BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Institute for Bioengineering of Catalonia - ECPv6.15.20//NONSGML v1.0//EN
CALSCALE:GREGORIAN
METHOD:PUBLISH
X-WR-CALNAME:Institute for Bioengineering of Catalonia
X-ORIGINAL-URL:https://ibecbarcelona.eu
X-WR-CALDESC:Events for Institute for Bioengineering of Catalonia
REFRESH-INTERVAL;VALUE=DURATION:PT1H
X-Robots-Tag:noindex
X-PUBLISHED-TTL:PT1H
BEGIN:VTIMEZONE
TZID:Europe/Madrid
BEGIN:DAYLIGHT
TZOFFSETFROM:+0100
TZOFFSETTO:+0200
TZNAME:CEST
DTSTART:20180325T010000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:+0200
TZOFFSETTO:+0100
TZNAME:CET
DTSTART:20181028T010000
END:STANDARD
BEGIN:DAYLIGHT
TZOFFSETFROM:+0100
TZOFFSETTO:+0200
TZNAME:CEST
DTSTART:20190331T010000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:+0200
TZOFFSETTO:+0100
TZNAME:CET
DTSTART:20191027T010000
END:STANDARD
BEGIN:DAYLIGHT
TZOFFSETFROM:+0100
TZOFFSETTO:+0200
TZNAME:CEST
DTSTART:20200329T010000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:+0200
TZOFFSETTO:+0100
TZNAME:CET
DTSTART:20201025T010000
END:STANDARD
BEGIN:DAYLIGHT
TZOFFSETFROM:+0100
TZOFFSETTO:+0200
TZNAME:CEST
DTSTART:20210328T010000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:+0200
TZOFFSETTO:+0100
TZNAME:CET
DTSTART:20211031T010000
END:STANDARD
BEGIN:DAYLIGHT
TZOFFSETFROM:+0100
TZOFFSETTO:+0200
TZNAME:CEST
DTSTART:20220327T010000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:+0200
TZOFFSETTO:+0100
TZNAME:CET
DTSTART:20221030T010000
END:STANDARD
END:VTIMEZONE
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20210920T100000
DTEND;TZID=Europe/Madrid:20210920T130000
DTSTAMP:20260509T111253
CREATED:20210916T100813Z
LAST-MODIFIED:20210916T100929Z
UID:87218-1632132000-1632142800@ibecbarcelona.eu
SUMMARY:PhD Thesis Defence: Alexandre Gomila
DESCRIPTION:Development and characterization of in vivo models for photopharmacology\nAlexandre Gomila\, Nanoprobes and Nanoswitches \nThe defence will take place online\, if you wish to attend to this defence you can find the link here
URL:https://ibecbarcelona.eu/event/phd-thesis-defence-alexandre-gomila/
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20210909T113000
DTEND;TZID=Europe/Madrid:20210909T133000
DTSTAMP:20260509T111253
CREATED:20210727T101114Z
LAST-MODIFIED:20210727T101114Z
UID:86553-1631187000-1631194200@ibecbarcelona.eu
SUMMARY:PhD Thesis Defence: Adrianna Glinkowska
DESCRIPTION:Formulation and screening of drug nanocarriers using microfluidic technology\nAdrianna Glinkowska\, Nanoscopy for nanomedicine \nThe defence will take place online\, if you wish to attend to this defence you can find the link and more information here \n 
URL:https://ibecbarcelona.eu/event/phd-thesis-defence-adrianna-glinkowska/
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20210903T110000
DTEND;TZID=Europe/Madrid:20210903T130000
DTSTAMP:20260509T111253
CREATED:20210811T082116Z
LAST-MODIFIED:20210811T082205Z
UID:86797-1630666800-1630674000@ibecbarcelona.eu
SUMMARY:PhD Thesis Defence: Ana Candida Lopes Hortelão
DESCRIPTION:Enzyme Powered Nanomotors Towards Biomedical Applications\nAna Candida Lopes Hortelão\, Smart Nano-bio-devices group \nThe defence will take place online\, if you wish to attend to this defence you can find the link and more information here
URL:https://ibecbarcelona.eu/event/phd-thesis-defence-ana-candida-lopes-hortelao/
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20210701T093000
DTEND;TZID=Europe/Madrid:20210701T120000
DTSTAMP:20260509T111253
CREATED:20210622T093545Z
LAST-MODIFIED:20210622T093651Z
UID:85344-1625131800-1625140800@ibecbarcelona.eu
SUMMARY:PhD Thesis Defence: Ferran Velasco
DESCRIPTION:Carboxymethyl cellulose-based cryogels as scaffolds for pancreatic and skeletal muscle tissue engineering\nFerran Velasco\, Biosensors for bioengineering group \nThe defence will take place online\, if you wish to attend to this defence\, you have to send an email to doctoratmedicina@ub.edu and you  can find more information here \n 
URL:https://ibecbarcelona.eu/event/phd-thesis-defence-ferran-velasco/
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20210628T100000
DTEND;TZID=Europe/Madrid:20210628T120000
DTSTAMP:20260509T111253
CREATED:20210621T135519Z
LAST-MODIFIED:20210621T135842Z
UID:85281-1624874400-1624881600@ibecbarcelona.eu
SUMMARY:PhD Thesis Defence: Maria Arista
DESCRIPTION:Unveiling viral structures by single-molecule localization microscopy\nMaria Arista\, Nanoscopy for nanomedicine group \nThe defence will take place online\, if you wish to attend to this defence\, you can find the link to access here and you can find more information here
URL:https://ibecbarcelona.eu/event/phd-thesis-defence-maria-arista/
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20210623T100000
DTEND;TZID=Europe/Madrid:20210623T120000
DTSTAMP:20260509T111253
CREATED:20210622T131947Z
LAST-MODIFIED:20210622T131947Z
UID:85480-1624442400-1624449600@ibecbarcelona.eu
SUMMARY:PhD Thesis Defence: Xarxa Quiroga
DESCRIPTION:Plasma membrane mechanosensing upon stretch-induced topography remodelling\nXarxa Quiroga\, Cellular and molecular mechanobiology group. \nThe thesis defence takes place tomorrow at 10AM in the “Antoni Caparrós” auditorium\, located at the PCB Tower D\, with limited capacity.
URL:https://ibecbarcelona.eu/event/phd-thesis-defence-xarxa-quiroga/
LOCATION:Auditori Antoni Caparrós – PCB
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20210525T030000
DTEND;TZID=Europe/Madrid:20210525T170000
DTSTAMP:20260509T111253
CREATED:20210518T071812Z
LAST-MODIFIED:20210518T071846Z
UID:84387-1621911600-1621962000@ibecbarcelona.eu
SUMMARY:PhD Thesis Defence: Enara Larrañaga
DESCRIPTION:Effects of substrate-derived cues in driving the self-organization of organoid-derived intestinal epithelia\nEnara Larrañaga\, Biomimetic systems for cell engineering \nThe defence will take place online\, if you wish to attend to this defence\, you can find the link to access here and you can find more information here \n 
URL:https://ibecbarcelona.eu/event/phd-thesis-defence-enara-larranaga/
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20210512T100000
DTEND;TZID=Europe/Madrid:20210512T120000
DTSTAMP:20260509T111253
CREATED:20210507T092710Z
LAST-MODIFIED:20210507T094146Z
UID:84243-1620813600-1620820800@ibecbarcelona.eu
SUMMARY:PhD Thesis Defence: Harishankar Balakrishnan
DESCRIPTION:Nanoscale Tomography based in Electrostatic Force Microscopy\nHarishankar Balakrishnan\, Nanoscale bioelectrical characterization group \nThe defence will take place online\, if you wish to attend to this defence\, you can find the link to access here and you can find more information here \nPlease join the meeting few minutes before the mentioned time to avoid session interruption.  \nIf you are joining after the mentioned time\, please make sure your microphone is muted before joining the session.
URL:https://ibecbarcelona.eu/event/phd-thesis-defence-harishankar-balakrishnan/
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20210511T100000
DTEND;TZID=Europe/Madrid:20210511T120000
DTSTAMP:20260509T111253
CREATED:20210507T154643Z
LAST-MODIFIED:20210507T154643Z
UID:84258-1620727200-1620734400@ibecbarcelona.eu
SUMMARY:PhD Thesis Defence: Martina Di Muzio
DESCRIPTION:Nanoscale dielectric mapping of biomembranes with in-liquid Scanning Dielectric Microscopy\nMartina Di Muzio\, Nanoscale bioelectrical characterization group \nThe defence will take place online\, if you wish to attend to this defence\, you can find the link to access here and you can find more information here \nPlease join the meeting few minutes before the mentioned time to avoid session interruption. \nIf you are joining after the mentioned time\, please make sure your microphone is muted before joining the session.
URL:https://ibecbarcelona.eu/event/phd-thesis-defence-martina-di-muzio/
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20210426T100000
DTEND;TZID=Europe/Madrid:20210426T120000
DTSTAMP:20260509T111253
CREATED:20210422T071047Z
LAST-MODIFIED:20210422T071132Z
UID:83625-1619431200-1619438400@ibecbarcelona.eu
SUMMARY:PhD Thesis Defence: Laura Moya
DESCRIPTION:Deciphering the utility of Galleria mellonella as an infection and toxicity in vivo model\nLaura Moya\, Bacterial infections: Antimicrobial therapies \nThe defence will take place online\, if you wish to attend to this defence\, you will find the link to access and all the information here
URL:https://ibecbarcelona.eu/event/phd-thesis-defence-laura-moya/
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20210416T100000
DTEND;TZID=Europe/Madrid:20210416T120000
DTSTAMP:20260509T111253
CREATED:20210409T065700Z
LAST-MODIFIED:20210409T065700Z
UID:83305-1618567200-1618574400@ibecbarcelona.eu
SUMMARY:PhD Thesis Defence: Núria Blanco-Cabra
DESCRIPTION:Noves metodologies per al tractament de bacteris creixent en forma de biofilm\nNúria Blanco-Cabra\, Bacterial infections and antimicrobial therapies group at IBEC \nThe defence will take place online\, if you wish to attend to this defence\, write an email to doctoratmedicina@ub.edu at least 48 hours before the defence.
URL:https://ibecbarcelona.eu/event/phd-thesis-defence-nuria-blanco-cabra/
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20210407T100000
DTEND;TZID=Europe/Madrid:20210407T120000
DTSTAMP:20260509T111253
CREATED:20210326T095201Z
LAST-MODIFIED:20210326T095226Z
UID:83020-1617789600-1617796800@ibecbarcelona.eu
SUMMARY:PhD Thesis Defence: Patrica Prado Peralta
DESCRIPTION:Developing new strategies to understand human kidney development and target human disease\nPatricia Prado Peralta\, Pluripotency for organ regeneration group \nThe defence will take place online using the BBCollab platform
URL:https://ibecbarcelona.eu/event/phd-thesis-defence-patrica-prado-peralta/
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20210310T090000
DTEND;TZID=Europe/Madrid:20210310T230000
DTSTAMP:20260509T111253
CREATED:20210301T090512Z
LAST-MODIFIED:20210308T082914Z
UID:82191-1615366800-1615417200@ibecbarcelona.eu
SUMMARY:PhD Thesis Defence: Maider Badiola
DESCRIPTION:Compartmentalised microfluidic culture systems for in vitro modelling of neurological and neuromuscular microenvironments\nMaider Badiola\, Nanobioengineering group \nMovement of skeletal-muscle fibres is generated by the locomotion circuit. Failures in any part of the circuit can cause or define the severity of neuromuscular diseases (NMD)\, such as amyotrophic lateral sclerosis (ALS). Conventional in vitro study models coculturing motoneurons and skeletal muscle cells are not physiologically relevant. Moreover\, studying fragments of the circuit cannot provide a comprehensive and complete view of the pathological process. \nThis thesis aims to study the neuromuscular context in vitro through compartmentalised microfluidic culture systems (cµFCS) and to create physiologically relevant study models. It offers an evolving prospective of in vitro models\, moving from mice to human cells\, from 2D to 3D cell cultures\, from primary cells to human induced pluripotent stem cells (hiPSC)\, and analysing both healthy and diseased cells. \nThis thesis gathers many technological innovations from a Bioengineering point of view\, paving the way for future studies in the neuromuscular field. It shows that the integration of the entire neuromuscular circuit components in the developed in vitro systems provides a wider view of the neuromuscular physiology and the pathological processes. These results show first steps towards future 3D physiological neuromuscular circuit models on a chip for NMD studies. \nThe defence will take place online using the Microsoft Teams Platform
URL:https://ibecbarcelona.eu/event/phd-thesis-defence-maider-badiola/
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20210223T150000
DTEND;TZID=Europe/Madrid:20210223T170000
DTSTAMP:20260509T111253
CREATED:20210217T122107Z
LAST-MODIFIED:20210217T122142Z
UID:81819-1614092400-1614099600@ibecbarcelona.eu
SUMMARY:PhD Thesis Defence: Davia Prischich
DESCRIPTION:Development and applications of photoswitchable small molecules and peptides to control protein-protein interactions and GPCR activity\nDavia Prischich\, Nanoprobes and Nanoswitches group\, IBEC \nThe defense will be held online through the platform provided by the UB. For those who are interested in joining\, please remember that you have to write an email to vd.quimica.recerca@ub.edu at least 48 hours before the event.
URL:https://ibecbarcelona.eu/event/phd-thesis-defence-davia-prischich/
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20210115T110000
DTEND;TZID=Europe/Madrid:20210115T130000
DTSTAMP:20260509T111253
CREATED:20210111T111039Z
LAST-MODIFIED:20210113T080556Z
UID:80775-1610708400-1610715600@ibecbarcelona.eu
SUMMARY:PhD Thesis Defense: Maria Blancas Muñoz
DESCRIPTION:Knowing what you know. A pedagogical model based on learners’ metacognitive abilities\nMaria Blancas Muñoz\, Synthetic\, Perceptive\, Emotive and Cognitive Systems (SPECS) \nThis thesis defense will be held online next 15th January at 11\, via “zoom”\, using this link.
URL:https://ibecbarcelona.eu/event/phd-thesis-defense-maria-blancas-munoz/
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20201221T110000
DTEND;TZID=Europe/Madrid:20201221T130000
DTSTAMP:20260509T111253
CREATED:20201214T081415Z
LAST-MODIFIED:20201214T081428Z
UID:80334-1608548400-1608555600@ibecbarcelona.eu
SUMMARY:PhD Thesis Defense: Laia Lidón Gil
DESCRIPTION:Regulación de la expresión de PrPC como elemento clave en las modificaciones de tau en la enfermedad de Alzheimer\nLaia Lidón\, Molecular and Cellular Neurobiotechnology \nLa enfermedad de Alzheimer (EA) es la causa más común de demencia y tiene una elevada prevalencia a nivel mundial. Se caracteriza por un deterioro cognitivo progresivo y muestra como principales rasgos neuropatológicos la presencia de placas seniles enriquecidas en βamiloide y ovillos neurofibrilares intracelulares constituidos por la proteína tau hiperfosforilada. Una precisa regulación de la fosforilación de tau es esencial para que la proteína ejerza sus funciones normales\, ya que su hiperfosforilación interrumpe procesos neuronales básicos como el transporte axonal. \nPor otro lado\, la proteína priónica celular (PrPC) es una glicoproteína de unión a membrana que en humanos se expresa mayoritariamente en el sistema nervioso central a partir de un único gen\, PRNP. Sus funciones fisiológicas abarcan un conjunto de propiedades neuroprotectoras como la regulación de la homeostasis del calcio\, la actividad anti-apoptótica y la capacidad antioxidante. \nEn los últimos años\, el interés por la PrPC y su implicación en diversas enfermedades neurodegenerativas ha ido en aumento a medida que se han ido conociendo los múltiples rasgos comunes a nivel molecular y/o neuropatológico entre PrPC y dichas enfermedades. Por\nejemplo\, se ha descrito que PrPC interacciona directamente con las proteínas tau\, Aβ y αsinucleína participando así en diversos procesos patológicos y vías de señalización. Es por ello que PrPC ha sido asociada con la EA y otras taupatías o la enfermedad de Parkinson. \nEn este sentido\, se ha descrito que el aumento de expresión de PrPC provoca una reducción de los niveles de tau y una menor susceptibilidad a la fosforilación en modelos experimentales de EA. Además\, ha sido demostrado que durante el curso de la EA se producen cambios de expresión en el perfil de PrPC habiendo un incremento notable en estadios iniciales de la enfermedad\, mientras que en estadios avanzados la expresión de PrPC disminuye coincidiendo con el incremento de depósitos de ptau. Este hecho\, sugiere que PrPC podría estar ejerciendo un rol neuroprotector en las fases iniciales de la enfermedad y\, en cambio\, la reducción de su expresión en fases avanzadas contribuiría a la neurodegeneración y a la progresión de la patología. \nA pesar de ello\, se desconoce cuáles son los desencadenantes de los cambios de expresión de PRNP en la enfermedad y\, por este motivo\, uno de los objetivos principales de la presente tesis ha sido analizar dichos factores. Hemos estudiado diversos estímulos asociados a la EA que pueden estar implicados en la regulación transcripcional de PRNP en etapas iniciales de la enfermedad y nuestros resultados indican que el incremento celular de los niveles de tau promueve la activación del promotor de PRNP. Además\, hemos descrito que la vía de señalización JNK-c-jun-AP1 es la principalmente implicada en la activación del promotor de PRNP por tau. \nPor otro lado\, diversos estudios sugieren que PrPC participa en la diferenciación neuronal de progenitores neuronales\, un proceso altamente influenciado por la actividad de la glucógeno sintasa quinasa-3beta (GSK3β)\, siendo esta inhibida por PrPC . Múltiples trabajos han descrito un desequilibrio en la expresión de las diferentes isoformas de tau (tau3R y tau4R) derivadas del splicing diferencial que sufre el gen de tau\, MAPT\, en enfermedades que cursan acúmulo de tau\, como la EA. En dichas enfermedades también se han encontrado niveles alterados de diversas quinasas\, y entre ellas se encuentra la GSK3β\, que además de incidir sobre la hiperfosforilación de tau\, está directamente implicada en el splicing alternativo de MAPT. Por ello\, otro de los propósitos del presente estudio ha sido analizar la intervención de PrPC \, no solo en la fosforilación de tau y en el mantenimiento de sus niveles de expresión\, sino también\nen la generación de las diferentes isoformas tau3R y tau4R. Mediante el uso de animales transgénicos\, muestras humanas de pacientes con EA y modelos experimentales de estudio de la PrPC \, nuestros resultados corroboran la implicación de PrPC en el splicing alternativo del exón 10 de tau a través de su papel inhibidor de la actividad GSK3β. \n\nThis thesis defense will be held online next 21st December at 11\, in order to be able to attend the defense\, you have to write an email to: doctorat.biologia@ub.edu
URL:https://ibecbarcelona.eu/event/phd-thesis-defense-laia-lidon-gil/
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20201215T120000
DTEND;TZID=Europe/Madrid:20201215T140000
DTSTAMP:20260509T111253
CREATED:20201203T074210Z
LAST-MODIFIED:20201214T113928Z
UID:80200-1608033600-1608040800@ibecbarcelona.eu
SUMMARY:PhD Thesis Defense: Sock Ching Low
DESCRIPTION:Giving Centre Stage to Top-Down Inhibitory Mechanisms for Selective Attention\nSock Ching Low\, SPECS (Synthetic\, Perceptive\, Emotive and Cognitive Systems) \nSelective attention determines the sensory signals that are processed at higher levels at the expense of others and is biased by higher-order brain regions which anticipate task-relevant stimuli and increase neural sensitivity to them in the sensory cortex. Often\, this is thought to occur through excitation of selected neurons\, but some studies have suggested that it is not the full description of the process. Increasingly\, evidence has pointed to an alternative\, top-down inhibitory biasing mechanism. Here\, we investigated such an inhibitory model of attention. We first showed how sensitivity to stimulus features known to be task-irrelevant are reduced through top-down suppression. Secondly\, we demonstrated a biologically grounded spiking model’s ability to modulate information processing and benchmarked it to physiology. Lastly\, we explored the interaction between the excitatory and inhibitory models of top-down attention in a foraging agent. Our results support the inhibitory model of top-down attention as a biological attentional mechanism and show how it fits into the current zeitgeist of top-down attentional mechanisms. \nThis thesis defense will be held online using “Zoom” using this link.
URL:https://ibecbarcelona.eu/event/phd-thesis-defense-sock-ching-low/
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20201211T140000
DTEND;TZID=Europe/Madrid:20201211T170000
DTSTAMP:20260509T111253
CREATED:20201209T121743Z
LAST-MODIFIED:20201210T124757Z
UID:80270-1607695200-1607706000@ibecbarcelona.eu
SUMMARY:PhD Thesis Defense: Elena Lantero
DESCRIPTION:Targeting strategies against Plasmodium and practical applications: blocking parasite development with heparin derivatives and identifying new aptamers for diagnosis\nElena Lantero\, Nanomalaria Group\nThis thesis defense will take place ONLINE on the 11th December at 14.00 using the “BB Collaborate” streaming platform.
URL:https://ibecbarcelona.eu/event/phd-thesis-defense-elena-lantero/
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20201210T153000
DTEND;TZID=Europe/Madrid:20201210T170000
DTSTAMP:20260509T111253
CREATED:20201209T122744Z
LAST-MODIFIED:20201210T124825Z
UID:80273-1607614200-1607619600@ibecbarcelona.eu
SUMMARY:PhD Thesis Defense: Anna Vila Giraut
DESCRIPTION:Hydrogel co-networks of gelatin methacryloyl and poly(ethylene glycol)diacrylate sustain 3D functional in vitro models of intestinal mucosa\nAnna Vila Giraut\, Biomimetic systems for cell engineering Group\nConventional in vitro cell culture models do not possess the complexity that the native tissues offer. Because of this\, the functional properties of the tissues are not properly mimicked\, which causes poorly predictive capabilities. Engineered tissues\, which combine biofabrication and tissue engineering techniques\, try to overcome this gap by providing the cells with an environment similar to the native tissue\, recapitulating (I) the physicochemical and mechanical properties of the cellular matrix\, (II) the multicellular complexity of the different tissue compartments\, and (III) the 3D structures of the tissues. These new engineered models are key factors to improve the platforms for basic research studies\, testing new drugs or modelling diseases. Among all the engineered tissues\, the intestinal mucosa is not well represented. The intestinal mucosa is formed by the epithelium\, which is a multicellular monolayer laying on top of the lamina propria\, a connective tissue containing several cell types (mesenchymal cells\, immune cells). The gold standard intestinal models are based on epithelial cell lines derived from colon cancer cells grown on the hard porous membranes of the Transwell® inserts. The lack of the intestinal stromal compartment and the growth on a hard surface give high transepithelial electrical resistance and low apparent permeability. Therefore\, the development of better in vitro platforms\, which integrates both compartments and provides epithelium-lamina propria cell interactions\, is highly desirable. \nIn this work\, we describe an easy and cost-effective method to engineer a 3D intestinal mucosa model that combines both the epithelium and the lamina propria compartments. To build the 3D scaffolds we chose hydrogels as materials to mimic the physicochemical and mechanical properties of intestinal tissue. Thus\, hydrogel conetworks of gelatin methacryolyl (GelMA)\, a natural polymer\, and poly(ethylene glycol) diacrylate (PEGDA)\, a synthetic polymer\, are photopolymerized. On one hand\, GelMA provides biodegradation and cell adhesion sequences but it lacks long-term mechanical stability. On the other hand\, PEGDA\, is non-biodegradable and does not present cell adhesion motifs. Nevertheless\, it has good mechanical properties. By this technique\, the lamina propria compartment of the intestinal mucosa can be reproduced in vitro. To do that\, GelMA and PEGDA polymers are laden with mesenchymal cells (fibroblasts or myofibroblasts) and/or immune cells (macrophages). We demonstrated that GelMA – PEGDA hydrogel co-networks support the growth of these cells and epithelial monolayers on top of the scaffolds. Embedding fibroblasts or myofibroblasts on the hydrogel conetworks enhance the formation and the maturity of the Caco-2 epithelial monolayers\, providing barrier properties similar to in vivo. The presence of the stromal cells also enhances the recovery of the epithelial integrity when the epithelium is temporally damaged. Finally\, an immunocompetent model is obtained by the encapsulation of macrophages in the constructs. The presence of macrophages does not influence the formation of the epithelium. However\, when the epithelial monolayer is disrupted\, the presence of mesenchymal and immune cells in the stromal compartment increases cytokine secretion in a synergistic manner. Our model can successfully mimic the interactions between stromal and epithelial compartments found in vivo intestinal tissue\, offering a potential platform to be used to study absorption and toxicity of drugs\, as well as cell behaviour under physiological and pathological conditions. \nLocation: The defense will be online. People are invited to attend upon receiving a link that you have to request to vd.fisica.recerca@ub.edu
URL:https://ibecbarcelona.eu/event/phd-thesis-defense-anna-vila-giraut/
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20201204T110000
DTEND;TZID=Europe/Madrid:20201204T130000
DTSTAMP:20260509T111253
CREATED:20201202T085923Z
LAST-MODIFIED:20201202T092538Z
UID:80148-1607079600-1607086800@ibecbarcelona.eu
SUMMARY:PhD Thesis Defense: Javier Rodriguez Benítez
DESCRIPTION:Characterization and interpretation of cardiovascular and cardiorespiratory dynamics in cardiomyopathy patients\nJavier Rodriguez Benítez\, member of Biomedical Signal Processing and Interpretation (BIOSPIN) Group  \nFriday 4th December 2020\, at 11.00 am \nThis defense will be transmitted online at Google meet\, using this link \n 
URL:https://ibecbarcelona.eu/event/phd-thesis-defense-javier-rodriguez-benitez/
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20201204T110000
DTEND;TZID=Europe/Madrid:20201204T130000
DTSTAMP:20260509T111253
CREATED:20201201T133153Z
LAST-MODIFIED:20201202T090027Z
UID:80134-1607079600-1607086800@ibecbarcelona.eu
SUMMARY:PhD Thesis Defense: Arnau Biosca
DESCRIPTION:Discovery of protein aggregation in Plasmodium parasites and development of a combinational antimalarial therapy at the nanoscale\nArnau Biosca\, Nanomalaria Group \nThis thesis defense will take place ONLINE on the 4th December at 11.00 using the “BB Collaborate” streaming platform.
URL:https://ibecbarcelona.eu/event/phd-thesis-defense-arnau-biosca/
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20201125T000000
DTEND;TZID=Europe/Madrid:20201125T140000
DTSTAMP:20260509T111253
CREATED:20201120T124114Z
LAST-MODIFIED:20201120T124114Z
UID:79834-1606262400-1606312800@ibecbarcelona.eu
SUMMARY:PhD Thesis Defense: Jesús Ordoño
DESCRIPTION:Lactate: unraveling the regenerative potential for cardiac tissue engineering\nJesús Ordoño\, Biometerials for regenerative therapies grouop \nThis thesis defense will take place on the 25th November at 12.00 at Sala d’Actes de la Facultat de Matemàtiques i Estadística (FME)\, Campus Diagonal Sud. It is possible to attend to this defense but it will also be transmitted online at Google meet (meet.google.com/ufd-vtgp-gmd). \n  \n 
URL:https://ibecbarcelona.eu/event/phd-thesis-defense-jesus-ordono/
LOCATION:Sala d’Actes de la Facultat de Matemàtiques i Estadística (FME)\, Carrer de Pau Gargallo\, Barcelona\, 08028\, Spain
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20201109T150000
DTEND;TZID=Europe/Madrid:20201109T170000
DTSTAMP:20260509T111253
CREATED:20201104T112844Z
LAST-MODIFIED:20201104T112844Z
UID:78888-1604934000-1604941200@ibecbarcelona.eu
SUMMARY:PhD Thesis Defense: Dolores Blanco
DESCRIPTION:Noninvasive multimodal analysis of thoracic bioimpedance and myographic signals for the assessment of chronic obstructive pulmonary disease\nDolores Blanco\, Biomedical Signal Processing and Interpretation \nChronic respiratory diseases cause morbidity and premature mortality in adult population. In particular\, chronic obstructive pulmonary disease (COPD) represents a socioeconomic burden worldwide. COPD is usually evaluated by a spirometry test to quantify the airflow limitation. Classical spirometry requires the patients to move to the medical centers making difficult the continuous monitoring. Alternatively\, other noninvasive methods have been studied to monitor respiration because of their capability to provide valuable respiratory-related information. These techniques would lighten the intrusiveness of the measurements and ease the ambulatory monitoring of respiration. However\, the applicability of these methods into the clinics is still limited because of the lack of evidence in these applications. \nThe objective of this thesis is to propose and evaluate novel noninvasive methods to monitor respiration and assess obstructive diseases. We proposed a setup and a protocol to evaluate the applicability of thoracic bioimpedance and surface myographic signals for respiration assessment in healthy subjects and COPD patients. We acquired bioimpedance\, airflow and surface myographic signals in ten healthy subjects and fifty COPD patients. The physiological data was measured during an inspiratory threshold loading protocol to evaluate the methods during restrictive conditions. The thesis consisted of three different studies published in high impact factor journals. The two first studies delved into the changes of thoracic bioimpedance during restrictive breathing and\, the third one focused on the combination of bioimpedance and myographic signals for the assessment of COPD. \nPrevious studies showed a linear relationship between thoracic bioimpedance and respiratory volume during normal breathing. Firstly\, we assessed this linear relationship in healthy subjects for the first time\, during a loading protocol. We found a strong correlation between the signals even during highest loads. Nevertheless\, bioimpedance measurement is the combination of the different impedances of body tissues\, organs and fluids and consequently\, not only volume contributes to its measurement. Accordingly\, our second study aimed to evaluate the relevance of volume and chest movement to bioimpedance measurement at different levels of inspiratory muscle activity. We characterized bioimpedance using chest movement and volume signals by linear models and neural networks for different muscle effort. The results agreed with our previous results\, indicating that respiratory volume was the main contribution to bioimpedance\, but chest movement contributed substantially and more notably at high muscle activity. Both studies provided better knowledge of thoracic bioimpedance measurements which reinforces its use for noninvasive respiratory monitoring. \nFinally\, we evaluated the combination of thoracic bioimpedance and surface myographic signals in the COPD population. We proposed two novel ratios derived from the bioimpedance amplitude and myographic activity. These ratios showed significant differences between the mild and severe COPD patients meaning that the severest patients had lower inspiratory ventilation contribution of the inspiratory muscles. Consequently\, we suggest these novel ratios to provide valuable information to noninvasively monitor and complement the classical assessment of COPD. \nThe multimodal approach proposed in this thesis supports the application of thoracic bioimpedance for respiratory monitoring during normal and restrictive breathing. Furthermore\, the combination of bioimpedance and myographic information exhibited differences between COPD severity. The proposed methods will provide additional information about COPD condition which will be easily tracked by a single wearable device. Consequently\, the results of this thesis open up the way for a high-quality noninvasive monitoring of chronic respiratory patients. \n\nThis thesis defense will take place on Monday\, 9th November\, at 15:00 hours. \nLocation: The defense will be online using Microsoft Teams. People are invited to attend upon receiving a link that you have to request to Dolores Blanco (dblanco@ibecbarcelona.eu) or Raimon Jané (rjane@ibecbarcelona.eu).
URL:https://ibecbarcelona.eu/event/phd-thesis-defense-dolores-blanco/
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20200921T110000
DTEND;TZID=Europe/Madrid:20200921T130000
DTSTAMP:20260509T111253
CREATED:20200915T072231Z
LAST-MODIFIED:20200917T100832Z
UID:77259-1600686000-1600693200@ibecbarcelona.eu
SUMMARY:PhD Thesis defense: Martina Maier
DESCRIPTION:The principles of advanced virtual reality-based neurorehabilitation\nMartina Maier\, SPECS group \nHow the training in virtual reality and based on principles can support the recovery and diagnosis of disabilities after stroke. \n\nThis thesis defense will take place on Monday\, September 21st\, at 11:00 hours. \nLocation: The defense will be online. People are invited to attend upon receiving a link provided by UPF shortly before the defense.
URL:https://ibecbarcelona.eu/event/phd-thesis-defense-martina-maier/
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20200716T110000
DTEND;TZID=Europe/Madrid:20200716T130000
DTSTAMP:20260509T111253
CREATED:20200706T063623Z
LAST-MODIFIED:20200707T090653Z
UID:75980-1594897200-1594904400@ibecbarcelona.eu
SUMMARY:PhD Thesis defense: Helena Lozano
DESCRIPTION:Electrical and topographical study of bacterial appendages at the nanoscale\nHelena Lozano\, Nanoscale bioelectrical characterization group \nSome bacteria can exchange electrons with non-soluble electron acceptors\, such as minerals. This phenomenon is called Extracellular Electron Transfer (EET) and it can be done through several mechanisms\, especially through conductive bacterial nanowires. \nThe main objective of this thesis is the investigation of the polarization properties of electrochemically active bacteria and their appendages. Specifically\, I have studied two types of bacteria\, Shewanella oneidensis MR-1 and cable bacteria. I have used the Electrostatic Force Microscopy (EFM)\, which measures the electrostatic force using a nanometric probe\, combined with finite element simulations to obtain the polarization properties. The electrostatic force depends mainly on the geometry and dielectric constant of the probe-sample system. \nFirst\, I have developed a way to obtain the dimensions of objects avoiding physical contact with the sample by measuring the electrostatic force. I have tested this technique on silver nanowires and bacterial flagella\, optimizing the EFM technique to nanowire-like biological samples at the nanoscale. Afterward\, I have studied S. oneidensis Outer Membrane Extensions (OMEs)\, responsible for the EET. I have obtained a low value of the dielectric constant (εOME=3.7±0.7). However\, considering that the conduction mechanism of such OMEs is through electron hopping\, where electrons are localized\, these results do not contradict the literature. \nI have also studied the cable bacteria\, especially the fibers that are along this filamentous bacterium. The dielectric constant of the fibers was εr=7±1. This result is not compatible with the conductivity reported in the literature. Therefore\, a core-shell model was proposed with a conductive core of h~10–20nm. \nSubsequently\, I have performed qualitative EFM measurements in liquid over living and rehydrated S. oneidensis bacteria. \nFinally\, I have performed macroscale measurements in living S. oneidensis using a microfluidic device that I designed\, fabricated and characterized at the Denmark Technical University (DTU)\, Copenhagen. It was used to perform two-electrode impedance measurements. \n\nIn order to attend to the defense\, you must send an email to the president of the Doctoral Commission of the Faculty of Physics (Dr. Eugeni Grauges Pous – vd.fisica.recerca@ub.edu) with a minimum notice of 48 hours and will be held via Microsoft Teams.
URL:https://ibecbarcelona.eu/event/75980/
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20200224T113000
DTEND;TZID=Europe/Madrid:20200224T133000
DTSTAMP:20260509T111253
CREATED:20200205T152838Z
LAST-MODIFIED:20200205T154546Z
UID:71058-1582543800-1582551000@ibecbarcelona.eu
SUMMARY:PhD Thesis Defence: Martí Checa
DESCRIPTION:A Novel Scanning Probe Microscopy technique to study the nanoscale electrical properties of cells\nMartí Checa\, Nanoscale bioelectrical characterization group \nThe goal of this work of thesis is the study of electrical properties in cells. That is the study of how they can conduct electricity\, accumulate charges\, or polarize. Experimental techniques able to measure electrical properties of complex heterogeneous samples (like cells) with excellent spatial resolution are needed to accomplish such characterization at the single-cell level (microscale) or even at the subcellular level (nanoscale). During this work of thesis\, a new experimental technique named “Scanning Dielectric Force Volume Microscopy (SDFVM)” has been developed together with the theoretical modeling for its understanding when operated in a liquid environment. \nThe technique has been validated with known samples (both in dry and liquid) and applied to many different nanometric systems of interest. The first full map of the local dielectric constant of a prokaryotic cell in dry conditions has been obtained with unparalleled accuracy and spatial resolution\, demonstrating its capability for label-free composition and structural mapping. Moreover\, the method has been applied to liquid environment\, obtaining the first-ever local dielectric contrast in fixed eukaryotic cells. Furthermore\, the first preliminary results in living cells have also been shown. SDFVM is expected to have an important impact not only in Life Sciences but also in Material Science\, where the mapping of the dielectric properties of samples showing complex nanoscale topographies is often needed. \n  \n  \n 
URL:https://ibecbarcelona.eu/event/phd-thesis-defence-marti-checa/
LOCATION:Eduard Fontseré – Facultat de Física de la UB
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20200224T113000
DTEND;TZID=Europe/Madrid:20200224T133000
DTSTAMP:20260509T111253
CREATED:20200205T152838Z
LAST-MODIFIED:20200205T152838Z
UID:96620-1582543800-1582551000@ibecbarcelona.eu
SUMMARY:PhD Thesis Defence: Martí Checa
DESCRIPTION:A Novel Scanning Probe Microscopy technique to study the nanoscale electrical properties of cells\nMartí Checa\, Nanoscale bioelectrical characterization group \nThe goal of this work of thesis is the study of electrical properties in cells. That is the study of how they can conduct electricity\, accumulate charges\, or polarize. Experimental techniques able to measure electrical properties of complex heterogeneous samples (like cells) with excellent spatial resolution are needed to accomplish such characterization at the single-cell level (microscale) or even at the subcellular level (nanoscale). During this work of thesis\, a new experimental technique named “Scanning Dielectric Force Volume Microscopy (SDFVM)” has been developed together with the theoretical modeling for its understanding when operated in a liquid environment. \nThe technique has been validated with known samples (both in dry and liquid) and applied to many different nanometric systems of interest. The first full map of the local dielectric constant of a prokaryotic cell in dry conditions has been obtained with unparalleled accuracy and spatial resolution\, demonstrating its capability for label-free composition and structural mapping. Moreover\, the method has been applied to liquid environment\, obtaining the first-ever local dielectric contrast in fixed eukaryotic cells. Furthermore\, the first preliminary results in living cells have also been shown. SDFVM is expected to have an important impact not only in Life Sciences but also in Material Science\, where the mapping of the dielectric properties of samples showing complex nanoscale topographies is often needed. \n  \n  \n 
URL:https://ibecbarcelona.eu/event/phd-thesis-defence-marti-checa-4/
LOCATION:Eduard Fontseré – Facultat de Física de la UB
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20200115T113000
DTEND;TZID=Europe/Madrid:20200115T130000
DTSTAMP:20260509T111253
CREATED:20200113T155752Z
LAST-MODIFIED:20200113T160144Z
UID:70283-1579087800-1579093200@ibecbarcelona.eu
SUMMARY:PhD Thesis Defence: Aida Garrido
DESCRIPTION:Optical control of endogenous receptors and cellular excitability with light\nAida Garrido\, Nanoprobes and nanoswitches group \nLight-controlled manipulation of neuronal activity has transformed the field of neurobiology. Light provides temporal and spatial resolution over activation or inhibition of targeted populations of neurons\, one single neuron or single synapses. Such precision could be achieved with optogenetics\, which is based on the over-expression of light-sensitive proteins\, but it requires gene therapy and often alters cellular physiology. An alternative to optogenetics is offered by photopharmacology (the development of light-regulated drugs or photoswitches)\, which can operate on endogenous receptors without genetic manipulation. Several new photoswitches are described in this thesis to improve their pharmacological and optical properties.\nIn photopharmacology\, azobenzene is the most commonly used light switch. Photoswitchable tethered ligands (PTLs) are tri-modular molecules able to anchor to target receptors and alter their function by switching the azobenzene group. In the first chapter we demonstrate the ability to target endogenous receptors of hippocampal neurons and olfactory bulb neurons from Xenopus larvae. The chemical strategy used was to introduce a highly reactive anchoring group to a PTL with similar structure to the reported MAG compound used in the light regulated glutamate receptor\, LiGluR. These new kind of PTLs were called “Targeted Covalent Photoswitches” (TCPs).\nThe promiscuity of the reactive group of TCP limits the possibility to spatially confine the drug conjugation. Thus\, we designed a photolabile TCP that can be conjugated to its target with a specific wavelength\, and then be photoswitched at another wavelength.\nDespite the advantages of all molecules described above\, they share a common limitation: the activation wavelength of azobenzene is in the UV-violet range. Increasing the push-pull effect at the azobenzenic core by adding different substituents\, we achieved a TCP derivative activatable at the visible range and ultrafast relaxing. In this way a single wavelength of stimulation can be used. Both features make them great candidates to control ultrafast neurotransmission processes such as the ones implicated in sound coding in the cochlea. We demonstrated in a gerbil animal model the capacity of this blue-activated TCP to photosensitize native receptors of adult gerbil cochlea. This first proof of concept opens new possibilities to develop optical cochlear implants for the treatment of hearing loss avoiding gene therapy.\nChemical substitutions can also be rationally designed to enhance two-photon (2P) absorptivity without modifying the dynamics of photoswitches. In the third chapter we described two new 2P enhanced MAG derivatives to photocontrol LiGluR. We validated their properties with an all-optical approach\, by recording calcium induced neuronal responses in organotypic hippocampal slices\, and in vivo in Caenorhabditis elegans. The combination of slow relaxation lifetime and enhanced 2P absorptivity is translated into an accumulation of the active isomer of the photoswitch that successfully enhances its functional effect even at low illumination power.\nAnother way to spectrally modify the characteristics of a chromophore while avoiding mutation screening and new synthetic processes is by using light-harvesting fluorophores. Spectral overlapping of fluorophore emission and chromophore absorption broadens its activation spectrum. By means of chemical protection and deprotection\, we orthogonally control the conjugation of fluorophores and photoswitches. This is the first demonstration of light-harvesting strategy for optogenetics and photopharmacology.\nFinally\, we describe the use of novel PCLs containing chromophores other than linear azobenzene for the light-controlled activation of hippocampal neurons. Cyclic azobenzenes reverse isomer thermal stability and consequently also the activity of the photoswitch. On the other hand\, stilbenes allow the irreversible but non-photo-destructive activation of the original molecule\, thus avoiding the creation of photo-products.\nIn conclusion\, this thesis puts forward several advances in the photochromism and pharmacology of photoswitches for the control of neurotransmission without need of genetic manipulation.
URL:https://ibecbarcelona.eu/event/phd-thesis-defence-aida-garrido/
LOCATION:Sala de Graus – Campus de Bellvitge
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20200115T113000
DTEND;TZID=Europe/Madrid:20200115T130000
DTSTAMP:20260509T111253
CREATED:20200113T155752Z
LAST-MODIFIED:20200113T155752Z
UID:96587-1579087800-1579093200@ibecbarcelona.eu
SUMMARY:PhD Thesis Defence: Aida Garrido
DESCRIPTION:Optical control of endogenous receptors and cellular excitability with light\nAida Garrido\, Nanoprobes and nanoswitches group \nLight-controlled manipulation of neuronal activity has transformed the field of neurobiology. Light provides temporal and spatial resolution over activation or inhibition of targeted populations of neurons\, one single neuron or single synapses. Such precision could be achieved with optogenetics\, which is based on the over-expression of light-sensitive proteins\, but it requires gene therapy and often alters cellular physiology. An alternative to optogenetics is offered by photopharmacology (the development of light-regulated drugs or photoswitches)\, which can operate on endogenous receptors without genetic manipulation. Several new photoswitches are described in this thesis to improve their pharmacological and optical properties.\nIn photopharmacology\, azobenzene is the most commonly used light switch. Photoswitchable tethered ligands (PTLs) are tri-modular molecules able to anchor to target receptors and alter their function by switching the azobenzene group. In the first chapter we demonstrate the ability to target endogenous receptors of hippocampal neurons and olfactory bulb neurons from Xenopus larvae. The chemical strategy used was to introduce a highly reactive anchoring group to a PTL with similar structure to the reported MAG compound used in the light regulated glutamate receptor\, LiGluR. These new kind of PTLs were called “Targeted Covalent Photoswitches” (TCPs).\nThe promiscuity of the reactive group of TCP limits the possibility to spatially confine the drug conjugation. Thus\, we designed a photolabile TCP that can be conjugated to its target with a specific wavelength\, and then be photoswitched at another wavelength.\nDespite the advantages of all molecules described above\, they share a common limitation: the activation wavelength of azobenzene is in the UV-violet range. Increasing the push-pull effect at the azobenzenic core by adding different substituents\, we achieved a TCP derivative activatable at the visible range and ultrafast relaxing. In this way a single wavelength of stimulation can be used. Both features make them great candidates to control ultrafast neurotransmission processes such as the ones implicated in sound coding in the cochlea. We demonstrated in a gerbil animal model the capacity of this blue-activated TCP to photosensitize native receptors of adult gerbil cochlea. This first proof of concept opens new possibilities to develop optical cochlear implants for the treatment of hearing loss avoiding gene therapy.\nChemical substitutions can also be rationally designed to enhance two-photon (2P) absorptivity without modifying the dynamics of photoswitches. In the third chapter we described two new 2P enhanced MAG derivatives to photocontrol LiGluR. We validated their properties with an all-optical approach\, by recording calcium induced neuronal responses in organotypic hippocampal slices\, and in vivo in Caenorhabditis elegans. The combination of slow relaxation lifetime and enhanced 2P absorptivity is translated into an accumulation of the active isomer of the photoswitch that successfully enhances its functional effect even at low illumination power.\nAnother way to spectrally modify the characteristics of a chromophore while avoiding mutation screening and new synthetic processes is by using light-harvesting fluorophores. Spectral overlapping of fluorophore emission and chromophore absorption broadens its activation spectrum. By means of chemical protection and deprotection\, we orthogonally control the conjugation of fluorophores and photoswitches. This is the first demonstration of light-harvesting strategy for optogenetics and photopharmacology.\nFinally\, we describe the use of novel PCLs containing chromophores other than linear azobenzene for the light-controlled activation of hippocampal neurons. Cyclic azobenzenes reverse isomer thermal stability and consequently also the activity of the photoswitch. On the other hand\, stilbenes allow the irreversible but non-photo-destructive activation of the original molecule\, thus avoiding the creation of photo-products.\nIn conclusion\, this thesis puts forward several advances in the photochromism and pharmacology of photoswitches for the control of neurotransmission without need of genetic manipulation.
URL:https://ibecbarcelona.eu/event/phd-thesis-defence-aida-garrido-2/
LOCATION:Sala de Graus – Campus de Bellvitge
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20191209T110000
DTEND;TZID=Europe/Madrid:20191209T130000
DTSTAMP:20260509T111253
CREATED:20191128T121521Z
LAST-MODIFIED:20191128T121521Z
UID:96563-1575889200-1575896400@ibecbarcelona.eu
SUMMARY:PhD Thesis Defence: Roberto Paoli
DESCRIPTION:Cell Culture interfaces for different organ-on-chip applications: from photolithography to rapid-prototyping techniques with sensor embedding\nRoberto Paoli\, Nanobioengineering group \n 
URL:https://ibecbarcelona.eu/event/phd-thesis-defence-roberto-paoli-2/
LOCATION:Facultat de Física – Sala de Graus Antiga
CATEGORIES:PhD Thesis Defence
END:VEVENT
END:VCALENDAR