraine Laboratory of Research in Informatics and its Applications – CNRS\nI will present my work in computational neuroscience and neuro-robotics aiming at understanding the odour-guided behaviour of animals\, especially insects. At the application level\, the challenge is to create innovative olfactory sensors and robots that reproduce certain aspects of animal behaviour. A virtuous circle is created where biological models benefit from robotic experiments and inspire them in return. The most demonstrative result concerns a hybrid robot with insect antennae as biosensors for the detection and localization of chemical sources. If time allows\, I will also present another project carried out at our laboratory about modelling the brain oscillatory activity in Parkinson’s disease.\n \nDominque is a visiting researcher in the Signal and information processing for sensing systems group at IBEC \n 
URL:https://ibecbarcelona.eu/event/ibec-seminar-dominque-martinez-lorraine-laboratory-of-research-in-informatics-and-its-applications-cnrs/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20190201T100000
DTEND;TZID=Europe/Madrid:20190201T230000
DTSTAMP:20260406T022624
CREATED:20190110T092559Z
LAST-MODIFIED:20190110T092559Z
UID:96359-1549015200-1549062000@ibecbarcelona.eu
SUMMARY:IBEc Seminar: Dr Ben Goult
DESCRIPTION:Title to be confirmed\nDr Ben Goult \nMore information soon
URL:https://ibecbarcelona.eu/event/ibec-seminar-dr-ben-goult-2/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20190201T100000
DTEND;TZID=Europe/Madrid:20190201T230000
DTSTAMP:20260406T022624
CREATED:20190110T092559Z
LAST-MODIFIED:20190110T092559Z
UID:65078-1549015200-1549062000@ibecbarcelona.eu
SUMMARY:IBEc Seminar: Dr Ben Goult
DESCRIPTION:Title to be confirmed\nDr Ben Goult \nMore information soon
URL:https://ibecbarcelona.eu/event/ibec-seminar-dr-ben-goult/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20190301T100000
DTEND;TZID=Europe/Madrid:20190301T120000
DTSTAMP:20260406T022624
CREATED:20190220T155437Z
LAST-MODIFIED:20190220T155437Z
UID:96402-1551434400-1551441600@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Irene Marco
DESCRIPTION:Hyperpolarised magnetic resonance for real-time\, in situ monitoring of cell metabolism\nIrene Marco\, Biosensors for bioengineering – IBEC  \nThere is a clinical need for non-invasive and reliable markers to diagnose\, stage and evaluate treatment response in many diseases such as cancer or non-alcoholic fatty liver disease.\nMagnetic resonance (MR) methods now have the potential to revolutionise in the identification of such biomarkers in real time. Spectroscopic identification and quantitation of metabolites via carbon-13 chemical shifts can be combined with imaging (MRI) to simultaneously probe spatial (biodistribution) and temporal (kinetics) aspects of metabolism in vivo. These capabilities are enabled by so-called hyperpolarised (HP) MR techniques\, including Dynamic Nuclear Polarisation (DNP)\, which can transiently boost the carbon-13 MR signals by several orders of magnitude\, compared to traditional methods. DNP enables real-time measurement of enzymatic reactions in cell suspensions and in vivo. Multiple HP 13C-labelled substrates have provided insights in several metabolic pathways\, including glycolysis\, the pentose-phosphate pathway and the cellular redox state. I will present the potential of DNP to study metabolism in cell suspensions\, tissue ex vivo and animals in vivo\, as well as tap on the advances into the clinical translation of the technique. Also\, I will talk about how we intend to implement HP MR to monitor metabolism in organs-in-chips in the lab of Javier Ramón (IBEC).
URL:https://ibecbarcelona.eu/event/ibec-seminar-irene-marco-3/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20190301T100000
DTEND;TZID=Europe/Madrid:20190301T120000
DTSTAMP:20260406T022624
CREATED:20190220T155437Z
LAST-MODIFIED:20190220T155437Z
UID:65718-1551434400-1551441600@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Irene Marco
DESCRIPTION:Hyperpolarised magnetic resonance for real-time\, in situ monitoring of cell metabolism\nIrene Marco\, Biosensors for bioengineering – IBEC  \nThere is a clinical need for non-invasive and reliable markers to diagnose\, stage and evaluate treatment response in many diseases such as cancer or non-alcoholic fatty liver disease.\nMagnetic resonance (MR) methods now have the potential to revolutionise in the identification of such biomarkers in real time. Spectroscopic identification and quantitation of metabolites via carbon-13 chemical shifts can be combined with imaging (MRI) to simultaneously probe spatial (biodistribution) and temporal (kinetics) aspects of metabolism in vivo. These capabilities are enabled by so-called hyperpolarised (HP) MR techniques\, including Dynamic Nuclear Polarisation (DNP)\, which can transiently boost the carbon-13 MR signals by several orders of magnitude\, compared to traditional methods. DNP enables real-time measurement of enzymatic reactions in cell suspensions and in vivo. Multiple HP 13C-labelled substrates have provided insights in several metabolic pathways\, including glycolysis\, the pentose-phosphate pathway and the cellular redox state. I will present the potential of DNP to study metabolism in cell suspensions\, tissue ex vivo and animals in vivo\, as well as tap on the advances into the clinical translation of the technique. Also\, I will talk about how we intend to implement HP MR to monitor metabolism in organs-in-chips in the lab of Javier Ramón (IBEC).
URL:https://ibecbarcelona.eu/event/ibec-seminar-irene-marco/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20190315T100000
DTEND;TZID=Europe/Madrid:20190315T120000
DTSTAMP:20260406T022624
CREATED:20190306T164913Z
LAST-MODIFIED:20190306T164913Z
UID:96404-1552644000-1552651200@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Paul Wright
DESCRIPTION:Nanosafety research addressing public health concerns about metal oxide nanoparticles\nPaul Wright\, Head of RMIT Nanosafety Research Group – RMIT University \nPaul Wright is Australia’s foremost expert in nanotoxicology and nanosafety\, and founding co-ordinator of the Asia Nano Safe and NanoSafe Australia research networks. He is the toxicologist at RMIT University’s School of Health and Biomedical Sciences\, at Bundoora in Melbourne\, Australia. He heads RMIT’s Nanosafety Research Group and led RMIT’s large contribution to the Australian Consortium for the OECD’s recent nanosafety testing program. He is nanosafety advisor to the Australian Nanotechnology Network (ANN)\, and has directly advised several Australian Federal and state government authorities and committees on nanosafety issues. Paul is a Fellow of International Union of Pure and Applied Chemistry (IUPAC) and formerly an elected director of the Executive Committee of International Union of Toxicology (IUTOX).
URL:https://ibecbarcelona.eu/event/ibec-seminar-paul-wright-2/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar,Joint seminar / workshop / symposium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20190315T100000
DTEND;TZID=Europe/Madrid:20190315T120000
DTSTAMP:20260406T022624
CREATED:20190306T164913Z
LAST-MODIFIED:20190306T165355Z
UID:65852-1552644000-1552651200@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Paul Wright
DESCRIPTION:Nanosafety research addressing public health concerns about metal oxide nanoparticles\nPaul Wright\, Head of RMIT Nanosafety Research Group – RMIT University \nPaul Wright is Australia’s foremost expert in nanotoxicology and nanosafety\, and founding co-ordinator of the Asia Nano Safe and NanoSafe Australia research networks. He is the toxicologist at RMIT University’s School of Health and Biomedical Sciences\, at Bundoora in Melbourne\, Australia. He heads RMIT’s Nanosafety Research Group and led RMIT’s large contribution to the Australian Consortium for the OECD’s recent nanosafety testing program. He is nanosafety advisor to the Australian Nanotechnology Network (ANN)\, and has directly advised several Australian Federal and state government authorities and committees on nanosafety issues. Paul is a Fellow of International Union of Pure and Applied Chemistry (IUPAC) and formerly an elected director of the Executive Committee of International Union of Toxicology (IUTOX).
URL:https://ibecbarcelona.eu/event/ibec-seminar-paul-wright/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar,Joint seminar / workshop / symposium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20190322T100000
DTEND;TZID=Europe/Madrid:20190322T120000
DTSTAMP:20260406T022624
CREATED:20190319T101144Z
LAST-MODIFIED:20190319T101144Z
UID:96419-1553248800-1553256000@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Silvia Muro
DESCRIPTION:Spread the word!\nNest Friday we are glad to present to all those who are part of the IBEC community the IBEC FASTER FUTURE programme\, an initiative to accelerate our research in a collaborative way together with patients’ associations and hospitals. Everyone can be involved and we will comment the different ways to contribute to Faster Future. \nThis year\, we have added a new project led by Dr. Silvia Muro\, responsible for the Targeted therapeutics and nanodevices group\, related to Parkinson’s disease\, that affects millions of people around the world. \nIn this presentation\, Silvia Muro will talk about Enabling Delivery of Therapeutics Across the Blood-Brain Barrier for Treatment of Neurodegenerative Diseases. \nGet involved\, we count on you!\nEnabling Delivery of Therapeutics Across the Blood-Brain Barrier for Treatment of Neurodegenerative Diseases\nSilvia Muro\, IBEC Group Leader Targeted therapeutics and nanodevices / ICREA Research Professor\n \nAccessing the brain is key to study its function and pathology\, and for diagnostic and therapeutic purposes. Yet\, this remains a formidable challenge due to the blood-brain barrier (BBB). To overcome this obstacle\, new nanovehicles are being designed to cross this interface\, without much translational success. A prime obstacle is the lack of knowledge on the biological regulation of these devices\, as most efforts have been devoted to controling their chemical and physical properties. To brindge this gap of knowledge\, we designed nanovehicles targeted to receptors of the main routes of transcytosis across endothelial barriers\, i.e. clathrin-\, caveolar\, and cell adhesion molecule (CAM)-mediated pathways (identified in our lab)\, and compared their BBB transport in cellular and animal models. Targeting these three routes resulted in transport across the endothelial lining\, whereas the CAM pathway was the most effective across a broad spectrum of carrier sizes and targeting valencies. This is reminiscent of the CAM function\, which contributes to transcellular leukocyte migration\, and it happened through a remodeling of the lipid composition of the endothelial plasmalemma and reorganization of the actin cytoskeleton. By understanding the biological regulation of this pathway\, we were able to optimize carrier design parameters to enhance BBB crossing. This needed a fine balance between the ability of carriers to bind to BBB receptors at the apical (circulation) surface and to detach from them at the basolateral (brain) side. As a result\, cargoes such as enzyme therapeutics for the treatment of neurological lysosomal disorders\, were delivered in an active form in the brain after intravenous administration in mouse models. Our current efforts aim to implement this strategy for the development of new therapeutics against other neurodegenerative conditions\, such as Parkinson’s disease. \n 
URL:https://ibecbarcelona.eu/event/ibec-seminar-silvia-muro-2/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
ATTACH;FMTTYPE=image/jpeg:https://ibecbarcelona.eu/wp-content/uploads/2019/03/ibecfasterfuture1.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20190322T100000
DTEND;TZID=Europe/Madrid:20190322T120000
DTSTAMP:20260406T022624
CREATED:20190319T101144Z
LAST-MODIFIED:20190322T085625Z
UID:65995-1553248800-1553256000@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Silvia Muro
DESCRIPTION:Spread the word!\nNest Friday we are glad to present to all those who are part of the IBEC community the IBEC FASTER FUTURE programme\, an initiative to accelerate our research in a collaborative way together with patients’ associations and hospitals. Everyone can be involved and we will comment the different ways to contribute to Faster Future. \nThis year\, we have added a new project led by Dr. Silvia Muro\, responsible for the Targeted therapeutics and nanodevices group\, related to Parkinson’s disease\, that affects millions of people around the world. \nIn this presentation\, Silvia Muro will talk about Enabling Delivery of Therapeutics Across the Blood-Brain Barrier for Treatment of Neurodegenerative Diseases. \nGet involved\, we count on you!\nEnabling Delivery of Therapeutics Across the Blood-Brain Barrier for Treatment of Neurodegenerative Diseases\nSilvia Muro\, IBEC Group Leader Targeted therapeutics and nanodevices / ICREA Research Professor\n \nAccessing the brain is key to study its function and pathology\, and for diagnostic and therapeutic purposes. Yet\, this remains a formidable challenge due to the blood-brain barrier (BBB). To overcome this obstacle\, new nanovehicles are being designed to cross this interface\, without much translational success. A prime obstacle is the lack of knowledge on the biological regulation of these devices\, as most efforts have been devoted to controling their chemical and physical properties. To brindge this gap of knowledge\, we designed nanovehicles targeted to receptors of the main routes of transcytosis across endothelial barriers\, i.e. clathrin-\, caveolar\, and cell adhesion molecule (CAM)-mediated pathways (identified in our lab)\, and compared their BBB transport in cellular and animal models. Targeting these three routes resulted in transport across the endothelial lining\, whereas the CAM pathway was the most effective across a broad spectrum of carrier sizes and targeting valencies. This is reminiscent of the CAM function\, which contributes to transcellular leukocyte migration\, and it happened through a remodeling of the lipid composition of the endothelial plasmalemma and reorganization of the actin cytoskeleton. By understanding the biological regulation of this pathway\, we were able to optimize carrier design parameters to enhance BBB crossing. This needed a fine balance between the ability of carriers to bind to BBB receptors at the apical (circulation) surface and to detach from them at the basolateral (brain) side. As a result\, cargoes such as enzyme therapeutics for the treatment of neurological lysosomal disorders\, were delivered in an active form in the brain after intravenous administration in mouse models. Our current efforts aim to implement this strategy for the development of new therapeutics against other neurodegenerative conditions\, such as Parkinson’s disease. \n 
URL:https://ibecbarcelona.eu/event/ibec-seminar-silvia-muro/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
ATTACH;FMTTYPE=image/jpeg:https://ibecbarcelona.eu/wp-content/uploads/2019/03/ibecfasterfuture1.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20190705T100000
DTEND;TZID=Europe/Madrid:20190705T120000
DTSTAMP:20260406T022624
CREATED:20190701T075124Z
LAST-MODIFIED:20190701T075124Z
UID:96468-1562320800-1562328000@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Jordi Guiu
DESCRIPTION:Tracing the origin of adult intestinal stem cells\nJordi Guiu\, Biotech Research & Innovation Centre – University of Copenhagen \nJordi Guiu did his PhD in Anna Bigas laboratory (IMIM and Pompeu Fabra University-Barcelona) were he focused on the genetic circuitry that controls the establishment of hematopoietic stem cells during development. Then he joined Kim B. Jensen lab (Copenhagen University) as a postdoc\, were he obtained a Marie Curie fellowship. His current research is focused on the specification of intestinal stem cells during development using fate mapping technologies\, state of the art imaging\, biophysical modeling and a plethora of sequencing techniques.  \nThe adult small intestine is compartmentalized into villi and crypts containing post-mitotic differentiated and proliferative cells respectively. Intestinal stem cells (ISCs) located at the bottom of crypts express markers such as Lgr5 and fuel the constant replenishment of the intestinal epithelium. Importantly\, the cellular origin of adult ISCs remains unknown. Prior to birth the immature fetal intestine is structurally simpler than the adult intestine. It is characterized by villi separated by a continuous region composed of proliferative intervillus cells; crypts have not formed and there is no evidence of a stem cell niche. Interestingly\, intervillus cells located within the region between villi express the adult SAB marker Lgr5. Fate mapping studies have inferred the notion that fetal Lgr5 expressing cells are unique and specialized precursors for the adult ISCs. Using unbiased quantitative lineage-tracing approaches\, biophysical modeling and intestinal transplantation experiments\, we now demonstrate that in the fetal epithelium on-going tissue morphogenesis leads to a dynamic exchange of cells between the villi and intervillus regions and that all cells have got the potential to contribute to the adult stem cells. Moreover\, we present exciting data outlining the mechanism for tissue development based on 3D imaging and live microscopy. Our results demonstrate that large-scale tissue remodeling and cell fate specification are intertwined processes. Moreover\, these findings provide a direct link between the observed plasticity and cellular reprogramming of differentiating cells in adult tissue following damage\, revealing that stem cell identity is an induced rather than a hardwired property.
URL:https://ibecbarcelona.eu/event/ibec-seminar-jordi-guiu-2/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20190705T100000
DTEND;TZID=Europe/Madrid:20190705T120000
DTSTAMP:20260406T022624
CREATED:20190701T075124Z
LAST-MODIFIED:20190701T080442Z
UID:67051-1562320800-1562328000@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Jordi Guiu
DESCRIPTION:Tracing the origin of adult intestinal stem cells\nJordi Guiu\, Biotech Research & Innovation Centre – University of Copenhagen \nJordi Guiu did his PhD in Anna Bigas laboratory (IMIM and Pompeu Fabra University-Barcelona) were he focused on the genetic circuitry that controls the establishment of hematopoietic stem cells during development. Then he joined Kim B. Jensen lab (Copenhagen University) as a postdoc\, were he obtained a Marie Curie fellowship. His current research is focused on the specification of intestinal stem cells during development using fate mapping technologies\, state of the art imaging\, biophysical modeling and a plethora of sequencing techniques.  \nThe adult small intestine is compartmentalized into villi and crypts containing post-mitotic differentiated and proliferative cells respectively. Intestinal stem cells (ISCs) located at the bottom of crypts express markers such as Lgr5 and fuel the constant replenishment of the intestinal epithelium. Importantly\, the cellular origin of adult ISCs remains unknown. Prior to birth the immature fetal intestine is structurally simpler than the adult intestine. It is characterized by villi separated by a continuous region composed of proliferative intervillus cells; crypts have not formed and there is no evidence of a stem cell niche. Interestingly\, intervillus cells located within the region between villi express the adult SAB marker Lgr5. Fate mapping studies have inferred the notion that fetal Lgr5 expressing cells are unique and specialized precursors for the adult ISCs. Using unbiased quantitative lineage-tracing approaches\, biophysical modeling and intestinal transplantation experiments\, we now demonstrate that in the fetal epithelium on-going tissue morphogenesis leads to a dynamic exchange of cells between the villi and intervillus regions and that all cells have got the potential to contribute to the adult stem cells. Moreover\, we present exciting data outlining the mechanism for tissue development based on 3D imaging and live microscopy. Our results demonstrate that large-scale tissue remodeling and cell fate specification are intertwined processes. Moreover\, these findings provide a direct link between the observed plasticity and cellular reprogramming of differentiating cells in adult tissue following damage\, revealing that stem cell identity is an induced rather than a hardwired property.
URL:https://ibecbarcelona.eu/event/ibec-seminar-jordi-guiu/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20190715T120000
DTEND;TZID=Europe/Madrid:20190715T130000
DTSTAMP:20260406T022624
CREATED:20190701T080416Z
LAST-MODIFIED:20190701T080416Z
UID:96471-1563192000-1563195600@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Nicolas Minc
DESCRIPTION:Division positioning in early embryos from mechanisms to function\nNicolas Minc\, Insitut Jacques Monod\, Paris\, France \nNicolas Minc lab is located at the Institut Jacques Monod in Paris\, and studies general problems of cell morphogenesis\, ranging from the control of cell growth and shapes in single cells\, to cell division in multicellular embryos. One hallmark of the lab is to combine quantitative imaging\, biophysics methods and modelling to address fundamental questions in cell and developmental biology.
URL:https://ibecbarcelona.eu/event/ibec-seminar-nicolas-minc-2/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20190715T120000
DTEND;TZID=Europe/Madrid:20190715T130000
DTSTAMP:20260406T022624
CREATED:20190701T080416Z
LAST-MODIFIED:20190701T080423Z
UID:67054-1563192000-1563195600@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Nicolas Minc
DESCRIPTION:Division positioning in early embryos from mechanisms to function\nNicolas Minc\, Insitut Jacques Monod\, Paris\, France \nNicolas Minc lab is located at the Institut Jacques Monod in Paris\, and studies general problems of cell morphogenesis\, ranging from the control of cell growth and shapes in single cells\, to cell division in multicellular embryos. One hallmark of the lab is to combine quantitative imaging\, biophysics methods and modelling to address fundamental questions in cell and developmental biology.
URL:https://ibecbarcelona.eu/event/ibec-seminar-nicolas-minc/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
END:VCALENDAR