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DTSTART;TZID=Europe/Madrid:20190705T100000
DTEND;TZID=Europe/Madrid:20190705T120000
DTSTAMP:20260406T031658
CREATED:20190701T075124Z
LAST-MODIFIED:20190701T080442Z
UID:67051-1562320800-1562328000@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Jordi Guiu
DESCRIPTION:Tracing the origin of adult intestinal stem cells\nJordi Guiu\, Biotech Research & Innovation Centre – University of Copenhagen \nJordi Guiu did his PhD in Anna Bigas laboratory (IMIM and Pompeu Fabra University-Barcelona) were he focused on the genetic circuitry that controls the establishment of hematopoietic stem cells during development. Then he joined Kim B. Jensen lab (Copenhagen University) as a postdoc\, were he obtained a Marie Curie fellowship. His current research is focused on the specification of intestinal stem cells during development using fate mapping technologies\, state of the art imaging\, biophysical modeling and a plethora of sequencing techniques.  \nThe adult small intestine is compartmentalized into villi and crypts containing post-mitotic differentiated and proliferative cells respectively. Intestinal stem cells (ISCs) located at the bottom of crypts express markers such as Lgr5 and fuel the constant replenishment of the intestinal epithelium. Importantly\, the cellular origin of adult ISCs remains unknown. Prior to birth the immature fetal intestine is structurally simpler than the adult intestine. It is characterized by villi separated by a continuous region composed of proliferative intervillus cells; crypts have not formed and there is no evidence of a stem cell niche. Interestingly\, intervillus cells located within the region between villi express the adult SAB marker Lgr5. Fate mapping studies have inferred the notion that fetal Lgr5 expressing cells are unique and specialized precursors for the adult ISCs. Using unbiased quantitative lineage-tracing approaches\, biophysical modeling and intestinal transplantation experiments\, we now demonstrate that in the fetal epithelium on-going tissue morphogenesis leads to a dynamic exchange of cells between the villi and intervillus regions and that all cells have got the potential to contribute to the adult stem cells. Moreover\, we present exciting data outlining the mechanism for tissue development based on 3D imaging and live microscopy. Our results demonstrate that large-scale tissue remodeling and cell fate specification are intertwined processes. Moreover\, these findings provide a direct link between the observed plasticity and cellular reprogramming of differentiating cells in adult tissue following damage\, revealing that stem cell identity is an induced rather than a hardwired property.
URL:https://ibecbarcelona.eu/event/ibec-seminar-jordi-guiu/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20190705T100000
DTEND;TZID=Europe/Madrid:20190705T120000
DTSTAMP:20260406T031658
CREATED:20190701T075124Z
LAST-MODIFIED:20190701T075124Z
UID:96468-1562320800-1562328000@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Jordi Guiu
DESCRIPTION:Tracing the origin of adult intestinal stem cells\nJordi Guiu\, Biotech Research & Innovation Centre – University of Copenhagen \nJordi Guiu did his PhD in Anna Bigas laboratory (IMIM and Pompeu Fabra University-Barcelona) were he focused on the genetic circuitry that controls the establishment of hematopoietic stem cells during development. Then he joined Kim B. Jensen lab (Copenhagen University) as a postdoc\, were he obtained a Marie Curie fellowship. His current research is focused on the specification of intestinal stem cells during development using fate mapping technologies\, state of the art imaging\, biophysical modeling and a plethora of sequencing techniques.  \nThe adult small intestine is compartmentalized into villi and crypts containing post-mitotic differentiated and proliferative cells respectively. Intestinal stem cells (ISCs) located at the bottom of crypts express markers such as Lgr5 and fuel the constant replenishment of the intestinal epithelium. Importantly\, the cellular origin of adult ISCs remains unknown. Prior to birth the immature fetal intestine is structurally simpler than the adult intestine. It is characterized by villi separated by a continuous region composed of proliferative intervillus cells; crypts have not formed and there is no evidence of a stem cell niche. Interestingly\, intervillus cells located within the region between villi express the adult SAB marker Lgr5. Fate mapping studies have inferred the notion that fetal Lgr5 expressing cells are unique and specialized precursors for the adult ISCs. Using unbiased quantitative lineage-tracing approaches\, biophysical modeling and intestinal transplantation experiments\, we now demonstrate that in the fetal epithelium on-going tissue morphogenesis leads to a dynamic exchange of cells between the villi and intervillus regions and that all cells have got the potential to contribute to the adult stem cells. Moreover\, we present exciting data outlining the mechanism for tissue development based on 3D imaging and live microscopy. Our results demonstrate that large-scale tissue remodeling and cell fate specification are intertwined processes. Moreover\, these findings provide a direct link between the observed plasticity and cellular reprogramming of differentiating cells in adult tissue following damage\, revealing that stem cell identity is an induced rather than a hardwired property.
URL:https://ibecbarcelona.eu/event/ibec-seminar-jordi-guiu-2/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20190715T120000
DTEND;TZID=Europe/Madrid:20190715T130000
DTSTAMP:20260406T031658
CREATED:20190701T080416Z
LAST-MODIFIED:20190701T080423Z
UID:67054-1563192000-1563195600@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Nicolas Minc
DESCRIPTION:Division positioning in early embryos from mechanisms to function\nNicolas Minc\, Insitut Jacques Monod\, Paris\, France \nNicolas Minc lab is located at the Institut Jacques Monod in Paris\, and studies general problems of cell morphogenesis\, ranging from the control of cell growth and shapes in single cells\, to cell division in multicellular embryos. One hallmark of the lab is to combine quantitative imaging\, biophysics methods and modelling to address fundamental questions in cell and developmental biology.
URL:https://ibecbarcelona.eu/event/ibec-seminar-nicolas-minc/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20190715T120000
DTEND;TZID=Europe/Madrid:20190715T130000
DTSTAMP:20260406T031658
CREATED:20190701T080416Z
LAST-MODIFIED:20190701T080416Z
UID:96471-1563192000-1563195600@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Nicolas Minc
DESCRIPTION:Division positioning in early embryos from mechanisms to function\nNicolas Minc\, Insitut Jacques Monod\, Paris\, France \nNicolas Minc lab is located at the Institut Jacques Monod in Paris\, and studies general problems of cell morphogenesis\, ranging from the control of cell growth and shapes in single cells\, to cell division in multicellular embryos. One hallmark of the lab is to combine quantitative imaging\, biophysics methods and modelling to address fundamental questions in cell and developmental biology.
URL:https://ibecbarcelona.eu/event/ibec-seminar-nicolas-minc-2/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20190802T120000
DTEND;TZID=Europe/Madrid:20190802T140000
DTSTAMP:20260406T031658
CREATED:20190730T070132Z
LAST-MODIFIED:20190730T070146Z
UID:67507-1564747200-1564754400@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Kara Spiller
DESCRIPTION:Immunomodulatory Biomaterials for Limb Salvage\nKara Spiller\, School of Biomedical Engineering\, Science\, and Health Systems\, Drexel University \nDiabetes and peripheral arterial disease affect hundreds of millions of people worldwide. Patients with these conditions frequently develop chronic wounds on the lower limbs that lead to amputation\, with a 5-year mortality rate as high as 77%. Macrophages\, the primary cell of the innate immune system\, are critical regulators of angiogenesis and wound healing. Their dysfunction is strongly implicated in arterial dysfunction\, limb ischemia\, and poorly healing chronic wounds. The goal of the Biomaterials and Regenerative Medicine Laboratory at Drexel University is to understand the mechanisms by which macrophages orchestrate successful angiogenesis and tissue regeneration and to develop novel biomaterial strategies that apply these principles to pathological situations\, in order to ultimately prevent limb amputation. This talk will focus on the effects of temporal changes in macrophage phenotype on angiogenesis\, the design of biomaterials and drug delivery systems to modulate macrophage phenotype for enhanced angiogenesis\, and the development of macrophage phenotype-related biomarkers to assist in clinical decision making for a personalized medicine approach to wound care. \nDr. Kara Spiller is an Associate Professor in Drexel University’s School of Biomedical Engineering\, Science\, and Health Systems. Her research interests include the role of immune cells in tissue regeneration\, the design of immunomodulatory biomaterials\, and international engineering education. Her research is funded by the NIH\, the NSF\, and private foundations. Her awards include a Fulbright fellowship\, the NSF CAREER award\, and the United States nomination for the ASPIRE prize.
URL:https://ibecbarcelona.eu/event/ibec-seminar-kara-spiller/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20190802T120000
DTEND;TZID=Europe/Madrid:20190802T140000
DTSTAMP:20260406T031659
CREATED:20190730T070132Z
LAST-MODIFIED:20190730T070132Z
UID:96490-1564747200-1564754400@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Kara Spiller
DESCRIPTION:Immunomodulatory Biomaterials for Limb Salvage\nKara Spiller\, School of Biomedical Engineering\, Science\, and Health Systems\, Drexel University \nDiabetes and peripheral arterial disease affect hundreds of millions of people worldwide. Patients with these conditions frequently develop chronic wounds on the lower limbs that lead to amputation\, with a 5-year mortality rate as high as 77%. Macrophages\, the primary cell of the innate immune system\, are critical regulators of angiogenesis and wound healing. Their dysfunction is strongly implicated in arterial dysfunction\, limb ischemia\, and poorly healing chronic wounds. The goal of the Biomaterials and Regenerative Medicine Laboratory at Drexel University is to understand the mechanisms by which macrophages orchestrate successful angiogenesis and tissue regeneration and to develop novel biomaterial strategies that apply these principles to pathological situations\, in order to ultimately prevent limb amputation. This talk will focus on the effects of temporal changes in macrophage phenotype on angiogenesis\, the design of biomaterials and drug delivery systems to modulate macrophage phenotype for enhanced angiogenesis\, and the development of macrophage phenotype-related biomarkers to assist in clinical decision making for a personalized medicine approach to wound care. \nDr. Kara Spiller is an Associate Professor in Drexel University’s School of Biomedical Engineering\, Science\, and Health Systems. Her research interests include the role of immune cells in tissue regeneration\, the design of immunomodulatory biomaterials\, and international engineering education. Her research is funded by the NIH\, the NSF\, and private foundations. Her awards include a Fulbright fellowship\, the NSF CAREER award\, and the United States nomination for the ASPIRE prize.
URL:https://ibecbarcelona.eu/event/ibec-seminar-kara-spiller-2/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20191001T100000
DTEND;TZID=Europe/Madrid:20191001T110000
DTSTAMP:20260406T031659
CREATED:20190927T102638Z
LAST-MODIFIED:20190927T102638Z
UID:96500-1569924000-1569927600@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Carlos Rodríguez Cabello
DESCRIPTION:Dynamic Systems Based on Elastin-Like Recombinamers\nCarlos Rodríguez Cabello\, Bioforge Lab\, University of Valladolid CIBER-BBN \nThe use of recombinant technology in the production of macromolecule-based advanced biomaterials has caused a breakthrough increase in achievable degree of complexity and control on the molecular designs and compositions. Those recombinant macromolecules of polpeptide nature are called recombinamers. They are produced from a purely synthetic gene\, in which the amino-acid sequence is not restricted to those found in naturally occurring proteins and it is dictated only by engineering design parameters. The high degree of complexity and control of the recombinamer compositions permit to reach unmatched levels of functionality in the materials produced by this way and on the systems based on them. \nThe development of functionality in such systems comes by to different ways. In one hand\, these materials can display direct functionality. Such functionality is based on the presence in their composition of functional epitopes\, typically inspired by functional epitopes found in natural proteins. The other source of functionality is the holistic functionality that emerges by the precise combination and interactions of direct functions in a precise and well designed macromolecular composition. This holistic function is particularly evident in system with a dynamic nature; systems that rearrange and respond to changes in their environment. \nExamples of such dynamic systems will be presented. The examples will expand from complex 3D structures for regenerative medicine and tissue engineering that are able to incorporate a designed program of degradation and time evolution\, to more fundamental matters such as the hierarchical spontaneous development of morphology and macroscopical shapes in natural and artificial systems. \nDr. Rodríguez-Cabello is a full professor at the Dept. of Condensed Matter Physics of the University of Valladolid (UVa) Spain. During his career he has been teaching courses related to physics of polymers and biomaterials science in both undergraduate and graduate levels. In 1997\, he founded BIOFORGE in the UVa\, which nowadays is an internationally recognized and word leading group in the field of recombinamers. His current research interests include the development of biofunctional\, smart and customized protein polymers towards obtaining advanced biomedical devices.
URL:https://ibecbarcelona.eu/event/ibec-seminar-carlos-rodriguez-cabello-2/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20191001T100000
DTEND;TZID=Europe/Madrid:20191001T110000
DTSTAMP:20260406T031659
CREATED:20190927T102638Z
LAST-MODIFIED:20190927T103038Z
UID:68412-1569924000-1569927600@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Carlos Rodríguez Cabello
DESCRIPTION:Dynamic Systems Based on Elastin-Like Recombinamers\nCarlos Rodríguez Cabello\, Bioforge Lab\, University of Valladolid CIBER-BBN \nThe use of recombinant technology in the production of macromolecule-based advanced biomaterials has caused a breakthrough increase in achievable degree of complexity and control on the molecular designs and compositions. Those recombinant macromolecules of polpeptide nature are called recombinamers. They are produced from a purely synthetic gene\, in which the amino-acid sequence is not restricted to those found in naturally occurring proteins and it is dictated only by engineering design parameters. The high degree of complexity and control of the recombinamer compositions permit to reach unmatched levels of functionality in the materials produced by this way and on the systems based on them. \nThe development of functionality in such systems comes by to different ways. In one hand\, these materials can display direct functionality. Such functionality is based on the presence in their composition of functional epitopes\, typically inspired by functional epitopes found in natural proteins. The other source of functionality is the holistic functionality that emerges by the precise combination and interactions of direct functions in a precise and well designed macromolecular composition. This holistic function is particularly evident in system with a dynamic nature; systems that rearrange and respond to changes in their environment. \nExamples of such dynamic systems will be presented. The examples will expand from complex 3D structures for regenerative medicine and tissue engineering that are able to incorporate a designed program of degradation and time evolution\, to more fundamental matters such as the hierarchical spontaneous development of morphology and macroscopical shapes in natural and artificial systems. \nDr. Rodríguez-Cabello is a full professor at the Dept. of Condensed Matter Physics of the University of Valladolid (UVa) Spain. During his career he has been teaching courses related to physics of polymers and biomaterials science in both undergraduate and graduate levels. In 1997\, he founded BIOFORGE in the UVa\, which nowadays is an internationally recognized and word leading group in the field of recombinamers. His current research interests include the development of biofunctional\, smart and customized protein polymers towards obtaining advanced biomedical devices.
URL:https://ibecbarcelona.eu/event/ibec-seminar-carlos-rodriguez-cabello/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20191004T100000
DTEND;TZID=Europe/Madrid:20191004T110000
DTSTAMP:20260406T031659
CREATED:20190925T080454Z
LAST-MODIFIED:20190925T080454Z
UID:96496-1570183200-1570186800@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Martijn Gloerich
DESCRIPTION:Mechanical control of cell division\nMartijn Gloerich\, UMC Utrecth\, Center for Molecular Medicine\, Molecular Cancer Research \nDuring development and adult tissue homeostasis\, cellular behavior is controlled by signals that cells receive from their local environment. This is not limited to biochemical signals\, as cell behavior can be instructed by mechanical forces exerted by neighbouring cells and the surrounding tissue. Cells sense this mechanical information through numerous molecules\, including cell adhesion receptors\, which translate mechanical cues into an appropriate cellular response. I will discuss our recent findings on force transduction through the cell-cell adhesion protein E-cadherin\, and its central role in the mechanical control of cell division to regulate epithelial integrity and architecture. \nMartijn Gloerich is Assistant Professor at the department of Molecular Cancer Research at the University Medical Center Utrecht\, The Netherlands. Martijn obtained his PhD cum laude in 2011 from Utrecht University for his work on the regulation of small GTPases. Following his PhD\, he received fellowships from the Netherlands Organization for Scientific Research (NWO) and Dutch Cancer Foundation (KWF) to perform postdoctoral research in the lab of James Nelson at Stanford University. Here\, he gained experience with numerous microfabrication and bio-engineering techniques to study how communication between cells regulates cell behavior. In 2016 Martijn returned to the Netherlands to start his own research group at the University Medical Center Utrecht. His group uses an interdisciplinary approach to understand how cells sense and respond to mechanical forces to control tissue development and homeostasis\, and how its disruption contributes to tumor progression.
URL:https://ibecbarcelona.eu/event/ibec-seminar-martijn-gloerich-2/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
ORGANIZER;CN="IBEC":MAILTO:www.ibecbarcelona.eu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20191004T100000
DTEND;TZID=Europe/Madrid:20191004T110000
DTSTAMP:20260406T031659
CREATED:20190925T080454Z
LAST-MODIFIED:20190925T080506Z
UID:68382-1570183200-1570186800@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Martijn Gloerich
DESCRIPTION:Mechanical control of cell division\nMartijn Gloerich\, UMC Utrecth\, Center for Molecular Medicine\, Molecular Cancer Research \nDuring development and adult tissue homeostasis\, cellular behavior is controlled by signals that cells receive from their local environment. This is not limited to biochemical signals\, as cell behavior can be instructed by mechanical forces exerted by neighbouring cells and the surrounding tissue. Cells sense this mechanical information through numerous molecules\, including cell adhesion receptors\, which translate mechanical cues into an appropriate cellular response. I will discuss our recent findings on force transduction through the cell-cell adhesion protein E-cadherin\, and its central role in the mechanical control of cell division to regulate epithelial integrity and architecture. \nMartijn Gloerich is Assistant Professor at the department of Molecular Cancer Research at the University Medical Center Utrecht\, The Netherlands. Martijn obtained his PhD cum laude in 2011 from Utrecht University for his work on the regulation of small GTPases. Following his PhD\, he received fellowships from the Netherlands Organization for Scientific Research (NWO) and Dutch Cancer Foundation (KWF) to perform postdoctoral research in the lab of James Nelson at Stanford University. Here\, he gained experience with numerous microfabrication and bio-engineering techniques to study how communication between cells regulates cell behavior. In 2016 Martijn returned to the Netherlands to start his own research group at the University Medical Center Utrecht. His group uses an interdisciplinary approach to understand how cells sense and respond to mechanical forces to control tissue development and homeostasis\, and how its disruption contributes to tumor progression.
URL:https://ibecbarcelona.eu/event/ibec-seminar-martijn-gloerich/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
ORGANIZER;CN="IBEC":MAILTO:www.ibecbarcelona.eu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20191105T160000
DTEND;TZID=Europe/Madrid:20191105T170000
DTSTAMP:20260406T031659
CREATED:20191029T084555Z
LAST-MODIFIED:20191029T084604Z
UID:68942-1572969600-1572973200@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Christine Horejs
DESCRIPTION:Inside Nature Nanotechnology\, an editor’s view\nChristine Horejs\, Nature Nanotechnology \nNature Nanotechnology was launched in October 2006 with the aim of publishing the most significant results in fundamental aspects\, applications and implications on nanomaterials. In my presentation I will provide an overview of what the journal looks for in the field of nanomedicine and bioimaging\, and I will give insight into the editorial process and some tips and tricks for submitting to our journal. \nChristine Horejs received her MSci and PhD in nanobiotechnology from the University of Natural Resources and Life Sciences\, Vienna\, Austria\, studying protein conformations and self-assembly using biophysical and theoretical approaches. She then joined the lab of Molly Stevens at Imperial College London\, UK\, investigating the extracellular matrix and cell–material interactions. In 2015\, she moved to the Karolinska Institute\, Sweden\, conducting in vivo studies of anti-fibrotic biomaterials. In September 2017\, she joined the Nature Reviews Materials team as an Associate Editor\, and since July 2019 she is a Senior Editor at Nature Nanotechnology\, where she is primarily responsible for nanomedicine and nanobiotechnology. \nShe has been invited to IBEC by Xavier Trepat
URL:https://ibecbarcelona.eu/event/ibec-seminar-christine-horejs/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
ORGANIZER;CN="IBEC":MAILTO:www.ibecbarcelona.eu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20191105T160000
DTEND;TZID=Europe/Madrid:20191105T170000
DTSTAMP:20260406T031659
CREATED:20191029T084555Z
LAST-MODIFIED:20191029T084555Z
UID:96525-1572969600-1572973200@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Christine Horejs
DESCRIPTION:Inside Nature Nanotechnology\, an editor’s view\nChristine Horejs\, Nature Nanotechnology \nNature Nanotechnology was launched in October 2006 with the aim of publishing the most significant results in fundamental aspects\, applications and implications on nanomaterials. In my presentation I will provide an overview of what the journal looks for in the field of nanomedicine and bioimaging\, and I will give insight into the editorial process and some tips and tricks for submitting to our journal. \nChristine Horejs received her MSci and PhD in nanobiotechnology from the University of Natural Resources and Life Sciences\, Vienna\, Austria\, studying protein conformations and self-assembly using biophysical and theoretical approaches. She then joined the lab of Molly Stevens at Imperial College London\, UK\, investigating the extracellular matrix and cell–material interactions. In 2015\, she moved to the Karolinska Institute\, Sweden\, conducting in vivo studies of anti-fibrotic biomaterials. In September 2017\, she joined the Nature Reviews Materials team as an Associate Editor\, and since July 2019 she is a Senior Editor at Nature Nanotechnology\, where she is primarily responsible for nanomedicine and nanobiotechnology. \nShe has been invited to IBEC by Xavier Trepat
URL:https://ibecbarcelona.eu/event/ibec-seminar-christine-horejs-2/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
ORGANIZER;CN="IBEC":MAILTO:www.ibecbarcelona.eu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20191115T100000
DTEND;TZID=Europe/Madrid:20191115T120000
DTSTAMP:20260406T031659
CREATED:20191111T153956Z
LAST-MODIFIED:20191111T154047Z
UID:69125-1573812000-1573819200@ibecbarcelona.eu
SUMMARY:Clinical Colloquia
DESCRIPTION:Theoretical and practical aspects of biophysiotherapy\nJosep Pous\, Medical Director at Cematec-Teknon de Barcelona \nIn this clinical colloquia\, the different treatment methods used in Biophysiotherapy such as Multifrequency Laser Therapy\, Shock Waves\, Modular Electromagnetic Waves\, Mechanotherapy\, Growth Factors\, Stem Cells\, will be exposed. The different mechanisms of action will be discussed at the cellular level such as mechanotransduction\, mechanotranscription\, depolarization of membarane or at the mitochondrial level through REDOX mechanisms\, to achieve biological effects at the cellular and tissue levels. Biophysiotherapy aims to apply the possibilities of diagnosis and treatment of the laboratory (biosensors\, nanobiosensors\, quantum dots) to the medical practice with fewer drugs and fewer surgeries. \nDr. Josep Pous\, specialist in Orthopedic Surgery\, Traumatology and Rehabilitation\, works at Cematec-Teknon of Barcelona (Center of Advanced and Technological Medicine) using the latest technologies in arthroscopy and prosthesis of the shoulder\, hip\, knee and ankle joints. Dr. Pous is a pioneer in the use of new non-invasive treatments for all musculoskeletal pathology and has incorporated new methods for its integral treatment. \nHe has been invited to IBEC by Pau Gorostiza
URL:https://ibecbarcelona.eu/event/clinical-colloquia/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20191115T100000
DTEND;TZID=Europe/Madrid:20191115T120000
DTSTAMP:20260406T031659
CREATED:20191111T153956Z
LAST-MODIFIED:20191111T153956Z
UID:96538-1573812000-1573819200@ibecbarcelona.eu
SUMMARY:Clinical Colloquia
DESCRIPTION:Theoretical and practical aspects of biophysiotherapy\nJosep Pous\, Medical Director at Cematec-Teknon de Barcelona \nIn this clinical colloquia\, the different treatment methods used in Biophysiotherapy such as Multifrequency Laser Therapy\, Shock Waves\, Modular Electromagnetic Waves\, Mechanotherapy\, Growth Factors\, Stem Cells\, will be exposed. The different mechanisms of action will be discussed at the cellular level such as mechanotransduction\, mechanotranscription\, depolarization of membarane or at the mitochondrial level through REDOX mechanisms\, to achieve biological effects at the cellular and tissue levels. Biophysiotherapy aims to apply the possibilities of diagnosis and treatment of the laboratory (biosensors\, nanobiosensors\, quantum dots) to the medical practice with fewer drugs and fewer surgeries. \nDr. Josep Pous\, specialist in Orthopedic Surgery\, Traumatology and Rehabilitation\, works at Cematec-Teknon of Barcelona (Center of Advanced and Technological Medicine) using the latest technologies in arthroscopy and prosthesis of the shoulder\, hip\, knee and ankle joints. Dr. Pous is a pioneer in the use of new non-invasive treatments for all musculoskeletal pathology and has incorporated new methods for its integral treatment. \nHe has been invited to IBEC by Pau Gorostiza
URL:https://ibecbarcelona.eu/event/clinical-colloquia-2/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20191122T100000
DTEND;TZID=Europe/Madrid:20191122T120000
DTSTAMP:20260406T031659
CREATED:20191114T092711Z
LAST-MODIFIED:20191114T094956Z
UID:69228-1574416800-1574424000@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Taher Saif
DESCRIPTION:Emergent living machines\nTaher Saif \, Professor\, Mechanical Science and Engineering University of Illinois at Urbana-Champaign \nIndustrial revolution of the 19th century marked the onset of the era of machines that transformed societies. However\, these machines cannot self assemble or heal themselves. On the other hand\, since the discovery of genes\, there is a considerable body of knowledge on engineering living cells. It is now possible to envision biohybrid machines with engineered living cells and scaffolds. These machines may self assemble and emerge from complex interactions between the cells and the scaffolds at various hierarchical levels. In this talk we will present two elementary biohybrid machines. They are both small scale swimmers. One of the swimmers is powered by primary rat cardiomyocytes. These cells are plated without any patterning on a scaffold which consists of a head and a tail. The cells self-orient to maximize scaffold deformation\, and synchronize their beating. As a result\, the tail deforms periodically and propels the swimmer forward. As a first step towards intelligent machines\, the second swimmer consists of optogenetic neurons and muscle cells. It’s scaffold consists of a head and two tails. The muscle cells self assemble into myotubes around the tails\, while the neurons are hosted by the head. The neurons spontaneously send out long cables of axons preferentially towards the muscle forming functional neuro functional junctions. They also form a neural network within themselves. Upon shining light\, the neurons fire synchronously in a periodic fashion. The muscle contracts and bends the tails to propel the swimmer. This new generation of swimmer powered by neurons paves the way towards intelligent biohybrid machines. The central role of mechanics in the emergence of the biohybrid machines will be highlighted. \nDr Taher Saif received his BS and MS degrees in Civil Engineering from Bangladesh University of Engineering and Technology and Washington State University respectively in 1984 and 1986. He obtained his Ph.D degree in Theoretical and Applied Mechanics from Cornell University in 1993. He worked as a Post Doctoral Associate in Electrical Engineering and the National Nanofabrication Facility at Cornell University during 1993-97. He joined the Department of Mechanical Science and Engineering at the University of Illinois at Urbana-Champaign during 1997. He is curently the Gutgsell Professor in the department. His current research includes tumor micro environment\, mechanics of neurons and cardiac cells\, development of biological machines\, and electro-thermo-mechanical behavior of nano scale metals and semiconductors. \nHe has been invited to IBEC by Samuel Sánchez
URL:https://ibecbarcelona.eu/event/ibec-seminar-taher-saif/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20191122T100000
DTEND;TZID=Europe/Madrid:20191122T120000
DTSTAMP:20260406T031659
CREATED:20191114T092711Z
LAST-MODIFIED:20191114T092711Z
UID:96550-1574416800-1574424000@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Taher Saif
DESCRIPTION:Emergent living machines\nTaher Saif \, Professor\, Mechanical Science and Engineering University of Illinois at Urbana-Champaign \nIndustrial revolution of the 19th century marked the onset of the era of machines that transformed societies. However\, these machines cannot self assemble or heal themselves. On the other hand\, since the discovery of genes\, there is a considerable body of knowledge on engineering living cells. It is now possible to envision biohybrid machines with engineered living cells and scaffolds. These machines may self assemble and emerge from complex interactions between the cells and the scaffolds at various hierarchical levels. In this talk we will present two elementary biohybrid machines. They are both small scale swimmers. One of the swimmers is powered by primary rat cardiomyocytes. These cells are plated without any patterning on a scaffold which consists of a head and a tail. The cells self-orient to maximize scaffold deformation\, and synchronize their beating. As a result\, the tail deforms periodically and propels the swimmer forward. As a first step towards intelligent machines\, the second swimmer consists of optogenetic neurons and muscle cells. It’s scaffold consists of a head and two tails. The muscle cells self assemble into myotubes around the tails\, while the neurons are hosted by the head. The neurons spontaneously send out long cables of axons preferentially towards the muscle forming functional neuro functional junctions. They also form a neural network within themselves. Upon shining light\, the neurons fire synchronously in a periodic fashion. The muscle contracts and bends the tails to propel the swimmer. This new generation of swimmer powered by neurons paves the way towards intelligent biohybrid machines. The central role of mechanics in the emergence of the biohybrid machines will be highlighted. \nDr Taher Saif received his BS and MS degrees in Civil Engineering from Bangladesh University of Engineering and Technology and Washington State University respectively in 1984 and 1986. He obtained his Ph.D degree in Theoretical and Applied Mechanics from Cornell University in 1993. He worked as a Post Doctoral Associate in Electrical Engineering and the National Nanofabrication Facility at Cornell University during 1993-97. He joined the Department of Mechanical Science and Engineering at the University of Illinois at Urbana-Champaign during 1997. He is curently the Gutgsell Professor in the department. His current research includes tumor micro environment\, mechanics of neurons and cardiac cells\, development of biological machines\, and electro-thermo-mechanical behavior of nano scale metals and semiconductors. \nHe has been invited to IBEC by Samuel Sánchez
URL:https://ibecbarcelona.eu/event/ibec-seminar-taher-saif-3/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20191126T100000
DTEND;TZID=Europe/Madrid:20191126T120000
DTSTAMP:20260406T031659
CREATED:20191118T093609Z
LAST-MODIFIED:20191118T093609Z
UID:96552-1574762400-1574769600@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Emilio Parisini
DESCRIPTION:Drugging the undruggable: towards the development of selective modulators of cadherin-mediated cell-cell adhesion\nEmilio Parisi\, Italian Institute of Technology (Milano) and Latvian Institute of Organic Synthesis (Riga) \nCadherins are transmembrane calcium-dependent cell adhesion proteins that mediate cellular adherens junction formation and tissue morphogenesis. Loss of cadherin-mediated adhesion has been implicated in many different steps of tumor progression such as invasion and migration\, and is strongly related to cell–cell detachment and metastasis. Altered expression profiles of epithelial E-cadherin (CDH1) and neuronal N-cadherin (CDH2) have often been observed in cancer cells\, most notably in the context of the epithelial-to-mesenchymal transition (EMT) process that occurs during cancer progression. Interestingly\, while in the majority of carcinomas E-cadherin is down-regulated\, in some epithelial ovarian cancer (EOC) cells are characterized by high expression levels of E-cadherin\, which facilitates EOC cell proliferation. So far\, structural and mutational studies have provided a rather detailed picture of the highly dynamic cadherin homo-dimerization mechanism. However\, because of this intrinsic dynamic behavior\, the rational design of small ligands targeting cadherin homophilic interactions has proved difficult. We determined the crystal structure of an E-cadherin extracellular fragment in complex with a peptidomimetic compound that partially inhibits cadherin homophilic adhesion. The structure\, which is the first and to date the only crystal structure of a cadherin extracellular portion in complex with a small molecule inhibitor\, reveals an unexpected binding mode and allows the identification of a druggable cadherin interface. Effective cell−cell adhesion modulators may represent potential anti-angiogenic drugs or pharmaceutical excipients to improve drug delivery across biological barriers. \nEmilio Parisini is a Group Leader at the Center for Nano Science and Technology of the Istituto Italiano di Tecnologia (IIT) in Milano. After completing a PhD in Chemistry at the University of Bologna (Italy)\, he worked at the Universities of Göttingen (Germany)\, Cambridge (UK) and Harvard (USA). In his laboratory\, he studies structure-function relationship in several chemical and biological systems\, focusing primarily on the study of the interactions between proteins and their ligands\, substrates or inhibitors. His current research interests include the functional and structural characterization of different members of the Cadherin family of cell adhesion proteins and of several different classes of enzymes for diagnostic (biosensors)\, therapeutic (structure-based drug design) and technological (protein and enzyme engineering) applications. \nHe has been invited to IBEC by Pau Gorostiza.
URL:https://ibecbarcelona.eu/event/ibec-seminar-emilio-parisi-2/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
ORGANIZER;CN="IBEC":MAILTO:www.ibecbarcelona.eu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20191126T100000
DTEND;TZID=Europe/Madrid:20191126T120000
DTSTAMP:20260406T031659
CREATED:20191118T093609Z
LAST-MODIFIED:20191119T141506Z
UID:69274-1574762400-1574769600@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Emilio Parisini
DESCRIPTION:Drugging the undruggable: towards the development of selective modulators of cadherin-mediated cell-cell adhesion\nEmilio Parisi\, Italian Institute of Technology (Milano) and Latvian Institute of Organic Synthesis (Riga) \nCadherins are transmembrane calcium-dependent cell adhesion proteins that mediate cellular adherens junction formation and tissue morphogenesis. Loss of cadherin-mediated adhesion has been implicated in many different steps of tumor progression such as invasion and migration\, and is strongly related to cell–cell detachment and metastasis. Altered expression profiles of epithelial E-cadherin (CDH1) and neuronal N-cadherin (CDH2) have often been observed in cancer cells\, most notably in the context of the epithelial-to-mesenchymal transition (EMT) process that occurs during cancer progression. Interestingly\, while in the majority of carcinomas E-cadherin is down-regulated\, in some epithelial ovarian cancer (EOC) cells are characterized by high expression levels of E-cadherin\, which facilitates EOC cell proliferation. So far\, structural and mutational studies have provided a rather detailed picture of the highly dynamic cadherin homo-dimerization mechanism. However\, because of this intrinsic dynamic behavior\, the rational design of small ligands targeting cadherin homophilic interactions has proved difficult. We determined the crystal structure of an E-cadherin extracellular fragment in complex with a peptidomimetic compound that partially inhibits cadherin homophilic adhesion. The structure\, which is the first and to date the only crystal structure of a cadherin extracellular portion in complex with a small molecule inhibitor\, reveals an unexpected binding mode and allows the identification of a druggable cadherin interface. Effective cell−cell adhesion modulators may represent potential anti-angiogenic drugs or pharmaceutical excipients to improve drug delivery across biological barriers. \nEmilio Parisini is a Group Leader at the Center for Nano Science and Technology of the Istituto Italiano di Tecnologia (IIT) in Milano. After completing a PhD in Chemistry at the University of Bologna (Italy)\, he worked at the Universities of Göttingen (Germany)\, Cambridge (UK) and Harvard (USA). In his laboratory\, he studies structure-function relationship in several chemical and biological systems\, focusing primarily on the study of the interactions between proteins and their ligands\, substrates or inhibitors. His current research interests include the functional and structural characterization of different members of the Cadherin family of cell adhesion proteins and of several different classes of enzymes for diagnostic (biosensors)\, therapeutic (structure-based drug design) and technological (protein and enzyme engineering) applications. \nHe has been invited to IBEC by Pau Gorostiza.
URL:https://ibecbarcelona.eu/event/ibec-seminar-emilio-parisi/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
ORGANIZER;CN="IBEC":MAILTO:www.ibecbarcelona.eu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20200116T120000
DTEND;TZID=Europe/Madrid:20200116T140000
DTSTAMP:20260406T031659
CREATED:20200110T113019Z
LAST-MODIFIED:20200110T113019Z
UID:96580-1579176000-1579183200@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Anotine Huet
DESCRIPTION:Cochlear optical stimulation of the auditory pathway\nAntoine Huet \, Institut für Auditorische Neurowissenschaften\, Universitätsmedizin Göttingen \nOptical stimulation of spiral ganglion neurons (SGNs) in the ear for coding sound information provides an interesting alternative to electrical stimulation that is used in current cochlear implants for hearing restoration. As light can be conveniently confined in space\, optical stimulation promises not only to increase the number of independent stimulation channels\, but also potentially to restore temporal response of SGNs which are phase-locked to the periodicity of the sound. Sensitizing SGNs to light can be achieved either by optogenetic manipulation for expressing a light-sensitive protein\, or by photopharmacological manipulation of receptors native to the cochlea. \nPioneering studies have established proof of principle of optical cochlear stimulation to restore hearing in rodent models of deafness (Hernandez et al\, 2014; Wrobel\, Dieter et al\, 2018). More recent work from the last 2 years have demonstrated i) improvement of frequency selectivity in response to light-over electrical stimuli (Dieter et al\, 2019)\, and ii) activation of the auditory pathway by faster opsins (i.e. shorter closing kinetics) which are more suitable for fast spiking SGNs (Mager\, Lopez de la Morena et al\, 2018\, Keppeler et al\, 2018). Finally\, ongoing work\, in collaboration with the team of Pau Gorostiza\, is showing than a photopharmacological approach targeting AMPA receptors could be used to optically activate the auditory pathway with performance similar to current optogenetic tools. \nDr. Antoine Huet is a postdoctoral fellow in the Institute for Auditory Neuroscience (University Medical Center Göttingen) under the supervision of Prof. Dr. Tobias Moser. Dr Huet received his BS degree in Audiology from the Institut libre Marie-Haps (Brussel\, Belgium) and MS degree in Audiology and auditory neuroscience from the University of Montpellier 1 (Montpellier\, France). He obtained his PhD degree in Chemical and biological science for Health from the University of Montpellier 1 (Montpellier\, France). He worked as a Postdoctoral fellow under the supervision of Pr. J-L. Puel and Jerome Bourien\, PhD in the Institut des neurosciences de Montpellier (INSERM U1051\, France) till May 2018. After\, he joined the laboratory of Pr. Dr. Tobias Moser in the Institute for Auditory Neuroscience from the University Medical Center Göttingen (Germany). His current research interest include the development of viral transfer of suitable ChR variants into spiral ganglion neurons and of multichannel optical stimulation using cochlear implants with arrays of microscale light emitting diodes and waveguides\, characterizing neuronal responses along the auditory pathway using physiological and behavioral methods. Thus\, to finally compare optogenetic to acoustic and electric stimulation. \nHe has been invited to IBEC by Pau Gorostiza
URL:https://ibecbarcelona.eu/event/ibec-seminar-anotine-huet-2/
LOCATION:Torre I Sala 3 Planta -1\, Carrer Baldiri Reixac 4-8\, Barcelona
CATEGORIES:IBEC Seminar
ORGANIZER;CN="IBEC":MAILTO:www.ibecbarcelona.eu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20200116T120000
DTEND;TZID=Europe/Madrid:20200116T140000
DTSTAMP:20260406T031659
CREATED:20200110T113019Z
LAST-MODIFIED:20200110T113032Z
UID:70211-1579176000-1579183200@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Anotine Huet
DESCRIPTION:Cochlear optical stimulation of the auditory pathway\nAntoine Huet \, Institut für Auditorische Neurowissenschaften\, Universitätsmedizin Göttingen \nOptical stimulation of spiral ganglion neurons (SGNs) in the ear for coding sound information provides an interesting alternative to electrical stimulation that is used in current cochlear implants for hearing restoration. As light can be conveniently confined in space\, optical stimulation promises not only to increase the number of independent stimulation channels\, but also potentially to restore temporal response of SGNs which are phase-locked to the periodicity of the sound. Sensitizing SGNs to light can be achieved either by optogenetic manipulation for expressing a light-sensitive protein\, or by photopharmacological manipulation of receptors native to the cochlea. \nPioneering studies have established proof of principle of optical cochlear stimulation to restore hearing in rodent models of deafness (Hernandez et al\, 2014; Wrobel\, Dieter et al\, 2018). More recent work from the last 2 years have demonstrated i) improvement of frequency selectivity in response to light-over electrical stimuli (Dieter et al\, 2019)\, and ii) activation of the auditory pathway by faster opsins (i.e. shorter closing kinetics) which are more suitable for fast spiking SGNs (Mager\, Lopez de la Morena et al\, 2018\, Keppeler et al\, 2018). Finally\, ongoing work\, in collaboration with the team of Pau Gorostiza\, is showing than a photopharmacological approach targeting AMPA receptors could be used to optically activate the auditory pathway with performance similar to current optogenetic tools. \nDr. Antoine Huet is a postdoctoral fellow in the Institute for Auditory Neuroscience (University Medical Center Göttingen) under the supervision of Prof. Dr. Tobias Moser. Dr Huet received his BS degree in Audiology from the Institut libre Marie-Haps (Brussel\, Belgium) and MS degree in Audiology and auditory neuroscience from the University of Montpellier 1 (Montpellier\, France). He obtained his PhD degree in Chemical and biological science for Health from the University of Montpellier 1 (Montpellier\, France). He worked as a Postdoctoral fellow under the supervision of Pr. J-L. Puel and Jerome Bourien\, PhD in the Institut des neurosciences de Montpellier (INSERM U1051\, France) till May 2018. After\, he joined the laboratory of Pr. Dr. Tobias Moser in the Institute for Auditory Neuroscience from the University Medical Center Göttingen (Germany). His current research interest include the development of viral transfer of suitable ChR variants into spiral ganglion neurons and of multichannel optical stimulation using cochlear implants with arrays of microscale light emitting diodes and waveguides\, characterizing neuronal responses along the auditory pathway using physiological and behavioral methods. Thus\, to finally compare optogenetic to acoustic and electric stimulation. \nHe has been invited to IBEC by Pau Gorostiza
URL:https://ibecbarcelona.eu/event/ibec-seminar-anotine-huet/
LOCATION:Torre I Sala 3 Planta -1\, Carrer Baldiri Reixac 4-8\, Barcelona
CATEGORIES:IBEC Seminar
ORGANIZER;CN="IBEC":MAILTO:www.ibecbarcelona.eu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20200206T110000
DTEND;TZID=Europe/Madrid:20200206T130000
DTSTAMP:20260406T031659
CREATED:20200205T084613Z
LAST-MODIFIED:20200205T084613Z
UID:96610-1580986800-1580994000@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Andela Saric
DESCRIPTION:How to build a biological nanomachine\nAndela Saric \, University College London \nThe molecular machinery of life is largely created via self-organisation of individual molecules into functional larger-scaled structures. Such processes are multi-scale in nature and constantly driven far from thermodynamic equilibrium. Our group develops minimal coarse-grained computer models to help understand how the assembly of a large number of macromolecules results in a functional nanomachine\, as well as how such processes can go wrong\, leading to diseases. \nHere I will discuss the physical mechanisms behind two key biological nanomachines that operate via protein assembly – active elastic ESCRT-III filaments that remodel and cut cell membranes and split cells in two\, and bacterial mechanosensitive protein channels that convert mechanical signals into chemical. I will discuss the model development\, simulation results\, and the mapping of the simulation data to in vivo experiments. Beyond their biological context\, our findings can guide the design of artificial structures that are able to manipulate cell membranes and perform work at the nanoscale. \nAndela is an Associate Professor in the Department of Physics and Astronomy and Laboratory for Molecular Cell Biology at University College London. She obtained her PhD from Columbia University in 2013\, followed by postdoctoral research at the University of Cambridge. Andela works in the area of computational biological physics\, developing minimal models to study biological assembly and cell remodelling. She is a recipient of the ERC Starting Grant\, Royal Society University Research Fellowship\, and HFSP Cross-disciplinary Fellowship. \nShe has been invited to IBEC by Josep Samitier
URL:https://ibecbarcelona.eu/event/ibec-seminar-andela-saric-2-2/
LOCATION:Felix Serratosa\, Baldiri Reixac\, 10-12\, Barcelona\, Spain
CATEGORIES:IBEC Seminar
ORGANIZER;CN="IBEC":MAILTO:www.ibecbarcelona.eu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20200206T110000
DTEND;TZID=Europe/Madrid:20200206T130000
DTSTAMP:20260406T031659
CREATED:20200205T084613Z
LAST-MODIFIED:20200205T084613Z
UID:71046-1580986800-1580994000@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Andela Saric
DESCRIPTION:How to build a biological nanomachine\nAndela Saric \, University College London \nThe molecular machinery of life is largely created via self-organisation of individual molecules into functional larger-scaled structures. Such processes are multi-scale in nature and constantly driven far from thermodynamic equilibrium. Our group develops minimal coarse-grained computer models to help understand how the assembly of a large number of macromolecules results in a functional nanomachine\, as well as how such processes can go wrong\, leading to diseases. \nHere I will discuss the physical mechanisms behind two key biological nanomachines that operate via protein assembly – active elastic ESCRT-III filaments that remodel and cut cell membranes and split cells in two\, and bacterial mechanosensitive protein channels that convert mechanical signals into chemical. I will discuss the model development\, simulation results\, and the mapping of the simulation data to in vivo experiments. Beyond their biological context\, our findings can guide the design of artificial structures that are able to manipulate cell membranes and perform work at the nanoscale. \nAndela is an Associate Professor in the Department of Physics and Astronomy and Laboratory for Molecular Cell Biology at University College London. She obtained her PhD from Columbia University in 2013\, followed by postdoctoral research at the University of Cambridge. Andela works in the area of computational biological physics\, developing minimal models to study biological assembly and cell remodelling. She is a recipient of the ERC Starting Grant\, Royal Society University Research Fellowship\, and HFSP Cross-disciplinary Fellowship. \nShe has been invited to IBEC by Josep Samitier
URL:https://ibecbarcelona.eu/event/ibec-seminar-andela-saric-2/
LOCATION:Felix Serratosa\, Baldiri Reixac\, 10-12\, Barcelona\, Spain
CATEGORIES:IBEC Seminar
ORGANIZER;CN="IBEC":MAILTO:www.ibecbarcelona.eu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20200207T100000
DTEND;TZID=Europe/Madrid:20200207T120000
DTSTAMP:20260406T031659
CREATED:20200203T154847Z
LAST-MODIFIED:20200203T154847Z
UID:96605-1581069600-1581076800@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Gema Esquiva
DESCRIPTION:Alteraciones en el sistema melanopsínico en la retinosis pigmentaria y durante el proceso de envejecimiento\nGema Esquiva \, Universitat d’Alacant \nLa retinosis pigmentaria es la degeneración hereditaria de la retina más frecuente\, siendo la cuarta causa de ceguera en el mundo. Además\, en esta enfermedad\, se producen alteraciones en los ritmos circadianos\, esenciales para llevar una vida saludable\, ya que estas alteraciones se relacionan con aumento en el estrés\, insomnio\, depresión y muchas otras patologías. La regulación de los ritmos circadianos se lleva a cabo a través de un tipo de células ganglionares de la retina\, las células melanopsínicas. \nEn este trabajo se describen los diferentes tipos de células ganglionares melanopsínicas en la retina humana\, en la retina de rata y en un modelo animal de retinosis pigmentaria. Además\, evaluamos los cambios morfológicos y de densidad producidos en estas células\, y estudiamos los efectos producidos en los patrones circadianos durante la progresiva degeneración retiniana que ocurre en esta enfermedad. También evaluamos el efecto neuroprotector de la administración de melatonina exógena. \nEl estudio morfológico de la retina en estos animales puso de manifiesto la existencia de 3 tipos de células melanopsínicas en rata de las cuales únicamente dos habían sido descritas hasta el momento. Por otro lado\, observamos una disminución y degeneración de estas células\, asociada a la retinosis pigmentaria y al envejecimiento. \nLos resultados obtenidos mediante técnicas electrorretinográficas y mediante los registros de temperatura corporal y de actividad locomotora desvelaron que los animales modelo de retinosis pigmentaria tenían menor respuesta visual y una alteración de los ritmos circadianos. Los animales modelo de retinosis pigmentaria tratados con melatonina mostraron mayor respuesta visual y mejor regulación de los ritmos circadianos que los animales modelo sin tratar. \nEstos resultados indican que en modelos de retinosis pigmentaria la degeneración de los fotorreceptores clásicos se acompaña de un proceso de remodelación de la retina interna que afecta al sistema melanopsínico. Deducimos que la alteración en los ritmos circadianos se manifiesta a partir de las alteraciones observadas en la densidad y en los procesos dendríticos de las células ganglionares melanopsínicas. En este sentido\, la melatonina ejerce un efecto neuroprotector sobre los fotorreceptores en degeneración\, conos\, bastones y células melanopsínicas de la retina. Por otro lado\, tras el estudio de las retinas humanas concluimos que el envejecimiento se asocia con una pérdida de densidad y arborización dendrítica de las células melanopsínicas lo que posiblemente explica la aparición más frecuente de trastornos del ritmo circadiano en personas de edad avanzada. \nHa sido invitada al IBEC por Pau Gorostiza
URL:https://ibecbarcelona.eu/event/ibec-seminar-gema-esquiva-2/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
ORGANIZER;CN="IBEC":MAILTO:www.ibecbarcelona.eu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20200207T100000
DTEND;TZID=Europe/Madrid:20200207T120000
DTSTAMP:20260406T031659
CREATED:20200203T154847Z
LAST-MODIFIED:20200203T154847Z
UID:70948-1581069600-1581076800@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Gema Esquiva
DESCRIPTION:Alteraciones en el sistema melanopsínico en la retinosis pigmentaria y durante el proceso de envejecimiento\nGema Esquiva \, Universitat d’Alacant \nLa retinosis pigmentaria es la degeneración hereditaria de la retina más frecuente\, siendo la cuarta causa de ceguera en el mundo. Además\, en esta enfermedad\, se producen alteraciones en los ritmos circadianos\, esenciales para llevar una vida saludable\, ya que estas alteraciones se relacionan con aumento en el estrés\, insomnio\, depresión y muchas otras patologías. La regulación de los ritmos circadianos se lleva a cabo a través de un tipo de células ganglionares de la retina\, las células melanopsínicas. \nEn este trabajo se describen los diferentes tipos de células ganglionares melanopsínicas en la retina humana\, en la retina de rata y en un modelo animal de retinosis pigmentaria. Además\, evaluamos los cambios morfológicos y de densidad producidos en estas células\, y estudiamos los efectos producidos en los patrones circadianos durante la progresiva degeneración retiniana que ocurre en esta enfermedad. También evaluamos el efecto neuroprotector de la administración de melatonina exógena. \nEl estudio morfológico de la retina en estos animales puso de manifiesto la existencia de 3 tipos de células melanopsínicas en rata de las cuales únicamente dos habían sido descritas hasta el momento. Por otro lado\, observamos una disminución y degeneración de estas células\, asociada a la retinosis pigmentaria y al envejecimiento. \nLos resultados obtenidos mediante técnicas electrorretinográficas y mediante los registros de temperatura corporal y de actividad locomotora desvelaron que los animales modelo de retinosis pigmentaria tenían menor respuesta visual y una alteración de los ritmos circadianos. Los animales modelo de retinosis pigmentaria tratados con melatonina mostraron mayor respuesta visual y mejor regulación de los ritmos circadianos que los animales modelo sin tratar. \nEstos resultados indican que en modelos de retinosis pigmentaria la degeneración de los fotorreceptores clásicos se acompaña de un proceso de remodelación de la retina interna que afecta al sistema melanopsínico. Deducimos que la alteración en los ritmos circadianos se manifiesta a partir de las alteraciones observadas en la densidad y en los procesos dendríticos de las células ganglionares melanopsínicas. En este sentido\, la melatonina ejerce un efecto neuroprotector sobre los fotorreceptores en degeneración\, conos\, bastones y células melanopsínicas de la retina. Por otro lado\, tras el estudio de las retinas humanas concluimos que el envejecimiento se asocia con una pérdida de densidad y arborización dendrítica de las células melanopsínicas lo que posiblemente explica la aparición más frecuente de trastornos del ritmo circadiano en personas de edad avanzada. \nHa sido invitada al IBEC por Pau Gorostiza
URL:https://ibecbarcelona.eu/event/ibec-seminar-gema-esquiva/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
ORGANIZER;CN="IBEC":MAILTO:www.ibecbarcelona.eu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20200214T100000
DTEND;TZID=Europe/Madrid:20200214T120000
DTSTAMP:20260406T031659
CREATED:20200130T145950Z
LAST-MODIFIED:20200203T160844Z
UID:70818-1581674400-1581681600@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Marc Vendrell
DESCRIPTION:Translational chemistry\, optical imaging and precision medicine\nMarc Vendrell \, University of Edinburgh \nOptical imaging has revolutionised our understanding of how biological systems behave at the molecular level. In the last years\, my group has developed dynamic activatable fluorophores (DYNAFLUORS) as chemical tools to image the function and activity of immune cells in disease. We have used the probes to interrogate the dynamics of biology in real time and also translated some of them for clinical applications\, including first-in-human studies. My group is currently focused on creating new probes that can help us understand the roles that specific subsets of immune cells play in the tumour microenvironment and improve personalised therapeutic approaches.\nGroup website: www.dynafluors.co.uk \nMarc Vendrell graduated in Chemistry at the University of Barcelona in 2007. He then joined the Singapore Bioimaging Consortium to work with Young-Tae Chang in the design of synthetic fluorophores for optical imaging. In 2012 he started his independent career as an MRC Academic Fellow at the University of Edinburgh and is now a Senior Lecturer in Biomedical Imaging. He has over 90 publications\, including 11 patents with multiple fluorescent probes being commercialised by Merck and Biolegend and some currently undergoing clinical studies. His research has been recognised with several international awards and distinctions\, including an ERC Consolidator Grant (2017)\, the Marcial Moreno Lectureship (2018) and the SRUK Emerging Talent Award (2019). \nHe has been invited to Sílvia Pujals and Lorenzo Albertazzi
URL:https://ibecbarcelona.eu/event/ibec-seminar-andela-saric/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20200214T100000
DTEND;TZID=Europe/Madrid:20200214T120000
DTSTAMP:20260406T031659
CREATED:20200130T145950Z
LAST-MODIFIED:20200130T145950Z
UID:96600-1581674400-1581681600@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Marc Vendrell
DESCRIPTION:Translational chemistry\, optical imaging and precision medicine\nMarc Vendrell \, University of Edinburgh \nOptical imaging has revolutionised our understanding of how biological systems behave at the molecular level. In the last years\, my group has developed dynamic activatable fluorophores (DYNAFLUORS) as chemical tools to image the function and activity of immune cells in disease. We have used the probes to interrogate the dynamics of biology in real time and also translated some of them for clinical applications\, including first-in-human studies. My group is currently focused on creating new probes that can help us understand the roles that specific subsets of immune cells play in the tumour microenvironment and improve personalised therapeutic approaches.\nGroup website: www.dynafluors.co.uk \nMarc Vendrell graduated in Chemistry at the University of Barcelona in 2007. He then joined the Singapore Bioimaging Consortium to work with Young-Tae Chang in the design of synthetic fluorophores for optical imaging. In 2012 he started his independent career as an MRC Academic Fellow at the University of Edinburgh and is now a Senior Lecturer in Biomedical Imaging. He has over 90 publications\, including 11 patents with multiple fluorescent probes being commercialised by Merck and Biolegend and some currently undergoing clinical studies. His research has been recognised with several international awards and distinctions\, including an ERC Consolidator Grant (2017)\, the Marcial Moreno Lectureship (2018) and the SRUK Emerging Talent Award (2019). \nHe has been invited to Sílvia Pujals and Lorenzo Albertazzi
URL:https://ibecbarcelona.eu/event/ibec-seminar-andela-saric-3/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20200417T100000
DTEND;TZID=Europe/Madrid:20200417T120000
DTSTAMP:20260406T031659
CREATED:20200409T075542Z
LAST-MODIFIED:20200414T111359Z
UID:73222-1587117600-1587124800@ibecbarcelona.eu
SUMMARY:Online IBEC Seminar: Javier Ramón
DESCRIPTION:Bioprinting methods for organ-on-a-chip applications\n \nJavier Ramón \, IBEC \nEngineered tissues in three-dimensional (3D) cell culture platforms that resemble the complex native structure and organization can be used as in vitro models to study tissues physiology and metabolism. Our technology allows us to develop a new platform to model metabolic and muscle diseases in vitro in order to study its response to candidate therapeutics and to better understand disease mechanisms of pathogenesis. To this end\, we monitor the secretion of disease-associated biomarker proteins and metabolites. \nHere\, we present 3D skeletal muscle constructs\, fabricated by encapsulating C2C12 cells and pancreatic mouse islets in a photocrosslinkable Gelatin Methacrylate (GelMA) and Carboxymethylcellulose Methacrylate (GelMA:CMCMA) hydrogel and cryogel scaffolds. These scaffolds present a microgrooved topography that promotes cell alignment and differentiation. These 3D tissues are integrated with biosensors for in situ monitorization of cytokines and hormones released under different external stimuli\, toxins\, drugs or electrical stimulation. \nWe have obtained a new platform to study the evolution of congenital muscle diseases\, specifically myotonic dystrophy 1 and evaluate the functional tissues by metabolic and gene expression analysis. Monitor the secretion of biomarkers proteins\, metabolites\, and the glycolysis pathway of muscle tissues for different drug candidates. Discussion: This platform has been tested with different drugs assays and represent a step toward the goal of producing in vitro drug testing systems for medical and pharmaceutical industry applications. Finally\, such “multi tissue-on-a-chip” devices can be fabricated using patient’s own cells as a major step toward personalized medicine. \nThe seminar will take place online at the GoToMeeting Platform \nKnow more about Javier Ramón’s research here
URL:https://ibecbarcelona.eu/event/online-ibec-seminar-javier-ramon/
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20200421T160000
DTEND;TZID=Europe/Madrid:20200421T170000
DTSTAMP:20260406T031659
CREATED:20200415T101113Z
LAST-MODIFIED:20200415T101223Z
UID:73449-1587484800-1587488400@ibecbarcelona.eu
SUMMARY:Online IBEC Seminar: Lorenzo Albertazzi
DESCRIPTION:A super-resolved look at nanomedicine\n \nLorenzo Albertazzi \, IBEC \nNanomaterials revolutionized the field of biomedicine introducing innovative approaches towards drug delivery\, molecular imaging\, regenerative medicine and biosensing. However\, despite the large investments in nanotechnology the translation into clinical applications is still unsatisfactory. One of the main reasons is the lack of knowledge about the behavior of nanostructures in the biological environment that makes the rational design of effective materials extremely challenging. \nThe main aim of our group is to use advanced microscopy techniques to understand the interactions of nanomaterials with living matter and to exploit this information to design novel devices for biomedical applications with a particular focus on drug delivery. To this goal we employ innovative optical imaging techniques such as super resolution microscopy to visualize and understand the molecular interactions of nanomaterials with their cellular targets in unprecedented detail. Super resolution microscopy techniques such as stochastic optical reconstruction microscopy (STORM) and point accumulation for imaging in nanoscale topography (PAINT) offer nanometric resolution and multicolor ability\, therefore they are ideal tools to study nano-sized multicomponent functional objects in vitro and in cells. This allows to get a closer “look” at the mechanisms of the key phenomena responsible for device performances such as particle stability\, protein corona and targeting. The fundamental knowledge acquired will pave the way towards the “microscopy-guided” design of novel nanomaterials for drug and gene delivery. \nThe seminar will take place online at the GoToMeeting Platform \nKnow more about Lorenzo Albertazzi’s research here
URL:https://ibecbarcelona.eu/event/online-ibec-seminar-lorenzo-albertazzi/
CATEGORIES:IBEC Seminar
ORGANIZER;CN="IBEC":MAILTO:www.ibecbarcelona.eu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20200428T160000
DTEND;TZID=Europe/Madrid:20200428T180000
DTSTAMP:20260406T031659
CREATED:20200421T075141Z
LAST-MODIFIED:20200421T075153Z
UID:73630-1588089600-1588096800@ibecbarcelona.eu
SUMMARY:Online IBEC Seminar: Samuel Sánchez
DESCRIPTION:BioEngineering Hybrid Robotic Machines: from nanobots to 3D Bioprinted Robots\n \nSamuel Sánchez \, IBEC \nThe combination of biological components and artificial ones emerges into what we called hybrid machines/bots/robots. Here\, I will present two types of hybrid systems that we are currently developing in our lab which span across different length scales\, from a few nanometers to centimeters. \nAlike bacteria or small swimmers found in nature\, these artificial nanobots convert bio-available fuels to generate propulsion force to swim at the nanoscale. One of the dreams in nanotechnology is to engineer small vehicles which can eventually be applied in vivo for medical purposes. In the first part of my talk\, I will present how we bioengineer our hybrid nanobots combining the best from the two worlds: biology (enzymes) and (nano)technology (nano- micro-particles) providing swimming capabilities\, biocompatibility\, remote control\, multifunctionality and actuation. I will present some of the proof-of-concept applications such as the efficient transport of drugs into cancer cells and spheroids\, sensing capabilities and the use of molecular imaging techniques for their tracking and localization both in vitro and in vivo. \nIn the second part of my talk\, I will present the 3D bioprinting technique to fabricate hybrid 3D BIOBOTS which provides flexibility\, scalability\, rapid prototyping and simplicity. This technique has emerged as a powerful tool for the development of functional three-dimensional tissues and\, in particular\, skeletal muscle. By electrical stimulation\, we studied the adaptability of 3D hybrid Robots after long-term trainings and the force evolution during the trainings together with the dynamic gene expression. Two types of devices are bioengineered in our lab: (i) 3D Actuators which useful force measurement platform for drug screening against dystrophies and (ii) 3D BIOBOTS that can be a next generation of living soft robotics systems with swimming capabilities. \nThe seminar will take place online at the GoToMeeting Platform \nKnow more about Samuel Sánchez’s research here
URL:https://ibecbarcelona.eu/event/online-ibec-seminar-samuel-sanchez/
CATEGORIES:IBEC Seminar
ORGANIZER;CN="IBEC":MAILTO:www.ibecbarcelona.eu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20200508T100000
DTEND;TZID=Europe/Madrid:20200508T120000
DTSTAMP:20260406T031659
CREATED:20200421T095637Z
LAST-MODIFIED:20200429T141022Z
UID:73634-1588932000-1588939200@ibecbarcelona.eu
SUMMARY:Online IBEC Seminar: Elena Martínez
DESCRIPTION:Development of biomimetic models of intestinal tissue: guiding cellular self-organization through biofabrication techniques\n\nElena Martínez \, IBEC \nEpithelial tissues contain three-dimensional (3D) microstructures that guide cell self-organization at the tissue level. In the small intestine\, crypts and finger-like villi microstructures improve its absorbance function\, provides specific microenvironments and compartmentalizes cell types. Despite its physiological relevance\, tissue architecture and multicellular population are neglected in the standard in vitro models\, thus compromising their predictive capabilities. Our efforts in addressing these shortcomings by including key elements to mimic the native tissue in vitro will be discussed in this talk. First\, this will include strategies to promote cell’s self-organization capabilities giving rise to crypt-villus domains on 2D monolayers\, and strategies to engineer cell spatial positioning through micropatterning. Then\, our approach to include the 3D architecture of the tissue will be addressed. In here\, light-based biofabrication techniques to produce 3D villus-like structures will be discussed. Finally\, I will introduce our biofabrication proposal to produce tissue engineered models that include the epithelial and the stromal compartments. Improving the prediction capabilities of cell-based assays is a growing strategy to lead to more efficient drug development processes. As 2D-based systems are showing their limits\, new 3D strategies are gaining acceptance among the scientific community. Our approaches aim to further accelerate this trend by providing feasible strategies to routinely incorporate 3D multicellular structures at the tissue level in cell culture systems. \nThe seminar will take place online at the GoToMeeting Platform \nKnow more about Elena Martínez’s research here
URL:https://ibecbarcelona.eu/event/online-ibec-seminar-elena-martinez/
CATEGORIES:IBEC Seminar
ORGANIZER;CN="IBEC":MAILTO:www.ibecbarcelona.eu
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END:VCALENDAR