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X-WR-CALDESC:Events for Institute for Bioengineering of Catalonia
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DTSTART;TZID=Europe/Madrid:20230714T100000
DTEND;TZID=Europe/Madrid:20230714T150000
DTSTAMP:20260517T013621
CREATED:20230705T105639Z
LAST-MODIFIED:20230705T105639Z
UID:109521-1689328800-1689346800@ibecbarcelona.eu
SUMMARY:PhD Thesis Defence: Manuel López Ortiz
DESCRIPTION:Single molecule electrochemical studies of photosynthetic complexes\n\n\n\n\nAuthor: Manuel López Ortiz\, Nanoprobes and Nanoswitches group\n\n\nReading date: 14/07/2023\nReading time: 10:00 \nReading place: Aula de graus Dufort de la facultat de biologia
URL:https://ibecbarcelona.eu/event/phd-thesis-defence-manuel-lopez-ortiz/
CATEGORIES:PhD Thesis Defence
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BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20230714T120000
DTEND;TZID=Europe/Madrid:20230714T140000
DTSTAMP:20260517T013621
CREATED:20230712T061637Z
LAST-MODIFIED:20230712T061637Z
UID:109735-1689336000-1689343200@ibecbarcelona.eu
SUMMARY:PhD Thesis Defense: Gerardo Ceada
DESCRIPTION:Mechanics of crypt folding\, tissue compartmentalization and collective cell migration in intestinal organoids\n\n\n\n\nAuthor: Gerardo Ceada\, Integrative cell and Tissue Dynamics group\n\n\nReading date: 14/07/2023\nReading time: 12:00 \n\n\nReading place: Aula Magna de la Facultad de Medicina de la Universidad de Barcelona (Campus Clínic) \n\n 
URL:https://ibecbarcelona.eu/event/phd-thesis-defense-gerardo-ceada/
CATEGORIES:PhD Thesis Defence
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BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20230718T150000
DTEND;TZID=Europe/Madrid:20230718T170000
DTSTAMP:20260517T013621
CREATED:20230711T111654Z
LAST-MODIFIED:20230711T111654Z
UID:109689-1689692400-1689699600@ibecbarcelona.eu
SUMMARY:PhD Thesis Defense: Sefora Conti
DESCRIPTION:Mechanical phenotyping of cancer stemness in colorectal cancer.\n\n\n\n\nAuthor: Sefora Conti\, Integrative cell and Tissue Dynamics group\n\n\nReading date: 18/07/2023\nReading time: 15:00 \n\nAbstract: Colorectal cancer tumors are composed of heterogeneous and plastic cell populations\, including a pool of cancer stem cells that express LGR5. Whether these distinct cell populations display different mechanical properties\, and how these properties might contribute to metastasis is unknown. Using CRC patient derived organoids (PDOs)\, we found that compared to LGR5- cells\, LGR5+ cancer stem cells are stiffer\, adhere better to the extracellular matrix (ECM)\, move slower both as single cells and clusters\, display higher nuclear YAP\, show a higher survival rate in response to mechanical confinement\, and form larger transendothelial gaps. These differences are largely explained by the downregulation of the membrane to cortex attachment proteins Ezrin/Radixin/Moesin (ERMs) in the LGR5+ cells. By analyzing scRNA-seq expression patterns from a patient cohort\, we show that this downregulation is a robust signature of colorectal tumors. Our results show that LGR5- cells display a mechanically dynamic phenotype suitable for dissemination from the primary tumor whereas LGR5+ cells display a mechanically stable and resilient phenotype suitable for extravasation and metastatic growth. \n  \n\nReading place: Aula Marga\, Hospital Clinic \n\nMore information here.
URL:https://ibecbarcelona.eu/event/phd-thesis-defense-sefora-conti/
CATEGORIES:PhD Thesis Defence
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