BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Institute for Bioengineering of Catalonia - ECPv6.15.20//NONSGML v1.0//EN
CALSCALE:GREGORIAN
METHOD:PUBLISH
X-ORIGINAL-URL:https://ibecbarcelona.eu
X-WR-CALDESC:Events for Institute for Bioengineering of Catalonia
REFRESH-INTERVAL;VALUE=DURATION:PT1H
X-Robots-Tag:noindex
X-PUBLISHED-TTL:PT1H
BEGIN:VTIMEZONE
TZID:Europe/Madrid
BEGIN:DAYLIGHT
TZOFFSETFROM:+0100
TZOFFSETTO:+0200
TZNAME:CEST
DTSTART:20220327T010000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:+0200
TZOFFSETTO:+0100
TZNAME:CET
DTSTART:20221030T010000
END:STANDARD
BEGIN:DAYLIGHT
TZOFFSETFROM:+0100
TZOFFSETTO:+0200
TZNAME:CEST
DTSTART:20230326T010000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:+0200
TZOFFSETTO:+0100
TZNAME:CET
DTSTART:20231029T010000
END:STANDARD
BEGIN:DAYLIGHT
TZOFFSETFROM:+0100
TZOFFSETTO:+0200
TZNAME:CEST
DTSTART:20240331T010000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:+0200
TZOFFSETTO:+0100
TZNAME:CET
DTSTART:20241027T010000
END:STANDARD
END:VTIMEZONE
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20230203T100000
DTEND;TZID=Europe/Madrid:20230203T130000
DTSTAMP:20260424T044311
CREATED:20230126T085229Z
LAST-MODIFIED:20230126T085229Z
UID:103689-1675418400-1675429200@ibecbarcelona.eu
SUMMARY:PhD Discussions: Gerardo Ceada Torres
DESCRIPTION:Role of Eph/Ephrin in the Compartmentalization of the Intestinal Stem Cell Niche\nGerardo Ceada Torres\, Integrative cell and tissue dynamics Group \nThe intestinal epithelium is a monolayer of cells that covers the inner surface of the gut. It protects against pathogens\, absorbs nutrients\, and secretes hormones and other molecules. This monolayer is folded into finger-like protrusions composed of differentiated cells\, called villi\, and invaginations\, called crypts\, where stem cells reside. Essential features of the intestinal epithelium such as folding of the crypt\, spatial distribution of different cell types\, and cellular movements from crypt to villus-like domains can be recapitulated in vitro in intestinal organoids. Direct force measurements in mouse intestinal organoids grown on soft hydrogels show that tightly regulated cell-ECM and cell-cell forces compartmentalizes the tissue into crypts- and villus-like domains. A dynamic mechanical boundary composed of basally constricted cells is established between the stem cell niche and differentiated cells of the villus-like region. The Eph/Ephrin signaling pathway has been proposed as a key regulator of compartmentalization and cell positioning in the intestinal epithelium. Whether and how Eph/Ephrin signaling governs the mechanical phenotype observed at the crypt-villus boundary remains\, however\, an open question. We are currently addressing this question by genetically perturbing Eph/Ephrin signaling in intestinal organoids. Preliminary data show that EphB2/3 KO organoids display defects in cell positioning\, reduced basal constriction at the crypt-villus boundary and aberrant size of the proliferative and differentiated compartments. \n\n  \n  \nThis PhD Discussion session will be held at Tower I\, 11th floor Baobab room\, at 10:00am.
URL:https://ibecbarcelona.eu/event/phd-discussions-gerardo-ceada-torres/
LOCATION:Sala Dolors Aleu\, Cluster II\, IBEC\, Baldiri i Reixac\, Barcelona
CATEGORIES:PhD Discussions Session
END:VEVENT
END:VCALENDAR