BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Institute for Bioengineering of Catalonia - ECPv6.15.20//NONSGML v1.0//EN
CALSCALE:GREGORIAN
METHOD:PUBLISH
X-WR-CALNAME:Institute for Bioengineering of Catalonia
X-ORIGINAL-URL:https://ibecbarcelona.eu
X-WR-CALDESC:Events for Institute for Bioengineering of Catalonia
REFRESH-INTERVAL;VALUE=DURATION:PT1H
X-Robots-Tag:noindex
X-PUBLISHED-TTL:PT1H
BEGIN:VTIMEZONE
TZID:Europe/Madrid
BEGIN:DAYLIGHT
TZOFFSETFROM:+0100
TZOFFSETTO:+0200
TZNAME:CEST
DTSTART:20220327T010000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:+0200
TZOFFSETTO:+0100
TZNAME:CET
DTSTART:20221030T010000
END:STANDARD
BEGIN:DAYLIGHT
TZOFFSETFROM:+0100
TZOFFSETTO:+0200
TZNAME:CEST
DTSTART:20230326T010000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:+0200
TZOFFSETTO:+0100
TZNAME:CET
DTSTART:20231029T010000
END:STANDARD
BEGIN:DAYLIGHT
TZOFFSETFROM:+0100
TZOFFSETTO:+0200
TZNAME:CEST
DTSTART:20240331T010000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:+0200
TZOFFSETTO:+0100
TZNAME:CET
DTSTART:20241027T010000
END:STANDARD
END:VTIMEZONE
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20230609T100000
DTEND;TZID=Europe/Madrid:20230609T110000
DTSTAMP:20260509T145136
CREATED:20230529T161933Z
LAST-MODIFIED:20230529T161933Z
UID:108343-1686304800-1686308400@ibecbarcelona.eu
SUMMARY:PhD Complementary Skills: From Lab to Clinic
DESCRIPTION:From Lab to Clinic: An Overview of IBEC’s Clinical Mentoring Programme\nDo you know what IBEC’s Clinical Mentoring Programme is about? Have you considered participating in it?\nIn this Complementary Skills session\, Anna Gassol and Georgina Sorrosal from Col·legi official de Metges (COMB) together with Cristina Arimany from the Strategic Initiatives department at IBEC will explain the basis of the program. Meritxell Serra Casablancas (Smart Nano-Bio-Devices Group) and Luisa Camerin (Nanoprobes and Nanoswitches Group) will share their experience as the first mentees participating in the programme.\nThis will also be a great opportunity to learn how the programme can help in the clinical translation of the work done at IBEC and answer any questions you may have about it.
URL:https://ibecbarcelona.eu/event/phd-complementary-skills-from-lab-to-clinic/
LOCATION:Sala Dolors Aleu\, Cluster II\, IBEC\, Baldiri i Reixac\, Barcelona
CATEGORIES:PhD Discussions Complementary Skills Session
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20230630T100000
DTEND;TZID=Europe/Madrid:20230630T110000
DTSTAMP:20260509T145136
CREATED:20230621T150854Z
LAST-MODIFIED:20230623T093647Z
UID:108921-1688119200-1688122800@ibecbarcelona.eu
SUMMARY:PhD Discussion: Isabela Fortunato y Marina Martinez
DESCRIPTION:Cell migration up and down fibronectin gradients\nIsabela Fortunato\, Integrative cell and tissue dynamics group \nThe ability of cells to perform directed migration is essential for biological processes\, such as tissue morphogenesis\, immune function\, and cancer invasion. Directed cell migration is often triggered by spatial gradients in the cellular environment (e.g.\, chemical gradients\, called chemotaxis\, substrate stiffness gradients\, called durotaxis\, or substrate-bound ligand gradients\, called haptotaxis). Haptotaxis has been described in vivo as an important phenomenon during physiological and pathological conditions. However\, the molecular and mechanical processes that drive this form of directed cell migration remain elusive. Moreover\, generating accurate and reliable gradients of immobilized protein in vitro has been challenging and makes it harder to study haptotaxis. Here\, we explore how cells sense and respond to gradients of immobilized proteins. We used a photopatterning technique to create well-controlled fibronectin gradients and we studied the migration of single mammary epithelial cells (MCF-10A). This approach allowed us to map cell migration velocity\, traction forces\, and actin cytoskeleton dynamics as a function of fibronectin density. We observed that cells respond to fibronectin gradients by an initial polarization towards higher protein density in the first hours of migration. Surprisingly\, after the initial polarization\, cells maintained their directionality even if they were submitted to a negative protein gradient. This suggests that cells adapt their polarity features to maintain the preexisting structures and organelles geometry towards low fibronectin regions until a limitation on creating new adhesions. In this work we find that one key adaptation mechanism is driven by the actin flows\, specifically the increase in actin polymerization velocity at the leading edge. Besides haptotaxis\, we foresee that these results will shed light on other forms of directed cell migration in which cells integrate several internal and external cues to orient themselves in physiological and pathological processes. \n\nLiving myocardial slices as a representative in vitro platform for translational cardiovascular disease\nMarina Martínez\, Biomaterials for Regenerative Therapies group \nCardiovascular diseases are the leading cause of global mortality\, accounting for nearly 45% of all deaths in Europe. Myocardial infarction (MI) is a prevalent condition\, where a region of the cardiac muscle undergoes ischemia and up to one billion cardiomyocytes die in just a few hours. The heart has a limited regenerative ability; consequently\, cardiomyocytes lost due to MI cannot be replaced. In this scenario\, researchers have investigated and developed alternative therapies to promote cardiac repair and regeneration. \nLactate\, an important metabolite during cardiogenesis and cardiac development\, has been recently described as a potential modulator of the phenotype of cardiac cells in vitro. These findings support a novel use of lactate for endogenous heart regeneration strategies. Nevertheless\, effectiveness of ongoing therapeutic approaches is dependent on the level of maturation of cardiac tissue. Hitherto\, the regenerative capabilities of lactate in mature cardiac tissue have not been described. In this work\, we used living myocardial slices (LMS) as a model of mature cardiac tissue. LMS are 300 μm-thick slices of living myocardium with conserved physiological structure and function. Human and rat adult LMS were treated with lactate to evaluate early cellular\, molecular\, and functionality changes related to myocardial reprogramming\, cardiac structural rearrangements\, and fibrosis. Moreover\, the effect of lactate was characterized in both healthy and injured adult myocardium. \nFunctionally\, (8 mM) lactate-treated healthy and pathological human LMS displayed an increase in contractility. Expression of fibrotic\, pluripotency transcription factors\, and cardiomyocyte markers were detected. Exposure of healthy rat LMS to higher concentrations of lactate (20 mM) did not affect LMS viability nor altered LMS contractile force\, while promoted LMS stiffening. In cryoinjured rat LMS\, lactate drastically increased contractility and altered tissue remodeling in the region bordering the injury. \nLMS provide a representative in vitro platform for translational cardiovascular research. By using LMS\, characterization of the effect of lactate in mature cardiac tissue has been achieved. Exogenous lactate enhanced cardiac function in both human and injured rat LMS. Upregulation of transcription factors and cardiomyocyte markers may suggest an effect on partial cardiomyocyte reprogramming that would counteract the effects of tissue stiffening. Altogether\, this study further supports the prospective use of lactate as a bioactive signal in new endogenous cardiac regeneration strategies. \nThis PhD Discussion session will be held at Tower I\, 11th floor Baobab room\, at 10:00am.
URL:https://ibecbarcelona.eu/event/phd-discussion-isabela-fortunato/
LOCATION:Sala Dolors Aleu\, Cluster II\, IBEC\, Baldiri i Reixac\, Barcelona
CATEGORIES:PhD Discussions Complementary Skills Session
END:VEVENT
END:VCALENDAR