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DTSTART;TZID=Europe/Madrid:20181019T100000
DTEND;TZID=Europe/Madrid:20181019T110000
DTSTAMP:20260406T035150
CREATED:20181004T075517Z
LAST-MODIFIED:20181004T075517Z
UID:96310-1539943200-1539946800@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Alvaro Aytés\, IDIBELL
DESCRIPTION:Cross-species analysis of gene regulatory networks during prostate cancer progression\nAlvaro Aytés\, IDIBELL\nAnalysis of gene regulatory networks is a powerful tool to decipher drivers of phenotypic transitions\, oncogenic dependencies and potential vulnerabilities that can be exploited for therapeutic intervention. By modeling prostate cancer progression in genetically engineered mice we have been able to perform cross-species studies between mouse and human\, facilitating the identification and functional validation of cancer mechanisms. In particular we have a strong interest in understanding how aberrant control of transcriptional programs leads to treatment failure and resistance in prostate cancer. Whether this results in the emergence of new dependencies and vulnerabilities is also key to envision new treatment paradigms in the era of personalized medicine. \n 
URL:https://ibecbarcelona.eu/event/ibec-seminar-alvaro-aytes-idibell-2-2/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20181019T100000
DTEND;TZID=Europe/Madrid:20181019T110000
DTSTAMP:20260406T035150
CREATED:20181004T075517Z
LAST-MODIFIED:20181011T080137Z
UID:61876-1539943200-1539946800@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Alvaro Aytés\, IDIBELL
DESCRIPTION:Cross-species analysis of gene regulatory networks during prostate cancer progression\nAlvaro Aytés\, IDIBELL\nAnalysis of gene regulatory networks is a powerful tool to decipher drivers of phenotypic transitions\, oncogenic dependencies and potential vulnerabilities that can be exploited for therapeutic intervention. By modeling prostate cancer progression in genetically engineered mice we have been able to perform cross-species studies between mouse and human\, facilitating the identification and functional validation of cancer mechanisms. In particular we have a strong interest in understanding how aberrant control of transcriptional programs leads to treatment failure and resistance in prostate cancer. Whether this results in the emergence of new dependencies and vulnerabilities is also key to envision new treatment paradigms in the era of personalized medicine. \n 
URL:https://ibecbarcelona.eu/event/ibec-seminar-alvaro-aytes-idibell-2/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20181116T100000
DTEND;TZID=Europe/Madrid:20181116T110000
DTSTAMP:20260406T035150
CREATED:20181004T075934Z
LAST-MODIFIED:20181004T075934Z
UID:96320-1542362400-1542366000@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Benedetta Bolognesi
DESCRIPTION:The mutational landscape of a prion-like domain\nBenedetta Bolognesi\, IBEC\nAt least 70 human RNA-binding proteins (RBPs) contain a prion-like domain (PrLD). PrLDs are low complexity domains which resemble in composition the infectious yeast prions. Mutations in PrLDs are associated to the onset of many neurodegenerative conditions\, such as Amyotrophic Lateral Sclerosis (ALS). PrLDs are able to populate multiple physical states: diffuse\, liquid de-mixed\, insoluble amyloid. Pathological mutations affect these equilibria in ways we cannot yet fully understand\, or predict. The TAR DNA binding protein TDP-43 contains a 140 aa long PrLD and forms cytoplasmic aggregates in most cases of ALS. We use deep mutational scanning to understand how sequence determines the toxicity of TDP-43 in a yeast model. I will present the first “genotype-to-phenotype” map of TDP-43 where we quantify the effect of all possible amino acid substitutions in the PrLD on cellular fitness. While allowing us to understand the impact of mutations within low-complexity regions\, these data provide the basis to understand by which mechanism protein inclusions drive pathogenesis. \n 
URL:https://ibecbarcelona.eu/event/ibec-seminar-new-junior-group-leader-benedetta-bolognesi-2/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20181116T100000
DTEND;TZID=Europe/Madrid:20181116T110000
DTSTAMP:20260406T035150
CREATED:20181004T075934Z
LAST-MODIFIED:20181030T112433Z
UID:61884-1542362400-1542366000@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Benedetta Bolognesi
DESCRIPTION:The mutational landscape of a prion-like domain\nBenedetta Bolognesi\, IBEC\nAt least 70 human RNA-binding proteins (RBPs) contain a prion-like domain (PrLD). PrLDs are low complexity domains which resemble in composition the infectious yeast prions. Mutations in PrLDs are associated to the onset of many neurodegenerative conditions\, such as Amyotrophic Lateral Sclerosis (ALS). PrLDs are able to populate multiple physical states: diffuse\, liquid de-mixed\, insoluble amyloid. Pathological mutations affect these equilibria in ways we cannot yet fully understand\, or predict. The TAR DNA binding protein TDP-43 contains a 140 aa long PrLD and forms cytoplasmic aggregates in most cases of ALS. We use deep mutational scanning to understand how sequence determines the toxicity of TDP-43 in a yeast model. I will present the first “genotype-to-phenotype” map of TDP-43 where we quantify the effect of all possible amino acid substitutions in the PrLD on cellular fitness. While allowing us to understand the impact of mutations within low-complexity regions\, these data provide the basis to understand by which mechanism protein inclusions drive pathogenesis. \n 
URL:https://ibecbarcelona.eu/event/ibec-seminar-new-junior-group-leader-benedetta-bolognesi/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20181123T100000
DTEND;TZID=Europe/Madrid:20181123T110000
DTSTAMP:20260406T035150
CREATED:20181004T075739Z
LAST-MODIFIED:20181004T075739Z
UID:96317-1542967200-1542970800@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Rubén Moreno-Bote
DESCRIPTION:Aligned neuronal encoding of sensory information\, biases and choices in perceptual decision making\nRubén Moreno-Bote\, Serra Hunter Associate Professor\, UPF\nIdentifying what aspects of neuronal population activity are relevant for the encoding of information and choices is a crucial step toward understanding the neural code. Several statistical features of the neuronal population responses\, such as tuning\, synchronization and global activity could affect the amount of information encoded and modulate behavioral performance. Here we show\, however\, that only two of these features correlate wtih information: the length of the vector joining the mean responses across conditions and the inverse trial-by-trial variability of the responses projected along that vector. We find that modulations of the two statistical features are correlated with fluctuations of behavioral performance in various tasks. In contrast\, modulations in mean correlations among neurons and global activity have negligible or no consistent effects on information encoding and behavioral performance. These results suggest that the neuronal representation of sensory information and choices are aligned. Interestingly\, we also find that harmful\, intrinsically generated behavioral biases are aligned with the choice representation in neuronal populations in the prefrontal cortex. I will describe a recently published sequential theory of decision making that could explain why these variables are represented along aligned axes in neuronal activity space. \n 
URL:https://ibecbarcelona.eu/event/ibec-seminar-ruben-moreno-bote-2/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20181123T100000
DTEND;TZID=Europe/Madrid:20181123T110000
DTSTAMP:20260406T035150
CREATED:20181004T075739Z
LAST-MODIFIED:20181004T075739Z
UID:61880-1542967200-1542970800@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Rubén Moreno-Bote
DESCRIPTION:Aligned neuronal encoding of sensory information\, biases and choices in perceptual decision making\nRubén Moreno-Bote\, Serra Hunter Associate Professor\, UPF\nIdentifying what aspects of neuronal population activity are relevant for the encoding of information and choices is a crucial step toward understanding the neural code. Several statistical features of the neuronal population responses\, such as tuning\, synchronization and global activity could affect the amount of information encoded and modulate behavioral performance. Here we show\, however\, that only two of these features correlate wtih information: the length of the vector joining the mean responses across conditions and the inverse trial-by-trial variability of the responses projected along that vector. We find that modulations of the two statistical features are correlated with fluctuations of behavioral performance in various tasks. In contrast\, modulations in mean correlations among neurons and global activity have negligible or no consistent effects on information encoding and behavioral performance. These results suggest that the neuronal representation of sensory information and choices are aligned. Interestingly\, we also find that harmful\, intrinsically generated behavioral biases are aligned with the choice representation in neuronal populations in the prefrontal cortex. I will describe a recently published sequential theory of decision making that could explain why these variables are represented along aligned axes in neuronal activity space. \n 
URL:https://ibecbarcelona.eu/event/ibec-seminar-ruben-moreno-bote/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20190111T100000
DTEND;TZID=Europe/Madrid:20190111T110000
DTSTAMP:20260406T035150
CREATED:20181127T104913Z
LAST-MODIFIED:20181127T104913Z
UID:96350-1547200800-1547204400@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Dominque Martínez\, Lorraine Laboratory of Research in Informatics and its Applications - CNRS
DESCRIPTION:Neural computations of olfactory navigation\nDominque Martínez\, Lorraine Laboratory of Research in Informatics and its Applications – CNRS\nI will present my work in computational neuroscience and neuro-robotics aiming at understanding the odour-guided behaviour of animals\, especially insects. At the application level\, the challenge is to create innovative olfactory sensors and robots that reproduce certain aspects of animal behaviour. A virtuous circle is created where biological models benefit from robotic experiments and inspire them in return. The most demonstrative result concerns a hybrid robot with insect antennae as biosensors for the detection and localization of chemical sources. If time allows\, I will also present another project carried out at our laboratory about modelling the brain oscillatory activity in Parkinson’s disease.\n \nDominque is a visiting researcher in the Signal and information processing for sensing systems group at IBEC \n 
URL:https://ibecbarcelona.eu/event/ibec-seminar-dominque-martinez-lorraine-laboratory-of-research-in-informatics-and-its-applications-cnrs-2/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20190111T100000
DTEND;TZID=Europe/Madrid:20190111T110000
DTSTAMP:20260406T035150
CREATED:20181127T104913Z
LAST-MODIFIED:20181211T083944Z
UID:63562-1547200800-1547204400@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Dominque Martínez\, Lorraine Laboratory of Research in Informatics and its Applications - CNRS
DESCRIPTION:Neural computations of olfactory navigation\nDominque Martínez\, Lorraine Laboratory of Research in Informatics and its Applications – CNRS\nI will present my work in computational neuroscience and neuro-robotics aiming at understanding the odour-guided behaviour of animals\, especially insects. At the application level\, the challenge is to create innovative olfactory sensors and robots that reproduce certain aspects of animal behaviour. A virtuous circle is created where biological models benefit from robotic experiments and inspire them in return. The most demonstrative result concerns a hybrid robot with insect antennae as biosensors for the detection and localization of chemical sources. If time allows\, I will also present another project carried out at our laboratory about modelling the brain oscillatory activity in Parkinson’s disease.\n \nDominque is a visiting researcher in the Signal and information processing for sensing systems group at IBEC \n 
URL:https://ibecbarcelona.eu/event/ibec-seminar-dominque-martinez-lorraine-laboratory-of-research-in-informatics-and-its-applications-cnrs/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20190201T100000
DTEND;TZID=Europe/Madrid:20190201T230000
DTSTAMP:20260406T035150
CREATED:20190110T092559Z
LAST-MODIFIED:20190110T092559Z
UID:96359-1549015200-1549062000@ibecbarcelona.eu
SUMMARY:IBEc Seminar: Dr Ben Goult
DESCRIPTION:Title to be confirmed\nDr Ben Goult \nMore information soon
URL:https://ibecbarcelona.eu/event/ibec-seminar-dr-ben-goult-2/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20190201T100000
DTEND;TZID=Europe/Madrid:20190201T230000
DTSTAMP:20260406T035150
CREATED:20190110T092559Z
LAST-MODIFIED:20190110T092559Z
UID:65078-1549015200-1549062000@ibecbarcelona.eu
SUMMARY:IBEc Seminar: Dr Ben Goult
DESCRIPTION:Title to be confirmed\nDr Ben Goult \nMore information soon
URL:https://ibecbarcelona.eu/event/ibec-seminar-dr-ben-goult/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20190301T100000
DTEND;TZID=Europe/Madrid:20190301T120000
DTSTAMP:20260406T035150
CREATED:20190220T155437Z
LAST-MODIFIED:20190220T155437Z
UID:96402-1551434400-1551441600@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Irene Marco
DESCRIPTION:Hyperpolarised magnetic resonance for real-time\, in situ monitoring of cell metabolism\nIrene Marco\, Biosensors for bioengineering – IBEC  \nThere is a clinical need for non-invasive and reliable markers to diagnose\, stage and evaluate treatment response in many diseases such as cancer or non-alcoholic fatty liver disease.\nMagnetic resonance (MR) methods now have the potential to revolutionise in the identification of such biomarkers in real time. Spectroscopic identification and quantitation of metabolites via carbon-13 chemical shifts can be combined with imaging (MRI) to simultaneously probe spatial (biodistribution) and temporal (kinetics) aspects of metabolism in vivo. These capabilities are enabled by so-called hyperpolarised (HP) MR techniques\, including Dynamic Nuclear Polarisation (DNP)\, which can transiently boost the carbon-13 MR signals by several orders of magnitude\, compared to traditional methods. DNP enables real-time measurement of enzymatic reactions in cell suspensions and in vivo. Multiple HP 13C-labelled substrates have provided insights in several metabolic pathways\, including glycolysis\, the pentose-phosphate pathway and the cellular redox state. I will present the potential of DNP to study metabolism in cell suspensions\, tissue ex vivo and animals in vivo\, as well as tap on the advances into the clinical translation of the technique. Also\, I will talk about how we intend to implement HP MR to monitor metabolism in organs-in-chips in the lab of Javier Ramón (IBEC).
URL:https://ibecbarcelona.eu/event/ibec-seminar-irene-marco-3/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20190301T100000
DTEND;TZID=Europe/Madrid:20190301T120000
DTSTAMP:20260406T035150
CREATED:20190220T155437Z
LAST-MODIFIED:20190220T155437Z
UID:65718-1551434400-1551441600@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Irene Marco
DESCRIPTION:Hyperpolarised magnetic resonance for real-time\, in situ monitoring of cell metabolism\nIrene Marco\, Biosensors for bioengineering – IBEC  \nThere is a clinical need for non-invasive and reliable markers to diagnose\, stage and evaluate treatment response in many diseases such as cancer or non-alcoholic fatty liver disease.\nMagnetic resonance (MR) methods now have the potential to revolutionise in the identification of such biomarkers in real time. Spectroscopic identification and quantitation of metabolites via carbon-13 chemical shifts can be combined with imaging (MRI) to simultaneously probe spatial (biodistribution) and temporal (kinetics) aspects of metabolism in vivo. These capabilities are enabled by so-called hyperpolarised (HP) MR techniques\, including Dynamic Nuclear Polarisation (DNP)\, which can transiently boost the carbon-13 MR signals by several orders of magnitude\, compared to traditional methods. DNP enables real-time measurement of enzymatic reactions in cell suspensions and in vivo. Multiple HP 13C-labelled substrates have provided insights in several metabolic pathways\, including glycolysis\, the pentose-phosphate pathway and the cellular redox state. I will present the potential of DNP to study metabolism in cell suspensions\, tissue ex vivo and animals in vivo\, as well as tap on the advances into the clinical translation of the technique. Also\, I will talk about how we intend to implement HP MR to monitor metabolism in organs-in-chips in the lab of Javier Ramón (IBEC).
URL:https://ibecbarcelona.eu/event/ibec-seminar-irene-marco/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20190315T100000
DTEND;TZID=Europe/Madrid:20190315T120000
DTSTAMP:20260406T035150
CREATED:20190306T164913Z
LAST-MODIFIED:20190306T164913Z
UID:96404-1552644000-1552651200@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Paul Wright
DESCRIPTION:Nanosafety research addressing public health concerns about metal oxide nanoparticles\nPaul Wright\, Head of RMIT Nanosafety Research Group – RMIT University \nPaul Wright is Australia’s foremost expert in nanotoxicology and nanosafety\, and founding co-ordinator of the Asia Nano Safe and NanoSafe Australia research networks. He is the toxicologist at RMIT University’s School of Health and Biomedical Sciences\, at Bundoora in Melbourne\, Australia. He heads RMIT’s Nanosafety Research Group and led RMIT’s large contribution to the Australian Consortium for the OECD’s recent nanosafety testing program. He is nanosafety advisor to the Australian Nanotechnology Network (ANN)\, and has directly advised several Australian Federal and state government authorities and committees on nanosafety issues. Paul is a Fellow of International Union of Pure and Applied Chemistry (IUPAC) and formerly an elected director of the Executive Committee of International Union of Toxicology (IUTOX).
URL:https://ibecbarcelona.eu/event/ibec-seminar-paul-wright-2/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar,Joint seminar / workshop / symposium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20190315T100000
DTEND;TZID=Europe/Madrid:20190315T120000
DTSTAMP:20260406T035150
CREATED:20190306T164913Z
LAST-MODIFIED:20190306T165355Z
UID:65852-1552644000-1552651200@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Paul Wright
DESCRIPTION:Nanosafety research addressing public health concerns about metal oxide nanoparticles\nPaul Wright\, Head of RMIT Nanosafety Research Group – RMIT University \nPaul Wright is Australia’s foremost expert in nanotoxicology and nanosafety\, and founding co-ordinator of the Asia Nano Safe and NanoSafe Australia research networks. He is the toxicologist at RMIT University’s School of Health and Biomedical Sciences\, at Bundoora in Melbourne\, Australia. He heads RMIT’s Nanosafety Research Group and led RMIT’s large contribution to the Australian Consortium for the OECD’s recent nanosafety testing program. He is nanosafety advisor to the Australian Nanotechnology Network (ANN)\, and has directly advised several Australian Federal and state government authorities and committees on nanosafety issues. Paul is a Fellow of International Union of Pure and Applied Chemistry (IUPAC) and formerly an elected director of the Executive Committee of International Union of Toxicology (IUTOX).
URL:https://ibecbarcelona.eu/event/ibec-seminar-paul-wright/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar,Joint seminar / workshop / symposium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20190322T100000
DTEND;TZID=Europe/Madrid:20190322T120000
DTSTAMP:20260406T035150
CREATED:20190319T101144Z
LAST-MODIFIED:20190319T101144Z
UID:96419-1553248800-1553256000@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Silvia Muro
DESCRIPTION:Spread the word!\nNest Friday we are glad to present to all those who are part of the IBEC community the IBEC FASTER FUTURE programme\, an initiative to accelerate our research in a collaborative way together with patients’ associations and hospitals. Everyone can be involved and we will comment the different ways to contribute to Faster Future. \nThis year\, we have added a new project led by Dr. Silvia Muro\, responsible for the Targeted therapeutics and nanodevices group\, related to Parkinson’s disease\, that affects millions of people around the world. \nIn this presentation\, Silvia Muro will talk about Enabling Delivery of Therapeutics Across the Blood-Brain Barrier for Treatment of Neurodegenerative Diseases. \nGet involved\, we count on you!\nEnabling Delivery of Therapeutics Across the Blood-Brain Barrier for Treatment of Neurodegenerative Diseases\nSilvia Muro\, IBEC Group Leader Targeted therapeutics and nanodevices / ICREA Research Professor\n \nAccessing the brain is key to study its function and pathology\, and for diagnostic and therapeutic purposes. Yet\, this remains a formidable challenge due to the blood-brain barrier (BBB). To overcome this obstacle\, new nanovehicles are being designed to cross this interface\, without much translational success. A prime obstacle is the lack of knowledge on the biological regulation of these devices\, as most efforts have been devoted to controling their chemical and physical properties. To brindge this gap of knowledge\, we designed nanovehicles targeted to receptors of the main routes of transcytosis across endothelial barriers\, i.e. clathrin-\, caveolar\, and cell adhesion molecule (CAM)-mediated pathways (identified in our lab)\, and compared their BBB transport in cellular and animal models. Targeting these three routes resulted in transport across the endothelial lining\, whereas the CAM pathway was the most effective across a broad spectrum of carrier sizes and targeting valencies. This is reminiscent of the CAM function\, which contributes to transcellular leukocyte migration\, and it happened through a remodeling of the lipid composition of the endothelial plasmalemma and reorganization of the actin cytoskeleton. By understanding the biological regulation of this pathway\, we were able to optimize carrier design parameters to enhance BBB crossing. This needed a fine balance between the ability of carriers to bind to BBB receptors at the apical (circulation) surface and to detach from them at the basolateral (brain) side. As a result\, cargoes such as enzyme therapeutics for the treatment of neurological lysosomal disorders\, were delivered in an active form in the brain after intravenous administration in mouse models. Our current efforts aim to implement this strategy for the development of new therapeutics against other neurodegenerative conditions\, such as Parkinson’s disease. \n 
URL:https://ibecbarcelona.eu/event/ibec-seminar-silvia-muro-2/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
ATTACH;FMTTYPE=image/jpeg:https://ibecbarcelona.eu/wp-content/uploads/2019/03/ibecfasterfuture1.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20190322T100000
DTEND;TZID=Europe/Madrid:20190322T120000
DTSTAMP:20260406T035150
CREATED:20190319T101144Z
LAST-MODIFIED:20190322T085625Z
UID:65995-1553248800-1553256000@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Silvia Muro
DESCRIPTION:Spread the word!\nNest Friday we are glad to present to all those who are part of the IBEC community the IBEC FASTER FUTURE programme\, an initiative to accelerate our research in a collaborative way together with patients’ associations and hospitals. Everyone can be involved and we will comment the different ways to contribute to Faster Future. \nThis year\, we have added a new project led by Dr. Silvia Muro\, responsible for the Targeted therapeutics and nanodevices group\, related to Parkinson’s disease\, that affects millions of people around the world. \nIn this presentation\, Silvia Muro will talk about Enabling Delivery of Therapeutics Across the Blood-Brain Barrier for Treatment of Neurodegenerative Diseases. \nGet involved\, we count on you!\nEnabling Delivery of Therapeutics Across the Blood-Brain Barrier for Treatment of Neurodegenerative Diseases\nSilvia Muro\, IBEC Group Leader Targeted therapeutics and nanodevices / ICREA Research Professor\n \nAccessing the brain is key to study its function and pathology\, and for diagnostic and therapeutic purposes. Yet\, this remains a formidable challenge due to the blood-brain barrier (BBB). To overcome this obstacle\, new nanovehicles are being designed to cross this interface\, without much translational success. A prime obstacle is the lack of knowledge on the biological regulation of these devices\, as most efforts have been devoted to controling their chemical and physical properties. To brindge this gap of knowledge\, we designed nanovehicles targeted to receptors of the main routes of transcytosis across endothelial barriers\, i.e. clathrin-\, caveolar\, and cell adhesion molecule (CAM)-mediated pathways (identified in our lab)\, and compared their BBB transport in cellular and animal models. Targeting these three routes resulted in transport across the endothelial lining\, whereas the CAM pathway was the most effective across a broad spectrum of carrier sizes and targeting valencies. This is reminiscent of the CAM function\, which contributes to transcellular leukocyte migration\, and it happened through a remodeling of the lipid composition of the endothelial plasmalemma and reorganization of the actin cytoskeleton. By understanding the biological regulation of this pathway\, we were able to optimize carrier design parameters to enhance BBB crossing. This needed a fine balance between the ability of carriers to bind to BBB receptors at the apical (circulation) surface and to detach from them at the basolateral (brain) side. As a result\, cargoes such as enzyme therapeutics for the treatment of neurological lysosomal disorders\, were delivered in an active form in the brain after intravenous administration in mouse models. Our current efforts aim to implement this strategy for the development of new therapeutics against other neurodegenerative conditions\, such as Parkinson’s disease. \n 
URL:https://ibecbarcelona.eu/event/ibec-seminar-silvia-muro/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
ATTACH;FMTTYPE=image/jpeg:https://ibecbarcelona.eu/wp-content/uploads/2019/03/ibecfasterfuture1.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20190705T100000
DTEND;TZID=Europe/Madrid:20190705T120000
DTSTAMP:20260406T035150
CREATED:20190701T075124Z
LAST-MODIFIED:20190701T075124Z
UID:96468-1562320800-1562328000@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Jordi Guiu
DESCRIPTION:Tracing the origin of adult intestinal stem cells\nJordi Guiu\, Biotech Research & Innovation Centre – University of Copenhagen \nJordi Guiu did his PhD in Anna Bigas laboratory (IMIM and Pompeu Fabra University-Barcelona) were he focused on the genetic circuitry that controls the establishment of hematopoietic stem cells during development. Then he joined Kim B. Jensen lab (Copenhagen University) as a postdoc\, were he obtained a Marie Curie fellowship. His current research is focused on the specification of intestinal stem cells during development using fate mapping technologies\, state of the art imaging\, biophysical modeling and a plethora of sequencing techniques.  \nThe adult small intestine is compartmentalized into villi and crypts containing post-mitotic differentiated and proliferative cells respectively. Intestinal stem cells (ISCs) located at the bottom of crypts express markers such as Lgr5 and fuel the constant replenishment of the intestinal epithelium. Importantly\, the cellular origin of adult ISCs remains unknown. Prior to birth the immature fetal intestine is structurally simpler than the adult intestine. It is characterized by villi separated by a continuous region composed of proliferative intervillus cells; crypts have not formed and there is no evidence of a stem cell niche. Interestingly\, intervillus cells located within the region between villi express the adult SAB marker Lgr5. Fate mapping studies have inferred the notion that fetal Lgr5 expressing cells are unique and specialized precursors for the adult ISCs. Using unbiased quantitative lineage-tracing approaches\, biophysical modeling and intestinal transplantation experiments\, we now demonstrate that in the fetal epithelium on-going tissue morphogenesis leads to a dynamic exchange of cells between the villi and intervillus regions and that all cells have got the potential to contribute to the adult stem cells. Moreover\, we present exciting data outlining the mechanism for tissue development based on 3D imaging and live microscopy. Our results demonstrate that large-scale tissue remodeling and cell fate specification are intertwined processes. Moreover\, these findings provide a direct link between the observed plasticity and cellular reprogramming of differentiating cells in adult tissue following damage\, revealing that stem cell identity is an induced rather than a hardwired property.
URL:https://ibecbarcelona.eu/event/ibec-seminar-jordi-guiu-2/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20190705T100000
DTEND;TZID=Europe/Madrid:20190705T120000
DTSTAMP:20260406T035150
CREATED:20190701T075124Z
LAST-MODIFIED:20190701T080442Z
UID:67051-1562320800-1562328000@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Jordi Guiu
DESCRIPTION:Tracing the origin of adult intestinal stem cells\nJordi Guiu\, Biotech Research & Innovation Centre – University of Copenhagen \nJordi Guiu did his PhD in Anna Bigas laboratory (IMIM and Pompeu Fabra University-Barcelona) were he focused on the genetic circuitry that controls the establishment of hematopoietic stem cells during development. Then he joined Kim B. Jensen lab (Copenhagen University) as a postdoc\, were he obtained a Marie Curie fellowship. His current research is focused on the specification of intestinal stem cells during development using fate mapping technologies\, state of the art imaging\, biophysical modeling and a plethora of sequencing techniques.  \nThe adult small intestine is compartmentalized into villi and crypts containing post-mitotic differentiated and proliferative cells respectively. Intestinal stem cells (ISCs) located at the bottom of crypts express markers such as Lgr5 and fuel the constant replenishment of the intestinal epithelium. Importantly\, the cellular origin of adult ISCs remains unknown. Prior to birth the immature fetal intestine is structurally simpler than the adult intestine. It is characterized by villi separated by a continuous region composed of proliferative intervillus cells; crypts have not formed and there is no evidence of a stem cell niche. Interestingly\, intervillus cells located within the region between villi express the adult SAB marker Lgr5. Fate mapping studies have inferred the notion that fetal Lgr5 expressing cells are unique and specialized precursors for the adult ISCs. Using unbiased quantitative lineage-tracing approaches\, biophysical modeling and intestinal transplantation experiments\, we now demonstrate that in the fetal epithelium on-going tissue morphogenesis leads to a dynamic exchange of cells between the villi and intervillus regions and that all cells have got the potential to contribute to the adult stem cells. Moreover\, we present exciting data outlining the mechanism for tissue development based on 3D imaging and live microscopy. Our results demonstrate that large-scale tissue remodeling and cell fate specification are intertwined processes. Moreover\, these findings provide a direct link between the observed plasticity and cellular reprogramming of differentiating cells in adult tissue following damage\, revealing that stem cell identity is an induced rather than a hardwired property.
URL:https://ibecbarcelona.eu/event/ibec-seminar-jordi-guiu/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20190715T120000
DTEND;TZID=Europe/Madrid:20190715T130000
DTSTAMP:20260406T035150
CREATED:20190701T080416Z
LAST-MODIFIED:20190701T080416Z
UID:96471-1563192000-1563195600@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Nicolas Minc
DESCRIPTION:Division positioning in early embryos from mechanisms to function\nNicolas Minc\, Insitut Jacques Monod\, Paris\, France \nNicolas Minc lab is located at the Institut Jacques Monod in Paris\, and studies general problems of cell morphogenesis\, ranging from the control of cell growth and shapes in single cells\, to cell division in multicellular embryos. One hallmark of the lab is to combine quantitative imaging\, biophysics methods and modelling to address fundamental questions in cell and developmental biology.
URL:https://ibecbarcelona.eu/event/ibec-seminar-nicolas-minc-2/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20190715T120000
DTEND;TZID=Europe/Madrid:20190715T130000
DTSTAMP:20260406T035150
CREATED:20190701T080416Z
LAST-MODIFIED:20190701T080423Z
UID:67054-1563192000-1563195600@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Nicolas Minc
DESCRIPTION:Division positioning in early embryos from mechanisms to function\nNicolas Minc\, Insitut Jacques Monod\, Paris\, France \nNicolas Minc lab is located at the Institut Jacques Monod in Paris\, and studies general problems of cell morphogenesis\, ranging from the control of cell growth and shapes in single cells\, to cell division in multicellular embryos. One hallmark of the lab is to combine quantitative imaging\, biophysics methods and modelling to address fundamental questions in cell and developmental biology.
URL:https://ibecbarcelona.eu/event/ibec-seminar-nicolas-minc/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20190802T120000
DTEND;TZID=Europe/Madrid:20190802T140000
DTSTAMP:20260406T035150
CREATED:20190730T070132Z
LAST-MODIFIED:20190730T070146Z
UID:67507-1564747200-1564754400@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Kara Spiller
DESCRIPTION:Immunomodulatory Biomaterials for Limb Salvage\nKara Spiller\, School of Biomedical Engineering\, Science\, and Health Systems\, Drexel University \nDiabetes and peripheral arterial disease affect hundreds of millions of people worldwide. Patients with these conditions frequently develop chronic wounds on the lower limbs that lead to amputation\, with a 5-year mortality rate as high as 77%. Macrophages\, the primary cell of the innate immune system\, are critical regulators of angiogenesis and wound healing. Their dysfunction is strongly implicated in arterial dysfunction\, limb ischemia\, and poorly healing chronic wounds. The goal of the Biomaterials and Regenerative Medicine Laboratory at Drexel University is to understand the mechanisms by which macrophages orchestrate successful angiogenesis and tissue regeneration and to develop novel biomaterial strategies that apply these principles to pathological situations\, in order to ultimately prevent limb amputation. This talk will focus on the effects of temporal changes in macrophage phenotype on angiogenesis\, the design of biomaterials and drug delivery systems to modulate macrophage phenotype for enhanced angiogenesis\, and the development of macrophage phenotype-related biomarkers to assist in clinical decision making for a personalized medicine approach to wound care. \nDr. Kara Spiller is an Associate Professor in Drexel University’s School of Biomedical Engineering\, Science\, and Health Systems. Her research interests include the role of immune cells in tissue regeneration\, the design of immunomodulatory biomaterials\, and international engineering education. Her research is funded by the NIH\, the NSF\, and private foundations. Her awards include a Fulbright fellowship\, the NSF CAREER award\, and the United States nomination for the ASPIRE prize.
URL:https://ibecbarcelona.eu/event/ibec-seminar-kara-spiller/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20190802T120000
DTEND;TZID=Europe/Madrid:20190802T140000
DTSTAMP:20260406T035150
CREATED:20190730T070132Z
LAST-MODIFIED:20190730T070132Z
UID:96490-1564747200-1564754400@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Kara Spiller
DESCRIPTION:Immunomodulatory Biomaterials for Limb Salvage\nKara Spiller\, School of Biomedical Engineering\, Science\, and Health Systems\, Drexel University \nDiabetes and peripheral arterial disease affect hundreds of millions of people worldwide. Patients with these conditions frequently develop chronic wounds on the lower limbs that lead to amputation\, with a 5-year mortality rate as high as 77%. Macrophages\, the primary cell of the innate immune system\, are critical regulators of angiogenesis and wound healing. Their dysfunction is strongly implicated in arterial dysfunction\, limb ischemia\, and poorly healing chronic wounds. The goal of the Biomaterials and Regenerative Medicine Laboratory at Drexel University is to understand the mechanisms by which macrophages orchestrate successful angiogenesis and tissue regeneration and to develop novel biomaterial strategies that apply these principles to pathological situations\, in order to ultimately prevent limb amputation. This talk will focus on the effects of temporal changes in macrophage phenotype on angiogenesis\, the design of biomaterials and drug delivery systems to modulate macrophage phenotype for enhanced angiogenesis\, and the development of macrophage phenotype-related biomarkers to assist in clinical decision making for a personalized medicine approach to wound care. \nDr. Kara Spiller is an Associate Professor in Drexel University’s School of Biomedical Engineering\, Science\, and Health Systems. Her research interests include the role of immune cells in tissue regeneration\, the design of immunomodulatory biomaterials\, and international engineering education. Her research is funded by the NIH\, the NSF\, and private foundations. Her awards include a Fulbright fellowship\, the NSF CAREER award\, and the United States nomination for the ASPIRE prize.
URL:https://ibecbarcelona.eu/event/ibec-seminar-kara-spiller-2/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20191001T100000
DTEND;TZID=Europe/Madrid:20191001T110000
DTSTAMP:20260406T035150
CREATED:20190927T102638Z
LAST-MODIFIED:20190927T102638Z
UID:96500-1569924000-1569927600@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Carlos Rodríguez Cabello
DESCRIPTION:Dynamic Systems Based on Elastin-Like Recombinamers\nCarlos Rodríguez Cabello\, Bioforge Lab\, University of Valladolid CIBER-BBN \nThe use of recombinant technology in the production of macromolecule-based advanced biomaterials has caused a breakthrough increase in achievable degree of complexity and control on the molecular designs and compositions. Those recombinant macromolecules of polpeptide nature are called recombinamers. They are produced from a purely synthetic gene\, in which the amino-acid sequence is not restricted to those found in naturally occurring proteins and it is dictated only by engineering design parameters. The high degree of complexity and control of the recombinamer compositions permit to reach unmatched levels of functionality in the materials produced by this way and on the systems based on them. \nThe development of functionality in such systems comes by to different ways. In one hand\, these materials can display direct functionality. Such functionality is based on the presence in their composition of functional epitopes\, typically inspired by functional epitopes found in natural proteins. The other source of functionality is the holistic functionality that emerges by the precise combination and interactions of direct functions in a precise and well designed macromolecular composition. This holistic function is particularly evident in system with a dynamic nature; systems that rearrange and respond to changes in their environment. \nExamples of such dynamic systems will be presented. The examples will expand from complex 3D structures for regenerative medicine and tissue engineering that are able to incorporate a designed program of degradation and time evolution\, to more fundamental matters such as the hierarchical spontaneous development of morphology and macroscopical shapes in natural and artificial systems. \nDr. Rodríguez-Cabello is a full professor at the Dept. of Condensed Matter Physics of the University of Valladolid (UVa) Spain. During his career he has been teaching courses related to physics of polymers and biomaterials science in both undergraduate and graduate levels. In 1997\, he founded BIOFORGE in the UVa\, which nowadays is an internationally recognized and word leading group in the field of recombinamers. His current research interests include the development of biofunctional\, smart and customized protein polymers towards obtaining advanced biomedical devices.
URL:https://ibecbarcelona.eu/event/ibec-seminar-carlos-rodriguez-cabello-2/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20191001T100000
DTEND;TZID=Europe/Madrid:20191001T110000
DTSTAMP:20260406T035150
CREATED:20190927T102638Z
LAST-MODIFIED:20190927T103038Z
UID:68412-1569924000-1569927600@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Carlos Rodríguez Cabello
DESCRIPTION:Dynamic Systems Based on Elastin-Like Recombinamers\nCarlos Rodríguez Cabello\, Bioforge Lab\, University of Valladolid CIBER-BBN \nThe use of recombinant technology in the production of macromolecule-based advanced biomaterials has caused a breakthrough increase in achievable degree of complexity and control on the molecular designs and compositions. Those recombinant macromolecules of polpeptide nature are called recombinamers. They are produced from a purely synthetic gene\, in which the amino-acid sequence is not restricted to those found in naturally occurring proteins and it is dictated only by engineering design parameters. The high degree of complexity and control of the recombinamer compositions permit to reach unmatched levels of functionality in the materials produced by this way and on the systems based on them. \nThe development of functionality in such systems comes by to different ways. In one hand\, these materials can display direct functionality. Such functionality is based on the presence in their composition of functional epitopes\, typically inspired by functional epitopes found in natural proteins. The other source of functionality is the holistic functionality that emerges by the precise combination and interactions of direct functions in a precise and well designed macromolecular composition. This holistic function is particularly evident in system with a dynamic nature; systems that rearrange and respond to changes in their environment. \nExamples of such dynamic systems will be presented. The examples will expand from complex 3D structures for regenerative medicine and tissue engineering that are able to incorporate a designed program of degradation and time evolution\, to more fundamental matters such as the hierarchical spontaneous development of morphology and macroscopical shapes in natural and artificial systems. \nDr. Rodríguez-Cabello is a full professor at the Dept. of Condensed Matter Physics of the University of Valladolid (UVa) Spain. During his career he has been teaching courses related to physics of polymers and biomaterials science in both undergraduate and graduate levels. In 1997\, he founded BIOFORGE in the UVa\, which nowadays is an internationally recognized and word leading group in the field of recombinamers. His current research interests include the development of biofunctional\, smart and customized protein polymers towards obtaining advanced biomedical devices.
URL:https://ibecbarcelona.eu/event/ibec-seminar-carlos-rodriguez-cabello/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20191004T100000
DTEND;TZID=Europe/Madrid:20191004T110000
DTSTAMP:20260406T035150
CREATED:20190925T080454Z
LAST-MODIFIED:20190925T080454Z
UID:96496-1570183200-1570186800@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Martijn Gloerich
DESCRIPTION:Mechanical control of cell division\nMartijn Gloerich\, UMC Utrecth\, Center for Molecular Medicine\, Molecular Cancer Research \nDuring development and adult tissue homeostasis\, cellular behavior is controlled by signals that cells receive from their local environment. This is not limited to biochemical signals\, as cell behavior can be instructed by mechanical forces exerted by neighbouring cells and the surrounding tissue. Cells sense this mechanical information through numerous molecules\, including cell adhesion receptors\, which translate mechanical cues into an appropriate cellular response. I will discuss our recent findings on force transduction through the cell-cell adhesion protein E-cadherin\, and its central role in the mechanical control of cell division to regulate epithelial integrity and architecture. \nMartijn Gloerich is Assistant Professor at the department of Molecular Cancer Research at the University Medical Center Utrecht\, The Netherlands. Martijn obtained his PhD cum laude in 2011 from Utrecht University for his work on the regulation of small GTPases. Following his PhD\, he received fellowships from the Netherlands Organization for Scientific Research (NWO) and Dutch Cancer Foundation (KWF) to perform postdoctoral research in the lab of James Nelson at Stanford University. Here\, he gained experience with numerous microfabrication and bio-engineering techniques to study how communication between cells regulates cell behavior. In 2016 Martijn returned to the Netherlands to start his own research group at the University Medical Center Utrecht. His group uses an interdisciplinary approach to understand how cells sense and respond to mechanical forces to control tissue development and homeostasis\, and how its disruption contributes to tumor progression.
URL:https://ibecbarcelona.eu/event/ibec-seminar-martijn-gloerich-2/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
ORGANIZER;CN="IBEC":MAILTO:www.ibecbarcelona.eu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20191004T100000
DTEND;TZID=Europe/Madrid:20191004T110000
DTSTAMP:20260406T035150
CREATED:20190925T080454Z
LAST-MODIFIED:20190925T080506Z
UID:68382-1570183200-1570186800@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Martijn Gloerich
DESCRIPTION:Mechanical control of cell division\nMartijn Gloerich\, UMC Utrecth\, Center for Molecular Medicine\, Molecular Cancer Research \nDuring development and adult tissue homeostasis\, cellular behavior is controlled by signals that cells receive from their local environment. This is not limited to biochemical signals\, as cell behavior can be instructed by mechanical forces exerted by neighbouring cells and the surrounding tissue. Cells sense this mechanical information through numerous molecules\, including cell adhesion receptors\, which translate mechanical cues into an appropriate cellular response. I will discuss our recent findings on force transduction through the cell-cell adhesion protein E-cadherin\, and its central role in the mechanical control of cell division to regulate epithelial integrity and architecture. \nMartijn Gloerich is Assistant Professor at the department of Molecular Cancer Research at the University Medical Center Utrecht\, The Netherlands. Martijn obtained his PhD cum laude in 2011 from Utrecht University for his work on the regulation of small GTPases. Following his PhD\, he received fellowships from the Netherlands Organization for Scientific Research (NWO) and Dutch Cancer Foundation (KWF) to perform postdoctoral research in the lab of James Nelson at Stanford University. Here\, he gained experience with numerous microfabrication and bio-engineering techniques to study how communication between cells regulates cell behavior. In 2016 Martijn returned to the Netherlands to start his own research group at the University Medical Center Utrecht. His group uses an interdisciplinary approach to understand how cells sense and respond to mechanical forces to control tissue development and homeostasis\, and how its disruption contributes to tumor progression.
URL:https://ibecbarcelona.eu/event/ibec-seminar-martijn-gloerich/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
ORGANIZER;CN="IBEC":MAILTO:www.ibecbarcelona.eu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20191105T160000
DTEND;TZID=Europe/Madrid:20191105T170000
DTSTAMP:20260406T035150
CREATED:20191029T084555Z
LAST-MODIFIED:20191029T084555Z
UID:96525-1572969600-1572973200@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Christine Horejs
DESCRIPTION:Inside Nature Nanotechnology\, an editor’s view\nChristine Horejs\, Nature Nanotechnology \nNature Nanotechnology was launched in October 2006 with the aim of publishing the most significant results in fundamental aspects\, applications and implications on nanomaterials. In my presentation I will provide an overview of what the journal looks for in the field of nanomedicine and bioimaging\, and I will give insight into the editorial process and some tips and tricks for submitting to our journal. \nChristine Horejs received her MSci and PhD in nanobiotechnology from the University of Natural Resources and Life Sciences\, Vienna\, Austria\, studying protein conformations and self-assembly using biophysical and theoretical approaches. She then joined the lab of Molly Stevens at Imperial College London\, UK\, investigating the extracellular matrix and cell–material interactions. In 2015\, she moved to the Karolinska Institute\, Sweden\, conducting in vivo studies of anti-fibrotic biomaterials. In September 2017\, she joined the Nature Reviews Materials team as an Associate Editor\, and since July 2019 she is a Senior Editor at Nature Nanotechnology\, where she is primarily responsible for nanomedicine and nanobiotechnology. \nShe has been invited to IBEC by Xavier Trepat
URL:https://ibecbarcelona.eu/event/ibec-seminar-christine-horejs-2/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
ORGANIZER;CN="IBEC":MAILTO:www.ibecbarcelona.eu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20191105T160000
DTEND;TZID=Europe/Madrid:20191105T170000
DTSTAMP:20260406T035150
CREATED:20191029T084555Z
LAST-MODIFIED:20191029T084604Z
UID:68942-1572969600-1572973200@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Christine Horejs
DESCRIPTION:Inside Nature Nanotechnology\, an editor’s view\nChristine Horejs\, Nature Nanotechnology \nNature Nanotechnology was launched in October 2006 with the aim of publishing the most significant results in fundamental aspects\, applications and implications on nanomaterials. In my presentation I will provide an overview of what the journal looks for in the field of nanomedicine and bioimaging\, and I will give insight into the editorial process and some tips and tricks for submitting to our journal. \nChristine Horejs received her MSci and PhD in nanobiotechnology from the University of Natural Resources and Life Sciences\, Vienna\, Austria\, studying protein conformations and self-assembly using biophysical and theoretical approaches. She then joined the lab of Molly Stevens at Imperial College London\, UK\, investigating the extracellular matrix and cell–material interactions. In 2015\, she moved to the Karolinska Institute\, Sweden\, conducting in vivo studies of anti-fibrotic biomaterials. In September 2017\, she joined the Nature Reviews Materials team as an Associate Editor\, and since July 2019 she is a Senior Editor at Nature Nanotechnology\, where she is primarily responsible for nanomedicine and nanobiotechnology. \nShe has been invited to IBEC by Xavier Trepat
URL:https://ibecbarcelona.eu/event/ibec-seminar-christine-horejs/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
ORGANIZER;CN="IBEC":MAILTO:www.ibecbarcelona.eu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20191115T100000
DTEND;TZID=Europe/Madrid:20191115T120000
DTSTAMP:20260406T035150
CREATED:20191111T153956Z
LAST-MODIFIED:20191111T153956Z
UID:96538-1573812000-1573819200@ibecbarcelona.eu
SUMMARY:Clinical Colloquia
DESCRIPTION:Theoretical and practical aspects of biophysiotherapy\nJosep Pous\, Medical Director at Cematec-Teknon de Barcelona \nIn this clinical colloquia\, the different treatment methods used in Biophysiotherapy such as Multifrequency Laser Therapy\, Shock Waves\, Modular Electromagnetic Waves\, Mechanotherapy\, Growth Factors\, Stem Cells\, will be exposed. The different mechanisms of action will be discussed at the cellular level such as mechanotransduction\, mechanotranscription\, depolarization of membarane or at the mitochondrial level through REDOX mechanisms\, to achieve biological effects at the cellular and tissue levels. Biophysiotherapy aims to apply the possibilities of diagnosis and treatment of the laboratory (biosensors\, nanobiosensors\, quantum dots) to the medical practice with fewer drugs and fewer surgeries. \nDr. Josep Pous\, specialist in Orthopedic Surgery\, Traumatology and Rehabilitation\, works at Cematec-Teknon of Barcelona (Center of Advanced and Technological Medicine) using the latest technologies in arthroscopy and prosthesis of the shoulder\, hip\, knee and ankle joints. Dr. Pous is a pioneer in the use of new non-invasive treatments for all musculoskeletal pathology and has incorporated new methods for its integral treatment. \nHe has been invited to IBEC by Pau Gorostiza
URL:https://ibecbarcelona.eu/event/clinical-colloquia-2/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20191115T100000
DTEND;TZID=Europe/Madrid:20191115T120000
DTSTAMP:20260406T035150
CREATED:20191111T153956Z
LAST-MODIFIED:20191111T154047Z
UID:69125-1573812000-1573819200@ibecbarcelona.eu
SUMMARY:Clinical Colloquia
DESCRIPTION:Theoretical and practical aspects of biophysiotherapy\nJosep Pous\, Medical Director at Cematec-Teknon de Barcelona \nIn this clinical colloquia\, the different treatment methods used in Biophysiotherapy such as Multifrequency Laser Therapy\, Shock Waves\, Modular Electromagnetic Waves\, Mechanotherapy\, Growth Factors\, Stem Cells\, will be exposed. The different mechanisms of action will be discussed at the cellular level such as mechanotransduction\, mechanotranscription\, depolarization of membarane or at the mitochondrial level through REDOX mechanisms\, to achieve biological effects at the cellular and tissue levels. Biophysiotherapy aims to apply the possibilities of diagnosis and treatment of the laboratory (biosensors\, nanobiosensors\, quantum dots) to the medical practice with fewer drugs and fewer surgeries. \nDr. Josep Pous\, specialist in Orthopedic Surgery\, Traumatology and Rehabilitation\, works at Cematec-Teknon of Barcelona (Center of Advanced and Technological Medicine) using the latest technologies in arthroscopy and prosthesis of the shoulder\, hip\, knee and ankle joints. Dr. Pous is a pioneer in the use of new non-invasive treatments for all musculoskeletal pathology and has incorporated new methods for its integral treatment. \nHe has been invited to IBEC by Pau Gorostiza
URL:https://ibecbarcelona.eu/event/clinical-colloquia/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
END:VCALENDAR