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DTSTART:20170326T010000
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BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20180427T110000
DTEND;TZID=Europe/Madrid:20180427T130000
DTSTAMP:20260520T010405
CREATED:20180420T094131Z
LAST-MODIFIED:20180420T094236Z
UID:58499-1524826800-1524834000@ibecbarcelona.eu
SUMMARY:PhD thesis defence: Berta Gumí
DESCRIPTION:“Structural organization of model membranes: a complementary approach combining atomic force microscopy and x-ray techniques”\nBerta Gumí\, Nanoprobes and Nanoswitches group\nBerta will be defending her PhD thesis on Friday 27th April at 11:00 in the Sala Antiga de Graus\, Faculty of Physics\, University of Barcelona. \nEverybody is welcome to attend. \n—\nIf you’re an IBEC PhD student and would like to advertise your PhD defence on the IBEC calendar\, please contact vleigh@ibecbarcelona.eu
URL:https://ibecbarcelona.eu/event/phd-thesis-defence-berta-gumi/
LOCATION:Sala Antiga de Graus\, Faculty of Physics\, UB\, Barcelona\, 08028\, Spain
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20180427T110000
DTEND;TZID=Europe/Madrid:20180427T130000
DTSTAMP:20260520T010405
CREATED:20180420T094131Z
LAST-MODIFIED:20180420T094131Z
UID:96232-1524826800-1524834000@ibecbarcelona.eu
SUMMARY:PhD thesis defence: Berta Gumí
DESCRIPTION:“Structural organization of model membranes: a complementary approach combining atomic force microscopy and x-ray techniques”\nBerta Gumí\, Nanoprobes and Nanoswitches group\nBerta will be defending her PhD thesis on Friday 27th April at 11:00 in the Sala Antiga de Graus\, Faculty of Physics\, University of Barcelona. \nEverybody is welcome to attend. \n—\nIf you’re an IBEC PhD student and would like to advertise your PhD defence on the IBEC calendar\, please contact vleigh@ibecbarcelona.eu
URL:https://ibecbarcelona.eu/event/phd-thesis-defence-berta-gumi-2/
LOCATION:Sala Antiga de Graus\, Faculty of Physics\, UB\, Barcelona\, 08028\, Spain
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20180705T150000
DTEND;TZID=Europe/Madrid:20180705T170000
DTSTAMP:20260520T010405
CREATED:20180626T093114Z
LAST-MODIFIED:20180626T093114Z
UID:59703-1530802800-1530810000@ibecbarcelona.eu
SUMMARY:PhD thesis defense: Marina Uroz
DESCRIPTION:“Regulation of cell division and cell cycle progression by cell-cell and cell-matrix forces”\nMarina Uroz\, Integrative Cell and Tissue Dynamics group\nMarina will be defending her PhD thesis on Thursday 5th July at 15:00 at the UB’s Faculty of Medicine (Hospital Clinic)\, room 1. \nEverybody is welcome to attend. \n—\nIf you’re an IBEC PhD student and would like to advertise your PhD defense on the IBEC calendar\, please contact vleigh@ibecbarcelona.eu
URL:https://ibecbarcelona.eu/event/phd-thesis-defense-marina-uroz/
LOCATION:UB Faculty of Medicine\, c/ Casanova 143\, Barcelona\, Spain
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20180705T150000
DTEND;TZID=Europe/Madrid:20180705T170000
DTSTAMP:20260520T010405
CREATED:20180626T093114Z
LAST-MODIFIED:20180626T093114Z
UID:96271-1530802800-1530810000@ibecbarcelona.eu
SUMMARY:PhD thesis defense: Marina Uroz
DESCRIPTION:“Regulation of cell division and cell cycle progression by cell-cell and cell-matrix forces”\nMarina Uroz\, Integrative Cell and Tissue Dynamics group\nMarina will be defending her PhD thesis on Thursday 5th July at 15:00 at the UB’s Faculty of Medicine (Hospital Clinic)\, room 1. \nEverybody is welcome to attend. \n—\nIf you’re an IBEC PhD student and would like to advertise your PhD defense on the IBEC calendar\, please contact vleigh@ibecbarcelona.eu
URL:https://ibecbarcelona.eu/event/phd-thesis-defense-marina-uroz-2/
LOCATION:UB Faculty of Medicine\, c/ Casanova 143\, Barcelona\, Spain
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20180710T160000
DTEND;TZID=Europe/Madrid:20180710T180000
DTSTAMP:20260520T010405
CREATED:20180705T151455Z
LAST-MODIFIED:20180705T151455Z
UID:96278-1531238400-1531245600@ibecbarcelona.eu
SUMMARY:PhD thesis defense: Diogo Pata Santos
DESCRIPTION:“The dynamics of hippocampal coding: beyond the spatial metaphor”\nDiogo Pata Santos\, SPECS group\nDiogo will be defending his PhD thesis on Tuesday 10th July at 16:00 in Sala 55.003 (planta baixa) of the Tànger building\, UPF Campus del Poblenou. \nEverybody is welcome to attend. \n—\nIf you’re an IBEC PhD student and would like to advertise your PhD defense on the IBEC calendar\, please contact vleigh@ibecbarcelona.eu
URL:https://ibecbarcelona.eu/event/phd-thesis-defense-diogo-pata-santos-2/
LOCATION:Tànger building\, UPF: Campus del Poblenou\, Roc Boronat 138\, Barcelona\, 08018\, Spain
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20180710T160000
DTEND;TZID=Europe/Madrid:20180710T180000
DTSTAMP:20260520T010405
CREATED:20180705T151455Z
LAST-MODIFIED:20180705T151603Z
UID:59967-1531238400-1531245600@ibecbarcelona.eu
SUMMARY:PhD thesis defense: Diogo Pata Santos
DESCRIPTION:“The dynamics of hippocampal coding: beyond the spatial metaphor”\nDiogo Pata Santos\, SPECS group\nDiogo will be defending his PhD thesis on Tuesday 10th July at 16:00 in Sala 55.003 (planta baixa) of the Tànger building\, UPF Campus del Poblenou. \nEverybody is welcome to attend. \n—\nIf you’re an IBEC PhD student and would like to advertise your PhD defense on the IBEC calendar\, please contact vleigh@ibecbarcelona.eu
URL:https://ibecbarcelona.eu/event/phd-thesis-defense-diogo-pata-santos/
LOCATION:Tànger building\, UPF: Campus del Poblenou\, Roc Boronat 138\, Barcelona\, 08018\, Spain
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20180920T113000
DTEND;TZID=Europe/Madrid:20180920T133000
DTSTAMP:20260520T010405
CREATED:20180917T115446Z
LAST-MODIFIED:20180917T115446Z
UID:61409-1537443000-1537450200@ibecbarcelona.eu
SUMMARY:PhD thesis defense: Jaideep Katuri
DESCRIPTION:Guiding active particles through surface interactions\nJaideep Katuri\, Smart nano-bio-devices group\nJaideep will be defending his PhD thesis on Thursday 20th September at 11:30 in the Sala de Graus Eduard Fontseré of the UB’s Faculty of Physics. \nEverybody is welcome to attend. \n—\nIf you’re an IBEC PhD student and would like to advertise your PhD defense on the IBEC calendar\, please contact vleigh@ibecbarcelona.eu
URL:https://ibecbarcelona.eu/event/phd-thesis-defense-jaideep-katuri/
LOCATION:Sala de Graus Eduard Fontseré\, Martí i Franquès\, 1-11\, Barcelona\, 08028
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20180920T113000
DTEND;TZID=Europe/Madrid:20180920T133000
DTSTAMP:20260520T010405
CREATED:20180917T115446Z
LAST-MODIFIED:20180917T115446Z
UID:96294-1537443000-1537450200@ibecbarcelona.eu
SUMMARY:PhD thesis defense: Jaideep Katuri
DESCRIPTION:Guiding active particles through surface interactions\nJaideep Katuri\, Smart nano-bio-devices group\nJaideep will be defending his PhD thesis on Thursday 20th September at 11:30 in the Sala de Graus Eduard Fontseré of the UB’s Faculty of Physics. \nEverybody is welcome to attend. \n—\nIf you’re an IBEC PhD student and would like to advertise your PhD defense on the IBEC calendar\, please contact vleigh@ibecbarcelona.eu
URL:https://ibecbarcelona.eu/event/phd-thesis-defense-jaideep-katuri-2/
LOCATION:Sala de Graus Eduard Fontseré\, Martí i Franquès\, 1-11\, Barcelona\, 08028
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20181005T113000
DTEND;TZID=Europe/Madrid:20181005T133000
DTSTAMP:20260520T010405
CREATED:20181001T072859Z
LAST-MODIFIED:20181001T073006Z
UID:61728-1538739000-1538746200@ibecbarcelona.eu
SUMMARY:PhD Thesis Defence: Jemish Parmar
DESCRIPTION:Micromotors for Environmental Applications\nJemish Parmar\, Smart nano-bio-devices group\nJemish will be defending his PhD thesis on Friday 5th October at 11:30 in the Sala Antiga de Graus of the UB’s Faculty of Physics. \nEverybody is welcome to attend. \n—\nIf you’re an IBEC PhD student and would like to advertise your PhD defense on the IBEC calendar\, please contact vleigh@ibecbarcelona.eu
URL:https://ibecbarcelona.eu/event/phd-thesis-defence-jemish-parmar/
LOCATION:Sala Antiga de Graus\, Faculty of Physics\, UB\, Barcelona\, 08028\, Spain
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20181005T113000
DTEND;TZID=Europe/Madrid:20181005T133000
DTSTAMP:20260520T010405
CREATED:20181001T072859Z
LAST-MODIFIED:20181001T072859Z
UID:96306-1538739000-1538746200@ibecbarcelona.eu
SUMMARY:PhD Thesis Defence: Jemish Parmar
DESCRIPTION:Micromotors for Environmental Applications\nJemish Parmar\, Smart nano-bio-devices group\nJemish will be defending his PhD thesis on Friday 5th October at 11:30 in the Sala Antiga de Graus of the UB’s Faculty of Physics. \nEverybody is welcome to attend. \n—\nIf you’re an IBEC PhD student and would like to advertise your PhD defense on the IBEC calendar\, please contact vleigh@ibecbarcelona.eu
URL:https://ibecbarcelona.eu/event/phd-thesis-defence-jemish-parmar-2/
LOCATION:Sala Antiga de Graus\, Faculty of Physics\, UB\, Barcelona\, 08028\, Spain
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20181114T120000
DTEND;TZID=Europe/Madrid:20181114T140000
DTSTAMP:20260520T010405
CREATED:20181029T094546Z
LAST-MODIFIED:20181030T095833Z
UID:62278-1542196800-1542204000@ibecbarcelona.eu
SUMMARY:PhD Thesis Defence: Joan Martí Muñoz
DESCRIPTION:Chemical design and validation of Ca 2+ -releasing platforms to promote vascularization in tissue regeneration\nJoan Martí Muñoz\, Biomaterials for Regenerative Therapies group\nJoan will be defending his PhD thesis on Wednesday 14th November at 12:00 in the Sala d’Actes of the UPC’s Facultat de Matemàtiques i Estadística\, Campus Diagonal Sud\, Carrer de Pau Gargallo. \nEverybody is welcome to attend. \n—\nIf you’re an IBEC PhD student and would like to advertise your PhD defence on the IBEC calendar\, please contact vleigh@ibecbarcelona.eu
URL:https://ibecbarcelona.eu/event/phd-thesis-defence-joan-marti-munoz/
LOCATION:Sala d’Actes de la Facultat de Matemàtica i Estadística (FME)\, C. Pau Gargallo\, 5\, Barcelona\, 08028
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20181114T120000
DTEND;TZID=Europe/Madrid:20181114T140000
DTSTAMP:20260520T010405
CREATED:20181029T094546Z
LAST-MODIFIED:20181029T094546Z
UID:96332-1542196800-1542204000@ibecbarcelona.eu
SUMMARY:PhD Thesis Defence: Joan Martí Muñoz
DESCRIPTION:Chemical design and validation of Ca 2+ -releasing platforms to promote vascularization in tissue regeneration\nJoan Martí Muñoz\, Biomaterials for Regenerative Therapies group\nJoan will be defending his PhD thesis on Wednesday 14th November at 12:00 in the Sala d’Actes of the UPC’s Facultat de Matemàtiques i Estadística\, Campus Diagonal Sud\, Carrer de Pau Gargallo. \nEverybody is welcome to attend. \n—\nIf you’re an IBEC PhD student and would like to advertise your PhD defence on the IBEC calendar\, please contact vleigh@ibecbarcelona.eu
URL:https://ibecbarcelona.eu/event/phd-thesis-defence-joan-marti-munoz-2/
LOCATION:Sala d’Actes de la Facultat de Matemàtica i Estadística (FME)\, C. Pau Gargallo\, 5\, Barcelona\, 08028
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20181220T110000
DTEND;TZID=Europe/Madrid:20181220T130000
DTSTAMP:20260520T010405
CREATED:20181203T112559Z
LAST-MODIFIED:20181203T112559Z
UID:96353-1545303600-1545310800@ibecbarcelona.eu
SUMMARY:PhD Thesis Defence: Gizem Altay
DESCRIPTION:Towards the development of biomimetic in vitro models of intestinal epithelium derived from intestinal organoids\nGizem Altay\, Biomimetic systems for cell engineering group\nGizem will be defending her PhD thesis on Thursday 20th December at 11:00 in the Aula Magna Enric Casassas of the Facultat de Física i Química at the UB. \nEverybody is welcome to attend. \n—\nIf you’re an IBEC PhD student and would like to advertise your PhD defence on the IBEC calendar\, please contact vleigh@ibecbarcelona.eu
URL:https://ibecbarcelona.eu/event/phd-thesis-defence-gizem-altay-2/
LOCATION:Aula Magna Enric Casassas\, Facultat de Química\, UB\, Carrer Martí i Franquès\, 1\, 08028 Barcelona\, Spain
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20181220T110000
DTEND;TZID=Europe/Madrid:20181220T130000
DTSTAMP:20260520T010405
CREATED:20181203T112559Z
LAST-MODIFIED:20181203T112626Z
UID:63660-1545303600-1545310800@ibecbarcelona.eu
SUMMARY:PhD Thesis Defence: Gizem Altay
DESCRIPTION:Towards the development of biomimetic in vitro models of intestinal epithelium derived from intestinal organoids\nGizem Altay\, Biomimetic systems for cell engineering group\nGizem will be defending her PhD thesis on Thursday 20th December at 11:00 in the Aula Magna Enric Casassas of the Facultat de Física i Química at the UB. \nEverybody is welcome to attend. \n—\nIf you’re an IBEC PhD student and would like to advertise your PhD defence on the IBEC calendar\, please contact vleigh@ibecbarcelona.eu
URL:https://ibecbarcelona.eu/event/phd-thesis-defence-gizem-altay/
LOCATION:Aula Magna Enric Casassas\, Facultat de Química\, UB\, Carrer Martí i Franquès\, 1\, 08028 Barcelona\, Spain
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20190705T110000
DTEND;TZID=Europe/Madrid:20190705T130000
DTSTAMP:20260520T010405
CREATED:20190702T120406Z
LAST-MODIFIED:20190702T120406Z
UID:96474-1562324400-1562331600@ibecbarcelona.eu
SUMMARY:PhD Thesis defence: Klaudia Grechuta
DESCRIPTION:“Grounding body ownership and language in action: evidence from Healthy and damaged brains”\nKlaudia Grechuta\, Synthetic\, Perceptive\, Emotive and Cognitive Systems (SPECS) group \nKlaudia Grechuta be defending her PhD thesis in the Sala 55.309 (tercera planta) Edifici Tànger\, Campus del Poblenou on Friday 5th July 2019 at 11:00am. \nEveryone is warmly invited to attend. \n— \nIf you’re an IBEC PhD student and would like to advertise your PhD defence on the IBEC calendar\, please contact ibeccommunications@ibecbarcelona.eu
URL:https://ibecbarcelona.eu/event/phd-thesis-defence-klaudia-grechuta-2/
LOCATION:Campus Poblenou
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20190705T110000
DTEND;TZID=Europe/Madrid:20190705T130000
DTSTAMP:20260520T010405
CREATED:20190702T120406Z
LAST-MODIFIED:20190703T112634Z
UID:67080-1562324400-1562331600@ibecbarcelona.eu
SUMMARY:PhD Thesis defence: Klaudia Grechuta
DESCRIPTION:“Grounding body ownership and language in action: evidence from Healthy and damaged brains”\nKlaudia Grechuta\, Synthetic\, Perceptive\, Emotive and Cognitive Systems (SPECS) group \nKlaudia Grechuta be defending her PhD thesis in the Sala 55.309 (tercera planta) Edifici Tànger\, Campus del Poblenou on Friday 5th July 2019 at 11:00am. \nEveryone is warmly invited to attend. \n— \nIf you’re an IBEC PhD student and would like to advertise your PhD defence on the IBEC calendar\, please contact ibeccommunications@ibecbarcelona.eu
URL:https://ibecbarcelona.eu/event/phd-thesis-defence-klaudia-grechuta/
LOCATION:Campus Poblenou
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20190709T113000
DTEND;TZID=Europe/Madrid:20190709T133000
DTSTAMP:20260520T010405
CREATED:20190703T112612Z
LAST-MODIFIED:20190703T112612Z
UID:67083-1562671800-1562679000@ibecbarcelona.eu
SUMMARY:PhD Thesis defence: Javier Burgués
DESCRIPTION:“Signal Processing and Machine Learning for Gas Sensors: Gas Source Localization with a Nano-Drone”.\nJavier Burgués\, Signal and information processing for sensing systems group \nChemical source localization (CSL) by autonomous robots has been a topic of research since the early 1990s and still today remains elusive beyond simple scenarios. It has numerous potential applications\, such as the localization of toxic emissions\, malodors\, gas leaks and hazardous substances in general\, without risking human lives. An intuitive CSL approach is to mimic the known chemo-orientation behaviour of some flying insects\, such as moths and mosquitos\, which effectively use odor plumes for mating and foraging. However\, terrestrial robots are too slow to perform insect-like movements and the response time and limit of detection (LOD) of current odor sensors for key compounds of biological relevance for plume navigation is orders of magnitude higher than in biological chemoreceptors. Instead of using a slow terrestrial robot equipped with complex instrumentation\, in this thesis we address the CSL problem with a nano-drone\, i.e. a miniaturized aerial robot\, equipped with a simple metal oxide semiconductor (MOX) sensor. Improving key specifications of MOX sensors for this application is one of the core parts of this thesis. Specifically\, we introduce novel signal processing methods for estimating and optimizing the LOD\, reducing the power consumption and improving the response time. We propose a univariate LOD optimization method based on linearized calibration models and a multivariate approach based on orthogonal partial least squares (O-PLS). To improve the response time\, we use high-frequency features extracted from the MOX signal derivative\, which are optimized for changing wind conditions and real-time operation. A novel setup consisting on a 3D grid of MOX sensors is proposed for real-time visualization of the gas distribution. Two map-based CSL strategies are finally evaluated using the nano-drone in experiments performed in a large indoor environment (160 m2) where a chemical source is placed in challenging positions for the drone. The experimental results demonstrate that the proposed nano-drone can quickly (< 3 min) build a rough gas distribution map (3D) of the environment and localize the main chemical source within it with small errors.
URL:https://ibecbarcelona.eu/event/phd-thesis-defence-javier-burgues/
LOCATION:Sala de Graus Eduard Fontseré\, Martí i Franquès\, 1-11\, Barcelona\, 08028
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20190709T113000
DTEND;TZID=Europe/Madrid:20190709T133000
DTSTAMP:20260520T010405
CREATED:20190703T112612Z
LAST-MODIFIED:20190703T112612Z
UID:96478-1562671800-1562679000@ibecbarcelona.eu
SUMMARY:PhD Thesis defence: Javier Burgués
DESCRIPTION:“Signal Processing and Machine Learning for Gas Sensors: Gas Source Localization with a Nano-Drone”.\nJavier Burgués\, Signal and information processing for sensing systems group \nChemical source localization (CSL) by autonomous robots has been a topic of research since the early 1990s and still today remains elusive beyond simple scenarios. It has numerous potential applications\, such as the localization of toxic emissions\, malodors\, gas leaks and hazardous substances in general\, without risking human lives. An intuitive CSL approach is to mimic the known chemo-orientation behaviour of some flying insects\, such as moths and mosquitos\, which effectively use odor plumes for mating and foraging. However\, terrestrial robots are too slow to perform insect-like movements and the response time and limit of detection (LOD) of current odor sensors for key compounds of biological relevance for plume navigation is orders of magnitude higher than in biological chemoreceptors. Instead of using a slow terrestrial robot equipped with complex instrumentation\, in this thesis we address the CSL problem with a nano-drone\, i.e. a miniaturized aerial robot\, equipped with a simple metal oxide semiconductor (MOX) sensor. Improving key specifications of MOX sensors for this application is one of the core parts of this thesis. Specifically\, we introduce novel signal processing methods for estimating and optimizing the LOD\, reducing the power consumption and improving the response time. We propose a univariate LOD optimization method based on linearized calibration models and a multivariate approach based on orthogonal partial least squares (O-PLS). To improve the response time\, we use high-frequency features extracted from the MOX signal derivative\, which are optimized for changing wind conditions and real-time operation. A novel setup consisting on a 3D grid of MOX sensors is proposed for real-time visualization of the gas distribution. Two map-based CSL strategies are finally evaluated using the nano-drone in experiments performed in a large indoor environment (160 m2) where a chemical source is placed in challenging positions for the drone. The experimental results demonstrate that the proposed nano-drone can quickly (< 3 min) build a rough gas distribution map (3D) of the environment and localize the main chemical source within it with small errors.
URL:https://ibecbarcelona.eu/event/phd-thesis-defence-javier-burgues-2/
LOCATION:Sala de Graus Eduard Fontseré\, Martí i Franquès\, 1-11\, Barcelona\, 08028
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20190711T120000
DTEND;TZID=Europe/Madrid:20190711T140000
DTSTAMP:20260520T010405
CREATED:20190704T134259Z
LAST-MODIFIED:20190709T132751Z
UID:67121-1562846400-1562853600@ibecbarcelona.eu
SUMMARY:PhD Thesis Defence: Víctor González Tarragó
DESCRIPTION:Control of integrin-mediated mechanoresponse by binding partners and force loading rates\nVíctor González Tarragó\, Cellular and Molecular Mechanobiology group \nThis thesis is a study on the integrin-mediated mechanoresponse by binding partners and force loading rates. Regarding the binding partners\, here we demonstrate an alternative and counter-intuitive mechanism\, by which another adaptor protein (ZO-1) promotes activation but decreases mechanical resistance. Because such mechanical regulation is bound to impact in downstream mechanosensing processes\, this provides an interesting and novel way to regulate cell adhesion\, mechanoresponse\, and function in general. Regarding the force loading rates\, our results show that force loading rates drive mechanosensing by increasing reinforcement and adhesion growth at the local adhesion level\, in a talin-dependent way. However\, if mechanically induced deformations are too high or too fast\, the cytoskeleton fluidizes\, thereby decreasing force loading rates and mechanosensing. This provides a unifying mechanism to understand how cells respond not only to directly applied forces\, but also to passive mechanical stimuli such as tissue rigidity or ECM ligand distribution. Further\, it also provides a framework to understand how the seemingly opposed concepts of reinforcement and fluidization are coupled to drive mechanosensing. \n  \n  \n 
URL:https://ibecbarcelona.eu/event/phd-thesis-defence-victor-gonzalez-tarrago/
LOCATION:Aula 14\, Faculty of Medicine (Campus Clínic)\, Barcelona\, Spain
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20190711T120000
DTEND;TZID=Europe/Madrid:20190711T140000
DTSTAMP:20260520T010405
CREATED:20190704T134259Z
LAST-MODIFIED:20190704T134259Z
UID:96484-1562846400-1562853600@ibecbarcelona.eu
SUMMARY:PhD Thesis Defence: Víctor González Tarragó
DESCRIPTION:Control of integrin-mediated mechanoresponse by binding partners and force loading rates\nVíctor González Tarragó\, Cellular and Molecular Mechanobiology group \nThis thesis is a study on the integrin-mediated mechanoresponse by binding partners and force loading rates. Regarding the binding partners\, here we demonstrate an alternative and counter-intuitive mechanism\, by which another adaptor protein (ZO-1) promotes activation but decreases mechanical resistance. Because such mechanical regulation is bound to impact in downstream mechanosensing processes\, this provides an interesting and novel way to regulate cell adhesion\, mechanoresponse\, and function in general. Regarding the force loading rates\, our results show that force loading rates drive mechanosensing by increasing reinforcement and adhesion growth at the local adhesion level\, in a talin-dependent way. However\, if mechanically induced deformations are too high or too fast\, the cytoskeleton fluidizes\, thereby decreasing force loading rates and mechanosensing. This provides a unifying mechanism to understand how cells respond not only to directly applied forces\, but also to passive mechanical stimuli such as tissue rigidity or ECM ligand distribution. Further\, it also provides a framework to understand how the seemingly opposed concepts of reinforcement and fluidization are coupled to drive mechanosensing. \n  \n  \n 
URL:https://ibecbarcelona.eu/event/phd-thesis-defence-victor-gonzalez-tarrago-4/
LOCATION:Aula 14\, Faculty of Medicine (Campus Clínic)\, Barcelona\, Spain
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20191001T160000
DTEND;TZID=Europe/Madrid:20191001T170000
DTSTAMP:20260520T010405
CREATED:20191001T091508Z
LAST-MODIFIED:20191001T091508Z
UID:68464-1569945600-1569949200@ibecbarcelona.eu
SUMMARY:PhD Thesis Defence: Jordi-Ysard Puigbó
DESCRIPTION:Learning mechanisms of uncertainty and neuromodulation\n Jordi-Ysard Puigbó\, Synthetic\, Perceptive\, Emotive and Cognitive Systems (SPECS) group \nSupervisors: Dr. Paul F.M.J Verschure (IBEC) and Dr. Miguel Ángel González Ballester \nCommittee: President: Dr. Gustavo Deco (UPF) Secretary: Dr. Andrea Soltoggio (Loughborough Univ.) Member: Dr. Yves Boubenec (ENS) \n 
URL:https://ibecbarcelona.eu/event/phd-thesis-defence-jordi-ysard-puigbo/
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20191001T160000
DTEND;TZID=Europe/Madrid:20191001T170000
DTSTAMP:20260520T010405
CREATED:20191001T091508Z
LAST-MODIFIED:20191001T091508Z
UID:96512-1569945600-1569949200@ibecbarcelona.eu
SUMMARY:PhD Thesis Defence: Jordi-Ysard Puigbó
DESCRIPTION:Learning mechanisms of uncertainty and neuromodulation\n Jordi-Ysard Puigbó\, Synthetic\, Perceptive\, Emotive and Cognitive Systems (SPECS) group \nSupervisors: Dr. Paul F.M.J Verschure (IBEC) and Dr. Miguel Ángel González Ballester \nCommittee: President: Dr. Gustavo Deco (UPF) Secretary: Dr. Andrea Soltoggio (Loughborough Univ.) Member: Dr. Yves Boubenec (ENS) \n 
URL:https://ibecbarcelona.eu/event/phd-thesis-defence-jordi-ysard-puigbo-4/
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20191004T000000
DTEND;TZID=Europe/Madrid:20191004T140000
DTSTAMP:20260520T010405
CREATED:20190925T082459Z
LAST-MODIFIED:20191001T065920Z
UID:68387-1570147200-1570197600@ibecbarcelona.eu
SUMMARY:PhD Thesis Defence: Carlos Pérez González
DESCRIPTION:Active forces driving spreading and retraction of living tissues\nCarlos Pérez González\, Integrative Cell and Tissue Dynamics group\n \nDevelopment\, regeneration and cancer involve drastic transitions in tissue morphology. In analogy with the behaviour of inert fluids\, some of these transitions have been interpreted as wetting transitions. The validity and scope of this analogy are unclear\, however\, because the active cellular forces that drive tissue wetting have been neither measured nor theoretically accounted for. In this thesis\, we show that the transition between two-dimensional epithelial monolayers and three-dimensional spheroidal aggregates can be understood as an active wetting transition whose physics differs fundamentally from that of passive wetting phenomena. By combining an active polar fluid model with measurements of physical forces as a function of tissue size\, contractility\, cell–cell and cell–substrate adhesion\, and substrate stiffness\, we show that the wetting transition results from the competition between traction forces and contractile intercellular stresses. This competition defines a new intrinsic length scale that gives rise to a critical size for the wetting transition in tissues\, a striking feature that has no counterpart in classical wetting. Finally\, we show that active shape fluctuations are dynamically amplified during tissue dewetting. Overall\, we conclude that tissue spreading constitutes a prominent example of active wetting—a novel physical scenario that may explain morphological transitions during tissue morphogenesis and tumour progression.
URL:https://ibecbarcelona.eu/event/phd-thesis-defence-carlos-perez-gonzalez/
LOCATION:Hospital Clínic\, Sala 7\, Barcelona
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20191004T000000
DTEND;TZID=Europe/Madrid:20191004T140000
DTSTAMP:20260520T010405
CREATED:20190925T082459Z
LAST-MODIFIED:20190925T082459Z
UID:96499-1570147200-1570197600@ibecbarcelona.eu
SUMMARY:PhD Thesis Defence: Carlos Pérez González
DESCRIPTION:Active forces driving spreading and retraction of living tissues\nCarlos Pérez González\, Integrative Cell and Tissue Dynamics group\n \nDevelopment\, regeneration and cancer involve drastic transitions in tissue morphology. In analogy with the behaviour of inert fluids\, some of these transitions have been interpreted as wetting transitions. The validity and scope of this analogy are unclear\, however\, because the active cellular forces that drive tissue wetting have been neither measured nor theoretically accounted for. In this thesis\, we show that the transition between two-dimensional epithelial monolayers and three-dimensional spheroidal aggregates can be understood as an active wetting transition whose physics differs fundamentally from that of passive wetting phenomena. By combining an active polar fluid model with measurements of physical forces as a function of tissue size\, contractility\, cell–cell and cell–substrate adhesion\, and substrate stiffness\, we show that the wetting transition results from the competition between traction forces and contractile intercellular stresses. This competition defines a new intrinsic length scale that gives rise to a critical size for the wetting transition in tissues\, a striking feature that has no counterpart in classical wetting. Finally\, we show that active shape fluctuations are dynamically amplified during tissue dewetting. Overall\, we conclude that tissue spreading constitutes a prominent example of active wetting—a novel physical scenario that may explain morphological transitions during tissue morphogenesis and tumour progression.
URL:https://ibecbarcelona.eu/event/phd-thesis-defence-carlos-perez-gonzalez-2/
LOCATION:Hospital Clínic\, Sala 7\, Barcelona
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20191007T000000
DTEND;TZID=Europe/Madrid:20191007T130000
DTSTAMP:20260520T010405
CREATED:20191001T071338Z
LAST-MODIFIED:20191001T071338Z
UID:96507-1570406400-1570453200@ibecbarcelona.eu
SUMMARY:PhD Thesis Defence: Ignasi Jorba Masdéu
DESCRIPTION:Multiscale nonlinear mechanics of soft biological tissues\nIgnasi Jorba Masdéu\, Cellular and Respiratory Biomechanics group
URL:https://ibecbarcelona.eu/event/multiscale-nonlinear-mechanics-of-soft-biological-tissues-2/
LOCATION:Aula 11\, Facultat Medicina UB (Campus Clínic)\, Barcelona\, Spain
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20191007T000000
DTEND;TZID=Europe/Madrid:20191007T130000
DTSTAMP:20260520T010405
CREATED:20191001T071338Z
LAST-MODIFIED:20191004T122932Z
UID:68456-1570406400-1570453200@ibecbarcelona.eu
SUMMARY:PhD Thesis Defence: Ignasi Jorba Masdéu
DESCRIPTION:Multiscale nonlinear mechanics of soft biological tissues\nIgnasi Jorba Masdéu\, Cellular and Respiratory Biomechanics group
URL:https://ibecbarcelona.eu/event/multiscale-nonlinear-mechanics-of-soft-biological-tissues/
LOCATION:Aula 11\, Facultat Medicina UB (Campus Clínic)\, Barcelona\, Spain
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20191209T110000
DTEND;TZID=Europe/Madrid:20191209T130000
DTSTAMP:20260520T010405
CREATED:20191128T121521Z
LAST-MODIFIED:20191128T121521Z
UID:96563-1575889200-1575896400@ibecbarcelona.eu
SUMMARY:PhD Thesis Defence: Roberto Paoli
DESCRIPTION:Cell Culture interfaces for different organ-on-chip applications: from photolithography to rapid-prototyping techniques with sensor embedding\nRoberto Paoli\, Nanobioengineering group \n 
URL:https://ibecbarcelona.eu/event/phd-thesis-defence-roberto-paoli-2/
LOCATION:Facultat de Física – Sala de Graus Antiga
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20191209T110000
DTEND;TZID=Europe/Madrid:20191209T130000
DTSTAMP:20260520T010405
CREATED:20191128T121521Z
LAST-MODIFIED:20191128T121600Z
UID:69696-1575889200-1575896400@ibecbarcelona.eu
SUMMARY:PhD Thesis Defence: Roberto Paoli
DESCRIPTION:Cell Culture interfaces for different organ-on-chip applications: from photolithography to rapid-prototyping techniques with sensor embedding\nRoberto Paoli\, Nanobioengineering group \n 
URL:https://ibecbarcelona.eu/event/phd-thesis-defence-roberto-paoli/
LOCATION:Facultat de Física – Sala de Graus Antiga
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20200115T113000
DTEND;TZID=Europe/Madrid:20200115T130000
DTSTAMP:20260520T010405
CREATED:20200113T155752Z
LAST-MODIFIED:20200113T155752Z
UID:96587-1579087800-1579093200@ibecbarcelona.eu
SUMMARY:PhD Thesis Defence: Aida Garrido
DESCRIPTION:Optical control of endogenous receptors and cellular excitability with light\nAida Garrido\, Nanoprobes and nanoswitches group \nLight-controlled manipulation of neuronal activity has transformed the field of neurobiology. Light provides temporal and spatial resolution over activation or inhibition of targeted populations of neurons\, one single neuron or single synapses. Such precision could be achieved with optogenetics\, which is based on the over-expression of light-sensitive proteins\, but it requires gene therapy and often alters cellular physiology. An alternative to optogenetics is offered by photopharmacology (the development of light-regulated drugs or photoswitches)\, which can operate on endogenous receptors without genetic manipulation. Several new photoswitches are described in this thesis to improve their pharmacological and optical properties.\nIn photopharmacology\, azobenzene is the most commonly used light switch. Photoswitchable tethered ligands (PTLs) are tri-modular molecules able to anchor to target receptors and alter their function by switching the azobenzene group. In the first chapter we demonstrate the ability to target endogenous receptors of hippocampal neurons and olfactory bulb neurons from Xenopus larvae. The chemical strategy used was to introduce a highly reactive anchoring group to a PTL with similar structure to the reported MAG compound used in the light regulated glutamate receptor\, LiGluR. These new kind of PTLs were called “Targeted Covalent Photoswitches” (TCPs).\nThe promiscuity of the reactive group of TCP limits the possibility to spatially confine the drug conjugation. Thus\, we designed a photolabile TCP that can be conjugated to its target with a specific wavelength\, and then be photoswitched at another wavelength.\nDespite the advantages of all molecules described above\, they share a common limitation: the activation wavelength of azobenzene is in the UV-violet range. Increasing the push-pull effect at the azobenzenic core by adding different substituents\, we achieved a TCP derivative activatable at the visible range and ultrafast relaxing. In this way a single wavelength of stimulation can be used. Both features make them great candidates to control ultrafast neurotransmission processes such as the ones implicated in sound coding in the cochlea. We demonstrated in a gerbil animal model the capacity of this blue-activated TCP to photosensitize native receptors of adult gerbil cochlea. This first proof of concept opens new possibilities to develop optical cochlear implants for the treatment of hearing loss avoiding gene therapy.\nChemical substitutions can also be rationally designed to enhance two-photon (2P) absorptivity without modifying the dynamics of photoswitches. In the third chapter we described two new 2P enhanced MAG derivatives to photocontrol LiGluR. We validated their properties with an all-optical approach\, by recording calcium induced neuronal responses in organotypic hippocampal slices\, and in vivo in Caenorhabditis elegans. The combination of slow relaxation lifetime and enhanced 2P absorptivity is translated into an accumulation of the active isomer of the photoswitch that successfully enhances its functional effect even at low illumination power.\nAnother way to spectrally modify the characteristics of a chromophore while avoiding mutation screening and new synthetic processes is by using light-harvesting fluorophores. Spectral overlapping of fluorophore emission and chromophore absorption broadens its activation spectrum. By means of chemical protection and deprotection\, we orthogonally control the conjugation of fluorophores and photoswitches. This is the first demonstration of light-harvesting strategy for optogenetics and photopharmacology.\nFinally\, we describe the use of novel PCLs containing chromophores other than linear azobenzene for the light-controlled activation of hippocampal neurons. Cyclic azobenzenes reverse isomer thermal stability and consequently also the activity of the photoswitch. On the other hand\, stilbenes allow the irreversible but non-photo-destructive activation of the original molecule\, thus avoiding the creation of photo-products.\nIn conclusion\, this thesis puts forward several advances in the photochromism and pharmacology of photoswitches for the control of neurotransmission without need of genetic manipulation.
URL:https://ibecbarcelona.eu/event/phd-thesis-defence-aida-garrido-2/
LOCATION:Sala de Graus – Campus de Bellvitge
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20200115T113000
DTEND;TZID=Europe/Madrid:20200115T130000
DTSTAMP:20260520T010405
CREATED:20200113T155752Z
LAST-MODIFIED:20200113T160144Z
UID:70283-1579087800-1579093200@ibecbarcelona.eu
SUMMARY:PhD Thesis Defence: Aida Garrido
DESCRIPTION:Optical control of endogenous receptors and cellular excitability with light\nAida Garrido\, Nanoprobes and nanoswitches group \nLight-controlled manipulation of neuronal activity has transformed the field of neurobiology. Light provides temporal and spatial resolution over activation or inhibition of targeted populations of neurons\, one single neuron or single synapses. Such precision could be achieved with optogenetics\, which is based on the over-expression of light-sensitive proteins\, but it requires gene therapy and often alters cellular physiology. An alternative to optogenetics is offered by photopharmacology (the development of light-regulated drugs or photoswitches)\, which can operate on endogenous receptors without genetic manipulation. Several new photoswitches are described in this thesis to improve their pharmacological and optical properties.\nIn photopharmacology\, azobenzene is the most commonly used light switch. Photoswitchable tethered ligands (PTLs) are tri-modular molecules able to anchor to target receptors and alter their function by switching the azobenzene group. In the first chapter we demonstrate the ability to target endogenous receptors of hippocampal neurons and olfactory bulb neurons from Xenopus larvae. The chemical strategy used was to introduce a highly reactive anchoring group to a PTL with similar structure to the reported MAG compound used in the light regulated glutamate receptor\, LiGluR. These new kind of PTLs were called “Targeted Covalent Photoswitches” (TCPs).\nThe promiscuity of the reactive group of TCP limits the possibility to spatially confine the drug conjugation. Thus\, we designed a photolabile TCP that can be conjugated to its target with a specific wavelength\, and then be photoswitched at another wavelength.\nDespite the advantages of all molecules described above\, they share a common limitation: the activation wavelength of azobenzene is in the UV-violet range. Increasing the push-pull effect at the azobenzenic core by adding different substituents\, we achieved a TCP derivative activatable at the visible range and ultrafast relaxing. In this way a single wavelength of stimulation can be used. Both features make them great candidates to control ultrafast neurotransmission processes such as the ones implicated in sound coding in the cochlea. We demonstrated in a gerbil animal model the capacity of this blue-activated TCP to photosensitize native receptors of adult gerbil cochlea. This first proof of concept opens new possibilities to develop optical cochlear implants for the treatment of hearing loss avoiding gene therapy.\nChemical substitutions can also be rationally designed to enhance two-photon (2P) absorptivity without modifying the dynamics of photoswitches. In the third chapter we described two new 2P enhanced MAG derivatives to photocontrol LiGluR. We validated their properties with an all-optical approach\, by recording calcium induced neuronal responses in organotypic hippocampal slices\, and in vivo in Caenorhabditis elegans. The combination of slow relaxation lifetime and enhanced 2P absorptivity is translated into an accumulation of the active isomer of the photoswitch that successfully enhances its functional effect even at low illumination power.\nAnother way to spectrally modify the characteristics of a chromophore while avoiding mutation screening and new synthetic processes is by using light-harvesting fluorophores. Spectral overlapping of fluorophore emission and chromophore absorption broadens its activation spectrum. By means of chemical protection and deprotection\, we orthogonally control the conjugation of fluorophores and photoswitches. This is the first demonstration of light-harvesting strategy for optogenetics and photopharmacology.\nFinally\, we describe the use of novel PCLs containing chromophores other than linear azobenzene for the light-controlled activation of hippocampal neurons. Cyclic azobenzenes reverse isomer thermal stability and consequently also the activity of the photoswitch. On the other hand\, stilbenes allow the irreversible but non-photo-destructive activation of the original molecule\, thus avoiding the creation of photo-products.\nIn conclusion\, this thesis puts forward several advances in the photochromism and pharmacology of photoswitches for the control of neurotransmission without need of genetic manipulation.
URL:https://ibecbarcelona.eu/event/phd-thesis-defence-aida-garrido/
LOCATION:Sala de Graus – Campus de Bellvitge
CATEGORIES:PhD Thesis Defence
END:VEVENT
END:VCALENDAR