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BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20161122T150000
DTEND;TZID=Europe/Madrid:20161122T160000
DTSTAMP:20260405T222202
CREATED:20161116T160120Z
LAST-MODIFIED:20161116T160120Z
UID:95955-1479826800-1479830400@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Herbert Levine
DESCRIPTION:Models of individual and collective cell motility\nHerbert Levine\, Director\, Center for Theoretical Biological Physics (CTBP)\, Rice University\, Houston\nEukaryotic cells can move either individually or collectively and this property is crucial for many biological functions. Often cells use directional information to decide on their direction; for single cells this can take the form of chemical or mechanical gradients. For collective motion\, additional information can be obtained from neighboring cells through such processes as the contact inhibition of locomotion. Our group develops a variety of computational models for studying actin-based crawling motions. These models range from rather complex and detailed at the single cell levels to simple reduced representations that can handle tissue-level processes. This talk will focus on out recent progress in this direction\, specifically on collective chemotaxis of cellular clusters and the role of contact inhibition in the mechanical state of expanding tissues.
URL:https://ibecbarcelona.eu/event/ibec-seminar-herbert-levine-2/
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20161122T150000
DTEND;TZID=Europe/Madrid:20161122T160000
DTSTAMP:20260405T222202
CREATED:20161116T160120Z
LAST-MODIFIED:20161116T160456Z
UID:25914-1479826800-1479830400@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Herbert Levine
DESCRIPTION:Models of individual and collective cell motility\nHerbert Levine\, Director\, Center for Theoretical Biological Physics (CTBP)\, Rice University\, Houston\nEukaryotic cells can move either individually or collectively and this property is crucial for many biological functions. Often cells use directional information to decide on their direction; for single cells this can take the form of chemical or mechanical gradients. For collective motion\, additional information can be obtained from neighboring cells through such processes as the contact inhibition of locomotion. Our group develops a variety of computational models for studying actin-based crawling motions. These models range from rather complex and detailed at the single cell levels to simple reduced representations that can handle tissue-level processes. This talk will focus on out recent progress in this direction\, specifically on collective chemotaxis of cellular clusters and the role of contact inhibition in the mechanical state of expanding tissues.
URL:https://ibecbarcelona.eu/event/ibec-seminar-herbert-levine/
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20170116T120000
DTEND;TZID=Europe/Madrid:20170116T130000
DTSTAMP:20260405T222202
CREATED:20170111T111500Z
LAST-MODIFIED:20170111T111500Z
UID:95966-1484568000-1484571600@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Christian A. Nijhuis
DESCRIPTION:Molecular Diodes with Rectification Ratios of Nearly Six Orders of Magnitude\nChristian A. Nijhuis\, Department of Chemistry\, National University of Singapore\nOne of the major goals of molecular electronics is to relate the performance and electronic function of molecular devices to the chemical structure and intermolecular interactions of the organic molecules inside them. Molecular electronic devices are complex physical-organic systems that consist of at least two electrodes\, the organic component\, and two (different) organic/inorganic interfaces. Singling out the contribution of each of these components to the device performance is not straightforward. Besides\, fabrication of molecular junctions is still challenging and defects have to be minimized. \nDuring the talk\, I will discuss our recent progress of molecular diodes based on self-assembled monolayers (SAMs) of ferrocene-alkanethiolates of the form H(CH2)nFc (Fc = ferrocene) sandwiched between two electrodes. I will discuss in detail how we fabricate the junctions (using the well-characterized “EGaIn”-technique) and characterize our junctions and SAMs. We have investigated the various sources of defects in the junctions caused by the impurities in the SAM precursors\,[1] defects in the electrode material\,[2] or subtle changes to the electronic[3] and supramolecular structure of the junctions.[4] We used this accumulated knowledge to develop a well-performing diode that blocks the current in one direction of bias\, but allows it to pass through in the other\, with a difference of a factor of 6.3 x 105.[5\,6] \nWe hope that our findings will help to guide future experiments and to explain why some on paper promising diodes had disappointing performances.[7] \nReferences\n1) Jiang\, L.; Yuan\, L.; Cao\, L.; Nijhuis\, C. A. J. Am. Chem. Soc. 2014\, 136\, 1982.\n2) Yuan\, L.; jiang\, L.; Thompson\, D.; Nijhuis\, C. A. J. Am. Chem. Soc. 2014\, 136\, 6554.\n3) Yuan\, L.; Nerngchamnong\, N.; Cao\, L.; Hamoudi\, H.; Del Barco\, E.; Roemer\, M.; Sriramula\, R.; Thompson\, D.; Nijhuis\, C. A. Nat. Commun. 2015\, 6.\n4) Nerngchanmnong\, N.; Yuan\, L.; Qi\, D. C.; Jiang\, L.; Thompson\, D.; Nijhuis\, C. A. Nat. Nanotechnol. 2013\, 8\, 113.\n5) Yuan\, L.; Breuer\, R.; Jiang\, L.; Schmittel\, M.; Nijhuis\, C. A. Nano Lett. 2015\, 15\, 5506.\n6) Chen\, X.; Roemer\, M.; Yuan\, L.; Wei\, D.; Del Barco\, E.; Thompson\, D.; Nijhuis\, C.A. submitted\n7) Thompson\, D.; Nijhuis\, C. A. Acc. Chem. Res. 2016\, 49\, 2061
URL:https://ibecbarcelona.eu/event/ibec-seminar-christian-a-nijhuis-2/
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20170116T120000
DTEND;TZID=Europe/Madrid:20170116T130000
DTSTAMP:20260405T222202
CREATED:20170111T111500Z
LAST-MODIFIED:20170111T111500Z
UID:27046-1484568000-1484571600@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Christian A. Nijhuis
DESCRIPTION:Molecular Diodes with Rectification Ratios of Nearly Six Orders of Magnitude\nChristian A. Nijhuis\, Department of Chemistry\, National University of Singapore\nOne of the major goals of molecular electronics is to relate the performance and electronic function of molecular devices to the chemical structure and intermolecular interactions of the organic molecules inside them. Molecular electronic devices are complex physical-organic systems that consist of at least two electrodes\, the organic component\, and two (different) organic/inorganic interfaces. Singling out the contribution of each of these components to the device performance is not straightforward. Besides\, fabrication of molecular junctions is still challenging and defects have to be minimized. \nDuring the talk\, I will discuss our recent progress of molecular diodes based on self-assembled monolayers (SAMs) of ferrocene-alkanethiolates of the form H(CH2)nFc (Fc = ferrocene) sandwiched between two electrodes. I will discuss in detail how we fabricate the junctions (using the well-characterized “EGaIn”-technique) and characterize our junctions and SAMs. We have investigated the various sources of defects in the junctions caused by the impurities in the SAM precursors\,[1] defects in the electrode material\,[2] or subtle changes to the electronic[3] and supramolecular structure of the junctions.[4] We used this accumulated knowledge to develop a well-performing diode that blocks the current in one direction of bias\, but allows it to pass through in the other\, with a difference of a factor of 6.3 x 105.[5\,6] \nWe hope that our findings will help to guide future experiments and to explain why some on paper promising diodes had disappointing performances.[7] \nReferences\n1) Jiang\, L.; Yuan\, L.; Cao\, L.; Nijhuis\, C. A. J. Am. Chem. Soc. 2014\, 136\, 1982.\n2) Yuan\, L.; jiang\, L.; Thompson\, D.; Nijhuis\, C. A. J. Am. Chem. Soc. 2014\, 136\, 6554.\n3) Yuan\, L.; Nerngchamnong\, N.; Cao\, L.; Hamoudi\, H.; Del Barco\, E.; Roemer\, M.; Sriramula\, R.; Thompson\, D.; Nijhuis\, C. A. Nat. Commun. 2015\, 6.\n4) Nerngchanmnong\, N.; Yuan\, L.; Qi\, D. C.; Jiang\, L.; Thompson\, D.; Nijhuis\, C. A. Nat. Nanotechnol. 2013\, 8\, 113.\n5) Yuan\, L.; Breuer\, R.; Jiang\, L.; Schmittel\, M.; Nijhuis\, C. A. Nano Lett. 2015\, 15\, 5506.\n6) Chen\, X.; Roemer\, M.; Yuan\, L.; Wei\, D.; Del Barco\, E.; Thompson\, D.; Nijhuis\, C.A. submitted\n7) Thompson\, D.; Nijhuis\, C. A. Acc. Chem. Res. 2016\, 49\, 2061
URL:https://ibecbarcelona.eu/event/ibec-seminar-christian-a-nijhuis/
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20170203T100000
DTEND;TZID=Europe/Madrid:20170203T110000
DTSTAMP:20260405T222202
CREATED:20170202T075031Z
LAST-MODIFIED:20170202T075031Z
UID:95975-1486116000-1486119600@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Giuseppe Battaglia
DESCRIPTION:Bionic nanoscopic carriers for precision drug delivery\nGiuseppe Battaglia\, Department of Chemistry and Department of Chemical Engineering\, University College London\nGetting across biological barriers and deliver therapeutic cargo to the right site is indeed a very challenging task that requires the judicious combination of physiological information with carrier engineering. In the last decade\, we have approached this problem\, applying a constructionist approach where we mimic biological complexity in the form of design principles to produce functional bionic units from simple building blocks and their interactions. We combine synthetic and supramolecular chemistry to tune inter/intramolecular interactions and self-assembly processes to form dynamic soft materials. Among the different bionic efforts\, we have focussed our attention to possibly one of the few that encompasses polymerisation\, compartmentalisation and positional self-assembly in the same unit; Polymersomes. These are vesicles formed by the self-assembly of amphiphilic block copolymers in water. We have equipped polymersomes with the critical elements to address the challenges for getting across biological barriers. They have surface engineered to control both attractive (binding) and repulsive (anti-fouling) interaction with proteins and receptors to create systems that can avoid opsonisation and yet target specific cell populations. We have engineered their mechanical properties so as to be flexible and able to penetrate dense tissues exploiting size-exclusion percolation patterns. We have equipped them with both asymmetric topology and enzymes to control their fluid-dynamics and diffusion so as to create chemotactic and active propulsion toward endogenous signalling molecules. Finally\, we have engineered their shape and size to guide cellular endocytosis as well as to escape the endocytic sorting accessing and delivering cargo within the cell interior. \nI will present our design efforts discussing each structural and functional elements as a function of the respective biological challenge\, I will conclude presenting applications where these precision systems are being applied to address challenges in oncology\, immunology and neurology.
URL:https://ibecbarcelona.eu/event/ibec-seminar-giuseppe-battaglia-2/
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20170203T100000
DTEND;TZID=Europe/Madrid:20170203T110000
DTSTAMP:20260405T222202
CREATED:20170202T075031Z
LAST-MODIFIED:20170202T075031Z
UID:27390-1486116000-1486119600@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Giuseppe Battaglia
DESCRIPTION:Bionic nanoscopic carriers for precision drug delivery\nGiuseppe Battaglia\, Department of Chemistry and Department of Chemical Engineering\, University College London\nGetting across biological barriers and deliver therapeutic cargo to the right site is indeed a very challenging task that requires the judicious combination of physiological information with carrier engineering. In the last decade\, we have approached this problem\, applying a constructionist approach where we mimic biological complexity in the form of design principles to produce functional bionic units from simple building blocks and their interactions. We combine synthetic and supramolecular chemistry to tune inter/intramolecular interactions and self-assembly processes to form dynamic soft materials. Among the different bionic efforts\, we have focussed our attention to possibly one of the few that encompasses polymerisation\, compartmentalisation and positional self-assembly in the same unit; Polymersomes. These are vesicles formed by the self-assembly of amphiphilic block copolymers in water. We have equipped polymersomes with the critical elements to address the challenges for getting across biological barriers. They have surface engineered to control both attractive (binding) and repulsive (anti-fouling) interaction with proteins and receptors to create systems that can avoid opsonisation and yet target specific cell populations. We have engineered their mechanical properties so as to be flexible and able to penetrate dense tissues exploiting size-exclusion percolation patterns. We have equipped them with both asymmetric topology and enzymes to control their fluid-dynamics and diffusion so as to create chemotactic and active propulsion toward endogenous signalling molecules. Finally\, we have engineered their shape and size to guide cellular endocytosis as well as to escape the endocytic sorting accessing and delivering cargo within the cell interior. \nI will present our design efforts discussing each structural and functional elements as a function of the respective biological challenge\, I will conclude presenting applications where these precision systems are being applied to address challenges in oncology\, immunology and neurology.
URL:https://ibecbarcelona.eu/event/ibec-seminar-giuseppe-battaglia/
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20170208T120000
DTEND;TZID=Europe/Madrid:20170208T130000
DTSTAMP:20260405T222202
CREATED:20170203T102730Z
LAST-MODIFIED:20170213T120656Z
UID:27427-1486555200-1486558800@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Stijn Mertens
DESCRIPTION:Electrochemical surface science of TiO2 rutile (110)\, graphene and boron nitride\nStijn Mertens\, TU Wien\, Institute of Applied Physics / KU Leuven\, Chemistry Department\nThe rational design of catalysts and other functional materials requires an atomic-level understanding of their structure and of the interface to supporting surfaces. I will present an in situ electrochemical STM study of TiO2 rutile (110) with atomic resolution. This is achieved using a new wet-chemical cleaning procedure for the substrate and with Pt-Ir tips. If tungsten tips are used\, WO3 is spontaneously formed at the tungsten–liquid interface and strongly adsorbs on oxide surfaces below their point of zero charge through an electrostatic mechanism. Under clean conditions\, the TiO2 rutile (110) surface shows a bulk-like\, unreconstructed structure\, which resembles its appearance in vacuum\, even though the surface is probably fully hydroxylated. \nIn the second part of my talk\, I will focus on 2D materials graphene and hexagonal boron nitride. By combining electrochemical grafting of diazonium salts with tip-induced nanolithography\, nanopatterned sp3 defects can be introduced\, opening perspectives towards graphene band gap engineering [1\,2]. Hexagonal boron nitride\, isoelectronic with graphene\, can be grown on Rh(111) and forms a so-called nanomesh superstructure [3]\, characterized by a 3.2-nm lattice constant and strong electronic corrugation\, useful for trapping atoms and molecules. Electrochemical intercalation of hydrogen between the boron nitride layer and the rhodium substrate leads to microscopic flattening within the 2-dimensional material and a macroscopic 10% change in adsorption energy [4]. \n[1] Greenwood et al.\, ACS Nano 9\, 2015\, 5520.\n[2] Huynh et al.\, Nanoscale 9\, 2017\, 362.\n[3] Corso et al.\, Science 303\, 2004\, 217.\n[4] Mertens et al.\, Nature 534\, 2016\, 676.
URL:https://ibecbarcelona.eu/event/ibec-seminar-stijn-mertens/
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20170208T120000
DTEND;TZID=Europe/Madrid:20170208T130000
DTSTAMP:20260405T222202
CREATED:20170203T102730Z
LAST-MODIFIED:20170203T102730Z
UID:95984-1486555200-1486558800@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Stijn Mertens
DESCRIPTION:Electrochemical surface science of TiO2 rutile (110)\, graphene and boron nitride\nStijn Mertens\, TU Wien\, Institute of Applied Physics / KU Leuven\, Chemistry Department\nThe rational design of catalysts and other functional materials requires an atomic-level understanding of their structure and of the interface to supporting surfaces. I will present an in situ electrochemical STM study of TiO2 rutile (110) with atomic resolution. This is achieved using a new wet-chemical cleaning procedure for the substrate and with Pt-Ir tips. If tungsten tips are used\, WO3 is spontaneously formed at the tungsten–liquid interface and strongly adsorbs on oxide surfaces below their point of zero charge through an electrostatic mechanism. Under clean conditions\, the TiO2 rutile (110) surface shows a bulk-like\, unreconstructed structure\, which resembles its appearance in vacuum\, even though the surface is probably fully hydroxylated. \nIn the second part of my talk\, I will focus on 2D materials graphene and hexagonal boron nitride. By combining electrochemical grafting of diazonium salts with tip-induced nanolithography\, nanopatterned sp3 defects can be introduced\, opening perspectives towards graphene band gap engineering [1\,2]. Hexagonal boron nitride\, isoelectronic with graphene\, can be grown on Rh(111) and forms a so-called nanomesh superstructure [3]\, characterized by a 3.2-nm lattice constant and strong electronic corrugation\, useful for trapping atoms and molecules. Electrochemical intercalation of hydrogen between the boron nitride layer and the rhodium substrate leads to microscopic flattening within the 2-dimensional material and a macroscopic 10% change in adsorption energy [4]. \n[1] Greenwood et al.\, ACS Nano 9\, 2015\, 5520.\n[2] Huynh et al.\, Nanoscale 9\, 2017\, 362.\n[3] Corso et al.\, Science 303\, 2004\, 217.\n[4] Mertens et al.\, Nature 534\, 2016\, 676.
URL:https://ibecbarcelona.eu/event/ibec-seminar-stijn-mertens-2/
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20170216T100000
DTEND;TZID=Europe/Madrid:20170216T110000
DTSTAMP:20260405T222202
CREATED:20170213T100423Z
LAST-MODIFIED:20170213T100423Z
UID:95987-1487239200-1487242800@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Jesús Martínez de la Fuente
DESCRIPTION:Designing Hybrid Nanoparticles for Therapy and Diagnosis\nJesús Martínez de la Fuente\, Instituto de Ciencia de Materiales de Aragón\, CSIC/University of Zaragoza\nIn the last decades\, inorganic nanoparticles have been steadily gaining more attention from scientists from a wide variety of fields such as material science\, engineering\, physics or chemistry. The very different properties compared to that of the respective bulk\, and thus intriguing characteristics of materials in the nanometre scale\, have driven nanoscience to be the centre of many basic and applied research topics. Moreover\, a wide variety of recently developed methodologies for their surface functionalization provide these materials with very specific properties such as drug delivery and circulating cancer biomarkers detection. In this talk we describe the synthesis and functionalization of gold nanoparticles as therapeutic and diagnosis tools against cancer: \n-Pseudo-spherical gold nanoparticles derivatized with with fluorescent dyes\, cell penetrating peptides and small interfering RNA (siRNA) complementary to the proto-oncogene myc have been tested using a hierarchical approach including three biological systems of increasing complexity: in vitro cultured human cells\, in vivo invertebrate (freshwater polyp\, Hydra) and in vivo vertebrate (mouse) model. Selection of the most active functionalities was assisted step by step through functional testing adopting this hierarchical strategy.(1) Merging these chemical and biological approaches lead to a siRNA/RGD gold nanoparticle capable of targeting tumor cells in lung cancer xenograft mouse model\, resulting in successful and significant c-myc oncogene downregulation followed by tumor growth inhibition and prolonged survival of the animals.(2) \n-Gold nanoprisms (NPRs) have been functionalized with PEG\, glucose\, cell penetrating and RGD peptides\, antibodies and/or fluorescent dyes\, aiming to enhance NPRs stability\, cellular uptake and imaging capabilities\, respectively.(3) Cellular uptake and impact was assayed by a multiparametric investigation on the impact of surface modified NPRs on mice and human primary and transform cell lines. Under NIR illumination\, these nanoprobes can cause apoptosis. Moreover\, these nanoparticles have also been used for optoacoustic imaging and cancer treatment\,(4) as well as for tumoral marker detection using a novel type of thermal ELISA nanobiosensor using a thermosensitive support.(5) \nReferences\n[1] J. Conde\, A. Ambrosone\, V. Sanz\, Y. Hernandez\, F. Tian\, P. V. Baptista\, M. R. Ibarra\, C. Tortiglione\, J. M. de la Fuente. ACS Nano\, 2012\, 6\, 8316.\n[2] J. Conde\, F. Tian\, Y. Hernández\, C. Bao\, D. Cui\, M. R. Ibarra\, P. V. Baptista\, J. M. de la Fuente. Biomaterials. 2013\, 34\, 7744.\n[3] a) B. Pelaz\, V. Grazú\, A. Ibarra\, C. Magén\, P. del Pino\, J. M. de la Fuente. Langmuir\, 2012\, 28\, 8965 ; b) M. Perez-Hernandez\, P. del Pino\, S.G. Mitchell\, M. Moros\, G. Stepien\, B. Pelaz\, W.J. Parak\, E.M. Galvez\, J. Pardo\, J.M. de la Fuente. ACS Nano\, 2015\, 9\, 52\n[4] a) C. Bao\, N. Beziere\, P. del Pino\, B. Pelaz\, G. Estrada\, F. Tian\, V. Ntziachristos\, J. M. de la Fuente\, D. Cui. Small\, 2013\, 9\, 68 ; b) J. Han\, J. Zhang\, M. Yang\, D. Cui\, J.M. de la Fuente. Nanoscale\, 2016 (in press)\n[5] E. Polo\, P. del Pino\,  B. Pelaz\,  V. Grazu\, J.M. de la Fuente. Chemical Communications\, 2013\, 49\, 3676.
URL:https://ibecbarcelona.eu/event/ibec-seminar-jesus-martinez-de-la-fuente-2/
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20170216T100000
DTEND;TZID=Europe/Madrid:20170216T110000
DTSTAMP:20260405T222202
CREATED:20170213T100423Z
LAST-MODIFIED:20170214T123640Z
UID:27592-1487239200-1487242800@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Jesús Martínez de la Fuente
DESCRIPTION:Designing Hybrid Nanoparticles for Therapy and Diagnosis\nJesús Martínez de la Fuente\, Instituto de Ciencia de Materiales de Aragón\, CSIC/University of Zaragoza\nIn the last decades\, inorganic nanoparticles have been steadily gaining more attention from scientists from a wide variety of fields such as material science\, engineering\, physics or chemistry. The very different properties compared to that of the respective bulk\, and thus intriguing characteristics of materials in the nanometre scale\, have driven nanoscience to be the centre of many basic and applied research topics. Moreover\, a wide variety of recently developed methodologies for their surface functionalization provide these materials with very specific properties such as drug delivery and circulating cancer biomarkers detection. In this talk we describe the synthesis and functionalization of gold nanoparticles as therapeutic and diagnosis tools against cancer: \n-Pseudo-spherical gold nanoparticles derivatized with with fluorescent dyes\, cell penetrating peptides and small interfering RNA (siRNA) complementary to the proto-oncogene myc have been tested using a hierarchical approach including three biological systems of increasing complexity: in vitro cultured human cells\, in vivo invertebrate (freshwater polyp\, Hydra) and in vivo vertebrate (mouse) model. Selection of the most active functionalities was assisted step by step through functional testing adopting this hierarchical strategy.(1) Merging these chemical and biological approaches lead to a siRNA/RGD gold nanoparticle capable of targeting tumor cells in lung cancer xenograft mouse model\, resulting in successful and significant c-myc oncogene downregulation followed by tumor growth inhibition and prolonged survival of the animals.(2) \n-Gold nanoprisms (NPRs) have been functionalized with PEG\, glucose\, cell penetrating and RGD peptides\, antibodies and/or fluorescent dyes\, aiming to enhance NPRs stability\, cellular uptake and imaging capabilities\, respectively.(3) Cellular uptake and impact was assayed by a multiparametric investigation on the impact of surface modified NPRs on mice and human primary and transform cell lines. Under NIR illumination\, these nanoprobes can cause apoptosis. Moreover\, these nanoparticles have also been used for optoacoustic imaging and cancer treatment\,(4) as well as for tumoral marker detection using a novel type of thermal ELISA nanobiosensor using a thermosensitive support.(5) \nReferences\n[1] J. Conde\, A. Ambrosone\, V. Sanz\, Y. Hernandez\, F. Tian\, P. V. Baptista\, M. R. Ibarra\, C. Tortiglione\, J. M. de la Fuente. ACS Nano\, 2012\, 6\, 8316.\n[2] J. Conde\, F. Tian\, Y. Hernández\, C. Bao\, D. Cui\, M. R. Ibarra\, P. V. Baptista\, J. M. de la Fuente. Biomaterials. 2013\, 34\, 7744.\n[3] a) B. Pelaz\, V. Grazú\, A. Ibarra\, C. Magén\, P. del Pino\, J. M. de la Fuente. Langmuir\, 2012\, 28\, 8965 ; b) M. Perez-Hernandez\, P. del Pino\, S.G. Mitchell\, M. Moros\, G. Stepien\, B. Pelaz\, W.J. Parak\, E.M. Galvez\, J. Pardo\, J.M. de la Fuente. ACS Nano\, 2015\, 9\, 52\n[4] a) C. Bao\, N. Beziere\, P. del Pino\, B. Pelaz\, G. Estrada\, F. Tian\, V. Ntziachristos\, J. M. de la Fuente\, D. Cui. Small\, 2013\, 9\, 68 ; b) J. Han\, J. Zhang\, M. Yang\, D. Cui\, J.M. de la Fuente. Nanoscale\, 2016 (in press)\n[5] E. Polo\, P. del Pino\,  B. Pelaz\,  V. Grazu\, J.M. de la Fuente. Chemical Communications\, 2013\, 49\, 3676.
URL:https://ibecbarcelona.eu/event/ibec-seminar-jesus-martinez-de-la-fuente/
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20170303T100000
DTEND;TZID=Europe/Madrid:20170303T110000
DTSTAMP:20260405T222202
CREATED:20170213T103423Z
LAST-MODIFIED:20170213T103423Z
UID:95988-1488535200-1488538800@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Maria Virumbrales
DESCRIPTION:“Development of microfluidic tools to reproduce and characterize the tumor microenvironment”\nMaria Virumbrales\, University of Zaragoza\nCompelling evidence over the years has demonstrated that the tumor microenvironment (TME) shapes tumor initiation\, development and response to therapy. This results in a high heterogeneity within the same cancer type\, and hinders the process of finding effective treatments.[1\,2] \nIn this context\, microfluidics has proven a worthy sum of techniques to create comprehensive and personalized cancer in vitro 3D models reproducing the TME in a more relevant fashion than traditional in vitro setups. \nMicrofluidics also permits a high degree of control over the setup\, combining different cell types in an orderly manner\, as well as different physical and biochemical cues. [3] Furthermore\, microfluidics facilitates optical inspection and diminishes sample sizes and reagent volumes needed for each experiment. Microfluidic devices are also compatible with high-throughput approaches\, which make them an interesting option for drug testing\, research and development.[4] \nHence\, we developed two microfluidic tumor models\, which we used to model and characterize different aspects of the TME. TME was characterized in terms of hypoxia\, proliferation rates\, reactive oxygen species concentration\, apoptosis rate and glucose uptake.[5] Moreover\, the influence of tumor cells on an endothelium was investigated. Furthermore\, we carried out pharmacodynamic and drug efficiency studies in these newly-established models. Thereafter\, we developed a simple enzymatic protocol to extract cells seeded in 3D from the microfluidic devices. Cells could be sorted by flow cytometry according to the expression of specific surface markers or by using different fluorescent stains. RNA was extracted for downstream quantification and gene profiling was carried out for the mentioned aspects of the tumor microenvironment. \nAll in all\, we developed two easy-to-use microfluidic models for personalized medicine capable of comprehensive reproduction of the TME\, which allows characterization of tumor signatures by means of microscopy and traditional benchtop methods. \n\nBalkwill FR\, Capasso M\, Hagemann T (2012) The tumor microenvironment at a glance. J Cell Sci 125: 5591-5596.\nKlemm F\, Joyce JA (2015) Microenvironmental regulation of therapeutic response in cancer. Trends Cell Biol 25: 198-213.\nSackmann EK\, Fulton AL\, Beebe DJ (2014) The present and future role of microfluidics in biomedical research. Nature 507: 181-189.\nDu G\, Fang Q\, den Toonder JMJ (2016) Microfluidics for cell-based high throughput screening platforms—A review. Analytica Chimica Acta 903: 36-50.\nAyuso JM\, Virumbrales-Munoz M\, Lacueva A\, Lanuza PM\, Checa-Chavarria E\, et al. (2016) Development and characterization of a microfluidic model of the tumour microenvironment. Sci Rep 6: 36086.\n\n 
URL:https://ibecbarcelona.eu/event/ibec-seminar-maria-virumbrales-2/
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20170303T100000
DTEND;TZID=Europe/Madrid:20170303T110000
DTSTAMP:20260405T222202
CREATED:20170213T103423Z
LAST-MODIFIED:20170215T152756Z
UID:27594-1488535200-1488538800@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Maria Virumbrales
DESCRIPTION:“Development of microfluidic tools to reproduce and characterize the tumor microenvironment”\nMaria Virumbrales\, University of Zaragoza\nCompelling evidence over the years has demonstrated that the tumor microenvironment (TME) shapes tumor initiation\, development and response to therapy. This results in a high heterogeneity within the same cancer type\, and hinders the process of finding effective treatments.[1\,2] \nIn this context\, microfluidics has proven a worthy sum of techniques to create comprehensive and personalized cancer in vitro 3D models reproducing the TME in a more relevant fashion than traditional in vitro setups. \nMicrofluidics also permits a high degree of control over the setup\, combining different cell types in an orderly manner\, as well as different physical and biochemical cues. [3] Furthermore\, microfluidics facilitates optical inspection and diminishes sample sizes and reagent volumes needed for each experiment. Microfluidic devices are also compatible with high-throughput approaches\, which make them an interesting option for drug testing\, research and development.[4] \nHence\, we developed two microfluidic tumor models\, which we used to model and characterize different aspects of the TME. TME was characterized in terms of hypoxia\, proliferation rates\, reactive oxygen species concentration\, apoptosis rate and glucose uptake.[5] Moreover\, the influence of tumor cells on an endothelium was investigated. Furthermore\, we carried out pharmacodynamic and drug efficiency studies in these newly-established models. Thereafter\, we developed a simple enzymatic protocol to extract cells seeded in 3D from the microfluidic devices. Cells could be sorted by flow cytometry according to the expression of specific surface markers or by using different fluorescent stains. RNA was extracted for downstream quantification and gene profiling was carried out for the mentioned aspects of the tumor microenvironment. \nAll in all\, we developed two easy-to-use microfluidic models for personalized medicine capable of comprehensive reproduction of the TME\, which allows characterization of tumor signatures by means of microscopy and traditional benchtop methods. \n\nBalkwill FR\, Capasso M\, Hagemann T (2012) The tumor microenvironment at a glance. J Cell Sci 125: 5591-5596.\nKlemm F\, Joyce JA (2015) Microenvironmental regulation of therapeutic response in cancer. Trends Cell Biol 25: 198-213.\nSackmann EK\, Fulton AL\, Beebe DJ (2014) The present and future role of microfluidics in biomedical research. Nature 507: 181-189.\nDu G\, Fang Q\, den Toonder JMJ (2016) Microfluidics for cell-based high throughput screening platforms—A review. Analytica Chimica Acta 903: 36-50.\nAyuso JM\, Virumbrales-Munoz M\, Lacueva A\, Lanuza PM\, Checa-Chavarria E\, et al. (2016) Development and characterization of a microfluidic model of the tumour microenvironment. Sci Rep 6: 36086.\n\n 
URL:https://ibecbarcelona.eu/event/ibec-seminar-maria-virumbrales/
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20170306T120000
DTEND;TZID=Europe/Madrid:20170306T130000
DTSTAMP:20260405T222202
CREATED:20170222T083846Z
LAST-MODIFIED:20170222T083846Z
UID:96001-1488801600-1488805200@ibecbarcelona.eu
SUMMARY:IBEC Seminar: David Cahen
DESCRIPTION:Electron Transport across Peptides and Proteins\nProf. David Cahen\, Weizmann Institute of Science\nElectron transport (ETp)\, i.e.\, electronic conduction across peptides and proteins in a solid state–like configuration is surprisingly efficient\, and comparable to\, or at times even more efficient than via completely conjugated molecules of comparable length. Working with modified proteins and with homopeptides we find both cofactors and secondary structure to matter for ETp efficiency. An open question is if contact to the external world is the dominant factor\, or intra-protein transport. This is important\, also for electron transfer\, ET: nature regulates ET via redox chemistry\, i.e.\, injection and extraction of electrons; this is where ET and ETp are related\, because the analog in the latter is the coupling to the electrodes. In ET control over the process is achieved at the free energy price of a redox event\, but no redox process is required for ETp. This allows studying ETp via non-redox proteins\, such as rhodopsins or albumins (“dopable” proteins)\, pointing to peptides as efficient transport media; studying transport via\, including coupling to them\, can help to learn about protein ETp.
URL:https://ibecbarcelona.eu/event/ibec-seminar-david-cahen-2/
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20170306T120000
DTEND;TZID=Europe/Madrid:20170306T130000
DTSTAMP:20260405T222202
CREATED:20170222T083846Z
LAST-MODIFIED:20170303T081702Z
UID:27719-1488801600-1488805200@ibecbarcelona.eu
SUMMARY:IBEC Seminar: David Cahen
DESCRIPTION:Electron Transport across Peptides and Proteins\nProf. David Cahen\, Weizmann Institute of Science\nElectron transport (ETp)\, i.e.\, electronic conduction across peptides and proteins in a solid state–like configuration is surprisingly efficient\, and comparable to\, or at times even more efficient than via completely conjugated molecules of comparable length. Working with modified proteins and with homopeptides we find both cofactors and secondary structure to matter for ETp efficiency. An open question is if contact to the external world is the dominant factor\, or intra-protein transport. This is important\, also for electron transfer\, ET: nature regulates ET via redox chemistry\, i.e.\, injection and extraction of electrons; this is where ET and ETp are related\, because the analog in the latter is the coupling to the electrodes. In ET control over the process is achieved at the free energy price of a redox event\, but no redox process is required for ETp. This allows studying ETp via non-redox proteins\, such as rhodopsins or albumins (“dopable” proteins)\, pointing to peptides as efficient transport media; studying transport via\, including coupling to them\, can help to learn about protein ETp.
URL:https://ibecbarcelona.eu/event/ibec-seminar-david-cahen/
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20170329T120000
DTEND;TZID=Europe/Madrid:20170329T130000
DTSTAMP:20260405T222202
CREATED:20170308T135727Z
LAST-MODIFIED:20170308T135727Z
UID:28031-1490788800-1490792400@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Aranzazu Villasante
DESCRIPTION:Cancer Engineering: Strategies to Engineer Predictable Tumor Models\nDr. Aranzazu Villasante\, Department of Biomedical Engineering\, Columbia University\, New York\nAlthough many drugs show promise in monolayer or in animal models systems\, most fail to translate in humans and this is because they lack of ability to replicate the human microenvironment in patients. In response to these limitations\, I have generated a set of predictable tissue-engineered (TE) models of cancer by using different strategies. Today\, I am going to focus on some of these approaches to engineer pediatric tumors in vitro. Firstly\, I will show a TE model of Ewing’s sarcoma (ES) within its bone niche. This particular strategy is based on engineered human bone by introducing osteoclasts in co-culture with osteoblasts in the 3-dimensional bone niche. This model mimics bone remodeling and recapitulates some of the features observed in the osteolytic process in cancer and also\, the effects of the therapeutic reagent Zoledronic acid observed in patients. The second strategy consists in designing biomaterials with the same tumor composition to mimic the biological and mechanical properties of tumors from patients. I have developed 3D porous collagen 1-hyaluronic acid scaffolds (Col1-HA scaffolds) for studies of tumor derivedexosomes\, which are known to be initiators of pre-metastatic niche formation in certain sites. Interestingly\, I found high levels of a critical mediator of ES growth and metastasis (EZH2) in exosomes isolated from both patients and TE model of ES. Alternatively\, we cultured TE models based on Col1-HA scaffolds into a mechanical loading bioreactor for better mimicking biomechanical forces in ES. We found that biomechanical stimuli modulate osteolytic-related proteins (i.e. RUNX2) and sensitivity to anticancer drugs\, such as Sorafenib. I will also explain the use of perfusion bioreactors and cell sheet engineering to develop a novel model of Neuroblastoma (NB) to study the effect of consolidative drugs\, such as Isotretinoin\, on tumor vasculature and stem-like cells. Here\, I will show the existence of sub-populations of NB cells with different levels of stemness properties; these levels are related to the capacity of stem-like cells to transdifferentiate and also\, to chemoresistance and relapse. Finally\, the take-home message of my talk will be that TE models can bridge the gap between 2D in vitro cultures and in vivo animal models in a predictive\, inexpensive and low timeconsuming fashion for successfully understand cancer biology and improve cancer treatments.
URL:https://ibecbarcelona.eu/event/ibec-seminar-aranzazu-villasante/
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20170329T120000
DTEND;TZID=Europe/Madrid:20170329T130000
DTSTAMP:20260405T222202
CREATED:20170308T135727Z
LAST-MODIFIED:20170308T135727Z
UID:96007-1490788800-1490792400@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Aranzazu Villasante
DESCRIPTION:Cancer Engineering: Strategies to Engineer Predictable Tumor Models\nDr. Aranzazu Villasante\, Department of Biomedical Engineering\, Columbia University\, New York\nAlthough many drugs show promise in monolayer or in animal models systems\, most fail to translate in humans and this is because they lack of ability to replicate the human microenvironment in patients. In response to these limitations\, I have generated a set of predictable tissue-engineered (TE) models of cancer by using different strategies. Today\, I am going to focus on some of these approaches to engineer pediatric tumors in vitro. Firstly\, I will show a TE model of Ewing’s sarcoma (ES) within its bone niche. This particular strategy is based on engineered human bone by introducing osteoclasts in co-culture with osteoblasts in the 3-dimensional bone niche. This model mimics bone remodeling and recapitulates some of the features observed in the osteolytic process in cancer and also\, the effects of the therapeutic reagent Zoledronic acid observed in patients. The second strategy consists in designing biomaterials with the same tumor composition to mimic the biological and mechanical properties of tumors from patients. I have developed 3D porous collagen 1-hyaluronic acid scaffolds (Col1-HA scaffolds) for studies of tumor derivedexosomes\, which are known to be initiators of pre-metastatic niche formation in certain sites. Interestingly\, I found high levels of a critical mediator of ES growth and metastasis (EZH2) in exosomes isolated from both patients and TE model of ES. Alternatively\, we cultured TE models based on Col1-HA scaffolds into a mechanical loading bioreactor for better mimicking biomechanical forces in ES. We found that biomechanical stimuli modulate osteolytic-related proteins (i.e. RUNX2) and sensitivity to anticancer drugs\, such as Sorafenib. I will also explain the use of perfusion bioreactors and cell sheet engineering to develop a novel model of Neuroblastoma (NB) to study the effect of consolidative drugs\, such as Isotretinoin\, on tumor vasculature and stem-like cells. Here\, I will show the existence of sub-populations of NB cells with different levels of stemness properties; these levels are related to the capacity of stem-like cells to transdifferentiate and also\, to chemoresistance and relapse. Finally\, the take-home message of my talk will be that TE models can bridge the gap between 2D in vitro cultures and in vivo animal models in a predictive\, inexpensive and low timeconsuming fashion for successfully understand cancer biology and improve cancer treatments.
URL:https://ibecbarcelona.eu/event/ibec-seminar-aranzazu-villasante-2/
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20170519T100000
DTEND;TZID=Europe/Madrid:20170519T110000
DTSTAMP:20260405T222202
CREATED:20170425T125954Z
LAST-MODIFIED:20170425T125954Z
UID:96045-1495188000-1495191600@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Verena Ruprecht
DESCRIPTION:Tuning cell and tissue dynamics by the biomechanical microenvironment\nDr. Verena Ruprecht\, Cell & Developmental Biology program\, CRG\, Barcelona (Spain)\nResearch in our lab is focused on the control of cell and tissue dynamics in 3D environments. We study how single cells process multifactorial mechanochemical information from their surrounding and generate adaptive output dynamics such as shape change\, cell polarization and migration that collectively impact on tissue development and morphogenesis. We use Zebrafish embryos and primary embryonic progenitor stem cells as a model system to study molecular and cellular mechanisms driving complex three-dimensional tissue rearrangements and patterning in the embryo. Our lab follows a highly interdisciplinary approach combining molecular and cell biological tools with quantitative imaging approaches and advanced fluorescence microscopy. We implement a dual experiment strategy of in vivo experiments and minimalistic in vitro culture assays that allow for reconstituting the complexity of tissue morphogenesis in simplified environments.\nIn this talk I will specifically focus on how the  3D cellular microenvironment modulates cytoskeletal dynamics and motile cell behaviour and how a combination of physics and biology can help to elucidate generic patterns in cell motility.
URL:https://ibecbarcelona.eu/event/ibec-seminar-verena-ruprecht-2/
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20170519T100000
DTEND;TZID=Europe/Madrid:20170519T110000
DTSTAMP:20260405T222202
CREATED:20170425T125954Z
LAST-MODIFIED:20170425T125954Z
UID:28878-1495188000-1495191600@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Verena Ruprecht
DESCRIPTION:Tuning cell and tissue dynamics by the biomechanical microenvironment\nDr. Verena Ruprecht\, Cell & Developmental Biology program\, CRG\, Barcelona (Spain)\nResearch in our lab is focused on the control of cell and tissue dynamics in 3D environments. We study how single cells process multifactorial mechanochemical information from their surrounding and generate adaptive output dynamics such as shape change\, cell polarization and migration that collectively impact on tissue development and morphogenesis. We use Zebrafish embryos and primary embryonic progenitor stem cells as a model system to study molecular and cellular mechanisms driving complex three-dimensional tissue rearrangements and patterning in the embryo. Our lab follows a highly interdisciplinary approach combining molecular and cell biological tools with quantitative imaging approaches and advanced fluorescence microscopy. We implement a dual experiment strategy of in vivo experiments and minimalistic in vitro culture assays that allow for reconstituting the complexity of tissue morphogenesis in simplified environments.\nIn this talk I will specifically focus on how the  3D cellular microenvironment modulates cytoskeletal dynamics and motile cell behaviour and how a combination of physics and biology can help to elucidate generic patterns in cell motility.
URL:https://ibecbarcelona.eu/event/ibec-seminar-verena-ruprecht/
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20170602T100000
DTEND;TZID=Europe/Madrid:20170602T110000
DTSTAMP:20260405T222202
CREATED:20170529T132500Z
LAST-MODIFIED:20170529T132500Z
UID:96068-1496397600-1496401200@ibecbarcelona.eu
SUMMARY:IBEC Seminar:  Esteve Trias & Oscar Fariñas\, BTB
DESCRIPTION:Research challenges of the Barcelona Tissue Bank\n Esteve Trias\, Oscar Fariñas – Barcelona Tissue Bank (Banc de Sang I Teixits)\nThe Barcelona Tissue Bank (BTB) is a multi-tissue bank which belongs to the Banc de Sang i Teixits (BST)\, a public company of the Department of Health of the Generalitat de Catalunya\, whose mission is to ensure the supply and proper use of blood and Tissue in Catalonia.\nThe BTB controls the entire process of donation and transplantation globally\, from the process of detection and evaluation of the potential donor\, obtention or extraction\, processing of the different tissues\, storage and distribution until transplantation.\nIn the BTB we can distinguish five major banks: ocular\, cardiovascular\, skin\, musculoskeletal and reproductive.\nMusculoskeletal tissue bank represents 50% of the activity of BTB\, covering approximately 85% of transplanted tissue in the Spanish state. Different types of tissues are processed through a decontamination process to ensure maximum security. The purpose of the great variety of processed tissues is to meet the different needs of surgeons\, being the most common ligament reconstruction\, filling bone defects\, tumour surgery and meniscal transplantation.\nResearch\, development and innovation of new products and processes are constant priorities to provide the best solution for patients by setting up different lines of R & D in the short\, medium and long term.
URL:https://ibecbarcelona.eu/event/seminario-de-id-del-banc-de-sang-i-teixits-bst-2/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20170602T100000
DTEND;TZID=Europe/Madrid:20170602T110000
DTSTAMP:20260405T222202
CREATED:20170529T132500Z
LAST-MODIFIED:20170530T125041Z
UID:29677-1496397600-1496401200@ibecbarcelona.eu
SUMMARY:IBEC Seminar:  Esteve Trias & Oscar Fariñas\, BTB
DESCRIPTION:Research challenges of the Barcelona Tissue Bank\n Esteve Trias\, Oscar Fariñas – Barcelona Tissue Bank (Banc de Sang I Teixits)\nThe Barcelona Tissue Bank (BTB) is a multi-tissue bank which belongs to the Banc de Sang i Teixits (BST)\, a public company of the Department of Health of the Generalitat de Catalunya\, whose mission is to ensure the supply and proper use of blood and Tissue in Catalonia.\nThe BTB controls the entire process of donation and transplantation globally\, from the process of detection and evaluation of the potential donor\, obtention or extraction\, processing of the different tissues\, storage and distribution until transplantation.\nIn the BTB we can distinguish five major banks: ocular\, cardiovascular\, skin\, musculoskeletal and reproductive.\nMusculoskeletal tissue bank represents 50% of the activity of BTB\, covering approximately 85% of transplanted tissue in the Spanish state. Different types of tissues are processed through a decontamination process to ensure maximum security. The purpose of the great variety of processed tissues is to meet the different needs of surgeons\, being the most common ligament reconstruction\, filling bone defects\, tumour surgery and meniscal transplantation.\nResearch\, development and innovation of new products and processes are constant priorities to provide the best solution for patients by setting up different lines of R & D in the short\, medium and long term.
URL:https://ibecbarcelona.eu/event/seminario-de-id-del-banc-de-sang-i-teixits-bst/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20170714T100000
DTEND;TZID=Europe/Madrid:20170714T110000
DTSTAMP:20260405T222202
CREATED:20170630T073735Z
LAST-MODIFIED:20170630T073735Z
UID:96075-1500026400-1500030000@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Maria Vinaixa
DESCRIPTION:Mass spectrometry and metabolomics data analysis for synthetic biology\n Maria Vinaixa\, Synthetic Biology for Fine and Speciality Chemicals (SYNBIOCHEM)\, Manchester Institute of Biotechnology\nSynthetic biology builds upon the creation of new biologically inspired standardized parts that can be put together using design or simulations tools to build circuits that will create de-novo biological functions or modify existing ones. Using synthetic biology\, microbial cell factories can be engineered to provide new sustainable bio-routes for the production of fuels\, biopharmaceuticals\, fragrances\, and food flavors among others. In this regard\, the SYNBIOCHEM Centre (www.synbiochem.co.uk) has set-up an automated Design/Build/Test/Learn pipeline designed to provide access to target fine chemicals through iterative\, rapid and predictable engineering of production pathways and microbial strains. This pipeline moves from Design of new parts (e.g. enzymes\, regulatory circuits\, metabolic pathways)\, through to combinatorial high-throughput Build approaches (directed evolution\, components\, pathways and strain assembly) and high-throughput analytics in Test (product extraction\, instrumental analysis\, data analysis and sharing) feeding back to improved designs via an active Learning stage at each cycle iteration. This pipeline allows unprecedented possibilities for retro biosynthesis of non-natural products and for the expansion of natural products chemical diversity. Screening for the small-molecule structure diversity emanating from such pipeline is an analytically daunting challenge. In this regard\, mass spectrometry (MS) is a key analytical technology offering the high throughput screening capabilities as well as the versatility needed to cope with such chemical diversity. However\, curating MS data and merging it with all other types of data generated through iterative D/B/T/L cycle so that it can be used to learn and redesign remains a challenge. Despite Metabolomics has powered computational solutions for MS data analysis; such solutions do only partially cover the needs within a synthetic biology context. Thus\, we are building the next generation computational toolbox for MS data analysis and storage so it can be harvested across the entire pipeline. In this seminar\, main capabilities and functionalities on such toolbox are going to be discussed.
URL:https://ibecbarcelona.eu/event/ibec-seminar-maria-vinaixa-2/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20170714T100000
DTEND;TZID=Europe/Madrid:20170714T110000
DTSTAMP:20260405T222202
CREATED:20170630T073735Z
LAST-MODIFIED:20170630T073817Z
UID:30091-1500026400-1500030000@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Maria Vinaixa
DESCRIPTION:Mass spectrometry and metabolomics data analysis for synthetic biology\n Maria Vinaixa\, Synthetic Biology for Fine and Speciality Chemicals (SYNBIOCHEM)\, Manchester Institute of Biotechnology\nSynthetic biology builds upon the creation of new biologically inspired standardized parts that can be put together using design or simulations tools to build circuits that will create de-novo biological functions or modify existing ones. Using synthetic biology\, microbial cell factories can be engineered to provide new sustainable bio-routes for the production of fuels\, biopharmaceuticals\, fragrances\, and food flavors among others. In this regard\, the SYNBIOCHEM Centre (www.synbiochem.co.uk) has set-up an automated Design/Build/Test/Learn pipeline designed to provide access to target fine chemicals through iterative\, rapid and predictable engineering of production pathways and microbial strains. This pipeline moves from Design of new parts (e.g. enzymes\, regulatory circuits\, metabolic pathways)\, through to combinatorial high-throughput Build approaches (directed evolution\, components\, pathways and strain assembly) and high-throughput analytics in Test (product extraction\, instrumental analysis\, data analysis and sharing) feeding back to improved designs via an active Learning stage at each cycle iteration. This pipeline allows unprecedented possibilities for retro biosynthesis of non-natural products and for the expansion of natural products chemical diversity. Screening for the small-molecule structure diversity emanating from such pipeline is an analytically daunting challenge. In this regard\, mass spectrometry (MS) is a key analytical technology offering the high throughput screening capabilities as well as the versatility needed to cope with such chemical diversity. However\, curating MS data and merging it with all other types of data generated through iterative D/B/T/L cycle so that it can be used to learn and redesign remains a challenge. Despite Metabolomics has powered computational solutions for MS data analysis; such solutions do only partially cover the needs within a synthetic biology context. Thus\, we are building the next generation computational toolbox for MS data analysis and storage so it can be harvested across the entire pipeline. In this seminar\, main capabilities and functionalities on such toolbox are going to be discussed.
URL:https://ibecbarcelona.eu/event/ibec-seminar-maria-vinaixa/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20170725T100000
DTEND;TZID=Europe/Madrid:20170725T110000
DTSTAMP:20260405T222202
CREATED:20170717T120502Z
LAST-MODIFIED:20170717T120502Z
UID:96085-1500976800-1500980400@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Ronen Zaidel-Bar
DESCRIPTION:Regulation of actomyosin contractility in C. elegans\nRonen Zaidel-Bar\, Mechanobiology Institute Singapore and Tel-Aviv University Medical School\nThe actomyosin cortex is responsible for cell shape and for dynamic processes such as cell polarization and cytokinesis. We are studying the regulation of cortical contractility in the C. elegans zygote\, using genetic loss of function and live-imaging. In my talk\, I will discuss recent findings regarding two proteins: the actin cross-linking protein plastin (PLST-1) and the transmembrane receptor E-cadherin (HMR-1). Consistent with previous in-vitro reconstitution studies\, we show that an optimal level of cross-linking by plastin is required for the generation of coordinated long-range contractions in the cortex; without the connectivity afforded by plastin\, zygote polarization and cytokinesis are severely perturbed. E-cadherin is well known for its role as a cell-cell adhesion receptor. \nSurprisingly\, we discovered a role for non-junctional E-cadherin clusters in regulating cortical contractility. E-cadherin clusters inhibit RhoA and non-muscle myosin II activity at the cortex and form a physical barrier that slows actin flows. In the absence of non-junctional E-cadherin cytokinesis proceeds faster\, but the cortex is also at a risk of detaching from the plasma membrane. Thus\, our studies in the C. elegans zygote are shedding light on structural and regulatory mechanisms underlying cortex function.
URL:https://ibecbarcelona.eu/event/ibec-seminar-ronen-zaidel-bar-2/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20170725T100000
DTEND;TZID=Europe/Madrid:20170725T110000
DTSTAMP:20260405T222202
CREATED:20170717T120502Z
LAST-MODIFIED:20170717T120502Z
UID:30583-1500976800-1500980400@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Ronen Zaidel-Bar
DESCRIPTION:Regulation of actomyosin contractility in C. elegans\nRonen Zaidel-Bar\, Mechanobiology Institute Singapore and Tel-Aviv University Medical School\nThe actomyosin cortex is responsible for cell shape and for dynamic processes such as cell polarization and cytokinesis. We are studying the regulation of cortical contractility in the C. elegans zygote\, using genetic loss of function and live-imaging. In my talk\, I will discuss recent findings regarding two proteins: the actin cross-linking protein plastin (PLST-1) and the transmembrane receptor E-cadherin (HMR-1). Consistent with previous in-vitro reconstitution studies\, we show that an optimal level of cross-linking by plastin is required for the generation of coordinated long-range contractions in the cortex; without the connectivity afforded by plastin\, zygote polarization and cytokinesis are severely perturbed. E-cadherin is well known for its role as a cell-cell adhesion receptor. \nSurprisingly\, we discovered a role for non-junctional E-cadherin clusters in regulating cortical contractility. E-cadherin clusters inhibit RhoA and non-muscle myosin II activity at the cortex and form a physical barrier that slows actin flows. In the absence of non-junctional E-cadherin cytokinesis proceeds faster\, but the cortex is also at a risk of detaching from the plasma membrane. Thus\, our studies in the C. elegans zygote are shedding light on structural and regulatory mechanisms underlying cortex function.
URL:https://ibecbarcelona.eu/event/ibec-seminar-ronen-zaidel-bar/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20170928T143000
DTEND;TZID=Europe/Madrid:20170928T153000
DTSTAMP:20260405T222202
CREATED:20170922T075539Z
LAST-MODIFIED:20170922T075807Z
UID:31465-1506609000-1506612600@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Silvain Muller\, RegenHu
DESCRIPTION:Bioprinting Software for the RegenHU 3DBioprinting System\nSilvain Muller\, RegenHu\nBioprinting is a dynamic and exciting stage of evolution where\, recently\, considerable progress has been accomplished globally in the field of tissue engineering and bioprinting. These developments have in turn led to ground-breaking advancements in Bioprinting leading from fundamental research to Applied research and Clinical testing. Key components in the successful transition of this evolution are the software tools specifically designed to enable interaction between the hardware\, the biology and the users. \nDuring this seminar Silvain Muller from RegenHu will describe the capabilities of our 3D Bioprinter (3D Discovery) and will perform a presentation of the software package associated that that enables the design of complex structures and scaffolds and the transformation of DICOM images to 3D-bioprinted constructs.
URL:https://ibecbarcelona.eu/event/ibec-seminar-silvain-muller-regenhu/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20170928T143000
DTEND;TZID=Europe/Madrid:20170928T153000
DTSTAMP:20260405T222202
CREATED:20170922T075539Z
LAST-MODIFIED:20170922T075539Z
UID:96099-1506609000-1506612600@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Silvain Muller\, RegenHu
DESCRIPTION:Bioprinting Software for the RegenHU 3DBioprinting System\nSilvain Muller\, RegenHu\nBioprinting is a dynamic and exciting stage of evolution where\, recently\, considerable progress has been accomplished globally in the field of tissue engineering and bioprinting. These developments have in turn led to ground-breaking advancements in Bioprinting leading from fundamental research to Applied research and Clinical testing. Key components in the successful transition of this evolution are the software tools specifically designed to enable interaction between the hardware\, the biology and the users. \nDuring this seminar Silvain Muller from RegenHu will describe the capabilities of our 3D Bioprinter (3D Discovery) and will perform a presentation of the software package associated that that enables the design of complex structures and scaffolds and the transformation of DICOM images to 3D-bioprinted constructs.
URL:https://ibecbarcelona.eu/event/ibec-seminar-silvain-muller-regenhu-2/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20171006T100000
DTEND;TZID=Europe/Madrid:20171006T110000
DTSTAMP:20260405T222202
CREATED:20170926T091948Z
LAST-MODIFIED:20170926T091948Z
UID:96102-1507284000-1507287600@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Fabio Variola
DESCRIPTION:At the intersection of biomaterials\, surface science and medicine\nFabio Variola\, Associate Professor\, Biomedical Engineering\, Cellular and Molecular Medicine\, University of Ottawa\nIn the quest for the next generation of functional biomaterials and new solutions in health-related research\, investigators have sought inspiration from nature by developing better performing bio-derived materials (e.g. collagen\, chitosan)\, reproducing naturally occurring micro and nanostructures (e.g. nanoporosity of collagen-apatite interfaces in bone\, ECM nanotopography) and devising strategies that mimic naturally occurring phenomena (e.g. mussel attachment). In this context\, our team has employed bio-derived materials and bio-inspired structures towards the creation of platforms and interfaces to investigate and control cellular events. In particular\, we successfully reproduced a bioactive nanoporosity on titanium\, the gold standard in medicine\, by simple chemical and electrochemical methods\, capable of positively affecting cell activity providing antibacterial properties. Anodization permitted not only to create semiordered nanotubular surfaces which can be tuned in terms of diameter and spacing\, but also a nanometric 3-dimensional hierarchical surface that mimics that of biologically successful life forms such as diatoms. Moreover\, we are currently working on understanding the effects on cells of poly(dopamine)\, an adhesive polymer derived from mussels\, as a multifunctional layer for direct cueing to cells. In parallel\, our team has also contributed to the development of collagen- and chitosan-based materials for applications ranging from cardiac and neuronal tissue engineering to synthetic blood vessels and drug delivery platforms.
URL:https://ibecbarcelona.eu/event/ibec-seminar-fabio-variola-2/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20171006T100000
DTEND;TZID=Europe/Madrid:20171006T110000
DTSTAMP:20260405T222202
CREATED:20170926T091948Z
LAST-MODIFIED:20170926T091948Z
UID:31487-1507284000-1507287600@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Fabio Variola
DESCRIPTION:At the intersection of biomaterials\, surface science and medicine\nFabio Variola\, Associate Professor\, Biomedical Engineering\, Cellular and Molecular Medicine\, University of Ottawa\nIn the quest for the next generation of functional biomaterials and new solutions in health-related research\, investigators have sought inspiration from nature by developing better performing bio-derived materials (e.g. collagen\, chitosan)\, reproducing naturally occurring micro and nanostructures (e.g. nanoporosity of collagen-apatite interfaces in bone\, ECM nanotopography) and devising strategies that mimic naturally occurring phenomena (e.g. mussel attachment). In this context\, our team has employed bio-derived materials and bio-inspired structures towards the creation of platforms and interfaces to investigate and control cellular events. In particular\, we successfully reproduced a bioactive nanoporosity on titanium\, the gold standard in medicine\, by simple chemical and electrochemical methods\, capable of positively affecting cell activity providing antibacterial properties. Anodization permitted not only to create semiordered nanotubular surfaces which can be tuned in terms of diameter and spacing\, but also a nanometric 3-dimensional hierarchical surface that mimics that of biologically successful life forms such as diatoms. Moreover\, we are currently working on understanding the effects on cells of poly(dopamine)\, an adhesive polymer derived from mussels\, as a multifunctional layer for direct cueing to cells. In parallel\, our team has also contributed to the development of collagen- and chitosan-based materials for applications ranging from cardiac and neuronal tissue engineering to synthetic blood vessels and drug delivery platforms.
URL:https://ibecbarcelona.eu/event/ibec-seminar-fabio-variola/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20171011T090000
DTEND;TZID=Europe/Madrid:20171011T130000
DTSTAMP:20260405T222203
CREATED:20171006T095729Z
LAST-MODIFIED:20171006T095729Z
UID:96110-1507712400-1507726800@ibecbarcelona.eu
SUMMARY:Extra IBEC Seminar: Multimode Reader User Day
DESCRIPTION:Multimode Reader User Day\nStephan Haberstock\, Detection Specialist\, Tecan\nCore Facilities would like to invite you to a user day for multimode microplate readers. \nThe programme will offer practical insights on the following topics:\n• Introduction to the basic detection modes (Absorbance\, Fluorescence\, Luminescence) and advanced assays like FRET\, TRF\, and TR-FRET\n• Infinite 200 Pro\, a multimode reader highly configurable.\n• Spark®\, the new multimode readers from Tecan & application based configurations for: \no cell assays\no fluorescence assays\no luminescence assays\no nucleic acid analysis \nAfter the presentations we are happy to answer your specific questions & help you optimizing your personal methods. And\, obviously\, you’ll be able to test our readers on site!
URL:https://ibecbarcelona.eu/event/extra-ibec-seminar-multimode-reader-user-day-2/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20171011T090000
DTEND;TZID=Europe/Madrid:20171011T130000
DTSTAMP:20260405T222203
CREATED:20171006T095729Z
LAST-MODIFIED:20171006T095729Z
UID:38142-1507712400-1507726800@ibecbarcelona.eu
SUMMARY:Extra IBEC Seminar: Multimode Reader User Day
DESCRIPTION:Multimode Reader User Day\nStephan Haberstock\, Detection Specialist\, Tecan\nCore Facilities would like to invite you to a user day for multimode microplate readers. \nThe programme will offer practical insights on the following topics:\n• Introduction to the basic detection modes (Absorbance\, Fluorescence\, Luminescence) and advanced assays like FRET\, TRF\, and TR-FRET\n• Infinite 200 Pro\, a multimode reader highly configurable.\n• Spark®\, the new multimode readers from Tecan & application based configurations for: \no cell assays\no fluorescence assays\no luminescence assays\no nucleic acid analysis \nAfter the presentations we are happy to answer your specific questions & help you optimizing your personal methods. And\, obviously\, you’ll be able to test our readers on site!
URL:https://ibecbarcelona.eu/event/extra-ibec-seminar-multimode-reader-user-day/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
END:VCALENDAR