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BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20220413T150000
DTEND;TZID=Europe/Madrid:20220413T170000
DTSTAMP:20260509T102943
CREATED:20220309T132156Z
LAST-MODIFIED:20220309T132156Z
UID:96545-1649862000-1649869200@ibecbarcelona.eu
SUMMARY:PhD Thesis Defence: Ignasi Casanellas
DESCRIPTION:Cell-adhesive nanopatterns for musculoskeletal tissue engineering\nIgnasi Casanellas\, Nanobioengineering Group \nThis thesis defence will take place at “Sala de Graus Eduard Fontseré\, Facultat de Física\, Universitat de Barcelona” at 3PM. If you wish to follow this defence online\, you can contact Ignasi here. \nMore information here \n 
URL:https://ibecbarcelona.eu/event/phd-thesis-defence-ignasi-casanellas-2/
LOCATION:Molecular and cellular neurobiotechnology
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20220401T110000
DTEND;TZID=Europe/Madrid:20220401T130000
DTSTAMP:20260509T102943
CREATED:20220503T142336Z
LAST-MODIFIED:20220503T142337Z
UID:94005-1648810800-1648818000@ibecbarcelona.eu
SUMMARY:PhD Thesis Defence: Francina Mesquida Veny
DESCRIPTION:Activity-dependent mechanisms of axonal growth\n\n\n\nFrancina Mesquida Veny\, Molecular and cellular neurobiotechnology  \n\n\n\nThis thesis defence will take place at “Aula de Graus” Facultat de Biologia\, Universitat de Barcelona” at 11AM. \n\n\n\nIf anyone is interested in attending online\, you can contact Francina here
URL:https://ibecbarcelona.eu/event/phd-thesis-defence-francina-mesquida-veny/
LOCATION:Aula de Graus\, Faculty of Biology
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20220401T110000
DTEND;TZID=Europe/Madrid:20220401T130000
DTSTAMP:20260509T102943
CREATED:20220324T115911Z
LAST-MODIFIED:20220324T115911Z
UID:96566-1648810800-1648818000@ibecbarcelona.eu
SUMMARY:PhD Thesis Defence: Francina Mesquida Veny
DESCRIPTION:Activity-dependent mechanisms of axonal growth\nFrancina Mesquida Veny\, Molecular and cellular neurobiotechnology  \nThis thesis defence will take place at “Aula de Graus” Facultat de Biologia\, Universitat de Barcelona” at 11AM. \nIf anyone is interested in attending online\, you can contact Francina here \n 
URL:https://ibecbarcelona.eu/event/phd-thesis-defence-francina-mesquida-veny-2/
LOCATION:Aula de Graus\, Faculty of Biology\, Diagonal\, 643\, Barcelona\, Spain
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20220314T110000
DTEND;TZID=Europe/Madrid:20220314T130000
DTSTAMP:20260509T102943
CREATED:20220503T133307Z
LAST-MODIFIED:20220503T133308Z
UID:93986-1647255600-1647262800@ibecbarcelona.eu
SUMMARY:PhD Thesis Defence: Andrés Marco Giménez
DESCRIPTION:Generation and Validation of a CRISPR Platform for Rapid and Inducible Genome Editing in Human Pluripotent Stem Cells and Kidney Organoids\n\n\n\nAndrés Marco Giménez\, Pluripotency for organ regeneration group \n\n\n\nThis thesis defence will start at 11AM. If you wisth to attend to this PhD thesis defence\, you can join here via zoom.
URL:https://ibecbarcelona.eu/event/phd-thesis-defence-andres-marco-gimenez/
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20220314T110000
DTEND;TZID=Europe/Madrid:20220314T130000
DTSTAMP:20260509T102943
CREATED:20220309T120100Z
LAST-MODIFIED:20220309T120100Z
UID:96540-1647255600-1647262800@ibecbarcelona.eu
SUMMARY:PhD Thesis Defence: Andrés Marco Giménez
DESCRIPTION:Generation and Validation of a CRISPR Platform for Rapid and Inducible Genome Editing in Human Pluripotent Stem Cells and Kidney Organoids\nAndrés Marco Giménez\, Pluripotency for organ regeneration group \nThis thesis defence will start at 11AM. If you wisth to attend to this PhD thesis defence\, you can join here via zoom.
URL:https://ibecbarcelona.eu/event/phd-thesis-defence-andres-marco-gimenez-2/
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20220201T100000
DTEND;TZID=Europe/Madrid:20220201T120000
DTSTAMP:20260509T102943
CREATED:20220427T085100Z
LAST-MODIFIED:20220427T085101Z
UID:93896-1643709600-1643716800@ibecbarcelona.eu
SUMMARY:PhD Thesis Defence: Lucía Selfa Aspiroz
DESCRIPTION:Engineering human pluripotent stem cells to understand kidney development and disease\n\n\n\nLucía Selfa Aspiroz\, Pluripotency for organ regeneration group \n\n\n\nThis thesis defence will start at 10AM. If you wisth to attend to this PhD thesis defence\, you can join here via zoom.
URL:https://ibecbarcelona.eu/event/phd-thesis-defence-lucia-selfa-aspiroz/
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20220128T110000
DTEND;TZID=Europe/Madrid:20220128T130000
DTSTAMP:20260509T102943
CREATED:20220427T084623Z
LAST-MODIFIED:20220427T084623Z
UID:93895-1643367600-1643374800@ibecbarcelona.eu
SUMMARY:PhD Thesis Defence: Andrea García Lizarribar
DESCRIPTION:Development of tunable bioinks to fabricate 3D-printed in vitro models: a special focus on skeletal muscle models with potential applications in metabolic alteration studies\n\n\n\nAndrea García Lizarribar\, Nanobioengineering group \n\n\n\nThis thesis defence will be held online using the Teams App\, you can find the link here. You can find more information here
URL:https://ibecbarcelona.eu/event/phd-thesis-defence-andrea-garcia-lizarribar/
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20220127T110000
DTEND;TZID=Europe/Madrid:20220127T140000
DTSTAMP:20260509T102943
CREATED:20220114T093409Z
LAST-MODIFIED:20220114T095350Z
UID:89934-1643281200-1643292000@ibecbarcelona.eu
SUMMARY:PhD Thesis Defence: Ariadna Marín Llauradó
DESCRIPTION:Mechanical stress in curved epithelia of designed size and shape\nAriadna Marín Llauradó\, Integrative cell and tissue dynamics group \nThe function of organs such as lungs\, kidneys and mammary glands relies on the three-dimensional geometry of their epithelium. How epithelial geometry emerges from mechanical stresses remains poorly understood. To address this question systematically\, here we engineered curved epithelial monolayers of controlled size and shape and mapped their state of stress. We designed pressurized epithelia with spherical\, rectangular and ellipsoidal cross-sections. We developed a computational approach to map the stress tensor these epithelia from the measured pressure and geometry\, without assumptions of material properties.  In epithelia with spherical cross-section spanning more than one order of magnitude in radius\, we show that stress increases with areal strain in a size-independent manner. In epithelia with rectangular and ellipsoidal cross-section we found pronounced stress anisotropies consistent with asymmetric distribution tractions measured at the cell-substrate contact line. Cells tended to align with the direction of maximum principal stress\, but this alignment was non-universal and increased with monolayer anisotropy. Our study establishes how the size and shape of an epithelium depends on luminal pressure and mechanical stress. \nThis thesis defence will take place at Auditori Antoni Caparrós\, located at the Parc Científic de Barcelona\, Tower D with limited capacity\, seats will be assigned on a first come first served basis. The defence will start at 11 AM.
URL:https://ibecbarcelona.eu/event/phd-thesis-defence-ariadna-marin-llaurado/
LOCATION:Auditori Antoni Caparrós\, PCB\, Tower D\, c/Baldiri Reixac 4-8\, Barcelona\, Spain
CATEGORIES:PhD Thesis Defence
ORGANIZER;CN="IBEC":MAILTO:www.ibecbarcelona.eu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20220112T113000
DTEND;TZID=Europe/Madrid:20220112T133000
DTSTAMP:20260509T102943
CREATED:20220104T125256Z
LAST-MODIFIED:20220104T132247Z
UID:89869-1641987000-1641994200@ibecbarcelona.eu
SUMMARY:PhD Thesis Defence: Ana López Mengual
DESCRIPTION:Factores físicos y moleculares implicados en la migración celular y en el desarrollo de la corteza cerebral.\nAna López Mengual\, Molecular and cellular neurobiotechnology group \nAbstract \nCell migration acquires special relevance during embryonic development and tissue regeneration. During the development of the adult individual\, cells multiply\, differentiate and mature\, having to move to their destination regions through migration. Once the adult individual has formed\, these tissues can suffer damage\, leading to an altered state. In this process of tissue regeneration\, they try to set tissue homeostasis\, cell migration is essential. This thesis analyses the mechanical factors involved in cell migration in brain development and neural regeneration\, as a fundamental tool to understand these processes. OECs migrate greater distances over CXCL12 functionalized PLA 80/20 nanofibers\, thus responding to the chemotactic gradient. Measurements made with by means of BIO-AFM of the mouse embryonic brain reveals differences between the pallium and the subpallium. These differences determine the differential migration rates when transplanting explants of various origins outside their usual site and analysing the migration of Cajal-Retzius cells. In addition\, Cajal-Retzius cells respond by calcium entry to the inhibition of mechanosensitive cation channels\, changing their migration rate. So\, we conclude that physical factors are a key factor involved in the migration and disposition of Cajal-Retzius cells. \n  \n\n  \n  \nThe public event will take place at the Sala de Graus at the Faculty of Biology (University of Barcelona) on January 12th at 11:30. If you prefer to attend to this defence virtually\, contact with Ana López (alopezm@ibecbarcelona.eu). \n 
URL:https://ibecbarcelona.eu/event/phd-thesis-defence-ana-lopez-mengual/
LOCATION:Sala Graus\, Faculty of Biology\, Barcelona
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20211025T153000
DTEND;TZID=Europe/Madrid:20211025T173000
DTSTAMP:20260509T102944
CREATED:20211020T092852Z
LAST-MODIFIED:20211020T092852Z
UID:87921-1635175800-1635183000@ibecbarcelona.eu
SUMMARY:PhD Thesis Defence: Ignasi Ferrer Lluís
DESCRIPTION:Novel mHealth and multimodal physiological biomarkers for non-invasive monitoring and home healthcare of obstructive sleep apnea and COPD patients with comorbidities\nIgnasi Ferrer Lluís\, Biomedical Signal Processing and Interpretation \nhe defence will take place online\, using the “Google Meet” app. If you wish to attend to this defence you can find the link here
URL:https://ibecbarcelona.eu/event/phd-thesis-defence-ignasi-ferrer-lluis/
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20210920T100000
DTEND;TZID=Europe/Madrid:20210920T130000
DTSTAMP:20260509T102944
CREATED:20210916T100813Z
LAST-MODIFIED:20210916T100929Z
UID:87218-1632132000-1632142800@ibecbarcelona.eu
SUMMARY:PhD Thesis Defence: Alexandre Gomila
DESCRIPTION:Development and characterization of in vivo models for photopharmacology\nAlexandre Gomila\, Nanoprobes and Nanoswitches \nThe defence will take place online\, if you wish to attend to this defence you can find the link here
URL:https://ibecbarcelona.eu/event/phd-thesis-defence-alexandre-gomila/
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20210909T113000
DTEND;TZID=Europe/Madrid:20210909T133000
DTSTAMP:20260509T102944
CREATED:20210727T101114Z
LAST-MODIFIED:20210727T101114Z
UID:86553-1631187000-1631194200@ibecbarcelona.eu
SUMMARY:PhD Thesis Defence: Adrianna Glinkowska
DESCRIPTION:Formulation and screening of drug nanocarriers using microfluidic technology\nAdrianna Glinkowska\, Nanoscopy for nanomedicine \nThe defence will take place online\, if you wish to attend to this defence you can find the link and more information here \n 
URL:https://ibecbarcelona.eu/event/phd-thesis-defence-adrianna-glinkowska/
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20210903T110000
DTEND;TZID=Europe/Madrid:20210903T130000
DTSTAMP:20260509T102944
CREATED:20210811T082116Z
LAST-MODIFIED:20210811T082205Z
UID:86797-1630666800-1630674000@ibecbarcelona.eu
SUMMARY:PhD Thesis Defence: Ana Candida Lopes Hortelão
DESCRIPTION:Enzyme Powered Nanomotors Towards Biomedical Applications\nAna Candida Lopes Hortelão\, Smart Nano-bio-devices group \nThe defence will take place online\, if you wish to attend to this defence you can find the link and more information here
URL:https://ibecbarcelona.eu/event/phd-thesis-defence-ana-candida-lopes-hortelao/
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20210701T093000
DTEND;TZID=Europe/Madrid:20210701T120000
DTSTAMP:20260509T102944
CREATED:20210622T093545Z
LAST-MODIFIED:20210622T093651Z
UID:85344-1625131800-1625140800@ibecbarcelona.eu
SUMMARY:PhD Thesis Defence: Ferran Velasco
DESCRIPTION:Carboxymethyl cellulose-based cryogels as scaffolds for pancreatic and skeletal muscle tissue engineering\nFerran Velasco\, Biosensors for bioengineering group \nThe defence will take place online\, if you wish to attend to this defence\, you have to send an email to doctoratmedicina@ub.edu and you  can find more information here \n 
URL:https://ibecbarcelona.eu/event/phd-thesis-defence-ferran-velasco/
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20210628T100000
DTEND;TZID=Europe/Madrid:20210628T120000
DTSTAMP:20260509T102944
CREATED:20210621T135519Z
LAST-MODIFIED:20210621T135842Z
UID:85281-1624874400-1624881600@ibecbarcelona.eu
SUMMARY:PhD Thesis Defence: Maria Arista
DESCRIPTION:Unveiling viral structures by single-molecule localization microscopy\nMaria Arista\, Nanoscopy for nanomedicine group \nThe defence will take place online\, if you wish to attend to this defence\, you can find the link to access here and you can find more information here
URL:https://ibecbarcelona.eu/event/phd-thesis-defence-maria-arista/
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20210623T100000
DTEND;TZID=Europe/Madrid:20210623T120000
DTSTAMP:20260509T102944
CREATED:20210622T131947Z
LAST-MODIFIED:20210622T131947Z
UID:85480-1624442400-1624449600@ibecbarcelona.eu
SUMMARY:PhD Thesis Defence: Xarxa Quiroga
DESCRIPTION:Plasma membrane mechanosensing upon stretch-induced topography remodelling\nXarxa Quiroga\, Cellular and molecular mechanobiology group. \nThe thesis defence takes place tomorrow at 10AM in the “Antoni Caparrós” auditorium\, located at the PCB Tower D\, with limited capacity.
URL:https://ibecbarcelona.eu/event/phd-thesis-defence-xarxa-quiroga/
LOCATION:Auditori Antoni Caparrós – PCB
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20210525T030000
DTEND;TZID=Europe/Madrid:20210525T170000
DTSTAMP:20260509T102944
CREATED:20210518T071812Z
LAST-MODIFIED:20210518T071846Z
UID:84387-1621911600-1621962000@ibecbarcelona.eu
SUMMARY:PhD Thesis Defence: Enara Larrañaga
DESCRIPTION:Effects of substrate-derived cues in driving the self-organization of organoid-derived intestinal epithelia\nEnara Larrañaga\, Biomimetic systems for cell engineering \nThe defence will take place online\, if you wish to attend to this defence\, you can find the link to access here and you can find more information here \n 
URL:https://ibecbarcelona.eu/event/phd-thesis-defence-enara-larranaga/
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20210512T100000
DTEND;TZID=Europe/Madrid:20210512T120000
DTSTAMP:20260509T102944
CREATED:20210507T092710Z
LAST-MODIFIED:20210507T094146Z
UID:84243-1620813600-1620820800@ibecbarcelona.eu
SUMMARY:PhD Thesis Defence: Harishankar Balakrishnan
DESCRIPTION:Nanoscale Tomography based in Electrostatic Force Microscopy\nHarishankar Balakrishnan\, Nanoscale bioelectrical characterization group \nThe defence will take place online\, if you wish to attend to this defence\, you can find the link to access here and you can find more information here \nPlease join the meeting few minutes before the mentioned time to avoid session interruption.  \nIf you are joining after the mentioned time\, please make sure your microphone is muted before joining the session.
URL:https://ibecbarcelona.eu/event/phd-thesis-defence-harishankar-balakrishnan/
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20210511T100000
DTEND;TZID=Europe/Madrid:20210511T120000
DTSTAMP:20260509T102944
CREATED:20210507T154643Z
LAST-MODIFIED:20210507T154643Z
UID:84258-1620727200-1620734400@ibecbarcelona.eu
SUMMARY:PhD Thesis Defence: Martina Di Muzio
DESCRIPTION:Nanoscale dielectric mapping of biomembranes with in-liquid Scanning Dielectric Microscopy\nMartina Di Muzio\, Nanoscale bioelectrical characterization group \nThe defence will take place online\, if you wish to attend to this defence\, you can find the link to access here and you can find more information here \nPlease join the meeting few minutes before the mentioned time to avoid session interruption. \nIf you are joining after the mentioned time\, please make sure your microphone is muted before joining the session.
URL:https://ibecbarcelona.eu/event/phd-thesis-defence-martina-di-muzio/
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20210426T100000
DTEND;TZID=Europe/Madrid:20210426T120000
DTSTAMP:20260509T102944
CREATED:20210422T071047Z
LAST-MODIFIED:20210422T071132Z
UID:83625-1619431200-1619438400@ibecbarcelona.eu
SUMMARY:PhD Thesis Defence: Laura Moya
DESCRIPTION:Deciphering the utility of Galleria mellonella as an infection and toxicity in vivo model\nLaura Moya\, Bacterial infections: Antimicrobial therapies \nThe defence will take place online\, if you wish to attend to this defence\, you will find the link to access and all the information here
URL:https://ibecbarcelona.eu/event/phd-thesis-defence-laura-moya/
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20210416T100000
DTEND;TZID=Europe/Madrid:20210416T120000
DTSTAMP:20260509T102944
CREATED:20210409T065700Z
LAST-MODIFIED:20210409T065700Z
UID:83305-1618567200-1618574400@ibecbarcelona.eu
SUMMARY:PhD Thesis Defence: Núria Blanco-Cabra
DESCRIPTION:Noves metodologies per al tractament de bacteris creixent en forma de biofilm\nNúria Blanco-Cabra\, Bacterial infections and antimicrobial therapies group at IBEC \nThe defence will take place online\, if you wish to attend to this defence\, write an email to doctoratmedicina@ub.edu at least 48 hours before the defence.
URL:https://ibecbarcelona.eu/event/phd-thesis-defence-nuria-blanco-cabra/
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20210407T100000
DTEND;TZID=Europe/Madrid:20210407T120000
DTSTAMP:20260509T102944
CREATED:20210326T095201Z
LAST-MODIFIED:20210326T095226Z
UID:83020-1617789600-1617796800@ibecbarcelona.eu
SUMMARY:PhD Thesis Defence: Patrica Prado Peralta
DESCRIPTION:Developing new strategies to understand human kidney development and target human disease\nPatricia Prado Peralta\, Pluripotency for organ regeneration group \nThe defence will take place online using the BBCollab platform
URL:https://ibecbarcelona.eu/event/phd-thesis-defence-patrica-prado-peralta/
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20210310T090000
DTEND;TZID=Europe/Madrid:20210310T230000
DTSTAMP:20260509T102944
CREATED:20210301T090512Z
LAST-MODIFIED:20210308T082914Z
UID:82191-1615366800-1615417200@ibecbarcelona.eu
SUMMARY:PhD Thesis Defence: Maider Badiola
DESCRIPTION:Compartmentalised microfluidic culture systems for in vitro modelling of neurological and neuromuscular microenvironments\nMaider Badiola\, Nanobioengineering group \nMovement of skeletal-muscle fibres is generated by the locomotion circuit. Failures in any part of the circuit can cause or define the severity of neuromuscular diseases (NMD)\, such as amyotrophic lateral sclerosis (ALS). Conventional in vitro study models coculturing motoneurons and skeletal muscle cells are not physiologically relevant. Moreover\, studying fragments of the circuit cannot provide a comprehensive and complete view of the pathological process. \nThis thesis aims to study the neuromuscular context in vitro through compartmentalised microfluidic culture systems (cµFCS) and to create physiologically relevant study models. It offers an evolving prospective of in vitro models\, moving from mice to human cells\, from 2D to 3D cell cultures\, from primary cells to human induced pluripotent stem cells (hiPSC)\, and analysing both healthy and diseased cells. \nThis thesis gathers many technological innovations from a Bioengineering point of view\, paving the way for future studies in the neuromuscular field. It shows that the integration of the entire neuromuscular circuit components in the developed in vitro systems provides a wider view of the neuromuscular physiology and the pathological processes. These results show first steps towards future 3D physiological neuromuscular circuit models on a chip for NMD studies. \nThe defence will take place online using the Microsoft Teams Platform
URL:https://ibecbarcelona.eu/event/phd-thesis-defence-maider-badiola/
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20210223T150000
DTEND;TZID=Europe/Madrid:20210223T170000
DTSTAMP:20260509T102944
CREATED:20210217T122107Z
LAST-MODIFIED:20210217T122142Z
UID:81819-1614092400-1614099600@ibecbarcelona.eu
SUMMARY:PhD Thesis Defence: Davia Prischich
DESCRIPTION:Development and applications of photoswitchable small molecules and peptides to control protein-protein interactions and GPCR activity\nDavia Prischich\, Nanoprobes and Nanoswitches group\, IBEC \nThe defense will be held online through the platform provided by the UB. For those who are interested in joining\, please remember that you have to write an email to vd.quimica.recerca@ub.edu at least 48 hours before the event.
URL:https://ibecbarcelona.eu/event/phd-thesis-defence-davia-prischich/
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20210115T110000
DTEND;TZID=Europe/Madrid:20210115T130000
DTSTAMP:20260509T102944
CREATED:20210111T111039Z
LAST-MODIFIED:20210113T080556Z
UID:80775-1610708400-1610715600@ibecbarcelona.eu
SUMMARY:PhD Thesis Defense: Maria Blancas Muñoz
DESCRIPTION:Knowing what you know. A pedagogical model based on learners’ metacognitive abilities\nMaria Blancas Muñoz\, Synthetic\, Perceptive\, Emotive and Cognitive Systems (SPECS) \nThis thesis defense will be held online next 15th January at 11\, via “zoom”\, using this link.
URL:https://ibecbarcelona.eu/event/phd-thesis-defense-maria-blancas-munoz/
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20201221T110000
DTEND;TZID=Europe/Madrid:20201221T130000
DTSTAMP:20260509T102944
CREATED:20201214T081415Z
LAST-MODIFIED:20201214T081428Z
UID:80334-1608548400-1608555600@ibecbarcelona.eu
SUMMARY:PhD Thesis Defense: Laia Lidón Gil
DESCRIPTION:Regulación de la expresión de PrPC como elemento clave en las modificaciones de tau en la enfermedad de Alzheimer\nLaia Lidón\, Molecular and Cellular Neurobiotechnology \nLa enfermedad de Alzheimer (EA) es la causa más común de demencia y tiene una elevada prevalencia a nivel mundial. Se caracteriza por un deterioro cognitivo progresivo y muestra como principales rasgos neuropatológicos la presencia de placas seniles enriquecidas en βamiloide y ovillos neurofibrilares intracelulares constituidos por la proteína tau hiperfosforilada. Una precisa regulación de la fosforilación de tau es esencial para que la proteína ejerza sus funciones normales\, ya que su hiperfosforilación interrumpe procesos neuronales básicos como el transporte axonal. \nPor otro lado\, la proteína priónica celular (PrPC) es una glicoproteína de unión a membrana que en humanos se expresa mayoritariamente en el sistema nervioso central a partir de un único gen\, PRNP. Sus funciones fisiológicas abarcan un conjunto de propiedades neuroprotectoras como la regulación de la homeostasis del calcio\, la actividad anti-apoptótica y la capacidad antioxidante. \nEn los últimos años\, el interés por la PrPC y su implicación en diversas enfermedades neurodegenerativas ha ido en aumento a medida que se han ido conociendo los múltiples rasgos comunes a nivel molecular y/o neuropatológico entre PrPC y dichas enfermedades. Por\nejemplo\, se ha descrito que PrPC interacciona directamente con las proteínas tau\, Aβ y αsinucleína participando así en diversos procesos patológicos y vías de señalización. Es por ello que PrPC ha sido asociada con la EA y otras taupatías o la enfermedad de Parkinson. \nEn este sentido\, se ha descrito que el aumento de expresión de PrPC provoca una reducción de los niveles de tau y una menor susceptibilidad a la fosforilación en modelos experimentales de EA. Además\, ha sido demostrado que durante el curso de la EA se producen cambios de expresión en el perfil de PrPC habiendo un incremento notable en estadios iniciales de la enfermedad\, mientras que en estadios avanzados la expresión de PrPC disminuye coincidiendo con el incremento de depósitos de ptau. Este hecho\, sugiere que PrPC podría estar ejerciendo un rol neuroprotector en las fases iniciales de la enfermedad y\, en cambio\, la reducción de su expresión en fases avanzadas contribuiría a la neurodegeneración y a la progresión de la patología. \nA pesar de ello\, se desconoce cuáles son los desencadenantes de los cambios de expresión de PRNP en la enfermedad y\, por este motivo\, uno de los objetivos principales de la presente tesis ha sido analizar dichos factores. Hemos estudiado diversos estímulos asociados a la EA que pueden estar implicados en la regulación transcripcional de PRNP en etapas iniciales de la enfermedad y nuestros resultados indican que el incremento celular de los niveles de tau promueve la activación del promotor de PRNP. Además\, hemos descrito que la vía de señalización JNK-c-jun-AP1 es la principalmente implicada en la activación del promotor de PRNP por tau. \nPor otro lado\, diversos estudios sugieren que PrPC participa en la diferenciación neuronal de progenitores neuronales\, un proceso altamente influenciado por la actividad de la glucógeno sintasa quinasa-3beta (GSK3β)\, siendo esta inhibida por PrPC . Múltiples trabajos han descrito un desequilibrio en la expresión de las diferentes isoformas de tau (tau3R y tau4R) derivadas del splicing diferencial que sufre el gen de tau\, MAPT\, en enfermedades que cursan acúmulo de tau\, como la EA. En dichas enfermedades también se han encontrado niveles alterados de diversas quinasas\, y entre ellas se encuentra la GSK3β\, que además de incidir sobre la hiperfosforilación de tau\, está directamente implicada en el splicing alternativo de MAPT. Por ello\, otro de los propósitos del presente estudio ha sido analizar la intervención de PrPC \, no solo en la fosforilación de tau y en el mantenimiento de sus niveles de expresión\, sino también\nen la generación de las diferentes isoformas tau3R y tau4R. Mediante el uso de animales transgénicos\, muestras humanas de pacientes con EA y modelos experimentales de estudio de la PrPC \, nuestros resultados corroboran la implicación de PrPC en el splicing alternativo del exón 10 de tau a través de su papel inhibidor de la actividad GSK3β. \n\nThis thesis defense will be held online next 21st December at 11\, in order to be able to attend the defense\, you have to write an email to: doctorat.biologia@ub.edu
URL:https://ibecbarcelona.eu/event/phd-thesis-defense-laia-lidon-gil/
CATEGORIES:PhD Thesis Defence
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BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20201215T120000
DTEND;TZID=Europe/Madrid:20201215T140000
DTSTAMP:20260509T102944
CREATED:20201203T074210Z
LAST-MODIFIED:20201214T113928Z
UID:80200-1608033600-1608040800@ibecbarcelona.eu
SUMMARY:PhD Thesis Defense: Sock Ching Low
DESCRIPTION:Giving Centre Stage to Top-Down Inhibitory Mechanisms for Selective Attention\nSock Ching Low\, SPECS (Synthetic\, Perceptive\, Emotive and Cognitive Systems) \nSelective attention determines the sensory signals that are processed at higher levels at the expense of others and is biased by higher-order brain regions which anticipate task-relevant stimuli and increase neural sensitivity to them in the sensory cortex. Often\, this is thought to occur through excitation of selected neurons\, but some studies have suggested that it is not the full description of the process. Increasingly\, evidence has pointed to an alternative\, top-down inhibitory biasing mechanism. Here\, we investigated such an inhibitory model of attention. We first showed how sensitivity to stimulus features known to be task-irrelevant are reduced through top-down suppression. Secondly\, we demonstrated a biologically grounded spiking model’s ability to modulate information processing and benchmarked it to physiology. Lastly\, we explored the interaction between the excitatory and inhibitory models of top-down attention in a foraging agent. Our results support the inhibitory model of top-down attention as a biological attentional mechanism and show how it fits into the current zeitgeist of top-down attentional mechanisms. \nThis thesis defense will be held online using “Zoom” using this link.
URL:https://ibecbarcelona.eu/event/phd-thesis-defense-sock-ching-low/
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20201211T140000
DTEND;TZID=Europe/Madrid:20201211T170000
DTSTAMP:20260509T102944
CREATED:20201209T121743Z
LAST-MODIFIED:20201210T124757Z
UID:80270-1607695200-1607706000@ibecbarcelona.eu
SUMMARY:PhD Thesis Defense: Elena Lantero
DESCRIPTION:Targeting strategies against Plasmodium and practical applications: blocking parasite development with heparin derivatives and identifying new aptamers for diagnosis\nElena Lantero\, Nanomalaria Group\nThis thesis defense will take place ONLINE on the 11th December at 14.00 using the “BB Collaborate” streaming platform.
URL:https://ibecbarcelona.eu/event/phd-thesis-defense-elena-lantero/
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20201210T153000
DTEND;TZID=Europe/Madrid:20201210T170000
DTSTAMP:20260509T102944
CREATED:20201209T122744Z
LAST-MODIFIED:20201210T124825Z
UID:80273-1607614200-1607619600@ibecbarcelona.eu
SUMMARY:PhD Thesis Defense: Anna Vila Giraut
DESCRIPTION:Hydrogel co-networks of gelatin methacryloyl and poly(ethylene glycol)diacrylate sustain 3D functional in vitro models of intestinal mucosa\nAnna Vila Giraut\, Biomimetic systems for cell engineering Group\nConventional in vitro cell culture models do not possess the complexity that the native tissues offer. Because of this\, the functional properties of the tissues are not properly mimicked\, which causes poorly predictive capabilities. Engineered tissues\, which combine biofabrication and tissue engineering techniques\, try to overcome this gap by providing the cells with an environment similar to the native tissue\, recapitulating (I) the physicochemical and mechanical properties of the cellular matrix\, (II) the multicellular complexity of the different tissue compartments\, and (III) the 3D structures of the tissues. These new engineered models are key factors to improve the platforms for basic research studies\, testing new drugs or modelling diseases. Among all the engineered tissues\, the intestinal mucosa is not well represented. The intestinal mucosa is formed by the epithelium\, which is a multicellular monolayer laying on top of the lamina propria\, a connective tissue containing several cell types (mesenchymal cells\, immune cells). The gold standard intestinal models are based on epithelial cell lines derived from colon cancer cells grown on the hard porous membranes of the Transwell® inserts. The lack of the intestinal stromal compartment and the growth on a hard surface give high transepithelial electrical resistance and low apparent permeability. Therefore\, the development of better in vitro platforms\, which integrates both compartments and provides epithelium-lamina propria cell interactions\, is highly desirable. \nIn this work\, we describe an easy and cost-effective method to engineer a 3D intestinal mucosa model that combines both the epithelium and the lamina propria compartments. To build the 3D scaffolds we chose hydrogels as materials to mimic the physicochemical and mechanical properties of intestinal tissue. Thus\, hydrogel conetworks of gelatin methacryolyl (GelMA)\, a natural polymer\, and poly(ethylene glycol) diacrylate (PEGDA)\, a synthetic polymer\, are photopolymerized. On one hand\, GelMA provides biodegradation and cell adhesion sequences but it lacks long-term mechanical stability. On the other hand\, PEGDA\, is non-biodegradable and does not present cell adhesion motifs. Nevertheless\, it has good mechanical properties. By this technique\, the lamina propria compartment of the intestinal mucosa can be reproduced in vitro. To do that\, GelMA and PEGDA polymers are laden with mesenchymal cells (fibroblasts or myofibroblasts) and/or immune cells (macrophages). We demonstrated that GelMA – PEGDA hydrogel co-networks support the growth of these cells and epithelial monolayers on top of the scaffolds. Embedding fibroblasts or myofibroblasts on the hydrogel conetworks enhance the formation and the maturity of the Caco-2 epithelial monolayers\, providing barrier properties similar to in vivo. The presence of the stromal cells also enhances the recovery of the epithelial integrity when the epithelium is temporally damaged. Finally\, an immunocompetent model is obtained by the encapsulation of macrophages in the constructs. The presence of macrophages does not influence the formation of the epithelium. However\, when the epithelial monolayer is disrupted\, the presence of mesenchymal and immune cells in the stromal compartment increases cytokine secretion in a synergistic manner. Our model can successfully mimic the interactions between stromal and epithelial compartments found in vivo intestinal tissue\, offering a potential platform to be used to study absorption and toxicity of drugs\, as well as cell behaviour under physiological and pathological conditions. \nLocation: The defense will be online. People are invited to attend upon receiving a link that you have to request to vd.fisica.recerca@ub.edu
URL:https://ibecbarcelona.eu/event/phd-thesis-defense-anna-vila-giraut/
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20201204T110000
DTEND;TZID=Europe/Madrid:20201204T130000
DTSTAMP:20260509T102944
CREATED:20201202T085923Z
LAST-MODIFIED:20201202T092538Z
UID:80148-1607079600-1607086800@ibecbarcelona.eu
SUMMARY:PhD Thesis Defense: Javier Rodriguez Benítez
DESCRIPTION:Characterization and interpretation of cardiovascular and cardiorespiratory dynamics in cardiomyopathy patients\nJavier Rodriguez Benítez\, member of Biomedical Signal Processing and Interpretation (BIOSPIN) Group  \nFriday 4th December 2020\, at 11.00 am \nThis defense will be transmitted online at Google meet\, using this link \n 
URL:https://ibecbarcelona.eu/event/phd-thesis-defense-javier-rodriguez-benitez/
CATEGORIES:PhD Thesis Defence
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