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DTSTART;TZID=Europe/Madrid:20211203T100000
DTEND;TZID=Europe/Madrid:20211203T120000
DTSTAMP:20260403T200557
CREATED:20210917T110911Z
LAST-MODIFIED:20211123T152952Z
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SUMMARY:Online IBEC Seminar: Arnau Hervera
DESCRIPTION:Therapeutic effects of HDAC3 inhibition on spinal injuries and autoimmune demyelinating diseases\nArnau Hervera\, Molecular and Cellular Neurobiotechnology \nThe molecular mechanisms discriminating between regenerative failure and success remain elusive. While a regeneration-competent peripheral nerve injury mounts a regenerative gene expression response in bipolar dorsal root ganglia (DRG) sensory neurons\, a regeneration-incompetent central spinal cord injury does not. This dichotomic response offered us a unique opportunity to investigate the fundamental biological mechanisms underpinning this regenerative ability. Following a pharmacological screen with small molecule inhibitors targeting key epigenetic enzymes in DRG neurons we identified HDAC3 signaling as a novel candidate\, that hindered axonal regenerative growth. In vivo\, we found that only a peripheral but not a central axonal injury induced an increase in calcium\, activating protein phosphatase 4 (PP4) who in turn dephosphorylates HDAC3 thus impairing its activity and enhancing histone acetylation. Bioinformatics analysis of ex vivo H3K9ac ChIPseq and RNAseq from DRG followed by promoter acetylation and protein expression studies implicated HDAC3 in the regulation of multiple regenerative pathways. Additionally\, we and others have found that\, HDAC3 inhibition is able to modulate the neuroinflammatory environment in the CNS after injury. In that sense\, after CNS injury\, inflammatory phase transitions are poorly orchestrated leading to unresolved exaggerated inflammation that triggers secondary damage and functional deficits. We found that HDAC3 inhibition also altered the cytokinome after SCI\, and we are currently characterizing the effects of this inhibition on the functions of different immune cells after SCI. Additionally\, HDAC3 inhibition has been also previously described to play important roles in neuronal survival\, lymphocyte differentiation and myelination\, together with neuroinflammation\, all these processes are essential regulators on the development and outcome of autoimmune demyelinating diseases\, such as MS. In this direction\, we are also currently studying the potential therapeutic effects of HDAC3 inhibition in the multiple sclerosis mouse model Experimental Autoimmune Encephalitis (EAE)\, as well as their underlying mechanisms\, in neuroinflammation autoantigen presentation\, lymphocyte differentiation\, demyelination\, remyelination and oligodendrocyte survival and differentiation. \nThis seminar will be held using the GoToMeeting app
URL:https://ibecbarcelona.eu/event/online-ibec-seminar-arnau-hervera/
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20211130T160000
DTEND;TZID=Europe/Madrid:20211130T170000
DTSTAMP:20260403T200557
CREATED:20211110T120518Z
LAST-MODIFIED:20211124T114657Z
UID:88450-1638288000-1638291600@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Rob Jelier
DESCRIPTION:The effect of gene loss on adaptation | 3D cell shape analysis in embryos\nRob Jelier\, CMPG – Predictive Genetics and Multicellular Systems University of Leuven \nIn this talk I will summarize two research projects. First\, I will report on a large-scale experimental evolution study into the effect of gene deletion on adaptation. We found gene deletion can speed up adaptation. Further\, tracking adaptation after the systematic perturbation of genes involved in a complex trait informs on the genetic architecture of the trait. Second\, we have developed a segmentation-pipeline for membrane tagged cells from fluorescent microscopy timelapses. The pipeline uses a biophysical DEM model of cell shape to constrain the possible cell shapes. The retrieved accurate cell shapes are subsequently used for very sensitive characterization of cell shapes\, for example to identify changes after perturbations. \nThis seminar will be held at Tower I\, 11th floor Baobab room\, there will be 30 avialable seats\, the free spots will be assigned on a first come first served basis. If you wish to attend this seminar online\, please write to ibeccommunications@ibecbarcelona.eu.
URL:https://ibecbarcelona.eu/event/ibec-seminar-rob-jelier/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20211126T100000
DTEND;TZID=Europe/Madrid:20211126T120000
DTSTAMP:20260403T200557
CREATED:20210909T094150Z
LAST-MODIFIED:20211117T150528Z
UID:87087-1637920800-1637928000@ibecbarcelona.eu
SUMMARY:PhD Discussions: Yolanda Castillo and Marc Molina
DESCRIPTION:Assessment of trunk function in patients with spinal cord injury using electromyography and smartphone accelerometry\nYolanda Castillo\, Biomedical Signal Processing and Interpretation \nSpinal cord injury (SCI) causes motor and sensory impairment below the level of the injury\, but also many other health problems. A common consequence of SCI is the lack of control over trunk muscles\, leading to deficits in postural control and balance while sitting. Since trunk stability is essential to maintain upright posture and support functional movements\, impaired trunk function constitutes a major cause of motor disability in SCI patients\, limiting their independence and quality of life. However\, trunk stability is rarely examined in studies of mobility after SCI\, and one of the reasons is the lack of quantitative measures for assessing trunk function. Here we propose to record and analyze electromyographic (EMG) and smartphone accelerometric data to extract quantitative measures for the evaluation of trunk function. Our aims were: 1) to characterize muscle activity and movement patterns of trunk flexion during a reaching task in healthy subjects and patients with SCI\, 2) to compare the impact of cervical and thoracic injuries in trunk function\, and 3) to investigate the potentially destabilizing effects of a startling acoustic stimulus in this task. For these purposes\, during a reaching movement requiring trunk flexion\, we recorded the EMG activity of 8 trunk\, neck\, and shoulder muscles and smartphone accelerometer data from individuals with cervical SCI\, thoracic SCI\, and healthy control subjects. We analyzed these signals and extracted different features\, including the response time until pressing a target button\, EMG onset latencies and amplitudes\, and trunk tilt\, lateral deviation\, and other movement features from accelerometry. The proposed outcome measures revealed deficits in postural control and compensatory strategies employed by SCI patients\, including delayed responses and higher lateral deviations\, which might have important consequences for rehabilitation. The combination of EMG and smartphone accelerometer data can help to develop more suitable methods for the assessment of trunk function in individuals with SCI\, thus improving the follow-up and management of these patients. \nDevelopment of a model of “macro” substrates for the analysis of 3D chromatin structure and transcriptional profiling\nMarc Molina\, Cellular and Molecular Mechanobiology \nMechanically-induced changes in the genome are increasingly recognized as major drivers of cell and tissue function. However\, current and past studies on this topic in vitro have often been limited by the sample size required for these genomic analyses. Here we describe the development of a polyacrylamide gel (pAAg) substrate with larger area than gels previously generated in labs worldwide. These substrates display the same tunable stiffness as their smaller counterparts and are particularly suitable to accommodate large numbers of cells. We tested the substrates to assess the effect that changes in rigidity have in the cell’s genome\, both at the level of chromatin organization and transcriptional regulation. For this\, two different rigidities were used (soft vs stiff) with three conditions which included: i) a control group\, ii) a transiently expressing mutant of RanQ69L that prevents all nucleocytoplasmic transport and iii) a transiently expressing mutant of NES1-KASH that prevents force transmission to the nucleus. Our preliminary results suggest that cells seeded on pAAg substrates of different rigidities display differences in chromatin structure and gene expression\, but more data will be necessary to further support these results. Ultimately\, the aim of our project is to understand down the road how changes in rigidity affect: i) the 3D structure and interaction map of chromatin and ii) the activated or repressed transcriptional programs in soft and stiff substrates. Overall\, this new model will help us to characterize how the genome is affected by rigidity both at the structural and transcriptional levels. More broadly\, we expect the potential findings of this work to help the community detailing the effect of changes in tissue stiffness in the genome spatial organization. \nThis PhD Discussion will be hybrid. Yolanda Castillo will be doing her presentation online and Marc from the Baobab room\, located in tower I floor 11. To follow the session online\, find here the link\, we will be using the GoToMeeting app. If you wish to attend in person\, the free spots will be assigned on a first come first served basis\, the capacity of the room is for 30 people.
URL:https://ibecbarcelona.eu/event/phd-discussions-yolanda-castillo-and-marc-molina/
CATEGORIES:PhD Discussions Session
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20211119T100000
DTEND;TZID=Europe/Madrid:20211119T120000
DTSTAMP:20260403T200557
CREATED:20210901T151522Z
LAST-MODIFIED:20211110T120644Z
UID:86930-1637316000-1637323200@ibecbarcelona.eu
SUMMARY:IBEC Seminar: Cristina Mayor-Ruiz
DESCRIPTION:Targeted protein degradation: genetic determinants and drug discovery opportunities\nCristina Mayor-Ruiz\, IRBarcelona \nTargeted protein degradation is a new therapeutic modality based on drugs that destabilize proteins by inducing their proximity to E3 ubiquitin ligases. Of particular interest are “molecular glue degraders”: compounds that can degrade otherwise unligandable proteins by orchestrating direct interactions between target and E3. However\, their discovery has been serendipitous\, thus hampering broad translational efforts. I will present a scalable target-agnostic strategy toward glue degrader discovery. This approach is based on differential chemical screening coupled to a multi-omics target deconvolution campaign. Collectively\, our data outline a versatile and broadly applicable strategy to identify degraders and thus empower future drug discovery efforts. \n\nThis seminar will be held at Tower I\, 11th floor Baobab room\, there will be 30 avialable seats\, the free spots will be assigned on a first come first served basis. If you wish to attend this seminar online\, please write to ibeccommunications@ibecbarcelona.eu. \nMore information about Cristina Mayor-Ruiz’s research here \nCristina Mayor-Ruiz obtained her PhD in 2017 at the CNIO (Madrid) under the supervision of Óscar Fernández-Capetillo. There\, she explored mechanisms of resistance to anticancer therapies. In 2018\, she joined the group of Georg Winter at CeMM (Vienna) supported by EMBO and Marie Curie postdoctoral fellowships\, where her interests focused on different aspects of chemical biology and drug screening. Since January 2021\, she leads the “Targeted Protein Degradation & Drug discovery” lab at IRB Barcelona. Her research focuses on: \n(1) Developing screening strategies for early drug discovery. In particular\,  to identify monovalent degraders and other proximity-inducing drugs with therapeutic interest. \n(2) Tackling exciting biological questions that either benefit from the high kinetic resolution provided by targeted protein degradation\, or that involve E3 (dys)regulation dynamics. \n 
URL:https://ibecbarcelona.eu/event/online-ibec-seminar-cristina-mayor-ruiz/
LOCATION:IBEC\, floor 11\, Tower I\, Baldiri Reixac 4-8\, 08028 Barcelona\, Spain
CATEGORIES:IBEC Seminar
ORGANIZER;CN="IBEC":MAILTO:www.ibecbarcelona.eu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20211118T180000
DTEND;TZID=Europe/Madrid:20211118T190000
DTSTAMP:20260403T200557
CREATED:20211108T152048Z
LAST-MODIFIED:20211108T152108Z
UID:88405-1637258400-1637262000@ibecbarcelona.eu
SUMMARY:La recerca en Parkinson
DESCRIPTION:Vine a l’IBEC durant la Setmana de la Ciència i podràs conèixer els últims avenços sobre la recerca en Parkinson\, visitar els nostres laboratoris i parlar amb els i les protagonistes d’aquesta recerca.\n\n\n\n\n\nEn el marc de la setmana de la ciència\, us convidem a una jornada de portes obertes on podreu visitar els laboratoris de la Professora Sílvia Muro\, investigadora ICREA a l’IBEC i responsable del projecte de recerca en Parkinson. \nMés informació sobre aquesta investigació aquí
URL:https://ibecbarcelona.eu/event/la-recerca-en-parkinson/
LOCATION:IBEC
CATEGORIES:Outreach / Fair / Festival
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20211117T183000
DTEND;TZID=Europe/Madrid:20211117T193000
DTSTAMP:20260403T200557
CREATED:20211007T120350Z
LAST-MODIFIED:20211108T160240Z
UID:87683-1637173800-1637177400@ibecbarcelona.eu
SUMMARY:¡Adéntrate en la nano-escala: descubre y juega con el Microscopio de Fuerza Atómica! - Semana de la ciencia
DESCRIPTION:¡Adéntrate en la nano-escala: descubre y juega con el Microscopio de Fuerza Atómica!\n \nDesde que en la década de los 80 se inventara el microscopio de sonda de barrido\, han sido muchos y muy relevantes los descubrimientos que estas técnicas han proporcionado al conocimiento científico. Aun hoy\, es un instrumento capaz de detectar fenómenos increíbles que se dan en la escala de lo muy pequeño\, fenómenos que nos acercan más y más a la comprensión de este mundo sujeto a fuerzas muy distintas de lo cotidiano. \nEn esta charla con el investigador Rubén Millán del Instituto de Bioingeniería de Cataluña (IBEC)\, podréis descubrir cómo funciona un microscopio de AFM\, tendréis la posibilidad de probar en vivo el juego “Catch me AFM”\, y de conocer a nuestra superheroína científica IBBI. \n¡No os lo podéis perder! Inscripciones aquí. \n\nCharla divulgativa sobre la microscopia AFM en el marco de la “Setmana de la ciència 2021“
URL:https://ibecbarcelona.eu/event/adentrate-en-la-nano-escala-descubre-y-juega-con-el-microscopio-de-fuerza-atomica-semana-de-la-ciencia/
LOCATION:Sala Félix Serratosa – PCB\, c/ Baldiri i reixac 10-12\, Barcelona\, Spain\, 08028\, Spain
CATEGORIES:Outreach / Fair / Festival
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20211027T090000
DTEND;TZID=Europe/Madrid:20211028T183000
DTSTAMP:20260403T200557
CREATED:20210629T090725Z
LAST-MODIFIED:20210629T090725Z
UID:85746-1635325200-1635445800@ibecbarcelona.eu
SUMMARY:14th IBEC Symposium - Bioengineering for Regenerative Therapies
DESCRIPTION:Registration is now open for the 14th IBEC Symposium on Bioengineering for Regenerative Therapies\nThe 14th IBEC Symposium will focus on one of our three main areas of application of research at IBEC: Regenerative Therapies. Although this year the pandemic situation has improved\, we still believe it is not safe enough to organize the symposium on-site. So\, this year’s edition will be also celebrated online. \nWe will use the same online platform as last year\, where all the talks will be streamed and posters will be available. To adapt to the online format\, the Symposium will be divided into two days. \nAll the scientific community is invited to participate. Attendees from IBEC and abroad are welcome to present their research in their own virtual space by submitting an abstract. Moreover\, some of these contributions will be selected by the scientific committee for an oral flash presentation. \nThis year we will evaluate your virtual space\, which you will be able to personalise and upload all kinds of material (both visual and written) to show the attendees your work\, if you abstract is selected. The evaluation will be carried out by a scientific committee and also by vote by the attendees\, so two awards will be given. \nAlso\, it is important that you submit your abstract and register at the same time. \n\nImportant deadlines:\nAbstract submission: 15/09/2021\nNotification of acceptance: 06/10/2021\nRegistration deadline: 26/10/2021 \n\n 
URL:https://ibecbarcelona.eu/event/14th-ibec-symposium-bioengineering-for-regenerative-therapies/
CATEGORIES:IBEC Symposium / Conference / Congress / Workshop
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20211026T100000
DTEND;TZID=Europe/Madrid:20211026T130000
DTSTAMP:20260403T200557
CREATED:20211025T135932Z
LAST-MODIFIED:20211025T143408Z
UID:88028-1635242400-1635253200@ibecbarcelona.eu
SUMMARY:4th IBEC-ICMS Joint Symposium
DESCRIPTION:The event is in the framework of an alliance between the Institute for Bioengineering of Catalonia (IBEC) and the Institute for Complex Molecular Systems (ICMS)\, a research institute of the Eindhoven University of Technology (TU/e).\n \nThe event aims to identify synergies and potential for collaboration between IBEC groups and the researchers of ICMS. It is the 4th edition of a series of joint symposiums that started in Eindhoven on September 2018.  During that symposium many natural connections initiated for the benefit of both our organizations. We therefore feel that there are excellent opportunities to further strengthen the ties between our institutes. Therefore\, we are organizing a number of scientific exchanges and working on the identification of common research interests. \nThis fourth ICMS-IBEC Symposium will be a great opportunity to foster collaborations\, strengthen the existing ones\, and an opportunity for young researchers involved in the exchange program to present their activities in the partner organization. \nThe event will be held online using the Teams app. You can register here
URL:https://ibecbarcelona.eu/event/4th-ibec-icms-joint-symposium/
CATEGORIES:Joint seminar / workshop / symposium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20211025T153000
DTEND;TZID=Europe/Madrid:20211025T173000
DTSTAMP:20260403T200557
CREATED:20211020T092852Z
LAST-MODIFIED:20211020T092852Z
UID:87921-1635175800-1635183000@ibecbarcelona.eu
SUMMARY:PhD Thesis Defence: Ignasi Ferrer Lluís
DESCRIPTION:Novel mHealth and multimodal physiological biomarkers for non-invasive monitoring and home healthcare of obstructive sleep apnea and COPD patients with comorbidities\nIgnasi Ferrer Lluís\, Biomedical Signal Processing and Interpretation \nhe defence will take place online\, using the “Google Meet” app. If you wish to attend to this defence you can find the link here
URL:https://ibecbarcelona.eu/event/phd-thesis-defence-ignasi-ferrer-lluis/
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20211022T100000
DTEND;TZID=Europe/Madrid:20211022T120000
DTSTAMP:20260403T200557
CREATED:20211005T153325Z
LAST-MODIFIED:20211013T073030Z
UID:87598-1634896800-1634904000@ibecbarcelona.eu
SUMMARY:Hybrid IBEC Seminar: Cesar Rodriguez-Emmenegger
DESCRIPTION:Bio-inspired soft matter at the service of interactive biointerfaces and synthetic cells\nCesar Rodriguez-Emmenegger\, Group Leader\, DWI-Leibniz Institute for Interactive Materials \nNature achieves unmatched functionality by the self-assembly of (macro)molecular building blocks in a hierarchical manner. All information necessary for the function is encoded at the molecular level. Unraveling such blueprints serves as a powerful paradigm in the bio-inspired synthesis of materials that can seamlessly interface with living matter or perform non-natural functions. In this talk\, I will present a selection of research studies from my lab addressing the overarching task of developing bio-inspired interactive materials and their application in the biomedical field. Three themes will be considered. Firstly\, I will present hydrophilic arborescent polymers\, a new class of quasi-dendritic macromolecules in which the topology codes for extreme flexibility and enables a myriad of multivalent interactions. Secondly\, I will present highlights of the antimicrobial Kill&Repel and Adaptive hemocompatible nanocoatings and our efforts in translating them to medical devices. The last part of the talk will focus on the development of Membrane Machines\, tailor-made synthetic vesicles capable of recapitulating some fundamental biological properties and performing specific tasks. We take advantage of these systems to study how biological selectivity can emerge from the lateral organization of ligand in static and dynamic systems such as the bacterial divisome. We are also developing synthetic macrophage-mimetic microrobots capable of endocytosing bacteria and viruses\, including SARS-CoV-2. \nThis seminar will be hybrid\, using the GoToMeeting app and also at the Baobab meeting room located at Tower I\, 11th floor. Very few people will be able to attend this seminar in person due to the capacity of the meeting room.  If you wish to attend this seminar please write an email to ibeccommunications@ibecbarcelona.eu the free spots will be assigned on a first come first served basis.. The seminar will also be available on streaming\, by using the GoToMeeting app\, available in this link. \nMore information about his research team here
URL:https://ibecbarcelona.eu/event/hybrid-ibec-seminar-cesar-rodriguez-emmenegger/
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20211015T100000
DTEND;TZID=Europe/Madrid:20211015T120000
DTSTAMP:20260403T200557
CREATED:20210909T072358Z
LAST-MODIFIED:20211005T101926Z
UID:87071-1634292000-1634299200@ibecbarcelona.eu
SUMMARY:Online IBEC Seminar: Mohit Kumar
DESCRIPTION:Peptide based nanomaterials with life-like functions\nMohit Kumar\, Molecular Bionics group at IBEC \nChemists’ curiosity to create life de novo has sought inspiration from biological systems. In nature\, self-assembled nanostructures constantly form and degrade which provides unique features like on-demand function\, adaptation\, temporal and spatial control. Such processes are enabled by the metabolism and the ability to consume chemical energy to perform useful work. However\, these features are not trivial to obtain in synthetic systems. My talk will show that now peptide based self-assembled materials can also form and degrade over time and their nanostructures and functions can be regulated in time by consuming chemical fuel. Furthermore\, by using super-resolution imaging dynamic transformations in solution can be probed in real-time\, in situ. \nThis seminar will be held using the GoToMeeting app
URL:https://ibecbarcelona.eu/event/online-ibec-seminar-mohit-kumar/
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20211008T100000
DTEND;TZID=Europe/Madrid:20211008T120000
DTSTAMP:20260403T200557
CREATED:20210917T110652Z
LAST-MODIFIED:20210929T075522Z
UID:87233-1633687200-1633694400@ibecbarcelona.eu
SUMMARY:Online IBEC Seminar: Veronika Magdanz
DESCRIPTION:Development of biohybrid and bioinspired microrobots toward biomedical applications\nVeronika Magdanz\, Smart Nano-Bio-Devices \nAutonomous motion and precise control on the microscale is one of the main challenges in developing non-invasive medical microrobots. In this seminar\, I present my approaches of how to develop artificial\, biomimetic and biohybrid microrobots. We can be inspired by nature’s solutions to achieve such propulsion on the microscale. Specifically\, sperm cells offer beneficial features as components of microrobots: as propulsion sources\, as templates and as cargo. By combining smart microstructures with spermatozoa\, new ways to control and manipulate sperm cells emerge. \nThis seminar will be held using the GoToMeeting app \n 
URL:https://ibecbarcelona.eu/event/online-ibec-seminar-veronika-magdanz/
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20210920T100000
DTEND;TZID=Europe/Madrid:20210920T130000
DTSTAMP:20260403T200557
CREATED:20210916T100813Z
LAST-MODIFIED:20210916T100929Z
UID:87218-1632132000-1632142800@ibecbarcelona.eu
SUMMARY:PhD Thesis Defence: Alexandre Gomila
DESCRIPTION:Development and characterization of in vivo models for photopharmacology\nAlexandre Gomila\, Nanoprobes and Nanoswitches \nThe defence will take place online\, if you wish to attend to this defence you can find the link here
URL:https://ibecbarcelona.eu/event/phd-thesis-defence-alexandre-gomila/
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20210917T100000
DTEND;TZID=Europe/Madrid:20210917T120000
DTSTAMP:20260403T200557
CREATED:20210901T145722Z
LAST-MODIFIED:20210909T072941Z
UID:86914-1631872800-1631880000@ibecbarcelona.eu
SUMMARY:Online IBEC Seminar: Daniel Gonzalez-Carter
DESCRIPTION:Delivering Nanoparticles Specifically to the Brain by Generating Artificial Brain Targets\nDaniel Gonzalez-Carter\, Molecular Bionics group at IBEC \nAchieving efficient therapy delivery to the brain is one of the most pressing medical issues today. Therapy brain delivery is severely hampered by the protective blood-brain barrier (BBB)\, composed of the highly impermeable endothelial cells lining the brain vasculature.  To overcome the BBB\, therapies may be loaded onto nanoparticles functionalized with ligands which bind to target proteins expressed at the surface of brain endothelial cells (BEC)\, thereby increasing brain uptake. However\, such strategies have inherent brain-specificity limitations\, as the target proteins are also expressed on the vasculature of other organs\, resulting in increased ‘off-target’ nanoparticle accumulation. \nTo achieve truly selective brain targeting\, our group is developing a strategy to generate artificial targets exclusively at the BBB. This is done by exploiting the low endocytic rate of BEC\, a key requirement for their high impermeability\, to selectively retain exogenous targets on their surface. By generating nanoparticles capable of efficiently recognizing the artificial targets\, we hope to increase nanoparticle delivery exclusively to the brain with minimal ‘off-target’ nanoparticle accumulation. Furthermore\, we are developing an mRNA delivery platform to continuously re-generate the artificial targets from within the BEC to allow for repeated dosing in chronic diseases like Alzheimer’s disease.
URL:https://ibecbarcelona.eu/event/online-ibec-seminar-daniel-gonzalez-carter/
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20210909T113000
DTEND;TZID=Europe/Madrid:20210909T133000
DTSTAMP:20260403T200557
CREATED:20210727T101114Z
LAST-MODIFIED:20210727T101114Z
UID:86553-1631187000-1631194200@ibecbarcelona.eu
SUMMARY:PhD Thesis Defence: Adrianna Glinkowska
DESCRIPTION:Formulation and screening of drug nanocarriers using microfluidic technology\nAdrianna Glinkowska\, Nanoscopy for nanomedicine \nThe defence will take place online\, if you wish to attend to this defence you can find the link and more information here \n 
URL:https://ibecbarcelona.eu/event/phd-thesis-defence-adrianna-glinkowska/
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20210903T110000
DTEND;TZID=Europe/Madrid:20210903T130000
DTSTAMP:20260403T200557
CREATED:20210811T082116Z
LAST-MODIFIED:20210811T082205Z
UID:86797-1630666800-1630674000@ibecbarcelona.eu
SUMMARY:PhD Thesis Defence: Ana Candida Lopes Hortelão
DESCRIPTION:Enzyme Powered Nanomotors Towards Biomedical Applications\nAna Candida Lopes Hortelão\, Smart Nano-bio-devices group \nThe defence will take place online\, if you wish to attend to this defence you can find the link and more information here
URL:https://ibecbarcelona.eu/event/phd-thesis-defence-ana-candida-lopes-hortelao/
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20210716T100000
DTEND;TZID=Europe/Madrid:20210716T120000
DTSTAMP:20260403T200557
CREATED:20210628T090824Z
LAST-MODIFIED:20210628T105106Z
UID:85642-1626429600-1626436800@ibecbarcelona.eu
SUMMARY:Online IBEC Seminar: Pau Gorostiza
DESCRIPTION:Electrochemically Gated Charge Transport in Redox Proteins and Photosynthetic Complexes\n\nPau Gorostiza\, group leader of the Nanoprobes and nanoswitches group at IBEC \nInterprotein electron transport is an essential process in cell respiration and photosynthesis. It takes place between redox proteins and complexes\, and it displays an outstanding efficiency and environmental adaptability. Although the biochemistry of electron transport processes is well characterized\, nanoscale experimental methods are needed to understand electronic pathways in these redox protein structures\, both for fundamental and for technological purposes. Electrochemical scanning tunneling microscopy (ECSTM) is an excellent tool to study electronic materials and redox molecules including proteins. It offers single molecule resolution and allows working in aqueous solution\, in nearly physiological conditions in the case of proteins\, and under full electrochemical control. ECSTM also allows performing conductance measurements by current-potential and current-distance tunneling spectroscopy. An overview of these methods and current projects in the laboratory will be presented\, with special emphasis on cytochromes of the respiratory chain and on photosystem I complexes. \nMore information about Pau Gorostiza’s research here \nThis seminar will be held using the TEAMS app
URL:https://ibecbarcelona.eu/event/online-ibec-seminar-pau-gorostiza/
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20210709T100000
DTEND;TZID=Europe/Madrid:20210709T120000
DTSTAMP:20260403T200557
CREATED:20210628T090521Z
LAST-MODIFIED:20210628T105718Z
UID:85638-1625824800-1625832000@ibecbarcelona.eu
SUMMARY:Online IBEC Seminar: Xavier Fernàndez-Busquets
DESCRIPTION:Nanomalaria group: 20 years at IBEC\nXavier Fernàndez-Busques\, group leader of the Nanomalaria group at IBEC \nWe will start by briefly looking at the origins of our group back in 2001 as part of IBEC’s embryo\, the Research Center for Bioelectronics and Nanobioscience. Our current activities integrate two decades of cumulative research oriented to the development of targeted nanocarriers for parasitic diseases with focus on malaria but currently expanding to leishmaniasis. \nBecause eventual antimalarial nanomedicines need to be deployed in low per capita income regions\, their final components must take into account this particular economic landscape. Liposomes and polymeric nanocarriers offer advantages and suffer from limitations depending on the severity of the disease in each particular clinical case. Entering erythrocytes\, the host cell of Plasmodium in the blood circulation\, is a challenge in itself due to their lack of endocytic processes. Antibodies\, polysaccharides like heparin\, synthetic polymers and DNA aptamers have been used to target and eventually penetrate red blood cells. \nFinally\, we have recently launched an effort to discover new antimalarial drugs that should constitute the third and final element in the design of targeted nanocarriers for malaria. The know-how acquired in the development of nanocapsules\, targeting elements and drugs has the capacity of being exported to other infectious diseases. Because\, no matter how cost-efficient you can make a nanomedicine\, clinical trials will significantly increase its cost\, we are exploring a radical alternative: designing nanocarriers to target the parasites in their arthropod vectors. \nMore information about Xavier’s research here \nThis seminar will be held using the TEAMS app \n 
URL:https://ibecbarcelona.eu/event/online-ibec-seminar-xavier-fernandez-busquets/
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20210702T100000
DTEND;TZID=Europe/Madrid:20210702T120000
DTSTAMP:20260403T200558
CREATED:20210628T090118Z
LAST-MODIFIED:20210629T084516Z
UID:85634-1625220000-1625227200@ibecbarcelona.eu
SUMMARY:PhD Discussions: Ignasi Granero
DESCRIPTION:Ignasi Granero\, Celular and molecular mechanobiology group \nIn eukaryotic cells\, the cell nucleus contains the DNA and directs the reaction to important signalling cascades\, both biochemical and biomechanical. At the Cellular and Molecular Mechanobiology lab we study how forces and the physical characteristics of the cell environment affect cell behaviour and homeostasis. In my case\, I am interested in how the cell nucleus senses physical changes and triggers a cell response to them.\nFor this purpose\, we have engineered a battery of fluorescent proteins\, which change their location depending on the physical state of the nucleus. Higher forces in the nucleus correspond with higher nuclear accumulation of these proteins. Indicating that these proteins react to mechanical/morphological stimuli. Then\, we have chosen the variant that can be used as a mechano-sensor. Currently\, we are testing the sensor in single- and multi-cell approaches to understand its behaviour in different systems and the ruling principles under its functioning. \nThis PhD Discussion will be held online using the GoToMeeting app
URL:https://ibecbarcelona.eu/event/phd-discussions-ignasi-granero/
CATEGORIES:PhD Discussions Session
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20210701T093000
DTEND;TZID=Europe/Madrid:20210701T120000
DTSTAMP:20260403T200558
CREATED:20210622T093545Z
LAST-MODIFIED:20210622T093651Z
UID:85344-1625131800-1625140800@ibecbarcelona.eu
SUMMARY:PhD Thesis Defence: Ferran Velasco
DESCRIPTION:Carboxymethyl cellulose-based cryogels as scaffolds for pancreatic and skeletal muscle tissue engineering\nFerran Velasco\, Biosensors for bioengineering group \nThe defence will take place online\, if you wish to attend to this defence\, you have to send an email to doctoratmedicina@ub.edu and you  can find more information here \n 
URL:https://ibecbarcelona.eu/event/phd-thesis-defence-ferran-velasco/
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20210628T100000
DTEND;TZID=Europe/Madrid:20210628T120000
DTSTAMP:20260403T200558
CREATED:20210621T135519Z
LAST-MODIFIED:20210621T135842Z
UID:85281-1624874400-1624881600@ibecbarcelona.eu
SUMMARY:PhD Thesis Defence: Maria Arista
DESCRIPTION:Unveiling viral structures by single-molecule localization microscopy\nMaria Arista\, Nanoscopy for nanomedicine group \nThe defence will take place online\, if you wish to attend to this defence\, you can find the link to access here and you can find more information here
URL:https://ibecbarcelona.eu/event/phd-thesis-defence-maria-arista/
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20210623T100000
DTEND;TZID=Europe/Madrid:20210623T120000
DTSTAMP:20260403T200558
CREATED:20210622T131947Z
LAST-MODIFIED:20210622T131947Z
UID:85480-1624442400-1624449600@ibecbarcelona.eu
SUMMARY:PhD Thesis Defence: Xarxa Quiroga
DESCRIPTION:Plasma membrane mechanosensing upon stretch-induced topography remodelling\nXarxa Quiroga\, Cellular and molecular mechanobiology group. \nThe thesis defence takes place tomorrow at 10AM in the “Antoni Caparrós” auditorium\, located at the PCB Tower D\, with limited capacity.
URL:https://ibecbarcelona.eu/event/phd-thesis-defence-xarxa-quiroga/
LOCATION:Auditori Antoni Caparrós – PCB
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20210618T100000
DTEND;TZID=Europe/Madrid:20210618T120000
DTSTAMP:20260403T200558
CREATED:20210611T070229Z
LAST-MODIFIED:20210611T070255Z
UID:84958-1624010400-1624017600@ibecbarcelona.eu
SUMMARY:IBEC Online Seminar: Jessica Ilenburg
DESCRIPTION:Tissue Engineering in Microgravity\nJessica Ilenburg\, Gravitational Biotechnologist at Yuri gravity \nTissue Engineering and regenerative medicine are two fast growing and fast moving research fields. With the invention of bioprinting and tissue chips two breakthrough innovations have been made and now research in microgravity (for example on the ISS) promises even more and faster progress. A lot of advantages\, like less contact inhibition and unrestrained growth in all 3 dimensions make the cell structures grow bigger and more complex. This presentation focuses on the qualities of the unique research environment of microgravity and introduces a couple of research findings. \nJessica Ilenburg is doing her master studies in molecular biotechnology at Bielefeld University in Germany. Currently she is working at yuri GmbH as a gravitational biotechnologist focusing on Tissue Engineering\, bioprinting and protein crystal growth in microgravity. Previously she has worked at the Novo Nordisk Foundation Center for Biosustainability in Copenhagen working with thermophilic organisms and isolating proteins of the butanol pathway.
URL:https://ibecbarcelona.eu/event/ibec-online-seminar-jessica-ilenburg/
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20210608T080000
DTEND;TZID=Europe/Madrid:20210613T170000
DTSTAMP:20260403T200558
CREATED:20210607T145823Z
LAST-MODIFIED:20210607T145823Z
UID:84812-1623139200-1623603600@ibecbarcelona.eu
SUMMARY:Biennal Ciutat i Ciència
DESCRIPTION:Durant els dies 8 i 13 de juny tindrà lloc la segona edició de la Biennal Ciutat-Ciència de Barcelona\, i l’IBEC serà un dels centres que hi contribuirà\, a través dels seus experts. A més a més\, aquesta Biennal culmina amb la 14ª edició de la Festa de la Ciència\, amb moltes propostes per viure la ciència en primera persona.\n \nDes de l’IBEC\, diversos experts participen en les activitats programades per enguany: \n\nSamuel Sánchez\, Professor de Recerca ICREA\, i líder del grup “Smart Nano-bio-devices”\, paraticipa a   – “Pecha Kucha express: art\, ciència\, tecnologia”\nNuria Montserrat\, participa amb una  micro-xerrada sobre “Miniòrgans humans per entendre la covid-19”\nL´Anke Kleff\, Senior HR Development Officer a l´IBEC\, participarà en una taula rodona sobre “Expandim l´influència de la dona a la ciència”\, dins d’una nova Trobada de #100tífiques
URL:https://ibecbarcelona.eu/event/biennal-ciutat-i-ciencia-4/
CATEGORIES:Outreach / Fair / Festival
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20210604T143000
DTEND;TZID=Europe/Madrid:20210604T180000
DTSTAMP:20260403T200558
CREATED:20210513T114527Z
LAST-MODIFIED:20210513T114410Z
UID:84281-1622817000-1622829600@ibecbarcelona.eu
SUMMARY:M-CELS Workshop Barcelona Satellite
DESCRIPTION:EMBL and IBEC aim to contribute to the discussion on challenges and opportunities in the expanding field of Multi-cellular engineered living systems (M-CELS). \nWe have organized a satellite session to the M-CELS Workshop 2021 organized by the Center for Emergent Behaviors of Integrated Cellular Systems. The session aims also to be an appetizer to the 2nd EMBL-IBEC Winter Conference on Engineering Multicellular Systems to be held on 9-11th February 2022 in Barcelona. \n\n\n\n\n\n\n\n\nMulti-cellular engineered living systems are purpose-driven living systems with multiple interacting living components. They are engineered for specific goals or functions but take emergence into account during the design process\, allowing the final system to emerge through natural and non-natural biological processes. M-CELS research is intended to provide a fundamental engineering understanding that enables a quantitative approach bridging between single cells and organs or organisms. The field is still developing\, so M-CELS as a field of research is still rapidly expanding \nRegistration here
URL:https://ibecbarcelona.eu/event/m-cels-workshop-barcelona-satellite/
CATEGORIES:Joint seminar / workshop / symposium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20210525T030000
DTEND;TZID=Europe/Madrid:20210525T170000
DTSTAMP:20260403T200558
CREATED:20210518T071812Z
LAST-MODIFIED:20210518T071846Z
UID:84387-1621911600-1621962000@ibecbarcelona.eu
SUMMARY:PhD Thesis Defence: Enara Larrañaga
DESCRIPTION:Effects of substrate-derived cues in driving the self-organization of organoid-derived intestinal epithelia\nEnara Larrañaga\, Biomimetic systems for cell engineering \nThe defence will take place online\, if you wish to attend to this defence\, you can find the link to access here and you can find more information here \n 
URL:https://ibecbarcelona.eu/event/phd-thesis-defence-enara-larranaga/
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20210521T093000
DTEND;TZID=Europe/Madrid:20210521T133000
DTSTAMP:20260403T200558
CREATED:20210408T144743Z
LAST-MODIFIED:20210408T145058Z
UID:83289-1621589400-1621603800@ibecbarcelona.eu
SUMMARY:Research4Talent 2021
DESCRIPTION:On Friday 21st May we’ll open our doors virtually to UNDERGRADUATE & MASTER’s students interested in a research career\n \n  \nThe day is a chance for you to talk to our researchers and ask them questions about their day-to-day work in the lab\, career paths\, work-life balance\, mobility etc\, as well as a visit to our labs. \nIn 2020 IBEC signed more that 120 internship agreements for Undergraduate and Master Students with a wide range of national and international universities. \nThis year’s edition will be held virtually. If you are interested in IBEC’s seventh edition of reSEARCH4TALENT please stay connected\, we will soon provide more info with the links to acces the event. \nVisit the website here \n 
URL:https://ibecbarcelona.eu/event/research4talent-2021/
CATEGORIES:Outreach / Fair / Festival
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20210514T100000
DTEND;TZID=Europe/Madrid:20210514T120000
DTSTAMP:20260403T200558
CREATED:20210506T071033Z
LAST-MODIFIED:20210506T074133Z
UID:84141-1620986400-1620993600@ibecbarcelona.eu
SUMMARY:Online IBEC Seminar: Mónica Marro
DESCRIPTION:A new molecular dimension: exploiting Raman spectroscopy in Biomedicine\nMónica Marro\, ICFO\, The Institute of Photonic Sciences\n \nRaman spectroscopy is a promising optical technique that enables the investigation of the molecular content of biological samples in a rapid\, non-invasive\, label-free and multiplexed approach. In the biomedical field\, it is of special interest because the device can be portable and cost-effective. \nIn this seminar\, I will show my work exploiting Raman spectroscopy in a broad range of biomedical applications from the molecular\, to cellular and tissue level. I will present how Raman spectroscopy can represent a step forward into different fields\, namely: cancer diagnosis\, patient stratification\, and personalized medicine; neurodegeneration; and mechanobiology. I will show also optical developments that can improve Raman spectroscopy in the speed of image acquisition\, like the Raman light sheet approach\, or Surface Enhanced Raman spectroscopy. \nOverall\, I will show how Raman spectroscopy coupled with data science and developments in photonics and nano-engineering could revolutionize the biomedical field in the next years\, providing new and other-wise inaccessible molecular information\, and giving an unprecedented step towards a more rapid\, accurate\, personalized diagnosis and treatments.
URL:https://ibecbarcelona.eu/event/online-ibec-seminar-monica-marro/
CATEGORIES:IBEC Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20210512T100000
DTEND;TZID=Europe/Madrid:20210512T120000
DTSTAMP:20260403T200558
CREATED:20210507T092710Z
LAST-MODIFIED:20210507T094146Z
UID:84243-1620813600-1620820800@ibecbarcelona.eu
SUMMARY:PhD Thesis Defence: Harishankar Balakrishnan
DESCRIPTION:Nanoscale Tomography based in Electrostatic Force Microscopy\nHarishankar Balakrishnan\, Nanoscale bioelectrical characterization group \nThe defence will take place online\, if you wish to attend to this defence\, you can find the link to access here and you can find more information here \nPlease join the meeting few minutes before the mentioned time to avoid session interruption.  \nIf you are joining after the mentioned time\, please make sure your microphone is muted before joining the session.
URL:https://ibecbarcelona.eu/event/phd-thesis-defence-harishankar-balakrishnan/
CATEGORIES:PhD Thesis Defence
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Madrid:20210511T100000
DTEND;TZID=Europe/Madrid:20210511T120000
DTSTAMP:20260403T200558
CREATED:20210507T154643Z
LAST-MODIFIED:20210507T154643Z
UID:84258-1620727200-1620734400@ibecbarcelona.eu
SUMMARY:PhD Thesis Defence: Martina Di Muzio
DESCRIPTION:Nanoscale dielectric mapping of biomembranes with in-liquid Scanning Dielectric Microscopy\nMartina Di Muzio\, Nanoscale bioelectrical characterization group \nThe defence will take place online\, if you wish to attend to this defence\, you can find the link to access here and you can find more information here \nPlease join the meeting few minutes before the mentioned time to avoid session interruption. \nIf you are joining after the mentioned time\, please make sure your microphone is muted before joining the session.
URL:https://ibecbarcelona.eu/event/phd-thesis-defence-martina-di-muzio/
CATEGORIES:PhD Thesis Defence
END:VEVENT
END:VCALENDAR