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DTSTART;TZID=Europe/Madrid:20241213T100000
DTEND;TZID=Europe/Madrid:20241213T110000
DTSTAMP:20260424T192631
CREATED:20241122T100707Z
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UID:121781-1734084000-1734087600@ibecbarcelona.eu
SUMMARY:PhD Discussion: Anna Panteleeva and Miguel Gonzalez Martin
DESCRIPTION:Advancing Neurodegenerative Disease Research with Enhanced Brain-on-a-Chip Technology and Integrated Biosensor Systems \nAnna Panteleeva – Nanobioengineering\nNeurodegenerative disorders (NDDs)\, such as Alzheimer’s disease\, remain a critical global health challenge. A key obstacle in drug development is the blood-brain barrier (BBB)\, which plays a crucial role in regulating the exchange of substances between the bloodstream and the brain. While the BBB protects the brain\, its dysfunction contributes to NDD progression\, and it hinders drug delivery\, leaving most therapeutic candidates unsuccessful in clinical trials.\nTraditional animal models have provided valuable insights into NDDs\, but they fall short in fully replicating the complexity of human neural responses. Brain-on-a-chip (BoC) technology has emerged as a promising tool\, offering controlled environments to study neuronal networks. Integrating a BBB component into BoC systems significantly enhances their physiological relevance\, enabling the study of complex BBB properties.\nOur research advances BoC technology by combining a microfluidic device\, multi-electrode array (MEA) technology and biosensors to create a comprehensive BBB model. By co-culturing endothelial cells\, pericytes\, astrocytes\, and neurons\, we replicate key BBB elements and neural interactions. This setup allows real-time monitoring of BBB permeability and neural activity via MEA electrodes\, and neuronal degradation using biosensors. Preliminary results demonstrate promising outcomes\, though further optimization is required.\nThis innovative approach improves the physiological relevance of BoC systems and accelerates drug development and personalized therapies for NDDs\, providing a pathway toward more effective treatments. \nDesigning synthetic mechanosensitive molecules for the mechanical control of cellular transcription \nMiguel Gonzalez Martin – Cellular and Molecular Mechanobiology\nCells sense mechanical signals in the process of mechanotransduction\, activating pathways that govern cell behavior. However\, it remains a challenge to engineer mechanotransduction pathways in a controllable and predictable manner. Here we aim to engineer a synthetic mechanosensitive transcription factor (msTTA). To this end\, we exploit the force induced changes in nuclear transport\, linking nuclear mechanical perturbations to gene expression. To do so\, we are mechanically tuning the passive and facilitated transport properties of the synthetic msTTA. Through this we aim to recapitulate the localization behavior of endogenous mechanosensitive proteins such as YAP or Twist\, but with a synthetic factor that activates genes of choice in a controlled way. Optimizing our reporter cells\, we have set up a novel screening platform with substrates of different rigidity\, from which we expect to identify highly mechanosensitive TF candidates that function in a tunable manner\, as well as to elucidate which features make a transcription factor mechanosensitive. Overall\, we expect to unlock precise transcriptional control through mechanical forces\, and a state-of-the-art directed evolution platform for msTTAs. With the simplicity of this engineered regulatory module\, we expect to describe the minimal elements of mechano-regulation of gene expression\, as well as enabling the use of mechanotransduction in gene circuits control. This will open the field to use mechanotransduction approaches for complex synthetic biology applications.
URL:https://ibecbarcelona.eu/event/phd-discussion-3/
LOCATION:Sala Dolors Aleu\, Cluster II\, IBEC\, Baldiri i Reixac\, Barcelona
CATEGORIES:PhD Discussions Session
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BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20250124T100000
DTEND;TZID=Europe/Madrid:20250124T110000
DTSTAMP:20260424T192631
CREATED:20241122T101514Z
LAST-MODIFIED:20250107T141720Z
UID:121790-1737712800-1737716400@ibecbarcelona.eu
SUMMARY:PhD Discussion: Kristin Fichna and Gian Marco Tuveri
DESCRIPTION:Kristin Fichna – Smart nano-bio-devices \nGian Marco Tuveri –  Molecular bionics \n 
URL:https://ibecbarcelona.eu/event/phd-discussion-kristin-fichna-and-gian-marco/
CATEGORIES:PhD Discussions Session
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BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20250411T100000
DTEND;TZID=Europe/Madrid:20250411T110000
DTSTAMP:20260424T192631
CREATED:20250404T103254Z
LAST-MODIFIED:20250404T103254Z
UID:125030-1744365600-1744369200@ibecbarcelona.eu
SUMMARY:PHD Discussion: Miquel Bosch
DESCRIPTION:Force transmission in embryonic-like epithelia\nMiquel Bosch (Integrative Cell and Tissue Dynamics Group) \nDeveloping an adult organism from an embryo is a complex task. Cells need to divide\, differentiate and arrange themselves in complex three-dimensional structures\, a process known as morphogenesis. Apical constriction is a conserved morphogenetic mechanism in the animal kingdom\, but the role of cellular forces during it remains understudied\, especially in the human case. For this reason\, we use human PSCs expressing a novel optogenetic tool\, OptoShroom3. This tool allows to induce apical constriction in vitro on demand\, with precise spatiotemporal control. We study force transmission within the cell layer and to the substrate and find that\, contrary to our intuition\, the apical and basal layer are effectively mechanically decoupled. This decoupling enables long range force transmission in this epiblast-like epithelia. Secondly\, we can study the rheology of the tissue on multiple time and length scales by analyzing the induced deformation field. Since the state of the art for development and disease modelling relies heavily on stem cell systems\, we foresee our study will have broad implications in the field whenever morphogenesis comes at play.
URL:https://ibecbarcelona.eu/event/phd-discussion-miquel-bosch/
LOCATION:Sala Dolors Aleu\, Cluster II\, IBEC\, Baldiri i Reixac\, Barcelona
CATEGORIES:PhD Discussions Session
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