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DTSTART;TZID=Europe/Madrid:20221125T100000
DTEND;TZID=Europe/Madrid:20221125T120000
DTSTAMP:20260516T203929
CREATED:20221116T090407Z
LAST-MODIFIED:20221116T090407Z
UID:101122-1669370400-1669377600@ibecbarcelona.eu
SUMMARY:PhD Discussions: Maria Gallo and Nimesh Chahare
DESCRIPTION:Generation Of Reporter Human Pluripotent Stem Cell Lines To Study Cardiac Development And Disease\nMaria Gallo\, Pluripotency for organ regeneration Group \nThe development and the use of human pluripotent stem cells (hPSCs) represent an effective tool to recapitulate characteristics related to tissue differentiation\, morphogenesis and conversely\, human diseases. Through their inherent capacity to differentiate towards the three germ layers and their easy manipulation\, it has been possible to generate three dimensional (3D) self-organized organ-like structures\, the so-called organoids. In this context\, the advent of CRISPR-Cas9 technology has now allow to incorporate permanent or transient changes in the genome of living organisms and cells. Our laboratory has developed a cellular platform\, named iCRISPR2 (iC2)\, that allows to perform highly efficient genome editing in hPSCs through the insertion of an inducible Cas9 under the endogenous TET/ON promoter. This platform allowed us the generation of reporter\, knock-out and knock-in hPSCs lines. By exploiting the generation of cardiac reporter cell lines it has been possible to define new approaches for the generation of self-assembled cardiac-like organoids. Cardioids have been characterized at conventional molecular biology techniques\, confocal microscopy and functional analysis. Moreover\, taking advantages of specific cell culture conditions emulating early stages of diabetic cardiomyopathy it has been possible to establish a platform for the interrogation of transcriptional and functional changes during diabetic disease. \n\nMechanics of epithelial layers subjected to controlled pressure\nNimesh Chahare\, Integrative cell and tissue dynamics Group \nEpithelial sheets form specialized 3D structures suited to their physiological roles\, such as branched alveoli in the lungs\, tubes in the kidney\, and villi in the intestine. To generate and maintain these structures\, epithelia must undergo complex 3D deformations across length and time scales. How epithelial shape arises from active stresses\, viscoelasticity\, and luminal pressure remains poorly understood. To address this question\, we developed a microfluidic chip and a computational framework to engineer 3D epithelial tissues with controlled shape and pressure. In the setup\, an epithelial monolayer is grown on a porous surface with circular low adhesion zones. On applying hydrostatic pressure\, the monolayer delaminates into a spherical cap from the circular zone. This simple shape allows us to calculate epithelial tension using Laplace’s law. Through this approach\, we subject the monolayer to a range of lumen pressures at different rates and hence probe the relation between strain and tension in different regimes while computationally tracking actin dynamics and their mechanical effect at the tissue scale. Slow pressure changes relative to the actin dynamics allow the tissue to accommodate large strain variations. However\, under sudden pressure reductions\, the tissue develops buckling patterns and folds with different degrees of symmetry-breaking to store excess tissue area. These insights allow us to pattern epithelial folds through rationally directed buckling. Our study establishes a new approach for engineering epithelial morphogenetic events. \n  \nThis PhD Discussion session will be held at Tower I\, 11th floor Baobab room\, at 10:00am.
URL:https://ibecbarcelona.eu/event/phd-discussions-maria-gallo-and-nimesh-chahare/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:PhD Discussions Complementary Skills Session
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20230303T100000
DTEND;TZID=Europe/Madrid:20230303T120000
DTSTAMP:20260516T203929
CREATED:20230222T091933Z
LAST-MODIFIED:20230227T120702Z
UID:104641-1677837600-1677844800@ibecbarcelona.eu
SUMMARY:PhD Complementary Skills Session: Life at IBEC: Opportunities for PhD students
DESCRIPTION:Are you doing your PhD at IBEC? Do you know what you need to apply for the PhD Certificate of excellence or award? Do you know there are many different committees that you can join? Have you heard about the mentoring and training sessions that you can join? What about other mobility programmes? Would you like to participate in science education or outreach activities\, and you do not know who to talk to? Do you have any idea of how to proceed when you publish your first paper? \nAll these questions and many others will be answered in our next Complementary Skills session.  Come and learn with IBEC’s research management team and the IBEC PhD committee all the opportunities for PhDs that we offer at IBEC. \n  \nCarolina Mari and Arnau Fornell\, HR Department \nMaria Arista\, Communications Department \nCristina Arimany and Fidel Bellmunt\, Strategic Initiatives Department \nMiquel Bosch\, PhD Committee
URL:https://ibecbarcelona.eu/event/phd-complementary-skills-session-life-at-ibec-opportunities-for-phd-students/
LOCATION:Sala Dolors Aleu\, Cluster II\, IBEC\, Baldiri i Reixac\, Barcelona
CATEGORIES:PhD Discussions Complementary Skills Session
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20230609T100000
DTEND;TZID=Europe/Madrid:20230609T110000
DTSTAMP:20260516T203929
CREATED:20230529T161933Z
LAST-MODIFIED:20230529T161933Z
UID:108343-1686304800-1686308400@ibecbarcelona.eu
SUMMARY:PhD Complementary Skills: From Lab to Clinic
DESCRIPTION:From Lab to Clinic: An Overview of IBEC’s Clinical Mentoring Programme\nDo you know what IBEC’s Clinical Mentoring Programme is about? Have you considered participating in it?\nIn this Complementary Skills session\, Anna Gassol and Georgina Sorrosal from Col·legi official de Metges (COMB) together with Cristina Arimany from the Strategic Initiatives department at IBEC will explain the basis of the program. Meritxell Serra Casablancas (Smart Nano-Bio-Devices Group) and Luisa Camerin (Nanoprobes and Nanoswitches Group) will share their experience as the first mentees participating in the programme.\nThis will also be a great opportunity to learn how the programme can help in the clinical translation of the work done at IBEC and answer any questions you may have about it.
URL:https://ibecbarcelona.eu/event/phd-complementary-skills-from-lab-to-clinic/
LOCATION:Sala Dolors Aleu\, Cluster II\, IBEC\, Baldiri i Reixac\, Barcelona
CATEGORIES:PhD Discussions Complementary Skills Session
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20230630T100000
DTEND;TZID=Europe/Madrid:20230630T110000
DTSTAMP:20260516T203929
CREATED:20230621T150854Z
LAST-MODIFIED:20230623T093647Z
UID:108921-1688119200-1688122800@ibecbarcelona.eu
SUMMARY:PhD Discussion: Isabela Fortunato y Marina Martinez
DESCRIPTION:Cell migration up and down fibronectin gradients\nIsabela Fortunato\, Integrative cell and tissue dynamics group \nThe ability of cells to perform directed migration is essential for biological processes\, such as tissue morphogenesis\, immune function\, and cancer invasion. Directed cell migration is often triggered by spatial gradients in the cellular environment (e.g.\, chemical gradients\, called chemotaxis\, substrate stiffness gradients\, called durotaxis\, or substrate-bound ligand gradients\, called haptotaxis). Haptotaxis has been described in vivo as an important phenomenon during physiological and pathological conditions. However\, the molecular and mechanical processes that drive this form of directed cell migration remain elusive. Moreover\, generating accurate and reliable gradients of immobilized protein in vitro has been challenging and makes it harder to study haptotaxis. Here\, we explore how cells sense and respond to gradients of immobilized proteins. We used a photopatterning technique to create well-controlled fibronectin gradients and we studied the migration of single mammary epithelial cells (MCF-10A). This approach allowed us to map cell migration velocity\, traction forces\, and actin cytoskeleton dynamics as a function of fibronectin density. We observed that cells respond to fibronectin gradients by an initial polarization towards higher protein density in the first hours of migration. Surprisingly\, after the initial polarization\, cells maintained their directionality even if they were submitted to a negative protein gradient. This suggests that cells adapt their polarity features to maintain the preexisting structures and organelles geometry towards low fibronectin regions until a limitation on creating new adhesions. In this work we find that one key adaptation mechanism is driven by the actin flows\, specifically the increase in actin polymerization velocity at the leading edge. Besides haptotaxis\, we foresee that these results will shed light on other forms of directed cell migration in which cells integrate several internal and external cues to orient themselves in physiological and pathological processes. \n\nLiving myocardial slices as a representative in vitro platform for translational cardiovascular disease\nMarina Martínez\, Biomaterials for Regenerative Therapies group \nCardiovascular diseases are the leading cause of global mortality\, accounting for nearly 45% of all deaths in Europe. Myocardial infarction (MI) is a prevalent condition\, where a region of the cardiac muscle undergoes ischemia and up to one billion cardiomyocytes die in just a few hours. The heart has a limited regenerative ability; consequently\, cardiomyocytes lost due to MI cannot be replaced. In this scenario\, researchers have investigated and developed alternative therapies to promote cardiac repair and regeneration. \nLactate\, an important metabolite during cardiogenesis and cardiac development\, has been recently described as a potential modulator of the phenotype of cardiac cells in vitro. These findings support a novel use of lactate for endogenous heart regeneration strategies. Nevertheless\, effectiveness of ongoing therapeutic approaches is dependent on the level of maturation of cardiac tissue. Hitherto\, the regenerative capabilities of lactate in mature cardiac tissue have not been described. In this work\, we used living myocardial slices (LMS) as a model of mature cardiac tissue. LMS are 300 μm-thick slices of living myocardium with conserved physiological structure and function. Human and rat adult LMS were treated with lactate to evaluate early cellular\, molecular\, and functionality changes related to myocardial reprogramming\, cardiac structural rearrangements\, and fibrosis. Moreover\, the effect of lactate was characterized in both healthy and injured adult myocardium. \nFunctionally\, (8 mM) lactate-treated healthy and pathological human LMS displayed an increase in contractility. Expression of fibrotic\, pluripotency transcription factors\, and cardiomyocyte markers were detected. Exposure of healthy rat LMS to higher concentrations of lactate (20 mM) did not affect LMS viability nor altered LMS contractile force\, while promoted LMS stiffening. In cryoinjured rat LMS\, lactate drastically increased contractility and altered tissue remodeling in the region bordering the injury. \nLMS provide a representative in vitro platform for translational cardiovascular research. By using LMS\, characterization of the effect of lactate in mature cardiac tissue has been achieved. Exogenous lactate enhanced cardiac function in both human and injured rat LMS. Upregulation of transcription factors and cardiomyocyte markers may suggest an effect on partial cardiomyocyte reprogramming that would counteract the effects of tissue stiffening. Altogether\, this study further supports the prospective use of lactate as a bioactive signal in new endogenous cardiac regeneration strategies. \nThis PhD Discussion session will be held at Tower I\, 11th floor Baobab room\, at 10:00am.
URL:https://ibecbarcelona.eu/event/phd-discussion-isabela-fortunato/
LOCATION:Sala Dolors Aleu\, Cluster II\, IBEC\, Baldiri i Reixac\, Barcelona
CATEGORIES:PhD Discussions Complementary Skills Session
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20240112T100000
DTEND;TZID=Europe/Madrid:20240112T110000
DTSTAMP:20260516T203929
CREATED:20231221T143650Z
LAST-MODIFIED:20240103T092736Z
UID:113540-1705053600-1705057200@ibecbarcelona.eu
SUMMARY:Transversal skills: Tess Marschner
DESCRIPTION:ANIMAL REMINDER\nPosthuman\, queer and animate perspectives on (Techno)Sciences \nI will introduce my previous artistic work and share the current state of my project at Ibec. It would be magnificent if my presentation leads to further thoughts and collaborations that are of interest to my project. \nI will focus on my installation work ANIMAL REMINDER in terms of intertwining artistic and scientific knowledge production. The philosopher Martha C. Nussbaum describes animal reminders as parts or aspects of the human body that evoke a strong aversion or even disgust: Blood\, saliva\, urine\, sweat\, amniotic fluid\, pus\, breast milk\, faeces\, ejaculate. Body surfaces of living beings are perforated several times\, ANIMAL REMINDER emerge from pores and body orifices\, interfaces of skins and mucous membranes at the boundary to air\, water and earth. ANIMAL REMINDER are reminiscent of the process of decomposition\, of slimy animals\, the uncontrollable loss of bodily fluids. They remind us that we ourselves are mortal and animal beings. \nIn case you are heavily interested in my work but unable to attend\, feel free to write me a pm and we can figure out a personal meeting.
URL:https://ibecbarcelona.eu/event/transversal-skills-tess-marschner/
LOCATION:Sala Dolors Aleu\, Cluster II\, IBEC\, Baldiri i Reixac\, Barcelona
CATEGORIES:PhD Discussions Complementary Skills Session
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20241129T100000
DTEND;TZID=Europe/Madrid:20241129T110000
DTSTAMP:20260516T203929
CREATED:20241120T135537Z
LAST-MODIFIED:20241120T135537Z
UID:121631-1732874400-1732878000@ibecbarcelona.eu
SUMMARY:Complementary Skills Session: "Science: Comedy and Communication"
DESCRIPTION:Science: Comedy and Communication\nDr Matthew Murtha\, https://drmurtha.com/ \nDr Matthew Murtha earned his PhD at Ohio State University where his work contributed to several therapies that have passed clinical trials. He completed post-docs at NYU and IBIDELL where his pioneering functional genomics techniques were used to investigate molecular causes of autism. He has since left the lab to devote himself full time to science communication.\nIn his talk\, a combination of stand up and story telling\, he’ll talk about how he came to be a scientist and then communicator and will give some tips on how to communicate sciecne and make it more understandable and attractive for a non-scientific audience. \n 
URL:https://ibecbarcelona.eu/event/complementary-skills-session-science-comedy-and-communication/
LOCATION:Sala Dolors Aleu\, Cluster II\, IBEC\, Baldiri i Reixac\, Barcelona
CATEGORIES:PhD Discussions Complementary Skills Session
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20250207T100000
DTEND;TZID=Europe/Madrid:20250207T110000
DTSTAMP:20260516T203929
CREATED:20241120T140319Z
LAST-MODIFIED:20241120T140319Z
UID:121641-1738922400-1738926000@ibecbarcelona.eu
SUMMARY:Complementary Skills session: "Artificial Intelligence in Scientific Practice: From Research Labs to Lecture Halls"
DESCRIPTION:“Artificial Intelligence in Scientific Practice: From Research Labs to Lecture Halls”\nSalva Ferrer\, Eduscopi\, Barcelona. \nDiscover how AI is reshaping the landscape of scientific research\, teaching\, and public engagement. This seminar covers a wide range of uses for AI\, including content generation\, data analysis\, and information management tailored to scientists’ needs. Attendees will learn prompt engineering techniques\, compare AI models suited for reliable scientific text generation\, and navigate key ethical challenges like transparency and legalities. Featuring real-world tools for research\, social media\, and educational applications\, this session provides a comprehensive overview of responsible AI use in science. (Of course\, this title and description were generated by an AI).
URL:https://ibecbarcelona.eu/event/complementary-skills-session-artificial-intelligence-in-scientific-practice-from-research-labs-to-lecture-halls/
LOCATION:Sala Dolors Aleu\, Cluster II\, IBEC\, Baldiri i Reixac\, Barcelona
CATEGORIES:PhD Discussions Complementary Skills Session
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